IMP

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Rattus norvegicus

1 genes annotated in rat

Multi-species View

positive regulation of isotype switching

GO:0045830

Any process that activates or increases the frequency, rate or extent of isotype switching.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of isotype switching"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of isotype switching" (in gray)

Name	Description	Probability	Func Analog Organism
Cd37	CD37 molecule	0.632
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.302
RT1-Db1	RT1 class II, locus Db1	0.226
Eng	endoglin	0.208
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.181	Rat
Lcp2	lymphocyte cytosolic protein 2	0.163
Casp1	caspase 1	0.152
Ctse	cathepsin E	0.140
Syk	spleen tyrosine kinase	0.135
Cxcr4	chemokine (C-X-C motif) receptor 4	0.105
Arhgap25	Rho GTPase activating protein 25	0.101
Igsf6	immunoglobulin superfamily, member 6	0.094
Myh9	myosin, heavy chain 9, non-muscle	0.089
Slfn2	schlafen 2	0.089
Il2rg	interleukin 2 receptor, gamma	0.081
Vav1	vav 1 guanine nucleotide exchange factor	0.076
Mca32	mast cell antigen 32	0.076
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.071
Anpep	alanyl (membrane) aminopeptidase	0.068
Il1b	interleukin 1 beta	0.067
Ccnd3	cyclin D3	0.065
Stk10	serine/threonine kinase 10	0.059
Zyx	zyxin	0.058
Bak1	BCL2-antagonist/killer 1	0.058
Cd53	Cd53 molecule	0.057
Cd2	Cd2 molecule	0.051
Cd44	Cd44 molecule	0.050
Ccl3	chemokine (C-C motif) ligand 3	0.050
Mpeg1	macrophage expressed 1	0.049
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.049
Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	0.048
Hck	hemopoietic cell kinase	0.048
Ptafr	platelet-activating factor receptor	0.047
Il4ra	interleukin 4 receptor, alpha	0.047
Kcnj13	potassium inwardly-rectifying channel, subfamily J, member 13	0.044
Arl5c	ADP-ribosylation factor-like 5C	0.043
Il7r	interleukin 7 receptor	0.043
Apol3	apolipoprotein L, 3	0.042
Prkcd	protein kinase C, delta	0.041
Sec31a	SEC31 homolog A (S. cerevisiae)	0.040
Plcg2	phospholipase C, gamma 2	0.040
Vcan	versican	0.038
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.038
Akt2	v-akt murine thymoma viral oncogene homolog 2	0.038
Mcpt3	mast cell peptidase 3	0.038
RT1-Ba	RT1 class II, locus Ba	0.038
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.037
Acp5	acid phosphatase 5, tartrate resistant	0.037
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.037
Acta2	smooth muscle alpha-actin	0.036
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.035
ND4	NADH dehydrogenase subunit 4	0.035
Tln1	talin 1	0.034
Ly6c	Ly6-C antigen	0.034
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.034
Bcl2l1	Bcl2-like 1	0.033
Myo1e	myosin IE	0.033
Cd4	Cd4 molecule	0.032
Plek	pleckstrin	0.032
Clec9a	C-type lectin domain family 9, member a	0.032
Cybb	cytochrome b-245, beta polypeptide	0.031
Fmnl1	formin-like 1	0.031
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.031
Pdk4	pyruvate dehydrogenase kinase, isozyme 4	0.031
Il16	interleukin 16	0.030
Plaur	plasminogen activator, urokinase receptor	0.029
Fgfr1	Fibroblast growth factor receptor 1	0.028
Scamp2	secretory carrier membrane protein 2	0.028
Dab2	disabled homolog 2 (Drosophila)	0.028
Laptm5	lysosomal protein transmembrane 5	0.028
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.027
Ankra2	ankyrin repeat, family A (RFXANK-like), 2	0.027
Ripk3	receptor-interacting serine-threonine kinase 3	0.027
Defa	defensin, alpha 5, Paneth cell-specific	0.027
Cd22	CD22 molecule	0.025
Ccl5	chemokine (C-C motif) ligand 5	0.024
Arhgap4	Rho GTPase activating protein 4	0.024
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.024
Smad7	SMAD family member 7	0.024
Gpsm3	G-protein signaling modulator 3 (AGS3-like, C. elegans)	0.024
Ptpn7	protein tyrosine phosphatase, non-receptor type 7	0.023
Ets1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.023
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.023	Rat
Aspg	asparaginase homolog (S. cerevisiae)	0.023
Nucb1	nucleobindin 1	0.023
Psd4	pleckstrin and Sec7 domain containing 4	0.022
C3ar1	complement component 3a receptor 1	0.022
Fermt3	fermitin family homolog 3 (Drosophila)	0.022
Bcar1	breast cancer anti-estrogen resistance 1	0.022
Slc15a3	solute carrier family 15, member 3	0.022
P2ry2	purinergic receptor P2Y, G-protein coupled, 2	0.021
Bgn	biglycan	0.021
Hes2	hairy and enhancer of split 2 (Drosophila)	0.021
Myo1g	myosin IG	0.021
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.021
Sh2b2	SH2B adaptor protein 2	0.020
LOC100364854	similar to RIKEN cDNA A430107P09 gene-like	0.020
Il2rb	interleukin 2 receptor, beta	0.020
Dock8	dedicator of cytokinesis 8	0.020
Havcr1	hepatitis A virus cellular receptor 1	0.020
Cd3g	CD3 molecule, gamma	0.020
Rgs14	regulator of G-protein signaling 14	0.020
Mmp8	matrix metallopeptidase 8	0.020
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.020
Gna15	guanine nucleotide binding protein, alpha 15	0.020
Vom2r27	vomeronasal 2 receptor, 27	0.020
Amhr2	anti-Mullerian hormone receptor, type II	0.020
Kcnj8	potassium inwardly-rectifying channel, subfamily J, member 8	0.020
Evi2a	ecotropic viral integration site 2A	0.020
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.019
Ptpro	protein tyrosine phosphatase, receptor type, O	0.019
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.019
Tfec	transcription factor EC	0.019
RGD1311874	hypothetical LOC300751	0.019
Bcl2a1d	B-cell leukemia/lymphoma 2 related protein A1d	0.019
Trpv2	transient receptor potential cation channel, subfamily V, member 2	0.018
Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.018
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.018
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.018
Arrb2	arrestin, beta 2	0.018
Cnr2	cannabinoid receptor 2 (macrophage)	0.018
Sod3	superoxide dismutase 3, extracellular	0.017
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.017
Itgb7	integrin, beta 7	0.017
Cxcl10	chemokine (C-X-C motif) ligand 10	0.017
Csn1s1	casein alpha s1	0.017
Pparg	peroxisome proliferator-activated receptor gamma	0.017
RGD1564664	similar to LOC387763 protein	0.017
Adrb2	adrenergic, beta-2-, receptor, surface	0.017
Col4a4	collagen, type IV, alpha 4	0.017
Bche	butyrylcholinesterase	0.016
Aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.016
Cd247	Cd247 molecule	0.016
Gdf15	growth differentiation factor 15	0.016
Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	0.016
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.016
Lama3	laminin, alpha 3	0.016
Abcb4	ATP-binding cassette, subfamily B (MDR/TAP), member 4	0.016
Dok2	docking protein 2	0.016
Sirpa	signal-regulatory protein alpha	0.016
Sell	selectin L	0.016
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.016
Plau	plasminogen activator, urokinase	0.016
Ly6b	lymphocyte antigen 6 complex, locus B	0.016
Icam1	intercellular adhesion molecule 1	0.016
Wwtr1	WW domain containing transcription regulator 1	0.016
Dchs1	dachsous 1 (Drosophila)	0.016
Epha2	Eph receptor A2	0.016
Dusp2	dual specificity phosphatase 2	0.016
Itgb4	integrin, beta 4	0.016
Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	0.015
Hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.015
Cspg4	chondroitin sulfate proteoglycan 4	0.015
Cyp4f5	cytochrome P450, family 4, subfamily f, polypeptide 5	0.015
Accn5	amiloride-sensitive cation channel 5, intestinal	0.015
Prkch	protein kinase C, eta	0.015
Klf13	Kruppel-like factor 13	0.015
Rxra	retinoid X receptor alpha	0.015
Lcp1	lymphocyte cytosolic protein 1	0.015
Cd28	Cd28 molecule	0.015	Mouse
RGD1308350	similar to hypothetical protein MGC13251	0.015
Tgm4	transglutaminase 4 (prostate)	0.015
Map3k1	mitogen activated protein kinase kinase kinase 1	0.015
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.015
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.015
Mmp12	matrix metallopeptidase 12	0.015
Atp12a	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	0.015
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.015
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.015
Cd74	Cd74 molecule, major histocompatibility complex, class II invariant chain	0.015
Cd38	CD38 molecule	0.015
Gja4	gap junction protein, alpha 4	0.015
Erg	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.015
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.014
Ece1	endothelin converting enzyme 1	0.014
RGD1564387	similar to RIKEN cDNA C030014K22 gene	0.014
Bin2	bridging integrator 2	0.014
Tec	tec protein tyrosine kinase	0.014
Igh-6	immunoglobulin heavy chain 6	0.014
Chrne	cholinergic receptor, nicotinic, epsilon	0.014
Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	0.014
Tgfbr2	transforming growth factor, beta receptor II	0.014
Prx	periaxin	0.014
RT1-Da	RT1 class II, locus Da	0.014
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.014
Npr2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	0.014
Rassf9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	0.014
Reg1a	regenerating islet-derived 1 alpha	0.014
Ube2d4	ubiquitin-conjugating enzyme E2D 4	0.014
Krt20	keratin 20	0.014
Fam65b	family with sequence similarity 65, member B	0.014
Fam38a	family with sequence similarity 38, member A	0.013
Plac8	placenta-specific 8	0.013
Wt1	Wilms tumor 1	0.013
Rin3	Ras and Rab interactor 3	0.013
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.013
Rasa2	RAS p21 protein activator 2	0.013
Birc3	baculoviral IAP repeat-containing 3	0.013
RT1-Bb	RT1 class II, locus Bb	0.013
Tsc1	tuberous sclerosis 1	0.013
Pglyrp1	peptidoglycan recognition protein 1	0.013
Dact2	dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)	0.013
Gpr4	G protein-coupled receptor 4	0.013
Pim1	pim-1 oncogene	0.013
Col4a1	collagen, type IV, alpha 1	0.013
Itga2b	integrin, alpha 2B	0.013
Hdac7	histone deacetylase 7	0.013
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.013
Irf5	interferon regulatory factor 5	0.012
Sycp1	synaptonemal complex protein 1	0.012
Ncf1	neutrophil cytosolic factor 1	0.012
Slc28a2	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	0.012
Cyth1	cytohesin 1	0.012
Slc9a3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.012
Cyp2c12	cytochrome P450, family 2, subfamily c, polypeptide 12	0.012
Inpp5d	inositol polyphosphate-5-phosphatase D	0.012
LOC100363783	rCG53773-like	0.012
Ugcg	UDP-glucose ceramide glucosyltransferase	0.012
Ptprcap	protein tyrosine phosphatase, receptor type, C-associated protein	0.012
Grk5	G protein-coupled receptor kinase 5	0.012
Hbg1	hemoglobin, gamma A	0.012
Actg2	actin, gamma 2, smooth muscle, enteric	0.012
Slc22a3	solute carrier family 22 (extraneuronal monoamine transporter), member 3	0.012
Gjb2	gap junction protein, beta 2	0.012
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.012
Hemgn	hemogen	0.012
Cyp2c22	cytochrome P450, family 2, subfamily c, polypeptide 22	0.012
F13a1	coagulation factor XIII, A1 polypeptide	0.012
Pbsn	probasin	0.012
Abi3	ABI family, member 3	0.012
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.012
Tgfb1	transforming growth factor, beta 1	0.012	Human
Fam100a	family with sequence similarity 100, member A	0.012
Papss1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	0.012
Flnb	filamin, beta	0.012
Tgm1	transglutaminase 1, K polypeptide	0.012
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.012
Abcc3	ATP-binding cassette, subfamily C (CFTR/MRP), member 3	0.012
Gucy2c	guanylate cyclase 2C	0.012
Msn	moesin	0.012
Crlf2	cytokine receptor-like factor 2	0.012
Slco1a5	solute carrier organic anion transporter family, member 1a5	0.012
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.011
Ccl22	chemokine (C-C motif) ligand 22	0.011
Dnase2b	deoxyribonuclease II beta	0.011
Il18	interleukin 18	0.011
Sash3	SAM and SH3 domain containing 3	0.011
Cyp2a3	cytochrome P450, family 2, subfamily a, polypeptide 3	0.011
Fmo1	flavin containing monooxygenase 1	0.011
Ccl4	chemokine (C-C motif) ligand 4	0.011
Pcsk7	proprotein convertase subtilisin/kexin type 7	0.011
Pcsk9	proprotein convertase subtilisin/kexin type 9	0.011
Rnd3	Rho family GTPase 3	0.011
Arhgap9	Rho GTPase activating protein 9	0.011
Itgam	integrin, alpha M	0.011
Cd209b	CD209b antigen	0.011
LOC100361830	translocating chain-associating membrane protein 2	0.011
Usf2	upstream transcription factor 2, c-fos interacting	0.011
Il17b	interleukin 17B	0.011
Nos3	nitric oxide synthase 3, endothelial cell	0.011
Gfpt1	glutamine fructose-6-phosphate transaminase 1	0.011
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.011
Gpr114	G protein-coupled receptor 114	0.011
Aif1	allograft inflammatory factor 1	0.011
Card9	caspase recruitment domain family, member 9	0.011
Mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.011
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.011
Gfi1b	growth factor independent 1B transcription repressor	0.011
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.011
Arhgap27	Rho GTPase activating protein 27	0.011
Efna5	ephrin A5	0.011
Hivep1	human immunodeficiency virus type I enhancer binding protein 1	0.011
Zhx2	zinc fingers and homeoboxes 2	0.011
Pfkfb3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.011
Clic5	chloride intracellular channel 5	0.010
Trat1	T cell receptor associated transmembrane adaptor 1	0.010
Slc26a3	solute carrier family 26, member 3	0.010
Hsd17b7	hydroxysteroid (17-beta) dehydrogenase 7	0.010
RGD1561145	similar to novel protein	0.010
Pkib	protein kinase (cAMP-dependent, catalytic) inhibitor beta	0.010
Cybrd1	cytochrome b reductase 1	0.010
Tp53	tumor protein p53	0.010
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.010
Cma1	chymase 1, mast cell	0.010
Ncr1	natural cytotoxicity triggering receptor 1	0.010
Trim47	tripartite motif-containing 47	0.010
Clstn3	calsyntenin 3	0.010
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.010
Capn1	calpain 1	0.010
Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	0.010
Pde3b	phosphodiesterase 3B, cGMP-inhibited	0.010
Ehbp1l1	EH domain binding protein 1-like 1	0.010
Bhlhe40	basic helix-loop-helix family, member e40	0.010
Rhoh	ras homolog gene family, member H	0.010
Neb	nebulin	0.010
Triobp	TRIO and F-actin binding protein	0.010
Adam1a	a disintegrin and metallopeptidase domain 1a	0.010
Sept1	septin 1	0.010
Map3k11	mitogen-activated protein kinase kinase kinase 11	0.010