IMP

Process View

Danio rerio

12 genes annotated in zebrafish

enteric nervous system development

The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "enteric nervous system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "enteric nervous system development" (in gray)

Name	Description	Probability	Func Analog Organism
phox2a	paired-like homeobox 2a	0.770	Zebrafish
gfra1a	gdnf family receptor alpha 1a	0.759
crestin	crestin	0.701
foxd3	forkhead box D3	0.653
phox2b	paired-like homeobox 2b	0.565
foxi1	forkhead box I1	0.528	Zebrafish
hmx4	H6 family homeobox 4	0.493
foxa3	forkhead box A3	0.438	Zebrafish
nes	nestin	0.271
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.267
gfra1b	gdnf family receptor alpha 1b	0.221
sox10	SRY-box containing gene 10	0.202
mab21l2	mab-21-like 2	0.193
eya1	eyes absent homolog 1	0.189
pitx2	paired-like homeodomain transcription factor 2	0.162
neurod	neurogenic differentiation	0.151
foxi3b	forkhead box I3b	0.132	Zebrafish
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.123
neurog1	neurogenin 1	0.115
olfm1a	olfactomedin 1a	0.115
foxa2	forkhead box A2	0.101	Zebrafish
atoh8	atonal homolog 8	0.088
gbx2	gastrulation brain homeo box 2	0.083
smad7	MAD, mothers against decapentaplegic homolog 7 (Drosophila)	0.083
nr2f5	nuclear receptor subfamily 2, group F, member 5	0.078
gata3	GATA-binding protein 3	0.075
atp1a1a.2	ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide	0.065
six3a	sine oculis homeobox homolog 3a	0.063
foxi3a	forkhead box I3a	0.060	Zebrafish
otx2	orthodenticle homolog 2	0.060
ahi1	Abelson helper integration site 1	0.059
nadl1.1	neural adhesion molecule L1.1	0.050
plxnb2b	plexin b2b	0.050
dct	dopachrome tautomerase	0.049
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.048
cntn2	contactin 2	0.048
tlx2	T-cell leukemia, homeobox 2	0.044
tfe3b	transcription factor binding to IGHM enhancer 3b	0.043
slc16a10	solute carrier family 16, member 10 (aromatic amino acid transporter)	0.043
sim1a	single-minded homolog 1a (Drosophila)	0.041
ebf3	early B-cell factor 3	0.040
ret1	receptor tyrosine kinase	0.039
hmx3	homeo box (H6 family) 3	0.039
lmo4a	LIM domain only 4a	0.038
pax6b	paired box gene 6b	0.037
bmper	BMP binding endothelial regulator	0.037
dao.2	D-amino-acid oxidase 2	0.036
slc4a1b	solute carrier family 4, anion exchanger, member 1b	0.036
pcdh17	protocadherin 17	0.034
tbx2b	T-box 2b	0.032
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.031
pcdh19	protocadherin 19	0.031
six2a	sine oculis-related homeobox 2a	0.031
grhl1	grainyhead-like 1 (Drosophila)	0.031
zeb2b	zinc finger E-box binding homeobox 2b	0.030
zgc:194131	zgc:194131	0.029
vasn	vasorin	0.028
m17	IL-6 subfamily cytokine M17	0.028
dlx4b	distal-less homeobox gene 4b	0.028
foxa1	forkhead box A1	0.028	Zebrafish
ppp1r14ab	protein phosphatase 1, regulatory (inhibitor) subunit 14Ab	0.028
sfrp5	secreted frizzled-related protein 5	0.027
fli1b	friend leukemia integration 1b	0.026
irx4b	iroquois homeobox protein 4b	0.026
dnmt6	DNA (cytosine-5-)-methyltransferase 6	0.024
trpa1b	transient receptor potential cation channel, subfamily A, member 1b	0.024
rx3	retinal homeobox gene 3	0.024
stmn2b	stathmin-like 2b	0.024
cadm1a	cell adhesion molecule 1a	0.024
erbb3b	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b	0.023
vegfc	vascular endothelial growth factor c	0.023
prrx1a	paired related homeobox 1a	0.023	Zebrafish
hoxa4a	homeo box A4a	0.022
cdc25	cell division cycle 25 homolog	0.022
fsta	follistatin a	0.022
pax8	paired box gene 8	0.022
im:7156396	im:7156396	0.022
gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.021
arhgap29a	Rho GTPase activating protein 29a	0.021
loxl2b	lysyl oxidase-like 2b	0.021
irx1b	iroquois homeobox protein 1, b	0.020
gata2a	GATA-binding protein 2a	0.020
sema3aa	semaphorin 3aa	0.020
emx3	empty spiracles homeobox 3	0.019
gnao1a	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a	0.019
six1b	sine oculis homeobox homolog 1b	0.019
dpysl4	dihydropyrimidinase-like 4	0.019
tfeb	transcription factor EB	0.018
dbx1a	developing brain homeobox 1a	0.018
six4b	sine oculis homeobox homolog 4b	0.018
tyrp1b	tyrosinase-related protein 1b	0.018
pitx1	paired-like homeodomain transcription factor 1	0.018
gcm2	glial cells missing homolog 2 (Drosophila)	0.018
ddc	dopa decarboxylase	0.018
wu:fv91b12	wu:fv91b12	0.018
met	met proto-oncogene (hepatocyte growth factor receptor)	0.018
nkx2.2b	NK2 transcription factor related 2b	0.017
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.017
fgf5	fibroblast growth factor 5	0.017
bhlhe22	basic helix-loop-helix family, member e22	0.016
mmp13a	matrix metalloproteinase 13a	0.016
nrp1b	neuropilin 1b	0.016
fev	FEV (ETS oncogene family)	0.016
ncam1b	neural cell adhesion molecule 1b	0.016
myhz1.2	myosin, heavy polypeptide 1.2, skeletal muscle	0.016
raraa	retinoic acid receptor, alpha a	0.016
hgfb	hepatocyte growth factor b	0.016
pax2a	paired box gene 2a	0.015
rpl23a	ribosomal protein L23a	0.015
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.015
p2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.014
isl2a	islet2a	0.014
inka1a	induced in neural crest by AP2, 1a	0.014
crygs1	crystallin, gamma S1	0.014
rx2	retinal homeobox gene 2	0.014
drd4-rs	dopamine receptor D4 related sequence	0.014
dcn	decorin	0.014
rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.014
hoxb5a	homeo box B5a	0.013
eng2a	engrailed 2a	0.013
vsg1	vessel-specific 1	0.013
vwf	von Willebrand factor	0.013
ntm	neurotrimin	0.013
cap1	Cap1 CAP, adenylate cyclase-associated protein 1	0.013
olig2	oligodendrocyte lineage transcription factor 2	0.013
gria4a	glutamate receptor, ionotropic, AMPA 4a	0.013
slc4a4b	solute carrier family 4, sodium bicarbonate cotransporter, member 4b	0.012
pou1f1	POU domain, class 1, transcription factor 1	0.012
sox2	SRY-box containing gene 2	0.012
fgf3	fibroblast growth factor 3	0.012
tp63	tumor protein p63	0.012
nkx6.2	NK6 transcription factor related, locus 2	0.012
pax6a	paired box gene 6a	0.012
zgc:63947	zgc:63947	0.012
plagl2	pleiomorphic adenoma gene-like 2	0.012
dla	deltaA	0.012
irx3a	iroquois homeobox protein 3a	0.012
plxnb2a	plexin b2a	0.012
fgf8b	fibroblast growth factor 8 b	0.012
flt4	fms-related tyrosine kinase 4	0.012
prom1b	prominin 1 b	0.011
ildr1b	immunoglobulin-like domain containing receptor 1b	0.011
grhl2b	grainyhead-like 2b (Drosophila)	0.011
six3b	sine oculis homeobox homolog 3b	0.011
flh	floating head	0.011
srf	serum response factor	0.011
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.011
LOC569768	metabotropic glutamate receptor 8-like	0.011
eaf1	ELL associated factor 1	0.011
ncf1	neutrophil cytosolic factor 1	0.011
tfap2a	transcription factor AP-2 alpha	0.011
etv1	ets variant gene 1	0.011
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.011
chrm2a	cholinergic receptor, muscarinic 2a	0.011
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.011
tnw	tenascin W	0.011
jag2	jagged 2	0.011
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.010
chrna6	cholinergic receptor, nicotinic, alpha 6	0.010
fgfr3	fibroblast growth factor receptor 3	0.010
grem2	gremlin 2, cysteine knot superfamily	0.010
myod1	myogenic differentiation 1	0.010
mbp	myelin basic protein	0.010
LOC100534712	hypothetical protein LOC100534712	0.010