The network for 'negative regulation of reactive oxygen species metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of reactive oxygen species metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.

Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 0.958
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.946
IRAK2 interleukin-1 receptor-associated kinase 2 0.778
APOE apolipoprotein E 0.573
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.570
IL10RA interleukin 10 receptor, alpha 0.342
HSPB8 heat shock 22kDa protein 8 0.305
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.260
EP300 E1A binding protein p300 0.253
FBXO7 F-box protein 7 0.239
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.234
MEOX1 mesenchyme homeobox 1 0.209
CRYAA crystallin, alpha A 0.199
HSPB2 heat shock 27kDa protein 2 0.194
TTR transthyretin 0.152
NKX2-1 NK2 homeobox 1 0.146
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.143
PPP5C protein phosphatase 5, catalytic subunit 0.142
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.142
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.138
ZNF746 zinc finger protein 746 0.135
CRYBB2 crystallin, beta B2 0.133
TRAF1 TNF receptor-associated factor 1 0.125
ELN elastin 0.123
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 0.106
PINK1 PTEN induced putative kinase 1 0.104
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.102
TGFB1 transforming growth factor, beta 1 0.100
MYLK2 myosin light chain kinase 2 0.090
CALCA calcitonin-related polypeptide alpha 0.087
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.086
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.085
CD320 CD320 molecule 0.080
RIPK2 receptor-interacting serine-threonine kinase 2 0.076
CCL20 chemokine (C-C motif) ligand 20 0.075
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.072
BAG3 BCL2-associated athanogene 3 0.071
HSPB1 heat shock 27kDa protein 1 0.070
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.070
CRYGC crystallin, gamma C 0.069
TRAF6 TNF receptor-associated factor 6 0.068
MMP10 matrix metallopeptidase 10 (stromelysin 2) 0.066
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.065
CCL7 chemokine (C-C motif) ligand 7 0.063
TRAF3 TNF receptor-associated factor 3 0.060
KCTD1 potassium channel tetramerisation domain containing 1 0.060
MAX MYC associated factor X 0.059
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.059
THBS1 thrombospondin 1 0.057
SP1 Sp1 transcription factor 0.056
THBS2 thrombospondin 2 0.054
MEP1A meprin A, alpha (PABA peptide hydrolase) 0.054
MPDZ multiple PDZ domain protein 0.053
HDAC6 histone deacetylase 6 0.051
CDK6 cyclin-dependent kinase 6 0.051
DLG2 discs, large homolog 2 (Drosophila) 0.050
SH3BP4 SH3-domain binding protein 4 0.049
MMP13 matrix metallopeptidase 13 (collagenase 3) 0.048
HDAC1 histone deacetylase 1 0.047
CXCL5 chemokine (C-X-C motif) ligand 5 0.045
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.045
TOLLIP toll interacting protein 0.045
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.043
SPAG9 sperm associated antigen 9 0.042
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.042
EGR2 early growth response 2 0.041
RB1 retinoblastoma 1 0.040
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.040
F2R coagulation factor II (thrombin) receptor 0.040
A2M alpha-2-macroglobulin 0.040
SIRT5 sirtuin 5 0.040
CXCL3 chemokine (C-X-C motif) ligand 3 0.040
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.040
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.039
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.039
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.038
BBS1 Bardet-Biedl syndrome 1 0.037
CAV2 caveolin 2 0.036
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.034
MYOD1 myogenic differentiation 1 0.034
CRYBA1 crystallin, beta A1 0.034
KCNF1 potassium voltage-gated channel, subfamily F, member 1 0.033
SIRT3 sirtuin 3 0.033
C12orf4 chromosome 12 open reading frame 4 0.033
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.032
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.032
C2orf18 chromosome 2 open reading frame 18 0.031
RAB26 RAB26, member RAS oncogene family 0.031
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.031
PAX7 paired box 7 0.031
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.031
BECN1 beclin 1, autophagy related 0.030
NGFR nerve growth factor receptor 0.030
STAT5A signal transducer and activator of transcription 5A 0.029
PTEN phosphatase and tensin homolog 0.029
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.029
BBS10 Bardet-Biedl syndrome 10 0.029
PNOC prepronociceptin 0.029
SIRT4 sirtuin 4 0.028
HAGH hydroxyacylglutathione hydrolase 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Hsp27 Heat shock protein 27 0.906
Hsp23 Heat shock protein 23 0.622
Hsp68 Heat shock protein 68 0.545
Hsp26 Heat shock protein 26 0.471
CycJ Cyclin J 0.124
Hsp22 Heat shock protein 22 0.121
rux roughex 0.085
Pink1 PTEN-induced putative kinase 1 0.083
CG4461 CG4461 gene product from transcript CG4461-RA 0.043
Hsp67Bb Heat shock gene 67Bb 0.038
cdc14 CG7134 gene product from transcript CG7134-RB 0.036
Hsp70Ba Heat-shock-protein-70Ba 0.036
HtrA2 CG8464 gene product from transcript CG8464-RA 0.034
CG15199 CG15199 gene product from transcript CG15199-RA 0.031
CG11327 CG11327 gene product from transcript CG11327-RA 0.030
Hsp70Ab Heat-shock-protein-70Ab 0.028
lace CG4162 gene product from transcript CG4162-RA 0.024
park parkin 0.024
kermit CG11546 gene product from transcript CG11546-RB 0.022
CG11391 CG11391 gene product from transcript CG11391-RA 0.020
Ant2 Adenine nucleotide translocase 2 0.019
SdhB Succinate dehydrogenase B 0.019
CG10713 CG10713 gene product from transcript CG10713-RA 0.018
rpr reaper 0.017
CG3568 CG3568 gene product from transcript CG3568-RA 0.017
X11L CG5675 gene product from transcript CG5675-RB 0.016
Hsp83 Heat shock protein 83 0.016
CG4603 CG4603 gene product from transcript CG4603-RA 0.016
CG4586 CG4586 gene product from transcript CG4586-RA 0.016
Pvf3 PDGF- and VEGF-related factor 3 0.015
CG9472 CG9472 gene product from transcript CG9472-RA 0.015
DnaJ-1 DnaJ-like-1 0.014
rempA reduced mechanoreceptor potential A 0.014
CG42360 CG42360 gene product from transcript CG42360-RA 0.014
bw brown 0.014
Lasp CG3849 gene product from transcript CG3849-RB 0.014
CG9090 CG9090 gene product from transcript CG9090-RA 0.013
Hsp67Bc Heat shock gene 67Bc 0.012
CG14022 CG14022 gene product from transcript CG14022-RA 0.012
CG42369 CG42369 gene product from transcript CG42369-RA 0.012
wun2 wunen-2 0.012
p53 CG33336 gene product from transcript CG33336-RB 0.012
RASSF8 CG5053 gene product from transcript CG5053-RA 0.012
SP2637 CG5473 gene product from transcript CG5473-RC 0.012
CG8455 CG8455 gene product from transcript CG8455-RA 0.011
Marf Mitochondrial assembly regulatory factor 0.011
eIF4E-3 CG8023 gene product from transcript CG8023-RA 0.011
CG8818 CG8818 gene product from transcript CG8818-RA 0.011
fh frataxin homolog 0.010
DJ-1alpha CG6646 gene product from transcript CG6646-RA 0.010
ntc nutcracker 0.010
CG11368 CG11368 gene product from transcript CG11368-RA 0.010
Faa Fumarylacetoacetase 0.010
Tom Twin of m4 0.010
stv starvin 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.996
Trp63 transformation related protein 63 0.560
Trim30d tripartite motif-containing 30D 0.490
Pten phosphatase and tensin homolog 0.458
Shh sonic hedgehog 0.295
Col1a1 collagen, type I, alpha 1 0.285
Apc adenomatosis polyposis coli 0.279
Mdm2 transformed mouse 3T3 cell double minute 2 0.276
Gbx2 gastrulation brain homeobox 2 0.159
Trim30a tripartite motif-containing 30A 0.156
Pnpla2 patatin-like phospholipase domain containing 2 0.150
Lepr leptin receptor 0.146
Ikbkb inhibitor of kappaB kinase beta 0.141
Pax6 paired box gene 6 0.122
Pax3 paired box gene 3 0.116
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.109
Esr1 estrogen receptor 1 (alpha) 0.106
Tlr4 toll-like receptor 4 0.101
Ccl2 chemokine (C-C motif) ligand 2 0.097
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.084
Mdm4 transformed mouse 3T3 cell double minute 4 0.082
Rara retinoic acid receptor, alpha 0.080
Stat3 signal transducer and activator of transcription 3 0.079
Ctnnb1 catenin (cadherin associated protein), beta 1 0.076
Max Max protein 0.075
Dmd dystrophin, muscular dystrophy 0.069
Chd7 chromodomain helicase DNA binding protein 7 0.068
Fgfr2 fibroblast growth factor receptor 2 0.066
Foxc2 forkhead box C2 0.061
Emx2 empty spiracles homolog 2 (Drosophila) 0.058
Ptgs2 prostaglandin-endoperoxide synthase 2 0.056
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.055
Braf Braf transforming gene 0.053
Prlr prolactin receptor 0.053
Kit kit oncogene 0.045
Wasf2 WAS protein family, member 2 0.043
Rb1 retinoblastoma 1 0.042
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.040
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.040
Trim12a tripartite motif-containing 12A 0.039
Traf2 TNF receptor-associated factor 2 0.038
Tbx1 T-box 1 0.038
Ptrf polymerase I and transcript release factor 0.038
Ar androgen receptor 0.036
Esr2 estrogen receptor 2 (beta) 0.036
Kiss1 KiSS-1 metastasis-suppressor 0.036
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.036
Atm ataxia telangiectasia mutated homolog (human) 0.036
Ahr aryl-hydrocarbon receptor 0.035
Myd88 myeloid differentiation primary response gene 88 0.035
Brca2 breast cancer 2 0.035
Pparg peroxisome proliferator activated receptor gamma 0.034
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.034
Trp73 transformation related protein 73 0.033
Skil SKI-like 0.033
Notch1 Notch gene homolog 1 (Drosophila) 0.031
Parp14 poly (ADP-ribose) polymerase family, member 14 0.031
Vhl von Hippel-Lindau tumor suppressor 0.030
Emx1 empty spiracles homolog 1 (Drosophila) 0.029
Ncoa3 nuclear receptor coactivator 3 0.028
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.027
Irf9 interferon regulatory factor 9 0.027
Tgfbr2 transforming growth factor, beta receptor II 0.027
Fgf10 fibroblast growth factor 10 0.026
Hhat hedgehog acyltransferase 0.026
Hccs holocytochrome c synthetase 0.026
Rarb retinoic acid receptor, beta 0.026
Jag1 jagged 1 0.026
Mfn2 mitofusin 2 0.024
Amhr2 anti-Mullerian hormone type 2 receptor 0.024
En1 engrailed 1 0.023
Tbx10 T-box 10 0.023
Eya1 eyes absent 1 homolog (Drosophila) 0.023
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.023
Oas1b 2'-5' oligoadenylate synthetase 1B 0.022
Foxc1 forkhead box C1 0.022
Il6 interleukin 6 0.022
Tcta T-cell leukemia translocation altered gene 0.022
Diablo diablo homolog (Drosophila) 0.022
H2-M3 histocompatibility 2, M region locus 3 0.021
Pyhin1 pyrin and HIN domain family, member 1 0.021
Msx2 homeobox, msh-like 2 0.021
Ccnd1 cyclin D1 0.021
Il10 interleukin 10 0.020
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.020
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.020
Clcn5 chloride channel 5 0.020
Trim34a tripartite motif-containing 34A 0.020
Isl1 ISL1 transcription factor, LIM/homeodomain 0.020
Sox9 SRY-box containing gene 9 0.019
Hoxa1 homeobox A1 0.019
Otx2 orthodenticle homolog 2 (Drosophila) 0.019
Sox2 SRY-box containing gene 2 0.019
Meox2 mesenchyme homeobox 2 0.019
Trim12c tripartite motif-containing 12C 0.019
Ikbkg inhibitor of kappaB kinase gamma 0.019
Vegfa vascular endothelial growth factor A 0.019
Il6st interleukin 6 signal transducer 0.019
Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.019
Lif leukemia inhibitory factor 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspb1 heat shock protein 1 0.186
Hspa1a heat shock 70kD protein 1A 0.134
Cryab crystallin, alpha B 0.106
LOC100365106 rCG32755-like 0.050
Cd80 Cd80 molecule 0.038
Igtp interferon gamma induced GTPase 0.037
LOC100362108 poly (ADP-ribose) polymerase family, member 10 0.036
Des desmin 0.027
RGD1309537 similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) 0.026
Mybph myosin binding protein H 0.023
Olr1493 olfactory receptor gene Olr1493 0.023
Rrad Ras-related associated with diabetes 0.022
Mstn myostatin 0.021
Sstr1 somatostatin receptor 1 0.021
Slc48a1 solute carrier family 48 (heme transporter), member 1 0.020
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.020
Sp110 SP110 nuclear body protein 0.019
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.019
Stat1 signal transducer and activator of transcription 1 0.019
Flnc filamin C, gamma 0.019
LOC100359522 LRRGT00191-like 0.019
Sod2 superoxide dismutase 2, mitochondrial 0.018
S100a6 S100 calcium binding protein A6 0.018
Dlat dihydrolipoamide S-acetyltransferase 0.018
Prrx1 paired related homeobox 1 0.017
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.016
Mmp13 matrix metallopeptidase 13 0.016
Pcdhga11 protocadherin gamma subfamily A, 11 0.016
Fcer2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.016
RGD735029 SEL1 domain containing protein RGD735029 0.016
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.015
Hspd1 heat shock protein 1 (chaperonin) 0.015
Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon 0.014
Fgf18 fibroblast growth factor 18 0.014
Il2ra interleukin 2 receptor, alpha 0.014
Chrng cholinergic receptor, nicotinic, gamma 0.014
Musk muscle, skeletal, receptor tyrosine kinase 0.014
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.014
Dhfr dihydrofolate reductase 0.013
Ccng1 cyclin G1 0.013
Shc3 SHC (Src homology 2 domain containing) transforming protein 3 0.013
Col10a1 collagen, type X, alpha 1 0.013
Il1r1 interleukin 1 receptor, type I 0.013
Il10 interleukin 10 0.013
Ifi35 interferon-induced protein 35 0.012
Myo9a myosin IXA 0.012
Rcan2 regulator of calcineurin 2 0.012
Serpinb7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.012
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.012
Rnf213 ring finger protein 213 0.011
Sh3tc1 SH3 domain and tetratricopeptide repeats 1 0.011
Vom2r40 vomeronasal 2 receptor, 40 0.011
Mmp7 matrix metallopeptidase 7 0.011
RT1-M5 RT1 class Ib, locus M5 0.011
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.011
Irf7 interferon regulatory factor 7 0.011
Cd8b CD8b molecule 0.011
Tpm1 tropomyosin 1, alpha 0.011
Mvp major vault protein 0.011
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.010
Foxo1 forkhead box O1 0.010
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.010
Bcl2 B-cell CLL/lymphoma 2 0.010
Grpr gastrin releasing peptide receptor 0.010
Dnah1 dynein, axonemal, heavy chain 1 0.010
Ier3 immediate early response 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism