The network for 'regulation of histone methylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of histone methylation

Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.

Homo sapiens
Name Description Probability Func Analog Organism
CBX5 chromobox homolog 5 0.860
EED embryonic ectoderm development 0.781
EZH2 enhancer of zeste homolog 2 (Drosophila) 0.502
HDAC1 histone deacetylase 1 0.447
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.436
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.279
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.249
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.218
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.187
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.110
LIN9 lin-9 homolog (C. elegans) 0.105
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.102
WDR5 WD repeat domain 5 0.102
HIST1H3B histone cluster 1, H3b 0.085
BCL9 B-cell CLL/lymphoma 9 0.083
EP300 E1A binding protein p300 0.068
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.066
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.064
IK IK cytokine, down-regulator of HLA II 0.063
CBX3 chromobox homolog 3 0.063
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.051
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.049
KDM2B lysine (K)-specific demethylase 2B 0.041
TSC22D1 TSC22 domain family, member 1 0.039
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.035
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.034
ADNP activity-dependent neuroprotector homeobox 0.034
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.032
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.028
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.027
RBBP4 retinoblastoma binding protein 4 0.025
CHD8 chromodomain helicase DNA binding protein 8 0.024
MDC1 mediator of DNA-damage checkpoint 1 0.023
NCOA6 nuclear receptor coactivator 6 0.023
PRRC2B proline-rich coiled-coil 2B 0.023
AFF1 AF4/FMR2 family, member 1 0.023
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.023
LIN54 lin-54 homolog (C. elegans) 0.021
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.020
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.018
CCNT1 cyclin T1 0.018
ZNF512B zinc finger protein 512B 0.018
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.018
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.017
E2F4 E2F transcription factor 4, p107/p130-binding 0.017
HCFC1 host cell factor C1 (VP16-accessory protein) 0.016
SETDB1 SET domain, bifurcated 1 0.016
PARP1 poly (ADP-ribose) polymerase 1 0.016
ASXL1 additional sex combs like 1 (Drosophila) 0.016
PCNA proliferating cell nuclear antigen 0.015
CBX1 chromobox homolog 1 0.015
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.015
HIST1H3A histone cluster 1, H3a 0.014
STAG1 stromal antigen 1 0.014
LARP7 La ribonucleoprotein domain family, member 7 0.014
PCGF1 polycomb group ring finger 1 0.013
POGZ pogo transposable element with ZNF domain 0.013
RLF rearranged L-myc fusion 0.013
HEXIM1 hexamethylene bis-acetamide inducible 1 0.013
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.013
MEN1 multiple endocrine neoplasia I 0.013
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.013
RERE arginine-glutamic acid dipeptide (RE) repeats 0.013
RBBP5 retinoblastoma binding protein 5 0.012
SOCS1 suppressor of cytokine signaling 1 0.012
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.011
L3MBTL1 l(3)mbt-like 1 (Drosophila) 0.011
CDCA4 cell division cycle associated 4 0.011
MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 0.011
HIST2H3C histone cluster 2, H3c 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
trr-1 Protein TRR-1 0.018
CELE_F19F10.9 Protein F19F10.9 0.014
his-24 Protein HIS-24 0.013
cpsf-2 Protein CPSF-2 0.013
sop-2 Protein SOP-2 0.013
dcr-1 Protein DCR-1 0.012
lin-7 Protein LIN-7 0.011
lst-3 Protein LST-3 0.011
mig-38 Protein MIG-38 0.010
B0464.2 Protein B0464.2 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
gata1a GATA binding protein 1a 0.362
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.312
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.248
prdm9 PR domain containing 9 0.239
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.235
mpx myeloid-specific peroxidase 0.202
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.155
setdb1a SET domain, bifurcated 1a 0.120
si:ch211-57k11.10 si:ch211-57k11.10 0.104
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.103
pnp4a purine nucleoside phosphorylase 4a 0.100
setd5 SET domain containing 5 0.097
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.096
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.095
csf1ra colony stimulating factor 1 receptor, a 0.093
rif1 RAP1 interacting factor homolog (yeast) 0.092
dnmt3 DNA (cytosine-5-)-methyltransferase 3 0.090
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.087
top2a topoisomerase (DNA) II alpha 0.082
cbx1a chromobox homolog 1a (HP1 beta homolog Drosophila) 0.072
mcm7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.069
ssrp1a structure specific recognition protein 1a 0.068
ilf3a interleukin enhancer binding factor 3a 0.064
rag1 recombination activating gene 1 0.062
ncapd2 non-SMC condensin I complex, subunit D2 0.060
lyz lysozyme 0.058
mettl3 methyltransferase like 3 0.057
brd4 bromodomain containing 4 0.056
setd2 SET domain containing 2 0.055
LOC100151531 zinc finger protein Gfi-1b-like 0.051
wu:fi04c06 wu:fi04c06 0.049
ube2i ubiquitin-conjugating enzyme E2I 0.048
pknox1.2 pbx/knotted 1 homeobox 1.2 0.046
ahctf1 AT hook containing transcription factor 1 0.046
suv39h1a suppressor of variegation 3-9 homolog 1a 0.046
arglu1b arginine and glutamate rich 1b 0.045
ncaph non-SMC condensin I complex, subunit H 0.045
suv39h1b suppressor of variegation 3-9 homolog 1b 0.043
setd8b SET domain containing (lysine methyltransferase) 8b 0.042
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.041
paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.041
apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.041
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.040
rx2 retinal homeobox gene 2 0.040
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.039
prdm8b PR domain containing 8b 0.039
smc3 structural maintenance of chromosomes 3 0.039
hirip3 HIRA interacting protein 3 0.039
egr2b early growth response 2b 0.038
cdc23 CDC23 (cell division cycle 23, yeast, homolog) 0.038
prdm2b PR domain containing 2, with ZNF domain b 0.038
ehmt1a euchromatic histone-lysine N-methyltransferase 1a 0.038
smyd3 SET and MYND domain containing 3 0.038
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.038
skiv2l2 superkiller viralicidic activity 2-like 2 0.038
arid4a AT rich interactive domain 4A (RBP1-like) 0.037
smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.037
nrp1b neuropilin 1b 0.037
msh2 mutS homolog 2 (E. coli) 0.036
rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.035
prdm11 PR domain containing 11 0.035
nktr natural killer-tumor recognition sequence 0.035
atad5a ATPase family, AAA domain containing 5a 0.035
ipo9 importin 9 0.035
arglu1a arginine and glutamate rich 1a 0.035
myef2 myelin expression factor 2 0.035
sass6 spindle assembly 6 homolog (C. elegans) 0.035
foxi1 forkhead box I1 0.034
wdr18 WD repeat domain 18 0.034
zbtb4 zinc finger and BTB domain containing 4 0.033
il7r interleukin 7 receptor 0.033
bcas2 breast carcinoma amplified sequence 2 0.033
smyd5 SMYD family member 5 0.032
foxe3 forkhead box E3 0.032
setd6 SET domain containing 6 0.031
foxo3b forkhead box O3b 0.031
pdcd4a programmed cell death 4a 0.031
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.031
med4 mediator complex subunit 4 0.030
ehmt2 euchromatic histone-lysine N-methyltransferase 2 0.029
suv420h1 suppressor of variegation 4-20 homolog 1 (Drosophila) 0.029
mll4a myeloid/lymphoid or mixed-lineage leukemia 4a 0.029
hdac4 histone deacetylase 4 0.028
si:ch211-198a12.6 si:ch211-198a12.6 0.028
pou3f3a POU class 3 homeobox 3a 0.027
rbbp5 retinoblastoma binding protein 5 0.027
hat1 histone acetyltransferase 1 0.027
elk4 ELK4, ETS-domain protein 0.027
ep300b E1A binding protein p300 b 0.027
bub3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.027
mcm3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.026
chaf1b chromatin assembly factor 1, subunit B 0.026
csf3r colony stimulating factor 3 receptor (granulocyte) 0.026
pbrm1l polybromo 1, like 0.026
ehmt1b euchromatic histone-lysine N-methyltransferase 1b 0.026
rbbp6 retinoblastoma binding protein 6 0.026
tcea1 transcription elongation factor A (SII), 1 0.026
pnn pinin, desmosome associated protein 0.025
eed embryonic ectoderm development 0.025
pax7a paired box gene 7a 0.025
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
BicD Bicaudal D 0.024
Gug Grunge 0.019
pnut peanut 0.017
Nup154 Nucleoporin 154 0.016
Abi Abelson interacting protein 0.015
Rab11 Rab-protein 11 0.014
EcR Ecdysone receptor 0.014
Chc Clathrin heavy chain 0.014
Moe Moesin 0.014
Dl Delta 0.013
mRpL33 mitochondrial ribosomal protein L33 0.013
Tif-IA CG3278 gene product from transcript CG3278-RA 0.012
eIF-4E Eukaryotic initiation factor 4E 0.012
l(2)03709 lethal (2) 03709 0.011
Arp66B Actin-related protein 66B 0.011
Aats-ile Isoleucyl-tRNA synthetase 0.011
bs blistered 0.011
dlg1 discs large 1 0.010
Khc Kinesin heavy chain 0.010
CG11267 CG11267 gene product from transcript CG11267-RA 0.010
Hem HEM-protein 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.999
Kdm2b lysine (K)-specific demethylase 2B 0.998
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.997
Crebbp CREB binding protein 0.967
Jarid2 jumonji, AT rich interactive domain 2 0.943
Ncoa6 nuclear receptor coactivator 6 0.913
Rnf2 ring finger protein 2 0.895
Sin3a transcriptional regulator, SIN3A (yeast) 0.882
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.879
Dnmt3a DNA methyltransferase 3A 0.866
Trp53 transformation related protein 53 0.837
Trim28 tripartite motif-containing 28 0.815
Msx1 homeobox, msh-like 1 0.812
Pax2 paired box gene 2 0.727
Rbbp4 retinoblastoma binding protein 4 0.708
Trim24 tripartite motif-containing 24 0.689
Pax3 paired box gene 3 0.655
Mtf2 metal response element binding transcription factor 2 0.590
Clk1 CDC-like kinase 1 0.548
Kdm1a lysine (K)-specific demethylase 1A 0.541
Kdm5a lysine (K)-specific demethylase 5A 0.415
Hand1 heart and neural crest derivatives expressed transcript 1 0.408
Lef1 lymphoid enhancer binding factor 1 0.405
Ep300 E1A binding protein p300 0.405
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.388
Arid1a AT rich interactive domain 1A (SWI-like) 0.380
Ezh1 enhancer of zeste homolog 1 (Drosophila) 0.356
Ubtf upstream binding transcription factor, RNA polymerase I 0.355
Msh2 mutS homolog 2 (E. coli) 0.343
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.341
Hoxa1 homeobox A1 0.337
Brca2 breast cancer 2 0.326
Rb1 retinoblastoma 1 0.323
Brd8 bromodomain containing 8 0.315
Lmx1a LIM homeobox transcription factor 1 alpha 0.314
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.314
Ccnt2 cyclin T2 0.303
Atm ataxia telangiectasia mutated homolog (human) 0.290
Foxo3 forkhead box O3 0.289
Chd2 chromodomain helicase DNA binding protein 2 0.284
Aebp2 AE binding protein 2 0.280
Tbx1 T-box 1 0.266
Fgf10 fibroblast growth factor 10 0.255
Brd4 bromodomain containing 4 0.248
Notch1 Notch gene homolog 1 (Drosophila) 0.239
Hist1h3g histone cluster 1, H3g 0.232
Zfp292 zinc finger protein 292 0.230
Runx1 runt related transcription factor 1 0.219
Gata3 GATA binding protein 3 0.213
Setx senataxin 0.207
Zeb1 zinc finger E-box binding homeobox 1 0.196
Clk4 CDC like kinase 4 0.186
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.184
Bap1 Brca1 associated protein 1 0.179
Stk38 serine/threonine kinase 38 0.176
Cbx3 chromobox homolog 3 (Drosophila HP1 gamma) 0.165
Gfi1b growth factor independent 1B 0.165
Eya1 eyes absent 1 homolog (Drosophila) 0.165
Foxg1 forkhead box G1 0.153
Ilf3 interleukin enhancer binding factor 3 0.152
Chaf1a chromatin assembly factor 1, subunit A (p150) 0.150
Zfp592 zinc finger protein 592 0.147
Brca1 breast cancer 1 0.144
Eed embryonic ectoderm development 0.143
Fbrs fibrosin 0.139
Hdac1 histone deacetylase 1 0.134
Zfp740 zinc finger protein 740 0.131
Parp1 poly (ADP-ribose) polymerase family, member 1 0.130
Fnbp4 formin binding protein 4 0.124
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.122
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.118
Sfrs18 serine/arginine-rich splicing factor 18 0.116
Csnk2a1 casein kinase 2, alpha 1 polypeptide 0.111
Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.110
Brwd1 bromodomain and WD repeat domain containing 1 0.108
Tnrc6b trinucleotide repeat containing 6b 0.105
Ctbp1 C-terminal binding protein 1 0.101
Rxra retinoid X receptor alpha 0.099
Numa1 nuclear mitotic apparatus protein 1 0.097
Smg1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.097
Safb scaffold attachment factor B 0.094
Mbd6 methyl-CpG binding domain protein 6 0.093
Pogz pogo transposable element with ZNF domain 0.091
Gata1 GATA binding protein 1 0.090
Tnrc6c trinucleotide repeat containing 6C 0.086
Tal1 T-cell acute lymphocytic leukemia 1 0.086
Ylpm1 YLP motif containing 1 0.086
Rere arginine glutamic acid dipeptide (RE) repeats 0.085
Rictor RPTOR independent companion of MTOR, complex 2 0.082
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.081
Epc1 enhancer of polycomb homolog 1 (Drosophila) 0.081
Mll2 myeloid/lymphoid or mixed-lineage leukemia 2 0.081
Hira histone cell cycle regulation defective homolog A (S. cerevisiae) 0.080
Dsg4 desmoglein 4 0.080
Cic capicua homolog (Drosophila) 0.079
Yy1 YY1 transcription factor 0.078
Mdm2 transformed mouse 3T3 cell double minute 2 0.077
Trp53bp1 transformation related protein 53 binding protein 1 0.077
Huwe1 HECT, UBA and WWE domain containing 1 0.075
Wdr5 WD repeat domain 5 0.074
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CTR9 Ctr9p 0.287
RTF1 Rtf1p 0.270
LEO1 Leo1p 0.116
CKA1 Cka1p 0.072
PAF1 Paf1p 0.059
SPT5 Spt5p 0.053
SPT16 Spt16p 0.030
TMA22 Tma22p 0.029
SPT6 Spt6p 0.024
CCT2 Cct2p 0.017
LEU2 Leu2p 0.014
SRD1 Srd1p 0.014
YLR264C-A hypothetical protein 0.013
HRB1 Hrb1p 0.013
YLR162W hypothetical protein 0.013
MF(ALPHA)2 Mf(alpha)2p 0.012
MER1 Mer1p 0.011
YOL038C-A hypothetical protein 0.011
ARP10 Arp10p 0.011
PTI1 Pti1p 0.011
MF(ALPHA)1 Mf(alpha)1p 0.011
YPR157W hypothetical protein 0.011
YLR042C hypothetical protein 0.011
ARG8 Arg8p 0.010
TFA1 Tfa1p 0.010
HXT3 Hxt3p 0.010
YAR068W hypothetical protein 0.010
HO Hop 0.010
CRP1 Crp1p 0.010