The network for 'interleukin 1 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 1 production

The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Homo sapiens
Name Description Probability Func Analog Organism
S100A6 S100 calcium binding protein A6 0.995
PYCARD PYD and CARD domain containing 0.987
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.978
NLRC4 NLR family, CARD domain containing 4 0.852
HDAC2 histone deacetylase 2 0.819
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.740
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.644
RIPK2 receptor-interacting serine-threonine kinase 2 0.496
S100A16 S100 calcium binding protein A16 0.408
HP haptoglobin 0.399
IL1R1 interleukin 1 receptor, type I 0.393
S100A4 S100 calcium binding protein A4 0.371
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.282
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.262
TICAM2 toll-like receptor adaptor molecule 2 0.236
SRGN serglycin 0.232
APOC1 apolipoprotein C-I 0.226
LY96 lymphocyte antigen 96 0.196
FKBP4 FK506 binding protein 4, 59kDa 0.189
ALB albumin 0.160
TMSB10 thymosin beta 10 0.156
AXL AXL receptor tyrosine kinase 0.152
CAPG capping protein (actin filament), gelsolin-like 0.139
S100B S100 calcium binding protein B 0.137
GNLY granulysin 0.131
PRF1 perforin 1 (pore forming protein) 0.129
CCL4 chemokine (C-C motif) ligand 4 0.126
PYDC2 pyrin domain containing 2 0.104
AREG amphiregulin 0.101
S100A10 S100 calcium binding protein A10 0.099
SOCS1 suppressor of cytokine signaling 1 0.090
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.086
IL1RAP interleukin 1 receptor accessory protein 0.081
A2M alpha-2-macroglobulin 0.080
EMP3 epithelial membrane protein 3 0.079
LGALS1 lectin, galactoside-binding, soluble, 1 0.079
LMNA lamin A/C 0.078
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.075
IL8 interleukin 8 0.067
S100A11 S100 calcium binding protein A11 0.064
LGALS3 lectin, galactoside-binding, soluble, 3 0.061
IRAK2 interleukin-1 receptor-associated kinase 2 0.058
IL7R interleukin 7 receptor 0.058
S100A2 S100 calcium binding protein A2 0.057
APOC3 apolipoprotein C-III 0.055
IDE insulin-degrading enzyme 0.054
IL1B interleukin 1, beta 0.054
FZD1 frizzled homolog 1 (Drosophila) 0.052
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.048
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.046
SP1 Sp1 transcription factor 0.044
SOCS3 suppressor of cytokine signaling 3 0.044
EGR2 early growth response 2 0.043
FHL2 four and a half LIM domains 2 0.042
LCAT lecithin-cholesterol acyltransferase 0.041
TIMP1 TIMP metallopeptidase inhibitor 1 0.041
TLR2 toll-like receptor 2 0.040
BCL2A1 BCL2-related protein A1 0.039
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.039
ITK IL2-inducible T-cell kinase 0.039
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.039
TRIM22 tripartite motif containing 22 0.038
NKG7 natural killer cell group 7 sequence 0.038
MPO myeloperoxidase 0.037
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.037
S100A1 S100 calcium binding protein A1 0.037
GPR171 G protein-coupled receptor 171 0.036
CARD16 caspase recruitment domain family, member 16 0.036
RRAS related RAS viral (r-ras) oncogene homolog 0.035
APOA1 apolipoprotein A-I 0.035
TSPO translocator protein (18kDa) 0.035
IFNGR1 interferon gamma receptor 1 0.035
MEFV Mediterranean fever 0.034
CFLAR CASP8 and FADD-like apoptosis regulator 0.034
IL1RN interleukin 1 receptor antagonist 0.033
SAMD9 sterile alpha motif domain containing 9 0.033
CSTB cystatin B (stefin B) 0.033
APOA2 apolipoprotein A-II 0.032
CLEC2B C-type lectin domain family 2, member B 0.032
TPSB2 tryptase beta 2 (gene/pseudogene) 0.032
GZMK granzyme K (granzyme 3; tryptase II) 0.031
C1QA complement component 1, q subcomponent, A chain 0.031
ARRB1 arrestin, beta 1 0.031
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.031
AZU1 azurocidin 1 0.030
IGF1R insulin-like growth factor 1 receptor 0.030
ATM ataxia telangiectasia mutated 0.030
TRAF3IP3 TRAF3 interacting protein 3 0.030
CD3D CD3d molecule, delta (CD3-TCR complex) 0.030
ELANE elastase, neutrophil expressed 0.029
LY9 lymphocyte antigen 9 0.029
HSPB8 heat shock 22kDa protein 8 0.029
CXCL9 chemokine (C-X-C motif) ligand 9 0.027
FAS Fas (TNF receptor superfamily, member 6) 0.026
BAG3 BCL2-associated athanogene 3 0.026
CCR7 chemokine (C-C motif) receptor 7 0.025
SMAD2 SMAD family member 2 0.025
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.025
APOC2 apolipoprotein C-II 0.025
AIM2 absent in melanoma 2 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.991
Casp1 caspase 1 0.984
Ccr2 chemokine (C-C motif) receptor 2 0.943
Pax2 paired box gene 2 0.801
Ccl2 chemokine (C-C motif) ligand 2 0.756
Gbp5 guanylate binding protein 5 0.736
Pycard PYD and CARD domain containing 0.729
Socs1 suppressor of cytokine signaling 1 0.669
Lyz2 lysozyme 2 0.599
Tlr4 toll-like receptor 4 0.596
Otx2 orthodenticle homolog 2 (Drosophila) 0.596
Ccl3 chemokine (C-C motif) ligand 3 0.532
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.523
Mndal myeloid nuclear differentiation antigen like 0.411
Nlrp3 NLR family, pyrin domain containing 3 0.378
Ccl4 chemokine (C-C motif) ligand 4 0.372
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.371
Ccl8 chemokine (C-C motif) ligand 8 0.327
Cxcl2 chemokine (C-X-C motif) ligand 2 0.327
Aim2 absent in melanoma 2 0.326
Ccr1 chemokine (C-C motif) receptor 1 0.307
Itgax integrin alpha X 0.305
C3ar1 complement component 3a receptor 1 0.298
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.285
B2m beta-2 microglobulin 0.268
Cd14 CD14 antigen 0.258
Irf1 interferon regulatory factor 1 0.254
Tnf tumor necrosis factor 0.249
Ctsw cathepsin W 0.244
Cd44 CD44 antigen 0.241
Grid1 glutamate receptor, ionotropic, delta 1 0.237
Lhx3 LIM homeobox protein 3 0.232
Cx3cr1 chemokine (C-X3-C) receptor 1 0.229
Has1 hyaluronan synthase1 0.225
Mmp3 matrix metallopeptidase 3 0.219
Il12rb2 interleukin 12 receptor, beta 2 0.218
Gdnf glial cell line derived neurotrophic factor 0.217
H2-Q7 histocompatibility 2, Q region locus 7 0.213
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.210
Emx2 empty spiracles homolog 2 (Drosophila) 0.205
Fas Fas (TNF receptor superfamily member 6) 0.195
Il1b interleukin 1 beta 0.191
Il27ra interleukin 27 receptor, alpha 0.185
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.182
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.175
Gzmb granzyme B 0.172
Selp selectin, platelet 0.170
Lhx1 LIM homeobox protein 1 0.169
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.161
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.158
Slamf8 SLAM family member 8 0.152
Ccr5 chemokine (C-C motif) receptor 5 0.152
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.152
Batf basic leucine zipper transcription factor, ATF-like 0.141
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.140
Ubd ubiquitin D 0.140
Cxcl10 chemokine (C-X-C motif) ligand 10 0.133
Ccl22 chemokine (C-C motif) ligand 22 0.132
Fasl Fas ligand (TNF superfamily, member 6) 0.132
H2-M3 histocompatibility 2, M region locus 3 0.126
Pitx3 paired-like homeodomain transcription factor 3 0.124
Birc3 baculoviral IAP repeat-containing 3 0.121
Myd88 myeloid differentiation primary response gene 88 0.118
Osr1 odd-skipped related 1 (Drosophila) 0.117
Mybph myosin binding protein H 0.117
Ntf3 neurotrophin 3 0.116
Xcr1 chemokine (C motif) receptor 1 0.116
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.114
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.111
Cd40 CD40 antigen 0.111
H2-Q6 histocompatibility 2, Q region locus 6 0.105
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.101
H2-D1 histocompatibility 2, D region locus 1 0.098
Adra2b adrenergic receptor, alpha 2b 0.097
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.096
Sfrp4 secreted frizzled-related protein 4 0.096
Ifngr1 interferon gamma receptor 1 0.095
Drd2 dopamine receptor D2 0.092
Il10 interleukin 10 0.091
Wnt4 wingless-related MMTV integration site 4 0.091
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.090
Gzma granzyme A 0.090
Il1f9 interleukin 1 family, member 9 0.087
Ptgir prostaglandin I receptor (IP) 0.087
Gpr132 G protein-coupled receptor 132 0.087
Ifnar1 interferon (alpha and beta) receptor 1 0.086
Chrne cholinergic receptor, nicotinic, epsilon polypeptide 0.086
Pdcd1 programmed cell death 1 0.086
Sh2d2a SH2 domain protein 2A 0.086
AI607873 expressed sequence AI607873 0.085
Folr2 folate receptor 2 (fetal) 0.081
Meox1 mesenchyme homeobox 1 0.081
Pyhin1 pyrin and HIN domain family, member 1 0.080
Ncr1 natural cytotoxicity triggering receptor 1 0.080
Ret ret proto-oncogene 0.079
Ccl5 chemokine (C-C motif) ligand 5 0.079
Mmp12 matrix metallopeptidase 12 0.079
Nkg7 natural killer cell group 7 sequence 0.077
Oxt oxytocin 0.077
Gzmk granzyme K 0.076
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.134
Ccl2 chemokine (C-C motif) ligand 2 0.113
Ccl3 chemokine (C-C motif) ligand 3 0.081
Fgfr2 fibroblast growth factor receptor 2 0.063
Il1b interleukin 1 beta 0.055
Il1a interleukin 1 alpha 0.052
Ptprc protein tyrosine phosphatase, receptor type, C 0.045
Jak1 Janus kinase 1 0.040
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.039
Edn1 endothelin 1 0.036
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.036
Cdk4 cyclin-dependent kinase 4 0.034
Cdk2 cyclin dependent kinase 2 0.033
Casp12 caspase 12 0.031
RT1-Bb RT1 class II, locus Bb 0.030
Cd44 Cd44 molecule 0.030
Ccl4 chemokine (C-C motif) ligand 4 0.028
Cxcl10 chemokine (C-X-C motif) ligand 10 0.028
Mmp12 matrix metallopeptidase 12 0.027
Cxcl2 chemokine (C-X-C motif) ligand 2 0.026
Plau plasminogen activator, urokinase 0.026
Cd14 CD14 molecule 0.026
Il2rb interleukin 2 receptor, beta 0.025
Casp3 caspase 3 0.024
Pdcl phosducin-like 0.024
Ptger1 prostaglandin E receptor 1 (subtype EP1) 0.022
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.021
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.021
Igsf6 immunoglobulin superfamily, member 6 0.021
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.020
S1pr2 sphingosine-1-phosphate receptor 2 0.020
Cd38 CD38 molecule 0.019
Cd53 Cd53 molecule 0.018
Arl11 ADP-ribosylation factor-like 11 0.018
RGD1564664 similar to LOC387763 protein 0.018
Socs3 suppressor of cytokine signaling 3 0.017
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.016
Adam17 ADAM metallopeptidase domain 17 0.016
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.016
Spp1 secreted phosphoprotein 1 0.015
Cd200r1 CD200 receptor 1 0.015
Ucn urocortin 0.014
Mcpt8 mast cell protease 8 0.014
Rab20 RAB20, member RAS oncogene family 0.013
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.013
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.013
Igf2 insulin-like growth factor 2 0.013
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.013
Sell selectin L 0.012
Gfap glial fibrillary acidic protein 0.012
Rcn2 reticulocalbin 2, EF-hand calcium binding domain 0.012
Tlr2 toll-like receptor 2 0.012
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.012
Eif4h eukaryotic translation initiation factor 4H 0.011
Ccl7 chemokine (C-C motif) ligand 7 0.011
Sele selectin E 0.011
Ctsc cathepsin C 0.011
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.011
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.011
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.011
Nkg7 natural killer cell group 7 sequence 0.011
Ms4a11 membrane-spanning 4-domains, subfamily A, member 11 0.011
Cd48 Cd48 molecule 0.011
Csf1 colony stimulating factor 1 (macrophage) 0.011
Cxcl3 chemokine (C-X-C motif) ligand 3 0.010
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.010
Arhgap4 Rho GTPase activating protein 4 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism