The network for 'regulation of syncytium formation by plasma membrane fusion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of syncytium formation by plasma membrane fusion

Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.

Homo sapiens
Name Description Probability Func Analog Organism
ABI2 abl-interactor 2 0.943
PTK2 PTK2 protein tyrosine kinase 2 0.880
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.709
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.611
SLC7A5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.569
BCAR1 breast cancer anti-estrogen resistance 1 0.424
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.382
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.355
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.340
PTRF polymerase I and transcript release factor 0.333
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.303
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.270
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.261
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.259
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.226
MAP2K3 mitogen-activated protein kinase kinase 3 0.224
CXCL11 chemokine (C-X-C motif) ligand 11 0.224
MAPK1 mitogen-activated protein kinase 1 0.214
IL2RG interleukin 2 receptor, gamma 0.207
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.196
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.174
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.171
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.145
SH3D19 SH3 domain containing 19 0.143
LASS2 LAG1 homolog, ceramide synthase 2 0.119
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.114
MED31 mediator complex subunit 31 0.113
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.108
MAP2K1 mitogen-activated protein kinase kinase 1 0.103
DLG1 discs, large homolog 1 (Drosophila) 0.103
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.090
VCL vinculin 0.088
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.086
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.083
PXN paxillin 0.083
HOXA1 homeobox A1 0.080
JAK1 Janus kinase 1 0.078
LIMS1 LIM and senescent cell antigen-like domains 1 0.077
IQGAP1 IQ motif containing GTPase activating protein 1 0.072
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.070
IGFBP3 insulin-like growth factor binding protein 3 0.070
IL13RA1 interleukin 13 receptor, alpha 1 0.069
MAPK3 mitogen-activated protein kinase 3 0.069
UBQLN4 ubiquilin 4 0.069
IFNGR1 interferon gamma receptor 1 0.067
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.063
CXCL9 chemokine (C-X-C motif) ligand 9 0.060
YARS tyrosyl-tRNA synthetase 0.058
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.054
GARS glycyl-tRNA synthetase 0.052
DUSP3 dual specificity phosphatase 3 0.051
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.051
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.050
NCK2 NCK adaptor protein 2 0.049
CLTB clathrin, light chain B 0.049
FN1 fibronectin 1 0.049
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.045
WARS tryptophanyl-tRNA synthetase 0.045
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.044
STK10 serine/threonine kinase 10 0.043
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.043
LRRK2 leucine-rich repeat kinase 2 0.043
MFSD1 major facilitator superfamily domain containing 1 0.043
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.042
SDCBP syndecan binding protein (syntenin) 0.040
TRIB3 tribbles homolog 3 (Drosophila) 0.039
MYOD1 myogenic differentiation 1 0.039
BBS10 Bardet-Biedl syndrome 10 0.039
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.039
CD44 CD44 molecule (Indian blood group) 0.036
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.036
CARS cysteinyl-tRNA synthetase 0.036
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.035
COL1A1 collagen, type I, alpha 1 0.034
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.034
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.033
SARS seryl-tRNA synthetase 0.033
DPP4 dipeptidyl-peptidase 4 0.033
LAPTM4A lysosomal protein transmembrane 4 alpha 0.032
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.032
ZNF426 zinc finger protein 426 0.031
MYOG myogenin (myogenic factor 4) 0.030
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.030
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.030
DUSP7 dual specificity phosphatase 7 0.029
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.029
PEA15 phosphoprotein enriched in astrocytes 15 0.028
ARL8B ADP-ribosylation factor-like 8B 0.028
STAT5A signal transducer and activator of transcription 5A 0.028
CXCL13 chemokine (C-X-C motif) ligand 13 0.027
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.027
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.027
CXCR3 chemokine (C-X-C motif) receptor 3 0.027
IGFBP6 insulin-like growth factor binding protein 6 0.027
SDF2 stromal cell-derived factor 2 0.027
TRIM43 tripartite motif containing 43 0.026
PDLIM7 PDZ and LIM domain 7 (enigma) 0.026
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.026
UBD ubiquitin D 0.026
MYBPH myosin binding protein H 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vha-8 Protein VHA-8 0.406
vha-14 Protein VHA-14 0.112
vha-4 Protein VHA-4 0.085
vha-9 Protein VHA-9 0.078
vha-15 Protein VHA-15 0.070
vha-13 Protein VHA-13 0.068
vha-3 Protein VHA-3 0.059
vha-16 Protein VHA-16 0.034
vha-1 Protein VHA-1 0.032
unc-78 Protein UNC-78 0.028
aqp-11 Protein AQP-11 0.028
pssy-1 Protein PSSY-1 0.022
CELE_Y53C10A.5 Protein Y53C10A.5 0.021
acl-1 Protein ACL-1 0.020
idh-1 Protein IDH-1 0.019
F13E6.5 Protein F13E6.5 0.019
sft-4 Protein SFT-4 0.018
emo-1 Protein EMO-1 0.018
erm-1 Protein ERM-1 0.017
vha-10 Protein VHA-10 0.013
ucr-2.2 Protein UCR-2.2 0.013
C24A3.2 Protein C24A3.2 0.013
vha-17 Protein VHA-17 0.012
Y62E10A.13 Protein Y62E10A.13 0.011
nhr-142 Protein NHR-142 0.011
crm-1 Protein CRM-1 0.011
C10E2.6 Protein C10E2.6 0.011
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Danio rerio
Name Description Probability Func Analog Organism
myod1 myogenic differentiation 1 0.993
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.952
myf5 myogenic factor 5 0.708
myog myogenin 0.656
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.631
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.420
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.246
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.243
dld deltaD 0.203
hspb1 heat shock protein, alpha-crystallin-related, 1 0.200
pax3a paired box gene 3a 0.149
si:dkey-27i16.2 si:dkey-27i16.2 0.143
ndfip1 Nedd4 family interacting protein 1 0.118
dpysl3 dihydropyrimidinase-like 3 0.115
efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.113
pcdh10b protocadherin 10b 0.112
zgc:91860 zgc:91860 0.108
irx3b iroquois homeobox protein 3b 0.100
glula glutamate-ammonia ligase (glutamine synthase) a 0.098
meis3 myeloid ecotropic viral integration site 3 0.093
sh3gl2 SH3-domain GRB2-like 2 0.091
lfng lunatic fringe homolog 0.091
atp6v1g1 ATPase, H+ transporting, V1 subunit G isoform 1 0.090
hand2 heart and neural crest derivatives expressed transcript 2 0.088
jam2b junctional adhesion molecule 2b 0.082
atp6v1f ATPase, H+ transporting, V1 subunit F 0.077
laptm4b lysosomal associated protein transmembrane 4 beta 0.075
samsn1a SAM domain, SH3 domain and nuclear localisation signals, 1a 0.073
ctsc cathepsin C 0.071
osr2 odd-skipped related 2 (Drosophila) 0.067
eno1 enolase 1, (alpha) 0.066
dusp2 dual specificity phosphatase 2 0.064
egr2b early growth response 2b 0.063
sema3d semaphorin 3d 0.063
LOC566969 similar to MOX-2 protein 0.061
fstl1a follistatin-like 1a 0.058
olig4 oligodendrocyte transcription factor 4 0.055
osr1 odd-skipped related 1 (Drosophila) 0.055
pcdh8 protocadherin 8 0.054
fstl1b follistatin-like 1b 0.054
jam3b junctional adhesion molecule 3b 0.053
lbx2 ladybird homeobox homolog 2 (Drosophila) 0.053
lmo4a LIM domain only 4a 0.050
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.050
dusp6 dual specificity phosphatase 6 0.050
nptna neuroplastin a 0.049
tcea2 transcription elongation factor A (SII), 2 0.049
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.048
gmfg glia maturation factor, gamma 0.047
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.046
tnnt1 troponin T1, skeletal, slow 0.046
hsp90a.1 heat shock protein 90-alpha 1 0.045
arfip2a ADP-ribosylation factor interacting protein 2a 0.044
rogdi rogdi homolog (Drosophila) 0.043
mpp1 membrane protein, palmitoylated 1 0.042
ckbb creatine kinase, brain b 0.041
stac3 SH3 and cysteine rich domain 3 0.040
ctssb.2 cathepsin S, b.2 0.038
etv2 ets variant gene 2 0.038
ctsf cathepsin F 0.038
jam2a junctional adhesion molecule 2a 0.038
zgc:109987 zgc:109987 0.037
si:dkey-261h17.1 si:dkey-261h17.1 0.036
acvr1b activin A receptor, type IB 0.036
vgll2b vestigial like 2b 0.036
lrrc15 leucine rich repeat containing 15 0.036
hoxb5a homeo box B5a 0.036
flncb filamin C, gamma b (actin binding protein 280) 0.036
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.035
gngt2b guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b 0.035
myf6 myogenic factor 6 0.034
slc3a2 solute carrier family 3, member 2 0.034
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.034
frzb frizzled-related protein 0.034
uncx4.1 Unc4.1 homeobox (C. elegans) 0.033
zfand5a zinc finger, AN1-type domain 5a 0.033
ntn2 netrin 2 0.032
id1 inhibitor of DNA binding 1 0.032
sulf2l sulfatase 2, like 0.032
calm2a calmodulin 2a (phosphorylase kinase, delta) 0.032
rgs13 regulator of G-protein signaling 13 0.030
pax3b paired box gene 3b 0.030
atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.030
gsc goosecoid 0.029
efnb2a ephrin B2a 0.029
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.029
scg3 secretogranin III 0.028
ak3 adenylate kinase 3 0.028
meox1 mesenchyme homeobox 1 0.028
cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.027
cd63 Cd63 antigen 0.027
LOC100002342 carboxypeptidase A6-like 0.027
prtga protogenin homolog a (Gallus gallus) 0.027
calm1a calmodulin 1a 0.027
LOC557062 hypothetical protein LOC557062 0.026
zgc:85889 zgc:85889 0.026
rgs4 regulator of G-protein signalling 4 0.026
hspd1 heat shock 60kD protein 1 (chaperonin) 0.026
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.026
zmynd11 zinc finger, MYND domain containing 11 0.025
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Drosophila melanogaster
Name Description Probability Func Analog Organism
sns sticks and stones 0.990
kirre kin of irre 0.983
Vrp1 Verprolin 1 0.675
lbe ladybird early 0.594
hbs hibris 0.492
eve even skipped 0.340
blow blown fuse 0.307
nau nautilus 0.180
rols rolling pebbles 0.161
Mp20 Muscle protein 20 0.143
cno canoe 0.138
run runt 0.124
foxo forkhead box, sub-group O 0.106
LamC Lamin C 0.099
slou slouch 0.085
Kr Kruppel 0.078
gsb gooseberry 0.077
Pglym78 Phosphoglyceromutase 0.071
X11L CG5675 gene product from transcript CG5675-RB 0.070
Wnt4 Wnt oncogene analog 4 0.063
tin tinman 0.062
Act57B Actin 57B 0.062
byn brachyenteron 0.039
slp1 sloppy paired 1 0.030
Hey Hairy/E(spl)-related with YRPW motif 0.028
Pax Paxillin 0.028
rst roughest 0.028
sing singles bar 0.027
Mlp84B Muscle LIM protein at 84B 0.023
pfk piefke 0.022
sw short wing 0.021
Notum CG13076 gene product from transcript CG13076-RB 0.017
Parp Poly-(ADP-ribose) polymerase 0.016
otk off-track 0.016
Cpr72Ea Cuticular protein 72Ea 0.015
bin biniou 0.014
CG5794 CG5794 gene product from transcript CG5794-RB 0.013
Pvf2 PDGF- and VEGF-related factor 2 0.013
cdi center divider 0.013
sna snail 0.012
Mef2 Myocyte enhancer factor 2 0.012
lmd lame duck 0.011
CG34350 CG34350 gene product from transcript CG34350-RA 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.964
Stat3 signal transducer and activator of transcription 3 0.956
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.753
Ifng interferon gamma 0.724
Tnf tumor necrosis factor 0.717
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.623
Ccl2 chemokine (C-C motif) ligand 2 0.554
Il10 interleukin 10 0.529
Stat5b signal transducer and activator of transcription 5B 0.493
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.399
Ccl7 chemokine (C-C motif) ligand 7 0.375
Irf9 interferon regulatory factor 9 0.332
Il1rn interleukin 1 receptor antagonist 0.330
Il6 interleukin 6 0.324
Cxcl1 chemokine (C-X-C motif) ligand 1 0.313
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.305
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.280
Stat6 signal transducer and activator of transcription 6 0.273
Il1b interleukin 1 beta 0.250
Cd28 CD28 antigen 0.237
Nfatc4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.227
Il2 interleukin 2 0.218
Stat5a signal transducer and activator of transcription 5A 0.205
Fas Fas (TNF receptor superfamily member 6) 0.196
Mapkapk2 MAP kinase-activated protein kinase 2 0.170
Cxcl2 chemokine (C-X-C motif) ligand 2 0.164
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.162
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.151
Selp selectin, platelet 0.145
Il4ra interleukin 4 receptor, alpha 0.137
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.135
Iigp1 interferon inducible GTPase 1 0.130
Pax7 paired box gene 7 0.128
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.123
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.113
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.108
C3ar1 complement component 3a receptor 1 0.107
Ccl20 chemokine (C-C motif) ligand 20 0.105
Vcl vinculin 0.102
Irg1 immunoresponsive gene 1 0.100
Gbp2 guanylate binding protein 2 0.100
Il7 interleukin 7 0.096
Myd88 myeloid differentiation primary response gene 88 0.094
Saa3 serum amyloid A 3 0.093
Il1r1 interleukin 1 receptor, type I 0.091
Cxcl13 chemokine (C-X-C motif) ligand 13 0.089
Ch25h cholesterol 25-hydroxylase 0.089
Ccr1 chemokine (C-C motif) receptor 1 0.088
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.087
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.083
Ubd ubiquitin D 0.081
Lyz2 lysozyme 2 0.079
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.078
Msr1 macrophage scavenger receptor 1 0.077
Skor1 SKI family transcriptional corepressor 1 0.077
Tlr4 toll-like receptor 4 0.073
Zfp36 zinc finger protein 36 0.073
Clec4d C-type lectin domain family 4, member d 0.072
Myf5 myogenic factor 5 0.071
Atf2 activating transcription factor 2 0.070
Irgm1 immunity-related GTPase family M member 1 0.068
Cd14 CD14 antigen 0.068
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.068
Irgm2 immunity-related GTPase family M member 2 0.066
Igtp interferon gamma induced GTPase 0.065
Cd40 CD40 antigen 0.065
Lta lymphotoxin A 0.063
Mefv Mediterranean fever 0.062
Mapk14 mitogen-activated protein kinase 14 0.061
Lmx1b LIM homeobox transcription factor 1 beta 0.060
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.059
Tlr2 toll-like receptor 2 0.058
Bcl3 B-cell leukemia/lymphoma 3 0.055
Mapk9 mitogen-activated protein kinase 9 0.055
Foxp3 forkhead box P3 0.054
Osmr oncostatin M receptor 0.054
Icos inducible T-cell co-stimulator 0.054
Ciita class II transactivator 0.052
Ccl12 chemokine (C-C motif) ligand 12 0.052
Myo1c myosin IC 0.051
Socs1 suppressor of cytokine signaling 1 0.050
Mmp3 matrix metallopeptidase 3 0.050
Gzmb granzyme B 0.049
Tgm2 transglutaminase 2, C polypeptide 0.048
Mmp12 matrix metallopeptidase 12 0.048
Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.046
Ifitm3 interferon induced transmembrane protein 3 0.045
Trem3 triggering receptor expressed on myeloid cells 3 0.045
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.045
Nphs2 nephrosis 2 homolog, podocin (human) 0.045
Smad3 MAD homolog 3 (Drosophila) 0.044
Ccl5 chemokine (C-C motif) ligand 5 0.043
Mvp major vault protein 0.043
Litaf LPS-induced TN factor 0.043
Cxcr5 chemokine (C-X-C motif) receptor 5 0.043
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.043
Il12b interleukin 12b 0.041
Rel reticuloendotheliosis oncogene 0.041
Myod1 myogenic differentiation 1 0.041
Csf1 colony stimulating factor 1 (macrophage) 0.040
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism