The network for 'negative regulation of tumor necrosis factor superfamily cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of tumor necrosis factor superfamily cytokine production

Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production.

Homo sapiens
Name Description Probability Func Analog Organism
IRAK2 interleukin-1 receptor-associated kinase 2 1.000
C1QA complement component 1, q subcomponent, A chain 0.887
MYD88 myeloid differentiation primary response gene (88) 0.808
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.751
TRAF6 TNF receptor-associated factor 6 0.609
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.560
IRAK1 interleukin-1 receptor-associated kinase 1 0.495
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.298
RXRA retinoid X receptor, alpha 0.284
IRAK3 interleukin-1 receptor-associated kinase 3 0.237
PILRA paired immunoglobin-like type 2 receptor alpha 0.161
C1QC complement component 1, q subcomponent, C chain 0.100
MED25 mediator complex subunit 25 0.092
MED15 mediator complex subunit 15 0.088
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.082
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.076
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.071
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.066
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.063
PELI3 pellino homolog 3 (Drosophila) 0.061
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.053
C1QB complement component 1, q subcomponent, B chain 0.053
ZNF263 zinc finger protein 263 0.050
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.047
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.046
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.039
SETD8 SET domain containing (lysine methyltransferase) 8 0.038
PML promyelocytic leukemia 0.036
RNF126 ring finger protein 126 0.034
ZC3H12A zinc finger CCCH-type containing 12A 0.033
CD14 CD14 molecule 0.033
XIAP X-linked inhibitor of apoptosis 0.032
TICAM2 toll-like receptor adaptor molecule 2 0.030
TRIM39 tripartite motif containing 39 0.029
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.028
SIGLEC7 sialic acid binding Ig-like lectin 7 0.024
VSIG4 V-set and immunoglobulin domain containing 4 0.022
IL10RA interleukin 10 receptor, alpha 0.022
PTAFR platelet-activating factor receptor 0.022
TOLLIP toll interacting protein 0.022
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.021
IRF7 interferon regulatory factor 7 0.020
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.020
CCR1 chemokine (C-C motif) receptor 1 0.020
BAG3 BCL2-associated athanogene 3 0.020
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.018
NCOA1 nuclear receptor coactivator 1 0.017
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.017
TNIP1 TNFAIP3 interacting protein 1 0.015
TRIM43 tripartite motif containing 43 0.015
C2orf18 chromosome 2 open reading frame 18 0.015
SPOP speckle-type POZ protein 0.015
MARCO macrophage receptor with collagenous structure 0.014
LY96 lymphocyte antigen 96 0.014
ZC3H12C zinc finger CCCH-type containing 12C 0.014
ZNF473 zinc finger protein 473 0.014
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.013
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.013
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.013
CLEC18C C-type lectin domain family 18, member C 0.013
TRIM26 tripartite motif containing 26 0.012
TRIM21 tripartite motif containing 21 0.012
CD163 CD163 molecule 0.012
CMKLR1 chemokine-like receptor 1 0.012
HK3 hexokinase 3 (white cell) 0.012
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.012
CSK c-src tyrosine kinase 0.012
IL1R1 interleukin 1 receptor, type I 0.012
PRKD2 protein kinase D2 0.012
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.011
TNIP2 TNFAIP3 interacting protein 2 0.011
SLAMF8 SLAM family member 8 0.011
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.011
SLC15A3 solute carrier family 15, member 3 0.010
TRIM5 tripartite motif containing 5 0.010
AVPR2 arginine vasopressin receptor 2 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Myd88 myeloid differentiation primary response gene 88 0.927
Axl AXL receptor tyrosine kinase 0.540
Neurod1 neurogenic differentiation 1 0.483
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.396
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.373
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.320
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.306
Neurog2 neurogenin 2 0.271
Otx2 orthodenticle homolog 2 (Drosophila) 0.248
Tnf tumor necrosis factor 0.247
Traf6 TNF receptor-associated factor 6 0.211
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.191
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.190
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.141
Gnrh1 gonadotropin releasing hormone 1 0.133
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.131
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.122
Trim30d tripartite motif-containing 30D 0.121
Neurod4 neurogenic differentiation 4 0.114
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.103
Cd44 CD44 antigen 0.103
Gab1 growth factor receptor bound protein 2-associated protein 1 0.099
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.091
Stat3 signal transducer and activator of transcription 3 0.091
Pycard PYD and CARD domain containing 0.081
Arrb1 arrestin, beta 1 0.079
Gli2 GLI-Kruppel family member GLI2 0.070
Isl1 ISL1 transcription factor, LIM/homeodomain 0.069
Trim30a tripartite motif-containing 30A 0.068
Pax6 paired box gene 6 0.068
Arrb2 arrestin, beta 2 0.053
Lyz2 lysozyme 2 0.053
Mecom MDS1 and EVI1 complex locus 0.046
Tyro3 TYRO3 protein tyrosine kinase 3 0.040
Gata4 GATA binding protein 4 0.039
Ccr2 chemokine (C-C motif) receptor 2 0.035
Myog myogenin 0.034
Cyld cylindromatosis (turban tumor syndrome) 0.032
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.031
Tnip1 TNFAIP3 interacting protein 1 0.030
Ptf1a pancreas specific transcription factor, 1a 0.029
Fshr follicle stimulating hormone receptor 0.028
Myf5 myogenic factor 5 0.027
Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 0.027
Nhlh1 nescient helix loop helix 1 0.026
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.026
Lhx3 LIM homeobox protein 3 0.025
Foxc2 forkhead box C2 0.024
Igf1 insulin-like growth factor 1 0.024
Trim12a tripartite motif-containing 12A 0.024
Shh sonic hedgehog 0.023
Kiss1 KiSS-1 metastasis-suppressor 0.023
Isl2 insulin related protein 2 (islet 2) 0.022
Lin28a lin-28 homolog A (C. elegans) 0.022
En1 engrailed 1 0.022
Gdf11 growth differentiation factor 11 0.022
Chrng cholinergic receptor, nicotinic, gamma polypeptide 0.021
Pax3 paired box gene 3 0.021
Gsx2 GS homeobox 2 0.020
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.020
Tgfbr2 transforming growth factor, beta receptor II 0.020
Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10 0.020
Pou4f2 POU domain, class 4, transcription factor 2 0.020
Snai1 snail homolog 1 (Drosophila) 0.020
Nkx2-9 NK2 transcription factor related, locus 9 (Drosophila) 0.019
Madcam1 mucosal vascular addressin cell adhesion molecule 1 0.018
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.018
Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide 0.018
Fcgr2b Fc receptor, IgG, low affinity IIb 0.017
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.017
Socs1 suppressor of cytokine signaling 1 0.017
Sykb spleen tyrosine kinase 0.017
Timp1 tissue inhibitor of metalloproteinase 1 0.017
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.016
Ccl2 chemokine (C-C motif) ligand 2 0.016
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.016
Dscam Down syndrome cell adhesion molecule 0.016
Onecut1 one cut domain, family member 1 0.015
Naip6 NLR family, apoptosis inhibitory protein 6 0.015
Amhr2 anti-Mullerian hormone type 2 receptor 0.015
Csf1 colony stimulating factor 1 (macrophage) 0.015
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.015
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.015
Rapsn receptor-associated protein of the synapse 0.015
Prrx1 paired related homeobox 1 0.015
Irak4 interleukin-1 receptor-associated kinase 4 0.014
Il10ra interleukin 10 receptor, alpha 0.014
Hoxa1 homeobox A1 0.014
Trim34a tripartite motif-containing 34A 0.014
Il1r1 interleukin 1 receptor, type I 0.014
Cacng1 calcium channel, voltage-dependent, gamma subunit 1 0.013
Hand2 heart and neural crest derivatives expressed transcript 2 0.013
Fgf6 fibroblast growth factor 6 0.013
Mertk c-mer proto-oncogene tyrosine kinase 0.013
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.013
Fgf15 fibroblast growth factor 15 0.013
Tifa TRAF-interacting protein with forkhead-associated domain 0.013
Ermap erythroblast membrane-associated protein 0.013
Mmp9 matrix metallopeptidase 9 0.013
Lhx6 LIM homeobox protein 6 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rpl31 ribosomal protein L31 0.020
Rap1b RAP1B, member of RAS oncogene family 0.018
Rpl36al ribosomal protein L36a-like 0.015
Rpl35 ribosomal protein L35 0.014
Tomm7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.014
Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism