The network for 'viral life cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

viral life cycle

A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.

Homo sapiens
Name Description Probability Func Analog Organism
THOC4 THO complex 4 1.000
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 1.000
IFI44 interferon-induced protein 44 1.000
THOC5 THO complex 5 0.999
SP110 SP110 nuclear body protein 0.999
MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.999
OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.999
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.999
ISG15 ISG15 ubiquitin-like modifier 0.998
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.998
IFI44L interferon-induced protein 44-like 0.997
SP1 Sp1 transcription factor 0.997
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.996
OASL 2'-5'-oligoadenylate synthetase-like 0.996
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.995
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.994
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.991
STAT1 signal transducer and activator of transcription 1, 91kDa 0.990
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.982
IL8 interleukin 8 0.981
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.980
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.979
SP100 SP100 nuclear antigen 0.978
TP53 tumor protein p53 0.977
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.977
CXCL10 chemokine (C-X-C motif) ligand 10 0.971
DTX3L deltex 3-like (Drosophila) 0.967
CXCL2 chemokine (C-X-C motif) ligand 2 0.959
PLSCR1 phospholipid scramblase 1 0.945
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.942
IFI6 interferon, alpha-inducible protein 6 0.936
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.933
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.933
IRF9 interferon regulatory factor 9 0.920
THOC1 THO complex 1 0.916
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.910
IFI27 interferon, alpha-inducible protein 27 0.904
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.899
IRF7 interferon regulatory factor 7 0.890
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.888
HDAC1 histone deacetylase 1 0.875
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.875
IFI35 interferon-induced protein 35 0.873
IFIH1 interferon induced with helicase C domain 1 0.864
PARP12 poly (ADP-ribose) polymerase family, member 12 0.861
FHL2 four and a half LIM domains 2 0.851
BST2 bone marrow stromal cell antigen 2 0.850
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.846
DICER1 dicer 1, ribonuclease type III 0.846
CXCL3 chemokine (C-X-C motif) ligand 3 0.842
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.824
CCL8 chemokine (C-C motif) ligand 8 0.824
IL1B interleukin 1, beta 0.816
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.814
PML promyelocytic leukemia 0.809
XAF1 XIAP associated factor 1 0.803
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.787
CCL2 chemokine (C-C motif) ligand 2 0.787
TRIM21 tripartite motif containing 21 0.780
IFI16 interferon, gamma-inducible protein 16 0.776
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.776
CXCL11 chemokine (C-X-C motif) ligand 11 0.766
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.732
ARID1B AT rich interactive domain 1B (SWI1-like) 0.727
IL6 interleukin 6 (interferon, beta 2) 0.726
ARID1A AT rich interactive domain 1A (SWI-like) 0.723
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.714
RSAD2 radical S-adenosyl methionine domain containing 2 0.707
HERC5 hect domain and RLD 5 0.689
NCOR1 nuclear receptor corepressor 1 0.683
EP300 E1A binding protein p300 0.675
HIPK2 homeodomain interacting protein kinase 2 0.671
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.660
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.642
ADAR adenosine deaminase, RNA-specific 0.637
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.618
CXCL9 chemokine (C-X-C motif) ligand 9 0.614
TRIM41 tripartite motif containing 41 0.606
CXCL5 chemokine (C-X-C motif) ligand 5 0.603
DPP4 dipeptidyl-peptidase 4 0.600
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.600
CCL20 chemokine (C-C motif) ligand 20 0.598
THOC2 THO complex 2 0.596
HDGF hepatoma-derived growth factor 0.589
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.588
ESR1 estrogen receptor 1 0.565
VCAM1 vascular cell adhesion molecule 1 0.561
PARP1 poly (ADP-ribose) polymerase 1 0.558
UBE2U ubiquitin-conjugating enzyme E2U (putative) 0.537
AXL AXL receptor tyrosine kinase 0.517
GBP1 guanylate binding protein 1, interferon-inducible 0.507
CCR5 chemokine (C-C motif) receptor 5 0.499
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.492
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.492
SAMD9L sterile alpha motif domain containing 9-like 0.482
USP18 ubiquitin specific peptidase 18 0.476
USP54 ubiquitin specific peptidase 54 0.473
TRIM22 tripartite motif containing 22 0.450
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.449
SMAD4 SMAD family member 4 0.447
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
vps24 Charged multivesicular body protein 3 0.033
shrb shrub 0.033
CG10103 CG10103 gene product from transcript CG10103-RA 0.020
Chmp1 CG4108 gene product from transcript CG4108-RA 0.017
CG6259 CG6259 gene product from transcript CG6259-RA 0.015
vps2 CG14542 gene product from transcript CG14542-RA 0.015
Atg18 Autophagy-specific gene 18 0.014
Tsc1 CG6147 gene product from transcript CG6147-RA 0.012
e(y)3 enhancer of yellow 3 0.012
milt milton 0.011
cnc cap-n-collar 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Irf9 interferon regulatory factor 9 0.981
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.974
Rsad2 radical S-adenosyl methionine domain containing 2 0.966
Irf7 interferon regulatory factor 7 0.962
Isg15 ISG15 ubiquitin-like modifier 0.959
Uba7 ubiquitin-like modifier activating enzyme 7 0.909
Usp18 ubiquitin specific peptidase 18 0.899
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.888
Stat1 signal transducer and activator of transcription 1 0.887
Trim30a tripartite motif-containing 30A 0.882
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.853
Tapbp TAP binding protein 0.821
Stat2 signal transducer and activator of transcription 2 0.811
Parp14 poly (ADP-ribose) polymerase family, member 14 0.807
Rtp4 receptor transporter protein 4 0.770
Irgm1 immunity-related GTPase family M member 1 0.769
Ifitm3 interferon induced transmembrane protein 3 0.744
Ifih1 interferon induced with helicase C domain 1 0.686
Irgm2 immunity-related GTPase family M member 2 0.675
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.631
Gbp7 guanylate binding protein 7 0.631
Ifi44 interferon-induced protein 44 0.622
Tor3a torsin family 3, member A 0.593
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.591
Mndal myeloid nuclear differentiation antigen like 0.497
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.488
Ifi35 interferon-induced protein 35 0.484
Trim25 tripartite motif-containing 25 0.469
Atg12 autophagy-related 12 (yeast) 0.433
Mx2 myxovirus (influenza virus) resistance 2 0.430
Trim30d tripartite motif-containing 30D 0.422
Gbp3 guanylate binding protein 3 0.407
Trim21 tripartite motif-containing 21 0.396
BC006779 cDNA sequence BC006779 0.385
Igtp interferon gamma induced GTPase 0.374
Bst2 bone marrow stromal cell antigen 2 0.356
Bax BCL2-associated X protein 0.356
Zbp1 Z-DNA binding protein 1 0.350
Parp9 poly (ADP-ribose) polymerase family, member 9 0.347
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.307
Trim28 tripartite motif-containing 28 0.307
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.303
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.299
Parp12 poly (ADP-ribose) polymerase family, member 12 0.296
Oas2 2'-5' oligoadenylate synthetase 2 0.290
Oas3 2'-5' oligoadenylate synthetase 3 0.284
Arid1a AT rich interactive domain 1A (SWI-like) 0.277
Trp53 transformation related protein 53 0.268
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.265
Lgals9 lectin, galactose binding, soluble 9 0.255
Dtx3l deltex 3-like (Drosophila) 0.254
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.250
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.234
Irf1 interferon regulatory factor 1 0.230
Oasl1 2'-5' oligoadenylate synthetase-like 1 0.218
Parp10 poly (ADP-ribose) polymerase family, member 10 0.199
Samd9l sterile alpha motif domain containing 9-like 0.181
Cdk4 cyclin-dependent kinase 4 0.176
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.172
Cmpk2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.172
Oas1a 2'-5' oligoadenylate synthetase 1A 0.166
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.163
Herc6 hect domain and RLD 6 0.147
Mx1 myxovirus (influenza virus) resistance 1 0.144
Tcf7 transcription factor 7, T-cell specific 0.142
Oas1b 2'-5' oligoadenylate synthetase 1B 0.138
Prmt1 protein arginine N-methyltransferase 1 0.132
Ube2l6 ubiquitin-conjugating enzyme E2L 6 0.131
Hdac2 histone deacetylase 2 0.130
Daxx Fas death domain-associated protein 0.127
Nmi N-myc (and STAT) interactor 0.125
Ifitm2 interferon induced transmembrane protein 2 0.119
D14Ertd668e DNA segment, Chr 14, ERATO Doi 668, expressed 0.118
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.115
Gbp2 guanylate binding protein 2 0.115
Ifi47 interferon gamma inducible protein 47 0.108
Traf3 TNF receptor-associated factor 3 0.105
Xaf1 XIAP associated factor 1 0.102
Cxcl10 chemokine (C-X-C motif) ligand 10 0.101
Slfn4 schlafen 4 0.100
Psme1 proteasome (prosome, macropain) 28 subunit, alpha 0.100
Bak1 BCL2-antagonist/killer 1 0.097
Srrt serrate RNA effector molecule homolog (Arabidopsis) 0.094
Srsf9 serine/arginine-rich splicing factor 9 0.091
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.084
H2-K1 histocompatibility 2, K1, K region 0.083
Znfx1 zinc finger, NFX1-type containing 1 0.083
Tmem106a transmembrane protein 106A 0.082
Ifi203 interferon activated gene 203 0.081
Skil SKI-like 0.081
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.080
Fos FBJ osteosarcoma oncogene 0.079
Pml promyelocytic leukemia 0.079
Bcl2 B-cell leukemia/lymphoma 2 0.077
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.076
Ifi27l2a interferon, alpha-inducible protein 27 like 2A 0.074
Rbbp4 retinoblastoma binding protein 4 0.071
Ifit2 interferon-induced protein with tetratricopeptide repeats 2 0.064
Ewsr1 Ewing sarcoma breakpoint region 1 0.062
Ddx39b DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.062
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism