The network for 'regulation of axon guidance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of axon guidance

Any process that modulates the frequency, rate or extent of axon guidance.

Homo sapiens
Name Description Probability Func Analog Organism
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 1.000
VEGFA vascular endothelial growth factor A 1.000
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 1.000
NRP1 neuropilin 1 1.000
FGFR1 fibroblast growth factor receptor 1 0.999
FGFR2 fibroblast growth factor receptor 2 0.998
RING1 ring finger protein 1 0.995
PLCG1 phospholipase C, gamma 1 0.991
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.987
PGF placental growth factor 0.984
CBX8 chromobox homolog 8 0.981
ELP2 elongation protein 2 homolog (S. cerevisiae) 0.979
RNF2 ring finger protein 2 0.978
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.977
CBX6 chromobox homolog 6 0.931
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.914
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.907
PCGF2 polycomb group ring finger 2 0.897
ELP4 elongation protein 4 homolog (S. cerevisiae) 0.897
MYBBP1A MYB binding protein (P160) 1a 0.881
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.878
PRKG1 protein kinase, cGMP-dependent, type I 0.866
USP11 ubiquitin specific peptidase 11 0.782
PLXND1 plexin D1 0.773
CBX7 chromobox homolog 7 0.767
CDK9 cyclin-dependent kinase 9 0.737
JAG2 jagged 2 0.702
AGTPBP1 ATP/GTP binding protein 1 0.688
CAV1 caveolin 1, caveolae protein, 22kDa 0.658
FGFR3 fibroblast growth factor receptor 3 0.622
FZD1 frizzled homolog 1 (Drosophila) 0.620
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.608
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.600
ZNF512B zinc finger protein 512B 0.598
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.583
CPE carboxypeptidase E 0.577
MAPK8 mitogen-activated protein kinase 8 0.568
FGF7 fibroblast growth factor 7 0.562
PCGF1 polycomb group ring finger 1 0.554
FGF1 fibroblast growth factor 1 (acidic) 0.545
SORBS1 sorbin and SH3 domain containing 1 0.529
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.525
FGF10 fibroblast growth factor 10 0.435
ATXN7 ataxin 7 0.425
LTBP4 latent transforming growth factor beta binding protein 4 0.423
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.415
AGRN agrin 0.409
BMPR1A bone morphogenetic protein receptor, type IA 0.395
RBBP7 retinoblastoma binding protein 7 0.384
ACVR1 activin A receptor, type I 0.382
PLXNB2 plexin B2 0.357
ATN1 atrophin 1 0.345
DPP4 dipeptidyl-peptidase 4 0.312
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.310
DMPK dystrophia myotonica-protein kinase 0.301
PTPRC protein tyrosine phosphatase, receptor type, C 0.291
LRP6 low density lipoprotein receptor-related protein 6 0.290
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.283
CBX4 chromobox homolog 4 0.257
PTPRD protein tyrosine phosphatase, receptor type, D 0.256
CDH5 cadherin 5, type 2 (vascular endothelium) 0.254
TCF4 transcription factor 4 0.247
BMI1 BMI1 polycomb ring finger oncogene 0.247
TGFB3 transforming growth factor, beta 3 0.244
PDIA3 protein disulfide isomerase family A, member 3 0.235
DCC deleted in colorectal carcinoma 0.230
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.204
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.198
SLIT2 slit homolog 2 (Drosophila) 0.195
SORBS2 sorbin and SH3 domain containing 2 0.174
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.172
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.169
RBL1 retinoblastoma-like 1 (p107) 0.161
MBIP MAP3K12 binding inhibitory protein 1 0.158
FRS2 fibroblast growth factor receptor substrate 2 0.153
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.149
STC2 stanniocalcin 2 0.147
SLC6A8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 0.144
PTPRS protein tyrosine phosphatase, receptor type, S 0.142
RBBP4 retinoblastoma binding protein 4 0.138
BCAM basal cell adhesion molecule (Lutheran blood group) 0.138
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.136
FGF2 fibroblast growth factor 2 (basic) 0.135
CHRD chordin 0.132
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.130
RBMS3 RNA binding motif, single stranded interacting protein 3 0.127
PTN pleiotrophin 0.126
FZD8 frizzled homolog 8 (Drosophila) 0.125
CAV2 caveolin 2 0.123
STC1 stanniocalcin 1 0.122
PLXNB1 plexin B1 0.115
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.108
BMP4 bone morphogenetic protein 4 0.107
GFI1B growth factor independent 1B transcription repressor 0.104
TGFB2 transforming growth factor, beta 2 0.099
HSPG2 heparan sulfate proteoglycan 2 0.098
FLNB filamin B, beta 0.097
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.094
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.093
LPHN1 latrophilin 1 0.088
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
robo3 roundabout homolog 3 0.945
bmp2a bone morphogenetic protein 2a 0.917
robo1 roundabout homolog 1 0.912
lhx2b LIM homeobox 2b 0.870
lef1 lymphocyte enhancer binding factor 1 0.826
wnt4a wingless-type MMTV integration site family, member 4a 0.815
tbx1 T-box 1 0.786
wnt8b wingless-type MMTV integration site family, member 8b 0.714
sim1a single-minded homolog 1a (Drosophila) 0.582
otx5 orthodenticle homolog 5 0.557
wnt1 wingless-type MMTV integration site family, member 1 0.543
slit3 slit (Drosophila) homolog 3 0.394
fezf2 FEZ family zinc finger 2 0.340
rdh10a retinol dehydrogenase 10a 0.297
flot1 flotillin 1 0.291
nrp2b neuropilin 2b 0.260
ascl1a achaete-scute complex-like 1a (Drosophila) 0.258
wnt3 wingless-type MMTV integration site family, member 3 0.235
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.230
itgav integrin, alpha V 0.223
mecom MDS1 and EVI1 complex locus 0.213
twist3 twist3 0.213
ntn1b netrin 1b 0.207
grem2 gremlin 2, cysteine knot superfamily 0.196
crestin crestin 0.195
dlx2a distal-less homeobox gene 2a 0.195
foxp2 forkhead box P2 0.186
wnt3a wingless-type MMTV integration site family, member 3A 0.179
sema3d semaphorin 3d 0.163
lhx3 LIM homeobox 3 0.162
shha sonic hedgehog a 0.157
eng1a engrailed 1a 0.149
fgf3 fibroblast growth factor 3 0.147
vcanb versican b 0.135
myf5 myogenic factor 5 0.119
tbx2b T-box 2b 0.118
esrrga estrogen-related receptor gamma a 0.116
lhx6 LIM homeobox 6 0.116
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.112
isl2a islet2a 0.110
vax2 ventral anterior homeobox 2 0.106
rx3 retinal homeobox gene 3 0.106
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.101
ret1 receptor tyrosine kinase 0.100
tbx2a T-box gene 2a 0.097
vcana versican a 0.095
sulf1 sulfatase 1 0.095
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.090
slit2 slit (Drosophila) homolog 2 0.089
ntn1a netrin 1a 0.083
barhl2 BarH-like 2 0.081
tbx4 T-box 4 0.077
spry4 sprouty (Drosophila) homolog 4 0.075
phox2a paired-like homeobox 2a 0.074
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.074
mapk14a mitogen-activated protein kinase 14a 0.073
arx aristaless related homeobox 0.073
dbx1a developing brain homeobox 1a 0.072
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.069
sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.069
mmp2 matrix metalloproteinase 2 0.067
her15.1 hairy and enhancer of split-related 15.1 0.064
slit1a slit homolog 1a (Drosophila) 0.062
dld deltaD 0.061
zgc:77752 zgc:77752 0.060
flh floating head 0.059
wls wntless homolog (Drosophila) 0.059
lmo4a LIM domain only 4a 0.058
osr2 odd-skipped related 2 (Drosophila) 0.057
nrp1a neuropilin 1a 0.055
efnb2a ephrin B2a 0.055
boc brother of CDO 0.054
klf4a Kruppel-like transcription factor 4a 0.052
foxd3 forkhead box D3 0.052
gfra1a gdnf family receptor alpha 1a 0.052
cdh2 cadherin 2, neuronal 0.051
wnt9b wingless-type MMTV integration site family, member 9B 0.050
sox2 SRY-box containing gene 2 0.050
fzd7a frizzled homolog 7a 0.050
etv2 ets variant gene 2 0.048
tbx5a T-box 5a 0.047
gli1 GLI-Kruppel family member 1 0.047
myod1 myogenic differentiation 1 0.047
epb4.1l4 erythrocyte protein band 4.1-like 4 0.047
pcdh10b protocadherin 10b 0.047
neo1 neogenin 1 0.047
hoxa13b homeo box A13b 0.046
pcdh19 protocadherin 19 0.045
wnt10a wingless-type MMTV integration site family, member 10a 0.045
cntn2 contactin 2 0.044
exorh extra-ocular rhodopsin 0.044
vax1 ventral anterior homeobox 1 0.044
sox4b SRY-box containing gene 4b 0.043
epha4a eph receptor A4a 0.043
ndel1a nudE nuclear distribution gene E homolog like 1 (A. nidulans) A 0.042
slit1b slit homolog 1b (Drosophila) 0.042
rxrab retinoid x receptor, alpha b 0.042
gli2a GLI-Kruppel family member GLI2a 0.042
msxd muscle segment homeobox D 0.040
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.039
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Drosophila melanogaster
Name Description Probability Func Analog Organism
unc-5 CG8166 gene product from transcript CG8166-RA 0.994
robo roundabout 0.992
Sema-2a CG4700 gene product from transcript CG4700-RC 0.992
trio CG18214 gene product from transcript CG18214-RA 0.992
Dscam Down syndrome cell adhesion molecule 0.987
NetB Netrin-B 0.985
fra frazzled 0.976
ato atonal 0.961
tutl turtle 0.958
comm commissureless 0.954
Wnt5 Wnt oncogene analog 5 0.948
lea leak 0.901
Sema-1a CG18405 gene product from transcript CG18405-RD 0.900
Ptp69D Protein tyrosine phosphatase 69D 0.889
robo3 CG5423 gene product from transcript CG5423-RA 0.885
plexB plexin B 0.838
plexA plexin A 0.836
dock dreadlocks 0.746
sli slit 0.683
E(spl) Enhancer of split 0.620
amos absent MD neurons and olfactory sensilla 0.585
LIMK1 LIM-kinase1 0.546
Mical Molecule interacting with CasL 0.513
Caps Calcium activated protein for secretion 0.499
stan starry night 0.453
futsch CG34387 gene product from transcript CG34387-RC 0.384
Pak PAK-kinase 0.379
nvy nervy 0.374
gogo golden goal 0.372
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.353
ems empty spiracles 0.342
gcm glial cells missing 0.312
ena enabled 0.268
Nrt Neurotactin 0.253
rg rugose 0.253
retn retained 0.252
HLHm7 E(spl) region transcript m7 0.244
sens senseless 0.239
Abl Abl tyrosine kinase 0.238
HGTX CG13475 gene product from transcript CG13475-RB 0.226
babo baboon 0.214
Gyc76C Guanylyl cyclase at 76C 0.194
Eph Eph receptor tyrosine kinase 0.186
exex extra-extra 0.182
CG12424 CG12424 gene product from transcript CG12424-RC 0.180
salm spalt major 0.177
Hr51 Hormone receptor 51 0.177
otk off-track 0.176
beat-Ia beaten path Ia 0.170
pod1 CG4532 gene product from transcript CG4532-RF 0.158
Sra-1 specifically Rac1-associated protein 1 0.157
Trim9 CG31721 gene product from transcript CG31721-RB 0.142
tll tailless 0.137
ac achaete 0.132
HLHmgamma E(spl) region transcript mgamma 0.125
CG33960 CG33960 gene product from transcript CG33960-RB 0.119
CadN Cadherin-N 0.106
vnd ventral nervous system defective 0.098
Sdc Syndecan 0.090
Ephrin CG1862 gene product from transcript CG1862-RA 0.087
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.082
VGlut Vesicular glutamate transporter 0.079
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.078
tok tolkin 0.078
btl breathless 0.077
nerfin-1 nervous fingers 1 0.076
Kr Kruppel 0.074
mid midline 0.072
Ptp52F CG18243 gene product from transcript CG18243-RB 0.072
side sidestep 0.070
ro rough 0.069
drl derailed 0.067
DAAM Dishevelled Associated Activator of Morphogenesis 0.067
beat-Ic beaten path Ic 0.065
CaMKII Calcium/calmodulin-dependent protein kinase II 0.064
grim CG4345 gene product from transcript CG4345-RA 0.063
Fas3 Fasciclin 3 0.062
Fak56D Focal Adhesion Kinase 0.062
malpha E(spl) region transcript malpha 0.059
jing CG9397 gene product from transcript CG9397-RI 0.057
Fas2 Fasciclin 2 0.056
mam mastermind 0.056
oc ocelliless 0.054
sqz squeeze 0.052
hkb huckebein 0.052
ey eyeless 0.051
nub nubbin 0.049
m2 E(spl) region transcript m2 0.046
Wnt2 Wnt oncogene analog 2 0.043
Lim3 CG10699 gene product from transcript CG10699-RB 0.042
repo reversed polarity 0.041
HLHm5 E(spl) region transcript m5 0.040
jeb jelly belly 0.039
stumps CG31317 gene product from transcript CG31317-RC 0.038
Notum CG13076 gene product from transcript CG13076-RB 0.037
daw dawdle 0.036
HLHmdelta E(spl) region transcript mdelta 0.036
gsb gooseberry 0.035
CBP sarcoplasmic calcium-binding protein 0.032
pdm3 pou domain motif 3 0.032
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Mus musculus
Name Description Probability Func Analog Organism
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.962
Robo1 roundabout homolog 1 (Drosophila) 0.908
Gli3 GLI-Kruppel family member GLI3 0.881
Ednra endothelin receptor type A 0.852
Slit2 slit homolog 2 (Drosophila) 0.851
Plxna1 plexin A1 0.850
Pax2 paired box gene 2 0.849
Tgfbr2 transforming growth factor, beta receptor II 0.811
Fgf8 fibroblast growth factor 8 0.785
Zfpm2 zinc finger protein, multitype 2 0.765
Axl AXL receptor tyrosine kinase 0.762
Tbx3 T-box 3 0.744
Epha4 Eph receptor A4 0.738
Fzd1 frizzled homolog 1 (Drosophila) 0.662
Fgfr2 fibroblast growth factor receptor 2 0.632
Ephb2 Eph receptor B2 0.600
Acvr1 activin A receptor, type 1 0.570
Kdr kinase insert domain protein receptor 0.567
Rarg retinoic acid receptor, gamma 0.563
Gdf11 growth differentiation factor 11 0.553
Shh sonic hedgehog 0.539
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.534
Gab1 growth factor receptor bound protein 2-associated protein 1 0.524
Pou3f3 POU domain, class 3, transcription factor 3 0.512
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.490
Dcc deleted in colorectal carcinoma 0.487
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.476
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.465
Mgat3 mannoside acetylglucosaminyltransferase 3 0.421
Nrp1 neuropilin 1 0.417
Unc5c unc-5 homolog C (C. elegans) 0.389
Tyro3 TYRO3 protein tyrosine kinase 3 0.383
Ptf1a pancreas specific transcription factor, 1a 0.378
Otx2 orthodenticle homolog 2 (Drosophila) 0.348
Pax3 paired box gene 3 0.338
Wnt2b wingless related MMTV integration site 2b 0.336
Flt4 FMS-like tyrosine kinase 4 0.304
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.299
Fgf10 fibroblast growth factor 10 0.295
Sdc3 syndecan 3 0.293
Emp2 epithelial membrane protein 2 0.293
Fzd8 frizzled homolog 8 (Drosophila) 0.283
Tbx1 T-box 1 0.276
Ret ret proto-oncogene 0.274
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.260
Grb10 growth factor receptor bound protein 10 0.249
Tbx2 T-box 2 0.228
Robo2 roundabout homolog 2 (Drosophila) 0.216
Tgfbr1 transforming growth factor, beta receptor I 0.215
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.209
Eng endoglin 0.207
Flt1 FMS-like tyrosine kinase 1 0.204
Ptprb protein tyrosine phosphatase, receptor type, B 0.202
Pax6 paired box gene 6 0.199
Apc adenomatosis polyposis coli 0.193
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.185
Hoxd11 homeobox D11 0.183
Tgfbr3 transforming growth factor, beta receptor III 0.177
Slit3 slit homolog 3 (Drosophila) 0.172
Lmx1a LIM homeobox transcription factor 1 alpha 0.172
Rara retinoic acid receptor, alpha 0.162
Gdnf glial cell line derived neurotrophic factor 0.156
Cdh6 cadherin 6 0.155
Lhx1 LIM homeobox protein 1 0.155
Neurog1 neurogenin 1 0.154
Wnt4 wingless-related MMTV integration site 4 0.152
Gpr27 G protein-coupled receptor 27 0.150
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.150
Epha3 Eph receptor A3 0.147
Nog noggin 0.146
Rarb retinoic acid receptor, beta 0.145
Mid2 midline 2 0.145
Fgf5 fibroblast growth factor 5 0.145
Nrp2 neuropilin 2 0.144
Ptk7 PTK7 protein tyrosine kinase 7 0.134
Hmx3 H6 homeobox 3 0.132
Fgf15 fibroblast growth factor 15 0.131
Fzd7 frizzled homolog 7 (Drosophila) 0.127
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.124
Foxc1 forkhead box C1 0.123
Pcdh12 protocadherin 12 0.119
Wnt3a wingless-related MMTV integration site 3A 0.116
Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 0.116
Ephb3 Eph receptor B3 0.115
Sox7 SRY-box containing gene 7 0.115
Cntn4 contactin 4 0.114
Wnt7a wingless-related MMTV integration site 7A 0.113
Mmp15 matrix metallopeptidase 15 0.111
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.110
Efnb2 ephrin B2 0.109
Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 0.107
Adra2a adrenergic receptor, alpha 2a 0.106
Bmp5 bone morphogenetic protein 5 0.106
Slit1 slit homolog 1 (Drosophila) 0.105
Msi1 Musashi homolog 1(Drosophila) 0.103
Ednrb endothelin receptor type B 0.100
Sult4a1 sulfotransferase family 4A, member 1 0.096
Cdh13 cadherin 13 0.096
Foxb1 forkhead box B1 0.096
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.096
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Rattus norvegicus
Name Description Probability Func Analog Organism
Grip1 glutamate receptor interacting protein 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism