The network for 'cyclic nucleotide mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cyclic nucleotide mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell.

Homo sapiens
Name Description Probability Func Analog Organism
IL8 interleukin 8 0.995
CXCL2 chemokine (C-X-C motif) ligand 2 0.979
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.968
CXCL3 chemokine (C-X-C motif) ligand 3 0.965
CCL5 chemokine (C-C motif) ligand 5 0.961
CCR5 chemokine (C-C motif) receptor 5 0.926
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.911
ARRB1 arrestin, beta 1 0.851
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.816
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.782
CCL20 chemokine (C-C motif) ligand 20 0.734
MPDZ multiple PDZ domain protein 0.711
CXCL10 chemokine (C-X-C motif) ligand 10 0.672
IL1B interleukin 1, beta 0.635
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.566
IFNG interferon, gamma 0.527
CXCL11 chemokine (C-X-C motif) ligand 11 0.490
IL2RB interleukin 2 receptor, beta 0.486
CXCL5 chemokine (C-X-C motif) ligand 5 0.455
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.447
CCL4 chemokine (C-C motif) ligand 4 0.438
DPP4 dipeptidyl-peptidase 4 0.422
CRH corticotropin releasing hormone 0.404
CXCL9 chemokine (C-X-C motif) ligand 9 0.376
TBXA2R thromboxane A2 receptor 0.340
POU3F2 POU class 3 homeobox 2 0.327
PAX3 paired box 3 0.309
CXCR5 chemokine (C-X-C motif) receptor 5 0.304
CCL22 chemokine (C-C motif) ligand 22 0.282
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.255
TBC1D10A TBC1 domain family, member 10A 0.230
CCL2 chemokine (C-C motif) ligand 2 0.228
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.223
IL6 interleukin 6 (interferon, beta 2) 0.212
CCL8 chemokine (C-C motif) ligand 8 0.210
INF2 inverted formin, FH2 and WH2 domain containing 0.201
SSTR3 somatostatin receptor 3 0.200
A2M alpha-2-macroglobulin 0.197
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.157
SOD2 superoxide dismutase 2, mitochondrial 0.154
CCL11 chemokine (C-C motif) ligand 11 0.151
CXCR3 chemokine (C-X-C motif) receptor 3 0.140
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.126
IL10 interleukin 10 0.115
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.111
CCR2 chemokine (C-C motif) receptor 2 0.110
TNF tumor necrosis factor 0.109
UBA1 ubiquitin-like modifier activating enzyme 1 0.093
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.092
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.090
CCL7 chemokine (C-C motif) ligand 7 0.085
PTEN phosphatase and tensin homolog 0.085
CD40LG CD40 ligand 0.084
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.082
FBXW5 F-box and WD repeat domain containing 5 0.075
APOC1 apolipoprotein C-I 0.074
HP haptoglobin 0.074
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.072
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.072
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.070
CXCL13 chemokine (C-X-C motif) ligand 13 0.068
MEOX2 mesenchyme homeobox 2 0.068
CCL19 chemokine (C-C motif) ligand 19 0.067
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.067
FAS Fas (TNF receptor superfamily, member 6) 0.066
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.061
IRF4 interferon regulatory factor 4 0.061
YAP1 Yes-associated protein 1 0.060
CCR4 chemokine (C-C motif) receptor 4 0.059
SELE selectin E 0.057
CCR7 chemokine (C-C motif) receptor 7 0.055
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.054
CALCA calcitonin-related polypeptide alpha 0.053
GHRHR growth hormone releasing hormone receptor 0.053
RGS1 regulator of G-protein signaling 1 0.052
SSTR2 somatostatin receptor 2 0.050
CACYBP calcyclin binding protein 0.050
SMAD7 SMAD family member 7 0.049
INHBA inhibin, beta A 0.049
PLEK pleckstrin 0.047
DRD2 dopamine receptor D2 0.047
SOCS3 suppressor of cytokine signaling 3 0.046
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.045
CXCR2 chemokine (C-X-C motif) receptor 2 0.042
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.041
SLAMF7 SLAM family member 7 0.041
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.041
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.040
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.040
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.040
CCL3 chemokine (C-C motif) ligand 3 0.039
CLEC7A C-type lectin domain family 7, member A 0.039
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.039
BTRC beta-transducin repeat containing 0.038
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.038
SKP1 S-phase kinase-associated protein 1 0.037
MATK megakaryocyte-associated tyrosine kinase 0.037
TAL1 T-cell acute lymphocytic leukemia 1 0.035
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.034
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.953
Lepr leptin receptor 0.854
Esr1 estrogen receptor 1 (alpha) 0.672
Kl klotho 0.581
Cckbr cholecystokinin B receptor 0.488
Drd2 dopamine receptor D2 0.430
Adrb1 adrenergic receptor, beta 1 0.400
Pnpla2 patatin-like phospholipase domain containing 2 0.363
Pparg peroxisome proliferator activated receptor gamma 0.351
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.347
Rims2 regulating synaptic membrane exocytosis 2 0.270
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.256
Cav1 caveolin 1, caveolae protein 0.251
Ret ret proto-oncogene 0.223
Smad4 MAD homolog 4 (Drosophila) 0.204
Lep leptin 0.201
Shc3 src homology 2 domain-containing transforming protein C3 0.184
Nos1 nitric oxide synthase 1, neuronal 0.168
Ghr growth hormone receptor 0.157
Esr2 estrogen receptor 2 (beta) 0.116
Pten phosphatase and tensin homolog 0.109
Ccl2 chemokine (C-C motif) ligand 2 0.100
Crhr1 corticotropin releasing hormone receptor 1 0.095
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.088
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.079
Nos3 nitric oxide synthase 3, endothelial cell 0.078
Fgf10 fibroblast growth factor 10 0.076
Thrb thyroid hormone receptor beta 0.075
Rims1 regulating synaptic membrane exocytosis 1 0.073
Pax8 paired box gene 8 0.070
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.066
Npy2r neuropeptide Y receptor Y2 0.062
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.051
Kitl kit ligand 0.050
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.048
Mrvi1 MRV integration site 1 0.048
Prkg1 protein kinase, cGMP-dependent, type I 0.047
Rorb RAR-related orphan receptor beta 0.047
Galr1 galanin receptor 1 0.043
Sncb synuclein, beta 0.043
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.042
Oprm1 opioid receptor, mu 1 0.041
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.040
Fbxl20 F-box and leucine-rich repeat protein 20 0.040
Lmx1b LIM homeobox transcription factor 1 beta 0.039
Ptgs2 prostaglandin-endoperoxide synthase 2 0.039
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.039
Rgs9 regulator of G-protein signaling 9 0.038
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.038
Apc adenomatosis polyposis coli 0.038
Plcg1 phospholipase C, gamma 1 0.037
Hcn1 hyperpolarization-activated, cyclic nucleotide-gated K+ 1 0.036
Smad1 MAD homolog 1 (Drosophila) 0.036
Npy1r neuropeptide Y receptor Y1 0.034
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.033
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.032
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.031
Syt7 synaptotagmin VII 0.031
Fabp4 fatty acid binding protein 4, adipocyte 0.031
Adipoq adiponectin, C1Q and collagen domain containing 0.030
Mitf microphthalmia-associated transcription factor 0.030
Rgs4 regulator of G-protein signaling 4 0.029
Plcb1 phospholipase C, beta 1 0.029
Acan aggrecan 0.029
Has2 hyaluronan synthase 2 0.029
Ccbp2 chemokine binding protein 2 0.029
Pdx1 pancreatic and duodenal homeobox 1 0.028
Sntb1 syntrophin, basic 1 0.028
Slc12a1 solute carrier family 12, member 1 0.028
Drd4 dopamine receptor D4 0.027
Drd3 dopamine receptor D3 0.027
Selp selectin, platelet 0.026
Neurog3 neurogenin 3 0.026
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.026
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.026
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.026
Tac2 tachykinin 2 0.026
Ar androgen receptor 0.025
Il10ra interleukin 10 receptor, alpha 0.025
Sstr2 somatostatin receptor 2 0.025
Nppb natriuretic peptide type B 0.025
Htra3 HtrA serine peptidase 3 0.025
Mc5r melanocortin 5 receptor 0.025
Sstr4 somatostatin receptor 4 0.024
Edil3 EGF-like repeats and discoidin I-like domains 3 0.024
Bcar1 breast cancer anti-estrogen resistance 1 0.024
Ptgfr prostaglandin F receptor 0.024
Nrgn neurogranin 0.024
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.024
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.024
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.023
Ncam2 neural cell adhesion molecule 2 0.023
Edn2 endothelin 2 0.023
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.023
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.023
Vdr vitamin D receptor 0.023
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.023
Fut1 fucosyltransferase 1 0.023
Epha6 Eph receptor A6 0.022
Sertad2 SERTA domain containing 2 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SSB2 Ssb2p 0.035
UBI4 Ubi4p 0.021
NOP1 Nop1p 0.020
RPL13A Rpl13ap 0.018
HAS1 Has1p 0.015
NOP58 Nop58p 0.014
RPL17B Rpl17bp 0.014
URA7 Ura7p 0.014
RPL7A Rpl7ap 0.013
YVH1 Yvh1p 0.013
PWP1 Pwp1p 0.013
RIX1 Rix1p 0.013
DBP9 Dbp9p 0.013
SUP45 Sup45p 0.012
BRX1 Brx1p 0.011
ASC1 Asc1p 0.011
RPS16B Rps16bp 0.011
RPS0A Rps0ap 0.011
RPC40 Rpc40p 0.011
RPL16B Rpl16bp 0.010
KAP123 Kap123p 0.010
RPS24A Rps24ap 0.010
RPS22A Rps22ap 0.010
TIF3 Tif3p 0.010
RPC53 Rpc53p 0.010