The network for 'response to exogenous dsrna' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to exogenous dsrna

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.838
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.701
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.530
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.479
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.291
SLC7A5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 0.187
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.180
BIRC3 baculoviral IAP repeat containing 3 0.156
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.151
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.151
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.148
IFI44 interferon-induced protein 44 0.147
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.100
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.095
PIAS4 protein inhibitor of activated STAT, 4 0.088
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.087
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.081
TNIP2 TNFAIP3 interacting protein 2 0.077
MAPK3 mitogen-activated protein kinase 3 0.073
BCL3 B-cell CLL/lymphoma 3 0.056
OASL 2'-5'-oligoadenylate synthetase-like 0.048
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.041
IFI44L interferon-induced protein 44-like 0.039
RTP4 receptor (chemosensory) transporter protein 4 0.038
HERC5 hect domain and RLD 5 0.036
IL1RAP interleukin 1 receptor accessory protein 0.036
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.035
IFIH1 interferon induced with helicase C domain 1 0.032
IRAK2 interleukin-1 receptor-associated kinase 2 0.031
ISG15 ISG15 ubiquitin-like modifier 0.031
TNIP1 TNFAIP3 interacting protein 1 0.028
CYLD cylindromatosis (turban tumor syndrome) 0.026
OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 0.024
DUSP1 dual specificity phosphatase 1 0.024
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.023
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.023
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.022
SP100 SP100 nuclear antigen 0.022
MAPK14 mitogen-activated protein kinase 14 0.021
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.021
XAF1 XIAP associated factor 1 0.020
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.019
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.019
RSAD2 radical S-adenosyl methionine domain containing 2 0.019
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.018
IL1R1 interleukin 1 receptor, type I 0.018
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.018
MAPK1 mitogen-activated protein kinase 1 0.014
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.014
TOP1 topoisomerase (DNA) I 0.013
ZNFX1 zinc finger, NFX1-type containing 1 0.013
TDRD7 tudor domain containing 7 0.013
SAMD9L sterile alpha motif domain containing 9-like 0.013
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.012
IL8 interleukin 8 0.011
ELK1 ELK1, member of ETS oncogene family 0.011
SAMD9 sterile alpha motif domain containing 9 0.010
CD14 CD14 molecule 0.010
EPSTI1 epithelial stromal interaction 1 (breast) 0.010
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.010
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.562
il6st interleukin 6 signal transducer 0.379
nod1 nucleotide-binding oligomerization domain containing 1 0.321
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.163
stc1l stanniocalcin 1, like 0.126
mapk3 mitogen-activated protein kinase 3 0.120
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.110
ifnphi1 interferon phi 1 0.100
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.099
LOC557072 caspase recruitment domain-containing protein 11-like 0.085
il1b interleukin 1, beta and interleukin 1, beta 0.082
tlr3 toll-like receptor 3 0.065
cd63 Cd63 antigen 0.063
nos2a nitric oxide synthase 2a, inducible 0.054
card9 caspase recruitment domain family, member 9 0.051
pth1a parathyroid hormone 1a 0.048
si:ch211-195h23.3 si:ch211-195h23.3 0.038
pkz protein kinase containing Z-DNA binding domains 0.036
il6r interleukin 6 receptor 0.034
tlr9 toll-like receptor 9 0.033
epor erythropoietin receptor 0.027
si:dkey-236e20.2 si:dkey-236e20.2 0.027
slc15a1b solute carrier family 15 (oligopeptide transporter), member 1b 0.026
mapk1 mitogen-activated protein kinase 1 0.025
mxa myxovirus (influenza) resistance A 0.023
slc4a4b solute carrier family 4, sodium bicarbonate cotransporter, member 4b 0.023
socs3a suppressor of cytokine signaling 3a 0.022
anxa2a annexin A2a 0.021
stat3 signal transduction and activation of transcription 3 0.021
gfer growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) 0.020
fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.020
mapk12 mitogen-activated protein kinase 12 0.016
smad1 MAD homolog 1 (Drosophila) 0.016
irf3 interferon regulatory factor 3 0.016
lndc1 ly6/neurotoxin domain containing 1 0.015
nod2 nucleotide-binding oligomerization domain containing 2 0.014
LOC100000934 hypothetical protein LOC100000934 0.014
mmp9 matrix metalloproteinase 9 0.013
il8 interleukin 8 0.013
ifng1-2 interferon, gamma 1-2 0.013
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.012
cyt1 type I cytokeratin, enveloping layer 0.011
skia nuclear oncoprotein skia 0.011
hcrt hypocretin (orexin) neuropeptide precursor 0.011
ripk2 receptor-interacting serine-threonine kinase 2 0.011
tnfb tumor necrosis factor b (TNF superfamily, member 2) 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.723
Myd88 myeloid differentiation primary response gene 88 0.681
Stat3 signal transducer and activator of transcription 3 0.291
Lyz2 lysozyme 2 0.248
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.236
Tlr4 toll-like receptor 4 0.232
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.174
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.146
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.132
Traf6 TNF receptor-associated factor 6 0.127
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.106
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.102
Il1r1 interleukin 1 receptor, type I 0.071
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.065
Stat5b signal transducer and activator of transcription 5B 0.063
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.060
Cd44 CD44 antigen 0.049
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.048
Unc93b1 unc-93 homolog B1 (C. elegans) 0.044
Stat5a signal transducer and activator of transcription 5A 0.044
Casp1 caspase 1 0.041
Foxp3 forkhead box P3 0.038
Tnf tumor necrosis factor 0.038
Irgm1 immunity-related GTPase family M member 1 0.035
Il1b interleukin 1 beta 0.033
Ikzf1 IKAROS family zinc finger 1 0.033
Bcl3 B-cell leukemia/lymphoma 3 0.032
Il4ra interleukin 4 receptor, alpha 0.031
Socs3 suppressor of cytokine signaling 3 0.027
Trim21 tripartite motif-containing 21 0.027
Sfn stratifin 0.026
Stat1 signal transducer and activator of transcription 1 0.026
Ticam1 toll-like receptor adaptor molecule 1 0.024
Tnip1 TNFAIP3 interacting protein 1 0.024
Ccl4 chemokine (C-C motif) ligand 4 0.024
Irak4 interleukin-1 receptor-associated kinase 4 0.024
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.023
Trp53 transformation related protein 53 0.023
Parp14 poly (ADP-ribose) polymerase family, member 14 0.023
Pycard PYD and CARD domain containing 0.022
Nlrp3 NLR family, pyrin domain containing 3 0.021
Sfpi1 SFFV proviral integration 1 0.021
Zfp36 zinc finger protein 36 0.021
Ikbkg inhibitor of kappaB kinase gamma 0.021
Trim25 tripartite motif-containing 25 0.021
Fas Fas (TNF receptor superfamily member 6) 0.020
Il6 interleukin 6 0.020
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.019
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.019
Igh immunoglobulin heavy chain complex 0.019
Traf3 TNF receptor-associated factor 3 0.019
Irf7 interferon regulatory factor 7 0.018
Rtp4 receptor transporter protein 4 0.018
Il10 interleukin 10 0.018
Casp8 caspase 8 0.017
Ifnar1 interferon (alpha and beta) receptor 1 0.017
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.017
Junb Jun-B oncogene 0.016
Isg15 ISG15 ubiquitin-like modifier 0.016
Inadl InaD-like (Drosophila) 0.016
Irak3 interleukin-1 receptor-associated kinase 3 0.015
1810019J16Rik RIKEN cDNA 1810019J16 gene 0.014
Mx1 myxovirus (influenza virus) resistance 1 0.014
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.014
Cyld cylindromatosis (turban tumor syndrome) 0.014
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.013
Ccl2 chemokine (C-C motif) ligand 2 0.013
Cd79b CD79B antigen 0.013
Cxcl2 chemokine (C-X-C motif) ligand 2 0.013
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.013
Lgals9 lectin, galactose binding, soluble 9 0.013
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.013
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.013
Ikbkb inhibitor of kappaB kinase beta 0.013
Icos inducible T-cell co-stimulator 0.012
BC006779 cDNA sequence BC006779 0.012
Rel reticuloendotheliosis oncogene 0.012
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.012
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.012
Itch itchy, E3 ubiquitin protein ligase 0.011
Icam1 intercellular adhesion molecule 1 0.011
Pim1 proviral integration site 1 0.011
Cd40 CD40 antigen 0.011
Samd9l sterile alpha motif domain containing 9-like 0.011
Atr ataxia telangiectasia and Rad3 related 0.011
Zbp1 Z-DNA binding protein 1 0.011
Irf5 interferon regulatory factor 5 0.011
Il6st interleukin 6 signal transducer 0.010
Usp18 ubiquitin specific peptidase 18 0.010
Irf1 interferon regulatory factor 1 0.010
Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.010
Tifa TRAF-interacting protein with forkhead-associated domain 0.010
Lepr leptin receptor 0.010
Ptgs2 prostaglandin-endoperoxide synthase 2 0.010
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Irf7 interferon regulatory factor 7 0.675
Usp18 ubiquitin specific peptidase 18 0.134
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.110
Oas1a 2'-5' oligoadenylate synthetase 1A 0.095
Oasl 2'-5'-oligoadenylate synthetase-like 0.055
Mx1 myxovirus (influenza virus) resistance 1 0.047
Errfi1 ERBB receptor feedback inhibitor 1 0.033
Irf9 interferon regulatory factor 9 0.030
Zfp36 zinc finger protein 36 0.024
Yme1l1 YME1-like 1 (S. cerevisiae) 0.022
Isg15 ISG15 ubiquitin-like modifier 0.021
Trio triple functional domain (PTPRF interacting) 0.014
Cxcl10 chemokine (C-X-C motif) ligand 10 0.012
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.012
Itgb7 integrin, beta 7 0.011
Dnm1l dynamin 1-like 0.011
LOC100365106 rCG32755-like 0.011
Ccl4 chemokine (C-C motif) ligand 4 0.011
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.010
Stat1 signal transducer and activator of transcription 1 0.010
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.010
Zbp1 Z-DNA binding protein 1 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism