The network for 'response to nitric oxide' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to nitric oxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.000
CCR5 chemokine (C-C motif) receptor 5 1.000
IL1B interleukin 1, beta 0.999
TRAF1 TNF receptor-associated factor 1 0.998
CCL4 chemokine (C-C motif) ligand 4 0.997
CXCL9 chemokine (C-X-C motif) ligand 9 0.975
IL1RN interleukin 1 receptor antagonist 0.969
CCL5 chemokine (C-C motif) ligand 5 0.963
CCL2 chemokine (C-C motif) ligand 2 0.948
CREBBP CREB binding protein 0.938
IDE insulin-degrading enzyme 0.899
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.893
CCR7 chemokine (C-C motif) receptor 7 0.840
VAC14 Vac14 homolog (S. cerevisiae) 0.838
CXCL10 chemokine (C-X-C motif) ligand 10 0.821
CCL13 chemokine (C-C motif) ligand 13 0.814
CCL8 chemokine (C-C motif) ligand 8 0.807
EPAS1 endothelial PAS domain protein 1 0.802
VHL von Hippel-Lindau tumor suppressor 0.785
DPP4 dipeptidyl-peptidase 4 0.771
EGLN3 egl nine homolog 3 (C. elegans) 0.704
TRADD TNFRSF1A-associated via death domain 0.667
TNF tumor necrosis factor 0.636
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.627
CXCL11 chemokine (C-X-C motif) ligand 11 0.623
IL1RAP interleukin 1 receptor accessory protein 0.618
TTR transthyretin 0.590
SSX4 synovial sarcoma, X breakpoint 4 0.556
MAP2K4 mitogen-activated protein kinase kinase 4 0.532
CCL22 chemokine (C-C motif) ligand 22 0.521
MAP2K7 mitogen-activated protein kinase kinase 7 0.506
TIFA TRAF-interacting protein with forkhead-associated domain 0.491
IL6 interleukin 6 (interferon, beta 2) 0.461
EGLN1 egl nine homolog 1 (C. elegans) 0.444
IFNG interferon, gamma 0.444
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.442
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.437
CCL19 chemokine (C-C motif) ligand 19 0.428
AR androgen receptor 0.414
PLEK pleckstrin 0.392
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.390
CCL3 chemokine (C-C motif) ligand 3 0.345
CXCL13 chemokine (C-X-C motif) ligand 13 0.315
IL10 interleukin 10 0.311
KCTD17 potassium channel tetramerisation domain containing 17 0.286
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.280
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.268
TICAM2 toll-like receptor adaptor molecule 2 0.254
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.249
CCL11 chemokine (C-C motif) ligand 11 0.247
IL2RB interleukin 2 receptor, beta 0.240
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.203
UBD ubiquitin D 0.199
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.194
ADAMTSL4 ADAMTS-like 4 0.184
SLAMF8 SLAM family member 8 0.179
CD83 CD83 molecule 0.175
ARRB1 arrestin, beta 1 0.168
CCR1 chemokine (C-C motif) receptor 1 0.167
IL1R2 interleukin 1 receptor, type II 0.167
IL7R interleukin 7 receptor 0.162
CXCL5 chemokine (C-X-C motif) ligand 5 0.152
DMBT1 deleted in malignant brain tumors 1 0.148
RGS1 regulator of G-protein signaling 1 0.143
ARNT aryl hydrocarbon receptor nuclear translocator 0.136
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.135
SP1 Sp1 transcription factor 0.133
CCL7 chemokine (C-C motif) ligand 7 0.132
VCAM1 vascular cell adhesion molecule 1 0.130
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.126
CD40 CD40 molecule, TNF receptor superfamily member 5 0.121
BIRC3 baculoviral IAP repeat containing 3 0.120
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.117
FPR3 formyl peptide receptor 3 0.116
CXCL2 chemokine (C-X-C motif) ligand 2 0.109
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.106
TRAF6 TNF receptor-associated factor 6 0.105
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.102
SELE selectin E 0.100
FKBP8 FK506 binding protein 8, 38kDa 0.098
FHL2 four and a half LIM domains 2 0.095
IL8 interleukin 8 0.084
CCL17 chemokine (C-C motif) ligand 17 0.079
IL18RAP interleukin 18 receptor accessory protein 0.078
IL1A interleukin 1, alpha 0.076
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.076
TGFB1 transforming growth factor, beta 1 0.075
LAMP3 lysosomal-associated membrane protein 3 0.074
SFTPD surfactant protein D 0.074
CXCR6 chemokine (C-X-C motif) receptor 6 0.074
CCR4 chemokine (C-C motif) receptor 4 0.073
CCL21 chemokine (C-C motif) ligand 21 0.072
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.071
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.069
IL2RG interleukin 2 receptor, gamma 0.066
GNLY granulysin 0.065
EBI3 Epstein-Barr virus induced 3 0.065
DUSP4 dual specificity phosphatase 4 0.065
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.063
MTA1 metastasis associated 1 0.062
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Mapk14 mitogen-activated protein kinase 14 0.998
Mapk11 mitogen-activated protein kinase 11 0.945
Pten phosphatase and tensin homolog 0.901
Cav1 caveolin 1, caveolae protein 0.673
Atf2 activating transcription factor 2 0.585
Vhl von Hippel-Lindau tumor suppressor 0.404
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.403
Mapkapk2 MAP kinase-activated protein kinase 2 0.317
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.298
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.264
Duox2 dual oxidase 2 0.222
Mdm2 transformed mouse 3T3 cell double minute 2 0.206
Mapk8 mitogen-activated protein kinase 8 0.178
Lepr leptin receptor 0.176
Cd44 CD44 antigen 0.175
Mapk9 mitogen-activated protein kinase 9 0.158
Mavs mitochondrial antiviral signaling protein 0.147
Igh immunoglobulin heavy chain complex 0.129
Cd40 CD40 antigen 0.127
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.110
Klc1 kinesin light chain 1 0.109
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.109
Vegfa vascular endothelial growth factor A 0.102
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.102
Tlr4 toll-like receptor 4 0.095
Traf2 TNF receptor-associated factor 2 0.077
Crebbp CREB binding protein 0.074
Irak3 interleukin-1 receptor-associated kinase 3 0.071
Myd88 myeloid differentiation primary response gene 88 0.071
Plat plasminogen activator, tissue 0.070
Birc3 baculoviral IAP repeat-containing 3 0.069
Thra thyroid hormone receptor alpha 0.068
Traf6 TNF receptor-associated factor 6 0.056
Rarg retinoic acid receptor, gamma 0.055
Hif1a hypoxia inducible factor 1, alpha subunit 0.053
Irak1 interleukin-1 receptor-associated kinase 1 0.053
Trp53 transformation related protein 53 0.049
Dlg1 discs, large homolog 1 (Drosophila) 0.048
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.046
Fst follistatin 0.045
Trafd1 TRAF type zinc finger domain containing 1 0.044
Spp1 secreted phosphoprotein 1 0.042
Mapk1 mitogen-activated protein kinase 1 0.042
Timp4 tissue inhibitor of metalloproteinase 4 0.040
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.038
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.038
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.038
Ccl2 chemokine (C-C motif) ligand 2 0.038
Jun Jun oncogene 0.038
Mapk12 mitogen-activated protein kinase 12 0.038
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.037
Npc1 Niemann Pick type C1 0.037
Prkce protein kinase C, epsilon 0.037
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.036
Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.036
Ptgs2 prostaglandin-endoperoxide synthase 2 0.035
Smad3 MAD homolog 3 (Drosophila) 0.034
Tgfb2 transforming growth factor, beta 2 0.034
Lep leptin 0.034
Il6 interleukin 6 0.034
Kiss1 KiSS-1 metastasis-suppressor 0.034
Srpx sushi-repeat-containing protein 0.033
Gdnf glial cell line derived neurotrophic factor 0.033
Tnc tenascin C 0.033
Npy1r neuropeptide Y receptor Y1 0.033
Mknk1 MAP kinase-interacting serine/threonine kinase 1 0.031
Dusp2 dual specificity phosphatase 2 0.031
Otud7b OTU domain containing 7B 0.029
Lama4 laminin, alpha 4 0.029
Agtr1a angiotensin II receptor, type 1a 0.029
Ep300 E1A binding protein p300 0.028
Zeb1 zinc finger E-box binding homeobox 1 0.027
Traf3ip2 TRAF3 interacting protein 2 0.026
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.026
Mdm4 transformed mouse 3T3 cell double minute 4 0.026
Met met proto-oncogene 0.026
P4htm prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.025
Wdfy2 WD repeat and FYVE domain containing 2 0.025
Foxo3 forkhead box O3 0.024
Gfpt2 glutamine fructose-6-phosphate transaminase 2 0.024
Stat3 signal transducer and activator of transcription 3 0.024
Dpt dermatopontin 0.023
Ikbkg inhibitor of kappaB kinase gamma 0.023
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.023
Map2k3 mitogen-activated protein kinase kinase 3 0.023
Plau plasminogen activator, urokinase 0.023
Ldlr low density lipoprotein receptor 0.023
Yap1 yes-associated protein 1 0.023
Map3k1 mitogen-activated protein kinase kinase kinase 1 0.022
Lama2 laminin, alpha 2 0.022
Gata6 GATA binding protein 6 0.022
Ctnnb1 catenin (cadherin associated protein), beta 1 0.021
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.021
Fgfr2 fibroblast growth factor receptor 2 0.021
Col16a1 collagen, type XVI, alpha 1 0.021
Epas1 endothelial PAS domain protein 1 0.021
Spag9 sperm associated antigen 9 0.020
Fbn1 fibrillin 1 0.020
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.020
Bcl6 B-cell leukemia/lymphoma 6 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100363106 LRRG00130-like 0.223
LOC100359522 LRRGT00191-like 0.015
LOC100364265 ribosomal protein L19-like 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism