The network for 'negative regulation of endothelial cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of endothelial cell proliferation

Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.

Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.685
CAV1 caveolin 1, caveolae protein, 22kDa 0.511
TGFB1 transforming growth factor, beta 1 0.298
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.202
EGFR epidermal growth factor receptor 0.185
RARA retinoic acid receptor, alpha 0.130
CCR5 chemokine (C-C motif) receptor 5 0.117
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.115
JAK2 Janus kinase 2 0.081
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.058
IRF9 interferon regulatory factor 9 0.055
JAK1 Janus kinase 1 0.049
INSR insulin receptor 0.047
HP haptoglobin 0.047
NCOA1 nuclear receptor coactivator 1 0.043
IL2RB interleukin 2 receptor, beta 0.039
CAV2 caveolin 2 0.038
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.034
IL4R interleukin 4 receptor 0.033
RXRA retinoid X receptor, alpha 0.031
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.025
MED25 mediator complex subunit 25 0.025
CCL5 chemokine (C-C motif) ligand 5 0.023
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.022
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.022
S100B S100 calcium binding protein B 0.020
APOC1 apolipoprotein C-I 0.020
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.019
IL12RB2 interleukin 12 receptor, beta 2 0.019
F2R coagulation factor II (thrombin) receptor 0.017
TGFB3 transforming growth factor, beta 3 0.017
SPOP speckle-type POZ protein 0.017
CCR4 chemokine (C-C motif) receptor 4 0.017
IRS1 insulin receptor substrate 1 0.017
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.017
CCR2 chemokine (C-C motif) receptor 2 0.016
IFNG interferon, gamma 0.016
PTPRF protein tyrosine phosphatase, receptor type, F 0.015
MET met proto-oncogene (hepatocyte growth factor receptor) 0.015
CCL22 chemokine (C-C motif) ligand 22 0.015
STAT5A signal transducer and activator of transcription 5A 0.015
IRF4 interferon regulatory factor 4 0.014
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.014
FSTL1 follistatin-like 1 0.014
BMPR1B bone morphogenetic protein receptor, type IB 0.014
A2M alpha-2-macroglobulin 0.014
NRP1 neuropilin 1 0.014
PROX1 prospero homeobox 1 0.014
TIMP3 TIMP metallopeptidase inhibitor 3 0.014
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.013
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.013
IFNGR1 interferon gamma receptor 1 0.013
GRB10 growth factor receptor-bound protein 10 0.013
SH2B1 SH2B adaptor protein 1 0.012
IL2RG interleukin 2 receptor, gamma 0.012
PTEN phosphatase and tensin homolog 0.012
FKBP1A FK506 binding protein 1A, 12kDa 0.012
KIAA1377 KIAA1377 0.012
CXCR6 chemokine (C-X-C motif) receptor 6 0.012
CAPN1 calpain 1, (mu/I) large subunit 0.012
CD40LG CD40 ligand 0.012
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.011
CXCL9 chemokine (C-X-C motif) ligand 9 0.011
CCR7 chemokine (C-C motif) receptor 7 0.011
IL13RA1 interleukin 13 receptor, alpha 1 0.011
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.011
TTR transthyretin 0.011
LCAT lecithin-cholesterol acyltransferase 0.010
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.010
PRKCDBP protein kinase C, delta binding protein 0.010
GJA1 gap junction protein, alpha 1, 43kDa 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tgfbr2 transforming growth factor, beta receptor II 0.998
Col1a1 collagen, type I, alpha 1 0.983
Nos3 nitric oxide synthase 3, endothelial cell 0.824
Apc adenomatosis polyposis coli 0.804
Bmp4 bone morphogenetic protein 4 0.753
Vegfa vascular endothelial growth factor A 0.743
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.646
Acvr1 activin A receptor, type 1 0.590
Lepr leptin receptor 0.426
Fgfr2 fibroblast growth factor receptor 2 0.419
Fgfr1 fibroblast growth factor receptor 1 0.408
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.369
Esr1 estrogen receptor 1 (alpha) 0.349
Pten phosphatase and tensin homolog 0.329
Ctnnb1 catenin (cadherin associated protein), beta 1 0.308
Tgfbr1 transforming growth factor, beta receptor I 0.305
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.288
Cav1 caveolin 1, caveolae protein 0.287
Ghr growth hormone receptor 0.279
Tgfb2 transforming growth factor, beta 2 0.271
Foxc1 forkhead box C1 0.248
Acvrl1 activin A receptor, type II-like 1 0.235
Egfr epidermal growth factor receptor 0.174
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.158
Prrx1 paired related homeobox 1 0.144
Bmpr1a bone morphogenetic protein receptor, type 1A 0.118
Sox9 SRY-box containing gene 9 0.115
Fgfr3 fibroblast growth factor receptor 3 0.105
Ece1 endothelin converting enzyme 1 0.104
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.103
Cdh5 cadherin 5 0.102
Smad4 MAD homolog 4 (Drosophila) 0.091
Smad3 MAD homolog 3 (Drosophila) 0.088
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.088
Shh sonic hedgehog 0.084
Ptrf polymerase I and transcript release factor 0.074
Ptgs2 prostaglandin-endoperoxide synthase 2 0.073
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.072
Jag1 jagged 1 0.071
Braf Braf transforming gene 0.069
Dmd dystrophin, muscular dystrophy 0.067
Pparg peroxisome proliferator activated receptor gamma 0.067
Eng endoglin 0.065
Rxra retinoid X receptor alpha 0.063
Amhr2 anti-Mullerian hormone type 2 receptor 0.060
Rara retinoic acid receptor, alpha 0.055
Ednra endothelin receptor type A 0.054
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.052
Nos1 nitric oxide synthase 1, neuronal 0.048
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.048
Lox lysyl oxidase 0.045
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.043
Smo smoothened homolog (Drosophila) 0.041
Tbx1 T-box 1 0.039
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.038
Lyz2 lysozyme 2 0.037
Ptch1 patched homolog 1 0.037
Hand2 heart and neural crest derivatives expressed transcript 2 0.037
Apoc4 apolipoprotein C-IV 0.036
Hif1a hypoxia inducible factor 1, alpha subunit 0.036
Mgp matrix Gla protein 0.034
Vhl von Hippel-Lindau tumor suppressor 0.034
Foxc2 forkhead box C2 0.033
Kiss1 KiSS-1 metastasis-suppressor 0.032
Zeb1 zinc finger E-box binding homeobox 1 0.031
Fermt2 fermitin family homolog 2 (Drosophila) 0.031
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.030
Fbn1 fibrillin 1 0.030
Trp53 transformation related protein 53 0.030
Bmp2 bone morphogenetic protein 2 0.028
Ptprb protein tyrosine phosphatase, receptor type, B 0.028
Prrx2 paired related homeobox 2 0.027
Eya1 eyes absent 1 homolog (Drosophila) 0.027
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.027
Csf1 colony stimulating factor 1 (macrophage) 0.026
Notch2 Notch gene homolog 2 (Drosophila) 0.025
Prkg1 protein kinase, cGMP-dependent, type I 0.024
Tgfbr3 transforming growth factor, beta receptor III 0.024
Kitl kit ligand 0.024
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.023
Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M 0.023
Rarg retinoic acid receptor, gamma 0.023
Mdm2 transformed mouse 3T3 cell double minute 2 0.022
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.022
Tlr4 toll-like receptor 4 0.022
Esr2 estrogen receptor 2 (beta) 0.021
Ret ret proto-oncogene 0.021
Lep leptin 0.020
Ar androgen receptor 0.020
Lama2 laminin, alpha 2 0.020
Rarb retinoic acid receptor, beta 0.019
Col4a1 collagen, type IV, alpha 1 0.019
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.018
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.018
Fgf8 fibroblast growth factor 8 0.017
Tgfb1 transforming growth factor, beta 1 0.017
Timp3 tissue inhibitor of metalloproteinase 3 0.017
Fas Fas (TNF receptor superfamily member 6) 0.017
Vangl2 vang-like 2 (van gogh, Drosophila) 0.016
Ldlr low density lipoprotein receptor 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100362824 caveolin 2-like 0.873
Cav1 caveolin 1, caveolae protein 0.826
Cav2 caveolin 2 0.709
Ahsg alpha-2-HS-glycoprotein 0.589
Ehd2 EH-domain containing 2 0.313
Alb albumin 0.188
Aqp9 aquaporin 9 0.179
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.144
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.090
Apoa2 apolipoprotein A-II 0.079
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.078
Apcs amyloid P component, serum 0.076
Cald1 caldesmon 1 0.066
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.060
Jak1 Janus kinase 1 0.055
Spp2 secreted phosphoprotein 2 0.050
Proc protein C 0.046
Gpr116 G protein-coupled receptor 116 0.042
Ambp alpha-1-microglobulin/bikunin precursor 0.039
Pla2g5 phospholipase A2, group V 0.038
Apoa5 apolipoprotein A-V 0.038
Gm2a GM2 ganglioside activator 0.037
Timp3 TIMP metallopeptidase inhibitor 3 0.033
Pea15a phosphoprotein enriched in astrocytes 15A 0.032
Nos3 nitric oxide synthase 3, endothelial cell 0.030
Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 0.029
LOC293989 cytochrome P450-like 0.028
F2 coagulation factor II (thrombin) 0.027
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.026
Emp1 epithelial membrane protein 1 0.024
Kng2 kininogen 2 0.022
Hal histidine ammonia lyase 0.020
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.019
Col4a2 collagen, type IV, alpha 2 0.018
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.017
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.017
Fga fibrinogen alpha chain 0.017
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.017
Spink1 serine peptidase inhibitor, Kazal type 1 0.016
A2m alpha-2-macroglobulin 0.015
Fbln5 fibulin 5 0.014
Igfbp5 insulin-like growth factor binding protein 5 0.013
Lamc1 laminin, gamma 1 0.013
Apom apolipoprotein M 0.012
Olr837 olfactory receptor 837 0.012
Igfals insulin-like growth factor binding protein, acid labile subunit 0.011
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.011
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.011
C8b complement component 8, beta polypeptide 0.011
S100b S100 calcium binding protein B 0.011
Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 0.011
Cd9 CD9 molecule 0.011
Lipc lipase, hepatic 0.010
Tmem88 transmembrane protein 88 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism