The network for 'organ induction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organ induction

The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 0.999
Hoxd11 homeobox D11 0.998
Fgf8 fibroblast growth factor 8 0.998
Gli3 GLI-Kruppel family member GLI3 0.997
Foxc1 forkhead box C1 0.983
Lhx1 LIM homeobox protein 1 0.975
Fgf10 fibroblast growth factor 10 0.959
Vangl2 vang-like 2 (van gogh, Drosophila) 0.955
Rarg retinoic acid receptor, gamma 0.954
Fgfr2 fibroblast growth factor receptor 2 0.931
Alx4 aristaless-like homeobox 4 0.926
Dok1 docking protein 1 0.911
Pax8 paired box gene 8 0.902
Pitx2 paired-like homeodomain transcription factor 2 0.893
Ret ret proto-oncogene 0.882
Nodal nodal 0.879
Fgfr3 fibroblast growth factor receptor 3 0.872
Hoxd13 homeobox D13 0.845
Gli2 GLI-Kruppel family member GLI2 0.829
Gdnf glial cell line derived neurotrophic factor 0.829
Tbx15 T-box 15 0.828
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.818
Nog noggin 0.811
Pax3 paired box gene 3 0.788
Prrx1 paired related homeobox 1 0.767
Hoxa13 homeobox A13 0.750
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.742
Fgfr1 fibroblast growth factor receptor 1 0.740
Hoxa2 homeobox A2 0.740
Tbx3 T-box 3 0.731
Wnt3a wingless-related MMTV integration site 3A 0.726
Sall4 sal-like 4 (Drosophila) 0.718
Twist2 twist homolog 2 (Drosophila) 0.690
Spry4 sprouty homolog 4 (Drosophila) 0.674
Chrd chordin 0.643
Ptk7 PTK7 protein tyrosine kinase 7 0.642
Msx1 homeobox, msh-like 1 0.618
Foxh1 forkhead box H1 0.608
Hoxa11 homeobox A11 0.606
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.605
Sox9 SRY-box containing gene 9 0.600
Otx2 orthodenticle homolog 2 (Drosophila) 0.574
Hand1 heart and neural crest derivatives expressed transcript 1 0.560
Rara retinoic acid receptor, alpha 0.551
Rarb retinoic acid receptor, beta 0.524
Tbx1 T-box 1 0.516
Msx2 homeobox, msh-like 2 0.516
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.502
Eya1 eyes absent 1 homolog (Drosophila) 0.501
Tcf21 transcription factor 21 0.484
Gli1 GLI-Kruppel family member GLI1 0.477
Prrx2 paired related homeobox 2 0.468
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.462
Hand2 heart and neural crest derivatives expressed transcript 2 0.435
Tcfap2a transcription factor AP-2, alpha 0.426
Emx2 empty spiracles homolog 2 (Drosophila) 0.422
Hoxa1 homeobox A1 0.411
Tbx2 T-box 2 0.403
Foxc2 forkhead box C2 0.376
Pou3f3 POU domain, class 3, transcription factor 3 0.357
Ctnnb1 catenin (cadherin associated protein), beta 1 0.344
Fzd8 frizzled homolog 8 (Drosophila) 0.341
Smad6 MAD homolog 6 (Drosophila) 0.337
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.337
Gata6 GATA binding protein 6 0.314
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.313
Btbd17 BTB (POZ) domain containing 17 0.300
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.295
Pitx1 paired-like homeodomain transcription factor 1 0.290
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.289
Acvr1 activin A receptor, type 1 0.286
Vangl1 vang-like 1 (van gogh, Drosophila) 0.284
Wnt2b wingless related MMTV integration site 2b 0.276
Tcfap2c transcription factor AP-2, gamma 0.268
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.255
Bmp7 bone morphogenetic protein 7 0.248
Wnt4 wingless-related MMTV integration site 4 0.247
Wnt6 wingless-related MMTV integration site 6 0.246
Hoxa3 homeobox A3 0.244
Dok2 docking protein 2 0.239
Phox2a paired-like homeobox 2a 0.239
Foxf1a forkhead box F1a 0.238
Bmp4 bone morphogenetic protein 4 0.235
Fgf18 fibroblast growth factor 18 0.234
Nkx2-1 NK2 homeobox 1 0.231
Dhh desert hedgehog 0.224
Col2a1 collagen, type II, alpha 1 0.222
Ntf3 neurotrophin 3 0.221
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.218
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.211
Meox2 mesenchyme homeobox 2 0.211
Fgf9 fibroblast growth factor 9 0.207
Alx3 aristaless-like homeobox 3 0.203
Wt1 Wilms tumor 1 homolog 0.193
Hoxd9 homeobox D9 0.192
Hoxb6 homeobox B6 0.191
Dlx5 distal-less homeobox 5 0.190
Rxra retinoid X receptor alpha 0.180
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.177
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
hh hedgehog 1.000
wg wingless 0.994
Egfr Epidermal growth factor receptor 0.965
eya eyes absent 0.935
dpp decapentaplegic 0.779
N Notch 0.656
en engrailed 0.607
arm armadillo 0.541
tkv thickveins 0.516
argos CG4531 gene product from transcript CG4531-RA 0.507
stumps CG31317 gene product from transcript CG31317-RC 0.414
ci cubitus interruptus 0.373
H Hairless 0.275
pan pangolin 0.264
Ser Serrate 0.262
ptc patched 0.241
sog short gastrulation 0.236
bnl branchless 0.203
rho rhomboid 0.194
sd scalloped 0.180
pnt pointed 0.171
par-1 CG8201 gene product from transcript CG8201-RA 0.148
btl breathless 0.128
Wnt2 Wnt oncogene analog 2 0.117
Dl Delta 0.116
tsh teashirt 0.112
hth homothorax 0.099
Ras85D Ras oncogene at 85D 0.086
spi spitz 0.086
sqh spaghetti squash 0.081
shg shotgun 0.076
twi twist 0.067
dally division abnormally delayed 0.061
fz2 frizzled 2 0.056
aop anterior open 0.052
fng fringe 0.048
gsb gooseberry 0.044
wb wing blister 0.043
dac dachshund 0.042
rib ribbon 0.042
fz frizzled 0.039
ara araucan 0.039
crb crumbs 0.035
kek1 kekkon-1 0.035
kni knirps 0.035
Ubx Ultrabithorax 0.034
rtv retroactive 0.032
Cdc42 CG12530 gene product from transcript CG12530-RA 0.030
Wnt4 Wnt oncogene analog 4 0.029
mxc multi sex combs 0.027
vari varicose 0.027
Dad Daughters against dpp 0.026
pb proboscipedia 0.025
sli slit 0.025
gbb glass bottom boat 0.025
ey eyeless 0.025
hpo hippo 0.025
cora coracle 0.025
hbs hibris 0.025
sev sevenless 0.023
conv convoluted 0.022
nkd naked cuticle 0.022
caup caupolican 0.022
abd-A abdominal A 0.021
elB elbow B 0.021
dy dusky 0.020
blow blown fuse 0.020
grh grainy head 0.020
gcm glial cells missing 0.020
tld tolloid 0.019
Mlp84B Muscle LIM protein at 84B 0.019
sr stripe 0.019
eff effete 0.019
bi bifid 0.019
GckIII Germinal centre kinase III 0.019
esg escargot 0.019
nrv2 nervana 2 0.018
Notum CG13076 gene product from transcript CG13076-RB 0.016
ex expanded 0.015
lz lozenge 0.015
rpr reaper 0.015
salm spalt major 0.014
sty sprouty 0.014
NetB Netrin-B 0.014
bdg bedraggled 0.013
brk brinker 0.013
nimC3 nimrod C3 0.013
byn brachyenteron 0.013
rst roughest 0.012
loqs loquacious 0.012
trx trithorax 0.012
ft fat 0.012
CG8965 CG8965 gene product from transcript CG8965-RA 0.012
run runt 0.012
por porcupine 0.012
Hmgcr HMG Coenzyme A reductase 0.012
D Dichaete 0.011
vvl ventral veins lacking 0.011
Traf4 TNF-receptor-associated factor 4 0.011
ttk tramtrack 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.997
CREBBP CREB binding protein 0.995
FGF1 fibroblast growth factor 1 (acidic) 0.993
FGFR1 fibroblast growth factor receptor 1 0.980
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.963
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.959
FOXD3 forkhead box D3 0.947
BMPR1A bone morphogenetic protein receptor, type IA 0.942
SP1 Sp1 transcription factor 0.910
NCOA2 nuclear receptor coactivator 2 0.870
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.851
FGF2 fibroblast growth factor 2 (basic) 0.844
CSNK1E casein kinase 1, epsilon 0.831
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.732
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.717
MYST2 MYST histone acetyltransferase 2 0.672
APC adenomatous polyposis coli 0.622
LRP6 low density lipoprotein receptor-related protein 6 0.532
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.467
PLCG1 phospholipase C, gamma 1 0.452
FOXO1 forkhead box O1 0.379
AXIN1 axin 1 0.329
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.320
CTNNBIP1 catenin, beta interacting protein 1 0.265
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.265
WT1 Wilms tumor 1 0.235
ZNF512B zinc finger protein 512B 0.232
FSTL1 follistatin-like 1 0.208
FZD1 frizzled homolog 1 (Drosophila) 0.206
SOX2 SRY (sex determining region Y)-box 2 0.205
CEP164 centrosomal protein 164kDa 0.194
SMAD1 SMAD family member 1 0.183
NCOA1 nuclear receptor coactivator 1 0.165
CTNND1 catenin (cadherin-associated protein), delta 1 0.141
NOSTRIN nitric oxide synthase trafficker 0.138
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.127
LRRK2 leucine-rich repeat kinase 2 0.119
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.115
SMAD7 SMAD family member 7 0.111
MDFI MyoD family inhibitor 0.099
HTT huntingtin 0.095
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.094
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.093
FOXA1 forkhead box A1 0.092
ZFYVE9 zinc finger, FYVE domain containing 9 0.090
JUP junction plakoglobin 0.090
NCOA6 nuclear receptor coactivator 6 0.071
FHL2 four and a half LIM domains 2 0.068
AR androgen receptor 0.061
HCFC1 host cell factor C1 (VP16-accessory protein) 0.059
GLIS2 GLIS family zinc finger 2 0.056
PSEN1 presenilin 1 0.054
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide 0.053
FBXW11 F-box and WD repeat domain containing 11 0.052
ESR1 estrogen receptor 1 0.050
FGF7 fibroblast growth factor 7 0.049
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.049
TCF4 transcription factor 4 0.047
FAM110C family with sequence similarity 110, member C 0.047
DSP desmoplakin 0.046
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.046
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.045
PITX1 paired-like homeodomain 1 0.044
SOX10 SRY (sex determining region Y)-box 10 0.043
NOG noggin 0.042
SPRY2 sprouty homolog 2 (Drosophila) 0.041
FERMT2 fermitin family member 2 0.040
BAHD1 bromo adjacent homology domain containing 1 0.039
HOXB9 homeobox B9 0.038
SHB Src homology 2 domain containing adaptor protein B 0.037
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.036
FZD8 frizzled homolog 8 (Drosophila) 0.035
EYA1 eyes absent homolog 1 (Drosophila) 0.035
YAP1 Yes-associated protein 1 0.035
EYA2 eyes absent homolog 2 (Drosophila) 0.035
FRS2 fibroblast growth factor receptor substrate 2 0.034
WDYHV1 WDYHV motif containing 1 0.034
LBX1 ladybird homeobox 1 0.034
FGF8 fibroblast growth factor 8 (androgen-induced) 0.033
HOXB5 homeobox B5 0.033
GAB1 GRB2-associated binding protein 1 0.033
BTRC beta-transducin repeat containing 0.031
HOXD10 homeobox D10 0.031
FOXO3 forkhead box O3 0.031
DIDO1 death inducer-obliterator 1 0.030
BMP4 bone morphogenetic protein 4 0.030
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.030
SOX11 SRY (sex determining region Y)-box 11 0.030
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.030
HOXC8 homeobox C8 0.030
MCC mutated in colorectal cancers 0.030
C16orf48 chromosome 16 open reading frame 48 0.030
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.030
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.029
POU4F1 POU class 4 homeobox 1 0.028
FGF4 fibroblast growth factor 4 0.028
OTP orthopedia homeobox 0.028
NKX2-1 NK2 homeobox 1 0.027
SIX2 SIX homeobox 2 0.027
HOXD13 homeobox D13 0.027
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Rattus norvegicus
Name Description Probability Func Analog Organism
Olfml2b olfactomedin-like 2B 0.134
Cxxc4 CXXC finger 4 0.127
Syt9 synaptotagmin IX 0.100
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.081
Prrx1 paired related homeobox 1 0.077
Tbr1 T-box, brain, 1 0.077
Gtf2a1 general transcription factor IIA, 1 0.075
Glg1 golgi apparatus protein 1 0.060
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.051
Unc5b unc-5 homolog B (C. elegans) 0.047
Synpo synaptopodin 0.042
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.041
F13a1 coagulation factor XIII, A1 polypeptide 0.040
Pde3a phosphodiesterase 3A, cGMP inhibited 0.038
Slc22a2 solute carrier family 22 (organic cation transporter), member 2 0.038
Gper G protein-coupled estrogen receptor 1 0.037
Vsnl1 visinin-like 1 0.036
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.036
Fgf5 fibroblast growth factor 5 0.036
Cpxm2 carboxypeptidase X (M14 family), member 2 0.034
Tpc1808 tropic 1808 0.034
Gja3 gap junction protein, alpha 3 0.034
Cdh6 cadherin 6 0.034
Pdc phosducin 0.034
Myo1c myosin IC 0.034
Spink3 serine peptidase inhibitor, Kazal type 3 0.033
Tnni1 troponin I type 1 (skeletal, slow) 0.032
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.032
Paqr8 progestin and adipoQ receptor family member VIII 0.030
Ednra endothelin receptor type A 0.030
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.029
Cacng6 calcium channel, voltage-dependent, gamma subunit 6 0.029
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.029
Cpa3 carboxypeptidase A3, mast cell 0.029
Csrp3 cysteine and glycine-rich protein 3 0.029
Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.028
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.028
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.027
Prap1 proline-rich acidic protein 1 0.027
Pde7b phosphodiesterase 7B 0.027
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.027
Mcam melanoma cell adhesion molecule 0.027
Bdkrb2 bradykinin receptor B2 0.026
Rcvrn recoverin 0.026
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.026
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.026
Dlg2 discs, large homolog 2 (Drosophila) 0.025
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.025
Fgf8 fibroblast growth factor 8 0.025
Serpinb12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 0.025
Masp1 mannan-binding lectin serine peptidase 1 0.025
Btc betacellulin 0.025
Tex101 testis expressed 101 0.025
Cst12 cystatin 12 0.025
Itga6 integrin, alpha 6 0.024
Cav3 caveolin 3 0.024
Clcn1 chloride channel 1 0.024
Slc13a1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.024
Foxc2 forkhead box C2 0.024
Ptgfr prostaglandin F receptor 0.024
Ubtf upstream binding transcription factor, RNA polymerase I 0.024
Mmp23 matrix metallopeptidase 23 0.024
Grm7 glutamate receptor, metabotropic 7 0.024
Scnn1b sodium channel, nonvoltage-gated 1, beta 0.024
Ucn2 urocortin 2 0.024
Smad3 SMAD family member 3 0.024
Adrb1 adrenergic, beta-1-, receptor 0.023
Stk11 serine/threonine kinase 11 0.023
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.023
RGD1309821 similar to KIAA1161 protein 0.022
Tgfb2 transforming growth factor, beta 2 0.022
Cercam cerebral endothelial cell adhesion molecule 0.022
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.022
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.022
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.022
Sox13 SRY (sex determining region Y)-box 13 0.022
Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 0.022
Slc10a2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.022
Lcn5 lipocalin 5 0.021
Fgf10 fibroblast growth factor 10 0.021
Cmklr1 chemokine-like receptor 1 0.021
Cel carboxyl ester lipase 0.021
LOC246267 resection-induced TPI (rs11) 0.021
Fcer2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.021
Acvr1 activin A receptor, type I 0.021
Mrgprf MAS-related GPR, member F 0.021
Snap25 synaptosomal-associated protein 25 0.021
Amh anti-Mullerian hormone 0.021
Ng23 Ng23 protein 0.021
Madcam1 mucosal vascular addressin cell adhesion molecule 1 0.021
Asb9 ankyrin repeat and SOCS box-containing 9 0.021
Lipf lipase, gastric 0.021
Hpcal4 hippocalcin-like 4 0.021
Il13ra2 interleukin 13 receptor, alpha 2 0.020
Stx2 syntaxin 2 0.020
Irs1 insulin receptor substrate 1 0.020
Scgb1a1 secretoglobin, family 1A, member 1 (uteroglobin) 0.020
Dact3 dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis) 0.020
Stmn4 stathmin-like 4 0.020
Wisp2 WNT1 inducible signaling pathway protein 2 0.020
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism