The network for 'skin morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

skin morphogenesis

The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

Mus musculus
Name Description Probability Func Analog Organism
Foxc1 forkhead box C1 1.000
Shh sonic hedgehog 0.999
Pax2 paired box gene 2 0.999
Gli3 GLI-Kruppel family member GLI3 0.996
Foxn1 forkhead box N1 0.994
Notch1 Notch gene homolog 1 (Drosophila) 0.989
Dlx5 distal-less homeobox 5 0.977
Vangl2 vang-like 2 (van gogh, Drosophila) 0.974
Pax8 paired box gene 8 0.969
Trp63 transformation related protein 63 0.965
Fgfr1 fibroblast growth factor receptor 1 0.962
Msx2 homeobox, msh-like 2 0.955
Gli2 GLI-Kruppel family member GLI2 0.945
Fgfr2 fibroblast growth factor receptor 2 0.944
Rarg retinoic acid receptor, gamma 0.940
Pthlh parathyroid hormone-like peptide 0.938
Tbx1 T-box 1 0.929
Sox9 SRY-box containing gene 9 0.925
Eya1 eyes absent 1 homolog (Drosophila) 0.915
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.901
Krt35 keratin 35 0.878
Foxc2 forkhead box C2 0.868
Psen1 presenilin 1 0.792
Pten phosphatase and tensin homolog 0.785
Bmp4 bone morphogenetic protein 4 0.781
Krt17 keratin 17 0.768
Lmx1a LIM homeobox transcription factor 1 alpha 0.753
Efnb2 ephrin B2 0.753
Hoxd13 homeobox D13 0.736
Wnt4 wingless-related MMTV integration site 4 0.728
Krt33b keratin 33B 0.716
Krt8 keratin 8 0.714
Ctnnb1 catenin (cadherin associated protein), beta 1 0.707
Twist2 twist homolog 2 (Drosophila) 0.706
Fgf10 fibroblast growth factor 10 0.683
Rarb retinoic acid receptor, beta 0.661
Pax9 paired box gene 9 0.648
Lhx1 LIM homeobox protein 1 0.648
Ptk7 PTK7 protein tyrosine kinase 7 0.643
Prrx1 paired related homeobox 1 0.627
Krt86 keratin 86 0.622
Wnt3a wingless-related MMTV integration site 3A 0.601
Prrx2 paired related homeobox 2 0.601
Krt5 keratin 5 0.599
Egfr epidermal growth factor receptor 0.599
Pax3 paired box gene 3 0.570
Tcfap2a transcription factor AP-2, alpha 0.555
Fgf8 fibroblast growth factor 8 0.551
Pkp1 plakophilin 1 0.536
Krt14 keratin 14 0.535
Pbx1 pre B-cell leukemia transcription factor 1 0.524
Jag1 jagged 1 0.523
Runx2 runt related transcription factor 2 0.493
Vangl1 vang-like 1 (van gogh, Drosophila) 0.493
Dlx3 distal-less homeobox 3 0.466
Bmp7 bone morphogenetic protein 7 0.465
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.459
Foxa2 forkhead box A2 0.457
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.454
Hoxd11 homeobox D11 0.431
Msx1 homeobox, msh-like 1 0.424
Ptch2 patched homolog 2 0.416
Rara retinoic acid receptor, alpha 0.408
Hmx3 H6 homeobox 3 0.404
Bcl2 B-cell leukemia/lymphoma 2 0.397
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.393
Krt6a keratin 6A 0.391
Bnc1 basonuclin 1 0.374
Cldn3 claudin 3 0.367
Neurog1 neurogenin 1 0.366
Cdx1 caudal type homeobox 1 0.365
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.364
Padi3 peptidyl arginine deiminase, type III 0.357
Pou3f3 POU domain, class 3, transcription factor 3 0.354
Hand2 heart and neural crest derivatives expressed transcript 2 0.353
Chd7 chromodomain helicase DNA binding protein 7 0.342
Gata3 GATA binding protein 3 0.334
Krt71 keratin 71 0.334
Gbx2 gastrulation brain homeobox 2 0.328
Tgfa transforming growth factor alpha 0.323
En1 engrailed 1 0.322
Notch2 Notch gene homolog 2 (Drosophila) 0.316
Hes1 hairy and enhancer of split 1 (Drosophila) 0.310
Mstn myostatin 0.310
Pax6 paired box gene 6 0.301
Hr hairless 0.300
Ctgf connective tissue growth factor 0.299
Lgals7 lectin, galactose binding, soluble 7 0.297
Gdnf glial cell line derived neurotrophic factor 0.294
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.293
Krt13 keratin 13 0.293
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.284
Hoxa1 homeobox A1 0.284
Krtap8-1 keratin associated protein 8-1 0.284
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.283
Hoxa2 homeobox A2 0.281
Ppl periplakin 0.280
Pitx1 paired-like homeodomain transcription factor 1 0.276
Krt19 keratin 19 0.274
Pitx3 paired-like homeodomain transcription factor 3 0.267
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-5 Protein UNC-5 0.029
mig-2 Protein MIG-2 0.024
unc-73 Protein UNC-73 0.019
unc-97 Protein UNC-97 0.018
calu-1 Protein CALU-1 0.016
egl-44 Protein EGL-44 0.014
egl-30 Protein EGL-30 0.013
daf-3 Protein DAF-3 0.012
R03E9.2 Protein R03E9.2 0.011
sdc-1 Protein SDC-1 0.011
C01F1.3 Protein C01F1.3 0.011
F53B3.5 Protein F53B3.5 0.010
nhr-34 Protein NHR-34 0.010
igcm-3 Protein IGCM-3 0.010
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
col1a2 collagen, type I, alpha 2 0.437
bmp1a bone morphogenetic protein 1a 0.309
col1a1a collagen, type I, alpha 1a 0.264
postn periostin, osteoblast specific factor 0.136
nr2f1a nuclear receptor subfamily 2, group F, member 1a 0.135
lama5 laminin, alpha 5 0.128
dag1 dystroglycan 1 0.116
lef1 lymphocyte enhancer binding factor 1 0.095
dcn decorin 0.086
lamc1 laminin, gamma 1 0.077
lamb1a laminin, beta 1a 0.075
fgfr2 fibroblast growth factor receptor 2 0.073
frem2a Fras1 related extracellular matrix protein 2a 0.062
itga3b integrin, alpha 3b 0.059
cdh1 cadherin 1, epithelial 0.057
lhx2b LIM homeobox 2b 0.053
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.052
smad5 MAD homolog 5 (Drosophila) 0.052
fstl1b follistatin-like 1b 0.049
col5a1 procollagen, type V, alpha 1 0.046
notch2 notch homolog 2 0.045
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.044
kal1b Kallmann syndrome 1b sequence 0.036
surf4l surfeit gene 4, like 0.036
fzd7a frizzled homolog 7a 0.035
copa coatomer protein complex, subunit alpha 0.035
waca WW domain containing adaptor with coiled-coil a 0.034
pitx3 paired-like homeodomain transcription factor 3 0.034
axin1 axin 1 0.034
frem1a Fras1 related extracellular matrix 1a 0.033
trim71 tripartite motif-containing 71 0.032
igfbp5a insulin-like growth factor binding protein 5a 0.030
robo3 roundabout homolog 3 0.026
kal1a Kallmann syndrome 1a sequence 0.025
grhl2b grainyhead-like 2b (Drosophila) 0.025
col5a2l collagen, type V, alpha 2-like 0.025
hoxb3a homeo box B3a 0.024
wif1 wnt inhibitory factor 1 0.024
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.024
atoh1b atonal homolog 1b 0.024
fzd7b frizzled homolog 7b 0.022
gyltl1b glycosyltransferase-like 1b 0.022
fktn fukutin 0.022
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.022
pcdh10b protocadherin 10b 0.022
fgfr1a fibroblast growth factor receptor 1a 0.022
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.022
neo1 neogenin 1 0.022
col19a1 collagen, type XIX, alpha 1 0.022
tll1 tolloid-like 1 0.022
irx5a iroquois homeobox protein 5a 0.021
wnt3 wingless-type MMTV integration site family, member 3 0.021
dlx3b distal-less homeobox gene 3b 0.021
robo1 roundabout homolog 1 0.019
emx2 empty spiracles homeobox 2 0.019
znf703 zinc finger protein 703 0.018
zgc:66100 zgc:66100 0.018
pomt2 protein-O-mannosyltransferase 2 0.017
dlx5a distal-less homeobox gene 5a 0.017
hhip hedgehog interacting protein 0.017
sfrp1a secreted frizzled-related protein 1a 0.017
col12a1 collagen, type XII, alpha 1 0.016
szl sizzled 0.016
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.016
sparc secreted acidic cysteine rich glycoprotein 0.014
hmcn2 hemicentin 2 0.014
matn4 matrilin 4 0.014
ryk receptor-like tyrosine kinase 0.014
zeb1 zinc finger E-box binding homeobox 1 0.014
kdm4b lysine (K)-specific demethylase 4B 0.013
krt4 keratin 4 0.013
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.013
boc brother of CDO 0.013
pbx4 pre-B-cell leukemia transcription factor 4 0.013
msxd muscle segment homeobox D 0.013
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.013
kif7 kinesin family member 7 0.013
spon1b spondin 1b 0.012
igf1rb insulin-like growth factor 1b receptor 0.012
dlx2a distal-less homeobox gene 2a 0.012
col4a5 collagen, type IV, alpha 5 (Alport syndrome) 0.011
col14a1 collagen, type XIV, alpha 1 0.011
gro2 groucho 2 0.011
ssbp3b single stranded DNA binding protein 3b 0.011
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.011
fbn2b fibrillin 2b 0.011
wu:fb54a03 wu:fb54a03 0.011
fgfrl1b fibroblast growth factor receptor-like 1b 0.011
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.011
cdk8 cyclin-dependent kinase 8 0.011
tgfbi transforming growth factor, beta-induced 0.010
col11a1a collagen, type XI, alpha 1a 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
arm armadillo 0.047
dm diminutive 0.031
Su(H) Suppressor of Hairless 0.027
spi spitz 0.015
bnl branchless 0.013
aop anterior open 0.011
nej nejire 0.011
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
KRT17 keratin 17 0.925
COL1A1 collagen, type I, alpha 1 0.842
KLK7 kallikrein-related peptidase 7 0.791
TP63 tumor protein p63 0.742
SFN stratifin 0.681
KRT15 keratin 15 0.642
KLK10 kallikrein-related peptidase 10 0.541
KRT5 keratin 5 0.534
TRIM29 tripartite motif containing 29 0.481
KRT14 keratin 14 0.440
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.427
KRT6A keratin 6A 0.417
KRT6B keratin 6B 0.324
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.287
COL1A2 collagen, type I, alpha 2 0.274
KLK5 kallikrein-related peptidase 5 0.214
KRT6C keratin 6C 0.204
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.204
PDZD11 PDZ domain containing 11 0.201
KRT19 keratin 19 0.191
HIPK2 homeodomain interacting protein kinase 2 0.189
NOTCH3 notch 3 0.184
COL5A2 collagen, type V, alpha 2 0.167
IVL involucrin 0.159
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.158
FGF1 fibroblast growth factor 1 (acidic) 0.137
JAG1 jagged 1 0.116
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.112
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.111
GJB3 gap junction protein, beta 3, 31kDa 0.106
PRSS2 protease, serine, 2 (trypsin 2) 0.095
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.091
BCL2L1 BCL2-like 1 0.088
COL3A1 collagen, type III, alpha 1 0.074
KRT16 keratin 16 0.072
FN1 fibronectin 1 0.072
COL6A1 collagen, type VI, alpha 1 0.070
FGF2 fibroblast growth factor 2 (basic) 0.067
SPRR1B small proline-rich protein 1B 0.065
FHL2 four and a half LIM domains 2 0.061
AR androgen receptor 0.061
PKP3 plakophilin 3 0.061
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.060
LAD1 ladinin 1 0.058
BAD BCL2-associated agonist of cell death 0.052
LYPD3 LY6/PLAUR domain containing 3 0.050
ALB albumin 0.050
DDR2 discoidin domain receptor tyrosine kinase 2 0.049
KRT18 keratin 18 0.049
JUB jub, ajuba homolog (Xenopus laevis) 0.042
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.038
COL4A1 collagen, type IV, alpha 1 0.034
KLK11 kallikrein-related peptidase 11 0.033
DSG3 desmoglein 3 0.033
COL5A1 collagen, type V, alpha 1 0.032
FLNB filamin B, beta 0.030
ADAM12 ADAM metallopeptidase domain 12 0.029
PPL periplakin 0.026
SPRR1A small proline-rich protein 1A 0.026
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.025
GJB5 gap junction protein, beta 5, 31.1kDa 0.025
SLURP1 secreted LY6/PLAUR domain containing 1 0.024
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.024
S100A2 S100 calcium binding protein A2 0.023
KLK8 kallikrein-related peptidase 8 0.022
MKL1 megakaryoblastic leukemia (translocation) 1 0.022
FGF10 fibroblast growth factor 10 0.022
KRT9 keratin 9 0.021
FGFR3 fibroblast growth factor receptor 3 0.020
CSNK1E casein kinase 1, epsilon 0.020
KRT13 keratin 13 0.020
EVPL envoplakin 0.019
LY6D lymphocyte antigen 6 complex, locus D 0.019
EP300 E1A binding protein p300 0.019
KRT1 keratin 1 0.018
AXIN1 axin 1 0.018
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.017
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.017
KRT34 keratin 34 0.017
ATN1 atrophin 1 0.016
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.016
FGFBP1 fibroblast growth factor binding protein 1 0.015
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.015
SH3BP4 SH3-domain binding protein 4 0.015
POSTN periostin, osteoblast specific factor 0.014
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.014
KLK12 kallikrein-related peptidase 12 0.014
MXRA5 matrix-remodelling associated 5 0.014
KLK6 kallikrein-related peptidase 6 0.013
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.013
TNS4 tensin 4 0.013
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.013
DSG1 desmoglein 1 0.012
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.012
CDSN corneodesmosin 0.012
RHOD ras homolog gene family, member D 0.012
KRT75 keratin 75 0.012
MYOCD myocardin 0.012
KRT81 keratin 81 0.012
S100A14 S100 calcium binding protein A14 0.012
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Col3a1 collagen, type III, alpha 1 0.280
Col12a1 collagen, type XII, alpha 1 0.167
Col1a1 collagen, type I, alpha 1 0.158
Col1a2 collagen, type I, alpha 2 0.126
Unc5b unc-5 homolog B (C. elegans) 0.095
Fstl1 follistatin-like 1 0.074
Col15a1 collagen, type XV, alpha 1 0.074
Lum lumican 0.073
Col5a1 collagen, type V, alpha 1 0.072
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.071
Lamp2 lysosomal-associated membrane protein 2 0.071
Bgn biglycan 0.069
Itpr3 inositol 1,4,5-triphosphate receptor, type 3 0.067
Postn periostin, osteoblast specific factor 0.067
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.062
Col5a2 collagen, type V, alpha 2 0.062
Col14a1 collagen, type XIV, alpha 1 0.060
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.051
Mfap4 microfibrillar-associated protein 4 0.047
Ednra endothelin receptor type A 0.045
Ednrb endothelin receptor type B 0.044
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.042
Eif3m eukaryotic translation initiation factor 3, subunit M 0.042
Chd4 chromodomain helicase DNA binding protein 4 0.041
Prrx1 paired related homeobox 1 0.040
Dchs1 dachsous 1 (Drosophila) 0.038
Podxl podocalyxin-like 0.037
Sept8 septin 8 0.036
Aif1l allograft inflammatory factor 1-like 0.036
Dcn decorin 0.036
Dmd dystrophin 0.033
Loxl1 lysyl oxidase-like 1 0.032
Olfml2b olfactomedin-like 2B 0.030
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.030
Calcrl calcitonin receptor-like 0.029
Eln elastin 0.028
Lamc1 laminin, gamma 1 0.028
RGD1562717 similar to ABI gene family, member 3 (NESH) binding protein 0.028
Glg1 golgi apparatus protein 1 0.028
Lama2 laminin, alpha 2 0.027
Ctsb cathepsin B 0.027
Igfbp5 insulin-like growth factor binding protein 5 0.027
Tgfb3 transforming growth factor, beta 3 0.027
Kitlg KIT ligand 0.027
Nradd neurotrophin receptor associated death domain 0.026
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.026
Hdlbp high density lipoprotein binding protein 0.025
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.025
Slit3 slit homolog 3 (Drosophila) 0.025
Pcdhgc3 protocadherin gamma subfamily C, 3 0.025
C1qtnf3 C1q and tumor necrosis factor related protein 3 0.024
Fbn1 fibrillin 1 0.024
Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.024
Mpeg1 macrophage expressed 1 0.024
Ddr2 discoidin domain receptor tyrosine kinase 2 0.023
Gdf10 growth differentiation factor 10 0.023
Capn6 calpain 6 0.023
Cd4 Cd4 molecule 0.023
Fgfr2 fibroblast growth factor receptor 2 0.022
Smad7 SMAD family member 7 0.022
Cpxm1 carboxypeptidase X (M14 family), member 1 0.022
Rab10 RAB10, member RAS oncogene family 0.022
Slc12a4 solute carrier family 12 (potassium/chloride transporters), member 4 0.021
Cxxc4 CXXC finger 4 0.021
Fbln2 fibulin 2 0.021
Tgfb2 transforming growth factor, beta 2 0.021
Plxdc2 plexin domain containing 2 0.021
Gpc3 glypican 3 0.021
Elf1 E74-like factor 1 0.021
Sirpa signal-regulatory protein alpha 0.020
Ubtf upstream binding transcription factor, RNA polymerase I 0.020
Igf2r insulin-like growth factor 2 receptor 0.020
Sf3b2 splicing factor 3b, subunit 2 0.020
Ccnd2 cyclin D2 0.020
RGD1564327 similar to integrin alpha 8 0.020
Utrn utrophin 0.020
Col8a1 collagen, type VIII, alpha 1 0.020
Tcf4 transcription factor 4 0.020
Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 0.020
Ly6b lymphocyte antigen 6 complex, locus B 0.020
Nfya nuclear transcription factor-Y alpha 0.020
Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 0.019
Axin1 axin 1 0.019
Ccdc80 coiled-coil domain containing 80 0.019
Dab2 disabled homolog 2 (Drosophila) 0.019
Bmp1 bone morphogenetic protein 1 0.018
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.018
Nfib nuclear factor I/B 0.018
Cstb cystatin B (stefin B) 0.018
Col4a5 collagen, type IV, alpha 5 0.018
Fzd2 frizzled homolog 2 (Drosophila) 0.018
LOC64038 sertolin 0.017
Aebp1 AE binding protein 1 0.017
Wnt5b wingless-type MMTV integration site family, member 5B 0.017
Slc30a2 solute carrier family 30 (zinc transporter), member 2 0.017
Gadd45a growth arrest and DNA-damage-inducible, alpha 0.017
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.017
Lox lysyl oxidase 0.016
Mmp2 matrix metallopeptidase 2 0.016
Fndc1 fibronectin type III domain containing 1 0.016
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism