The network for 'embryonic epithelial tube formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic epithelial tube formation

The morphogenesis of an embryonic epithelium into a tube-shaped structure.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Pax3 paired box gene 3 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Sox2 SRY-box containing gene 2 1.000
Nodal nodal 1.000
Fgf8 fibroblast growth factor 8 0.999
Pax6 paired box gene 6 0.999
Vangl2 vang-like 2 (van gogh, Drosophila) 0.999
Foxc1 forkhead box C1 0.998
Pbx1 pre B-cell leukemia transcription factor 1 0.997
Tbx1 T-box 1 0.997
Eya1 eyes absent 1 homolog (Drosophila) 0.996
Msx1 homeobox, msh-like 1 0.996
Bmp7 bone morphogenetic protein 7 0.994
Hand2 heart and neural crest derivatives expressed transcript 2 0.994
Hoxa13 homeobox A13 0.992
Nog noggin 0.991
Lhx1 LIM homeobox protein 1 0.991
Hes1 hairy and enhancer of split 1 (Drosophila) 0.991
Ret ret proto-oncogene 0.990
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.989
Tbx15 T-box 15 0.988
Chd7 chromodomain helicase DNA binding protein 7 0.988
Hoxa11 homeobox A11 0.986
Emx2 empty spiracles homolog 2 (Drosophila) 0.983
Rarb retinoic acid receptor, beta 0.983
Hoxa1 homeobox A1 0.982
Hoxd13 homeobox D13 0.981
Gli2 GLI-Kruppel family member GLI2 0.981
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.981
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.979
Vegfa vascular endothelial growth factor A 0.975
Ctnnb1 catenin (cadherin associated protein), beta 1 0.974
Lhx3 LIM homeobox protein 3 0.974
Gata4 GATA binding protein 4 0.973
Sfrp2 secreted frizzled-related protein 2 0.973
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.972
Hes5 hairy and enhancer of split 5 (Drosophila) 0.972
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.970
Foxg1 forkhead box G1 0.968
Chrd chordin 0.968
Fgfr1 fibroblast growth factor receptor 1 0.967
Zic3 zinc finger protein of the cerebellum 3 0.967
Prrx1 paired related homeobox 1 0.966
Foxc2 forkhead box C2 0.963
Pitx1 paired-like homeodomain transcription factor 1 0.958
Wnt3a wingless-related MMTV integration site 3A 0.958
Sall4 sal-like 4 (Drosophila) 0.957
Apc adenomatosis polyposis coli 0.953
Hoxd11 homeobox D11 0.949
Pax9 paired box gene 9 0.939
Dlx5 distal-less homeobox 5 0.937
Jag1 jagged 1 0.936
Tcfap2c transcription factor AP-2, gamma 0.936
Arid1a AT rich interactive domain 1A (SWI-like) 0.929
Tbx3 T-box 3 0.928
Gdnf glial cell line derived neurotrophic factor 0.927
Wt1 Wilms tumor 1 homolog 0.925
Smo smoothened homolog (Drosophila) 0.924
Emx1 empty spiracles homolog 1 (Drosophila) 0.921
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.916
Foxh1 forkhead box H1 0.907
Efna2 ephrin A2 0.906
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.905
Hoxa9 homeobox A9 0.902
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.896
Hoxd9 homeobox D9 0.896
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.891
Apaf1 apoptotic peptidase activating factor 1 0.887
Rnf2 ring finger protein 2 0.886
Isl1 ISL1 transcription factor, LIM/homeodomain 0.868
Neurog2 neurogenin 2 0.867
Smad3 MAD homolog 3 (Drosophila) 0.861
Sox9 SRY-box containing gene 9 0.861
Hoxa5 homeobox A5 0.860
Wnt6 wingless-related MMTV integration site 6 0.859
Smad1 MAD homolog 1 (Drosophila) 0.855
Sox3 SRY-box containing gene 3 0.851
Msx2 homeobox, msh-like 2 0.849
Wnt5a wingless-related MMTV integration site 5A 0.842
Alx4 aristaless-like homeobox 4 0.840
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.840
Pten phosphatase and tensin homolog 0.827
Pax2 paired box gene 2 0.827
Acvr1 activin A receptor, type 1 0.804
Hoxa2 homeobox A2 0.796
Hoxa10 homeobox A10 0.791
Foxa2 forkhead box A2 0.789
Prrx2 paired related homeobox 2 0.784
Onecut1 one cut domain, family member 1 0.778
Lmx1a LIM homeobox transcription factor 1 alpha 0.777
Hoxb6 homeobox B6 0.777
Fgfr3 fibroblast growth factor receptor 3 0.776
Rarg retinoic acid receptor, gamma 0.776
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cdh2 cadherin 2, neuronal 0.515
foxd3 forkhead box D3 0.482
gyltl1b glycosyltransferase-like 1b 0.478
pou3f3b POU class 3 homeobox 3b 0.404
nkd1 naked cuticle homolog 1 (Drosophila) 0.400
atoh1b atonal homolog 1b 0.394
wnt5b wingless-type MMTV integration site family, member 5b 0.331
etv5b ets variant 5b 0.313
raraa retinoic acid receptor, alpha a 0.301
wnt4a wingless-type MMTV integration site family, member 4a 0.299
dla deltaA 0.285
smad5 MAD homolog 5 (Drosophila) 0.282
gbx2 gastrulation brain homeo box 2 0.272
gdf6a growth differentiation factor 6a 0.255
fgf3 fibroblast growth factor 3 0.215
tbx1 T-box 1 0.210
hoxb1b homeo box B1b 0.191
otx2 orthodenticle homolog 2 0.191
kif17 kinesin family member 17 0.184
foxg1a forkhead box G1a 0.180
otpb orthopedia homolog b 0.173
fgf8b fibroblast growth factor 8 b 0.169
six1b sine oculis homeobox homolog 1b 0.161
rx3 retinal homeobox gene 3 0.159
bmp2b bone morphogenetic protein 2b 0.156
foxi1 forkhead box I1 0.155
sox19a SRY-box containing gene 19a 0.151
sox9a SRY-box containing gene 9a 0.150
chd chordin 0.139
ift88 intraflagellar transport 88 homolog 0.139
crb2a crumbs homolog 2a 0.135
olig3 oligodendrocyte transcription factor 3 0.116
sema3aa semaphorin 3aa 0.116
fzd10 frizzled homolog 10 0.115
pea3 ETS-domain transcription factor pea3 0.113
fgfr1b fibroblast growth factor receptor 1b 0.113
wnt11 wingless-type MMTV integration site family, member 11 0.110
six1a sine oculis homeobox homolog 1a 0.108
olig2 oligodendrocyte lineage transcription factor 2 0.108
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.107
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.106
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.104
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.103
hhip hedgehog interacting protein 0.102
sox3 SRY-box containing gene 3 0.099
foxj1a forkhead box J1a 0.097
fzd7b frizzled homolog 7b 0.096
pkd2 polycystic kidney disease 2 0.096
gli1 GLI-Kruppel family member 1 0.095
guca1c guanylate cyclase activator 1C 0.095
col2a1a collagen type II, alpha-1a 0.091
smo smoothened homolog (Drosophila) 0.090
six3b sine oculis homeobox homolog 3b 0.088
cc2d2a coiled-coil and C2 domain containing 2A 0.087
boc brother of CDO 0.086
shha sonic hedgehog a 0.083
six2a sine oculis-related homeobox 2a 0.083
spry2 sprouty homolog 2 0.082
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.082
neurod neurogenic differentiation 0.077
notch1a notch homolog 1a 0.077
spry1 sprouty homolog 1 (Drosophila) 0.075
hoxb3a homeo box B3a 0.074
osr2 odd-skipped related 2 (Drosophila) 0.074
six3a sine oculis homeobox homolog 3a 0.074
eng2b engrailed 2b 0.074
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.070
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.070
oc90 otoconin 90 0.070
fzd7a frizzled homolog 7a 0.070
zic4 zic family member 4 0.068
met met proto-oncogene (hepatocyte growth factor receptor) 0.066
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.065
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.063
mecom MDS1 and EVI1 complex locus 0.060
egr2b early growth response 2b 0.060
meis2.1 myeloid ecotropic viral integration site 2.1 0.060
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.060
odz4 odd Oz/ten-m homolog 4 0.060
fgfr4 fibroblast growth factor receptor 4 0.059
hapln1a hyaluronan and proteoglycan link protein 1a 0.059
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.058
wnt3 wingless-type MMTV integration site family, member 3 0.054
crabp2b cellular retinoic acid binding protein 2, b 0.054
prkci protein kinase C, iota 0.053
zeb2a zinc finger E-box binding homeobox 2a 0.052
fsta follistatin a 0.052
hoxd4a homeo box D4a 0.051
rhoub ras homolog gene family, member Ub 0.051
pcdh8 protocadherin 8 0.051
tfap2a transcription factor AP-2 alpha 0.049
efnb3b ephrin B3b 0.049
alcamb activated leukocyte cell adhesion molecule b 0.048
fn1 fibronectin 1 0.047
gdnf glial cell derived neurotrophic factor 0.046
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.046
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.045
hoxd3a homeo box D3a 0.045
lfng lunatic fringe homolog 0.044
isl1 islet1 0.044
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Drosophila melanogaster
Name Description Probability Func Analog Organism
HLHmdelta E(spl) region transcript mdelta 0.862
HLHm7 E(spl) region transcript m7 0.817
HLHmgamma E(spl) region transcript mgamma 0.672
HLHmbeta E(spl) region transcript mbeta 0.665
ci cubitus interruptus 0.650
HLHm3 E(spl) region transcript m3 0.408
opa odd paired 0.340
hh hedgehog 0.330
Ser Serrate 0.323
malpha E(spl) region transcript malpha 0.321
E(spl) Enhancer of split 0.306
en engrailed 0.266
Abd-B Abdominal B 0.252
Tom Twin of m4 0.227
bnl branchless 0.171
pnt pointed 0.161
hth homothorax 0.126
knk knickkopf 0.116
sc scute 0.099
btl breathless 0.082
rtv retroactive 0.080
argos CG4531 gene product from transcript CG4531-RA 0.076
odd odd skipped 0.071
eya eyes absent 0.065
cnc cap-n-collar 0.061
HLHm5 E(spl) region transcript m5 0.060
tup tailup 0.056
Dfd Deformed 0.056
esg escargot 0.050
tsh teashirt 0.048
m2 E(spl) region transcript m2 0.046
rib ribbon 0.045
pdm2 POU domain protein 2 0.044
fng fringe 0.043
kuz kuzbanian 0.041
gt giant 0.040
twi twist 0.040
caup caupolican 0.037
os outstretched 0.035
kni knirps 0.034
pnr pannier 0.034
ds dachsous 0.034
m4 E(spl) region transcript m4 0.033
bowl brother of odd with entrails limited 0.031
Btk29A Btk family kinase at 29A 0.029
tap target of Poxn 0.029
drm drumstick 0.028
fw furrowed 0.028
fas faint sausage 0.027
sna snail 0.024
kkv krotzkopf verkehrt 0.023
aop anterior open 0.023
byn brachyenteron 0.023
wg wingless 0.020
nub nubbin 0.020
Hmgcr HMG Coenzyme A reductase 0.019
oc ocelliless 0.018
tin tinman 0.018
lea leak 0.017
wb wing blister 0.017
nkd naked cuticle 0.016
sqd squid 0.014
slp1 sloppy paired 1 0.014
otk off-track 0.014
inv invected 0.012
gsb gooseberry 0.012
tsl torso-like 0.011
CG9867 CG9867 gene product from transcript CG9867-RA 0.011
mid midline 0.011
Antp Antennapedia 0.011
ush u-shaped 0.011
toc toucan 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.995
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.983
APC adenomatous polyposis coli 0.981
LRRK2 leucine-rich repeat kinase 2 0.971
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.961
TRRAP transformation/transcription domain-associated protein 0.955
PRKCZ protein kinase C, zeta 0.917
GSK3B glycogen synthase kinase 3 beta 0.906
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.898
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.871
BCOR BCL6 corepressor 0.858
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.840
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.831
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.827
ZRANB1 zinc finger, RAN-binding domain containing 1 0.808
AXIN1 axin 1 0.792
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.771
ACTB actin, beta 0.761
MEOX2 mesenchyme homeobox 2 0.760
STK3 serine/threonine kinase 3 0.741
ACTG1 actin, gamma 1 0.731
RXRA retinoid X receptor, alpha 0.728
ESR1 estrogen receptor 1 0.697
SEC23A Sec23 homolog A (S. cerevisiae) 0.681
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.656
STK4 serine/threonine kinase 4 0.648
SMAD2 SMAD family member 2 0.638
SMAD3 SMAD family member 3 0.637
CTBP1 C-terminal binding protein 1 0.630
SAV1 salvador homolog 1 (Drosophila) 0.611
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.600
INADL InaD-like (Drosophila) 0.592
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.582
CTNND1 catenin (cadherin-associated protein), delta 1 0.571
CSNK1E casein kinase 1, epsilon 0.553
EXOC7 exocyst complex component 7 0.530
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.528
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.527
SMAD4 SMAD family member 4 0.518
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.516
SOX10 SRY (sex determining region Y)-box 10 0.501
POU3F2 POU class 3 homeobox 2 0.499
PCM1 pericentriolar material 1 0.491
USP9X ubiquitin specific peptidase 9, X-linked 0.480
SETD8 SET domain containing (lysine methyltransferase) 8 0.474
TRIP6 thyroid hormone receptor interactor 6 0.473
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.472
CREBBP CREB binding protein 0.467
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.435
WNT3A wingless-type MMTV integration site family, member 3A 0.427
IQGAP1 IQ motif containing GTPase activating protein 1 0.425
SASS6 spindle assembly 6 homolog (C. elegans) 0.423
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.421
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.406
AKAP11 A kinase (PRKA) anchor protein 11 0.391
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.383
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.383
BMP7 bone morphogenetic protein 7 0.382
ZFX zinc finger protein, X-linked 0.380
MTA1 metastasis associated 1 0.379
NKX2-1 NK2 homeobox 1 0.371
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.340
ZFYVE9 zinc finger, FYVE domain containing 9 0.338
C9orf89 chromosome 9 open reading frame 89 0.336
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.330
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.329
NCOR1 nuclear receptor corepressor 1 0.329
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.326
SKI v-ski sarcoma viral oncogene homolog (avian) 0.326
PKP4 plakophilin 4 0.321
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.304
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.299
WASF1 WAS protein family, member 1 0.298
SEC24D SEC24 family, member D (S. cerevisiae) 0.297
MBD2 methyl-CpG binding domain protein 2 0.296
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.287
SQSTM1 sequestosome 1 0.284
LIN28B lin-28 homolog B (C. elegans) 0.281
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.281
LDB1 LIM domain binding 1 0.276
MED25 mediator complex subunit 25 0.275
CENPJ centromere protein J 0.270
CTBP2 C-terminal binding protein 2 0.267
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.266
TRAF6 TNF receptor-associated factor 6 0.266
LGALS8 lectin, galactoside-binding, soluble, 8 0.256
ANKRD28 ankyrin repeat domain 28 0.255
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.250
DLG5 discs, large homolog 5 (Drosophila) 0.250
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.248
WT1 Wilms tumor 1 0.245
SEC24A SEC24 family, member A (S. cerevisiae) 0.242
ZNF746 zinc finger protein 746 0.235
SP1 Sp1 transcription factor 0.235
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.233
EP300 E1A binding protein p300 0.232
GLIS2 GLIS family zinc finger 2 0.230
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.229
EXOC5 exocyst complex component 5 0.225
HIC1 hypermethylated in cancer 1 0.219
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ireb2 iron responsive element binding protein 2 0.024
Ptov1 prostate tumor overexpressed 1 0.019
Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 0.019
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.019
Foxe3 forkhead box E3 0.016
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.016
Tuba1c tubulin, alpha 1C 0.016
LOC100360919 Immunoglobulin lambda-like polypeptide 1-like 0.015
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.015
Pfn1 profilin 1 0.014
Ptms parathymosin 0.014
Csnk1g3 casein kinase 1, gamma 3 0.013
Pgm2 phosphoglucomutase 2 0.013
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.013
Sox17 SRY (sex determining region Y)-box 17 0.012
RT1-DOa RT1 class II, locus DOa 0.012
Crybb3 crystallin, beta B3 0.012
Vegfa vascular endothelial growth factor A 0.012
Ccna1 cyclin A1 0.012
Scaf1 SR-related CTD-associated factor 1 0.012
Crygb crystallin, gamma B 0.011
Cxxc4 CXXC finger 4 0.011
Bglap bone gamma-carboxyglutamate (gla) protein 0.011
Atf2 activating transcription factor 2 0.011
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.011
Mip major intrinsic protein of lens fiber 0.011
Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform 0.011
Prdm2 PR domain containing 2, with ZNF domain 0.011
Gpr176 G protein-coupled receptor 176 0.011
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.010
Dctn1 dynactin 1 0.010
Il11 interleukin 11 0.010
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.010
Col4a5 collagen, type IV, alpha 5 0.010
Fat1 FAT tumor suppressor homolog 1 (Drosophila) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism