IMP
Process View
The network for 'pancreatic a cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
pancreatic a cell fate commitment
The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 1.000 | |
| Pax6 | paired box gene 6 | 1.000 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.999 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.998 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.997 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.995 | |
| Ptf1a | pancreas specific transcription factor, 1a | 0.993 | |
| Pax3 | paired box gene 3 | 0.991 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.987 | |
| Fgf8 | fibroblast growth factor 8 | 0.987 | |
| Foxc2 | forkhead box C2 | 0.985 | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.970 | |
| Neurod1 | neurogenic differentiation 1 | 0.966 | |
| Neurog2 | neurogenin 2 | 0.964 | |
| Insm1 | insulinoma-associated 1 | 0.961 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.952 | |
| Gsc | goosecoid homeobox | 0.942 | |
| Sox11 | SRY-box containing gene 11 | 0.941 | |
| Nhlh1 | nescient helix loop helix 1 | 0.933 | |
| Lhx3 | LIM homeobox protein 3 | 0.933 | |
| Hoxd3 | homeobox D3 | 0.925 | |
| Gata4 | GATA binding protein 4 | 0.919 | |
| Neurod4 | neurogenic differentiation 4 | 0.914 | |
| Six3 | sine oculis-related homeobox 3 homolog (Drosophila) | 0.909 | |
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.905 | |
| En1 | engrailed 1 | 0.903 | |
| Neurog1 | neurogenin 1 | 0.903 | |
| Pdx1 | pancreatic and duodenal homeobox 1 | 0.898 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.896 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.878 | |
| Nkx6-1 | NK6 homeobox 1 | 0.873 | |
| Hoxd13 | homeobox D13 | 0.872 | |
| Atoh7 | atonal homolog 7 (Drosophila) | 0.866 | |
| Pax9 | paired box gene 9 | 0.849 | |
| T | brachyury | 0.843 | |
| Sox9 | SRY-box containing gene 9 | 0.839 | |
| Onecut1 | one cut domain, family member 1 | 0.838 | |
| Lhx5 | LIM homeobox protein 5 | 0.830 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.826 | |
| Nog | noggin | 0.825 | |
| Tlx3 | T-cell leukemia, homeobox 3 | 0.809 | |
| Hoxa1 | homeobox A1 | 0.802 | |
| Foxc1 | forkhead box C1 | 0.795 | |
| Prrx1 | paired related homeobox 1 | 0.780 | |
| Fgf15 | fibroblast growth factor 15 | 0.768 | |
| Msx1 | homeobox, msh-like 1 | 0.687 | |
| Neurog3 | neurogenin 3 | 0.686 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.683 | |
| Six6 | sine oculis-related homeobox 6 homolog (Drosophila) | 0.680 | |
| Hoxd11 | homeobox D11 | 0.649 | |
| Sox2 | SRY-box containing gene 2 | 0.638 | |
| Alx3 | aristaless-like homeobox 3 | 0.628 | |
| Gata1 | GATA binding protein 1 | 0.627 | |
| Col22a1 | collagen, type XXII, alpha 1 | 0.622 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.620 | |
| Zic1 | zinc finger protein of the cerebellum 1 | 0.619 | |
| Pou4f2 | POU domain, class 4, transcription factor 2 | 0.607 | |
| Tbx5 | T-box 5 | 0.594 | |
| Hoxd1 | homeobox D1 | 0.591 | |
| Hmx1 | H6 homeobox 1 | 0.590 | |
| Tbx1 | T-box 1 | 0.582 | |
| Col2a1 | collagen, type II, alpha 1 | 0.573 | |
| Nkx3-2 | NK3 homeobox 2 | 0.564 | |
| Fgf10 | fibroblast growth factor 10 | 0.555 | |
| Pou4f3 | POU domain, class 4, transcription factor 3 | 0.549 | |
| Sox3 | SRY-box containing gene 3 | 0.542 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.529 | |
| Foxe3 | forkhead box E3 | 0.528 | |
| Hoxa13 | homeobox A13 | 0.513 | |
| Mesp1 | mesoderm posterior 1 | 0.512 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.506 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.499 | |
| Ntf3 | neurotrophin 3 | 0.499 | |
| Lhx9 | LIM homeobox protein 9 | 0.488 | |
| Foxb1 | forkhead box B1 | 0.481 | |
| Nkx2-9 | NK2 transcription factor related, locus 9 (Drosophila) | 0.480 | |
| Mecom | MDS1 and EVI1 complex locus | 0.467 | |
| Nkx1-2 | NK1 transcription factor related, locus 2 (Drosophila) | 0.465 | |
| Meox2 | mesenchyme homeobox 2 | 0.462 | |
| Lhcgr | luteinizing hormone/choriogonadotropin receptor | 0.454 | |
| Uncx | UNC homeobox | 0.451 | |
| Foxd3 | forkhead box D3 | 0.448 | |
| Hoxd12 | homeobox D12 | 0.441 | |
| Vax1 | ventral anterior homeobox containing gene 1 | 0.434 | |
| Pthlh | parathyroid hormone-like peptide | 0.422 | |
| Hoxc5 | homeobox C5 | 0.415 | |
| Bmp4 | bone morphogenetic protein 4 | 0.415 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.414 | |
| Sall4 | sal-like 4 (Drosophila) | 0.407 | |
| Foxg1 | forkhead box G1 | 0.406 | |
| Pax1 | paired box gene 1 | 0.405 | |
| Hoxa5 | homeobox A5 | 0.400 | |
| Pitx3 | paired-like homeodomain transcription factor 3 | 0.393 | |
| Dlx1 | distal-less homeobox 1 | 0.392 | |
| Pou3f2 | POU domain, class 3, transcription factor 2 | 0.392 | |
| Tal2 | T-cell acute lymphocytic leukemia 2 | 0.386 | |
| Hes2 | hairy and enhancer of split 2 (Drosophila) | 0.382 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.377 | |
| Fgf17 | fibroblast growth factor 17 | 0.365 | |
| Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | 0.363 |
