The network for 'polarity specification of proximal distal axis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

polarity specification of proximal distal axis

Any process resulting in the establishment of polarity along the proximal/distal axis.

Name Description Probability Func Analog Organism
Lef1 lymphoid enhancer binding factor 1 0.998
Wnt4 wingless-related MMTV integration site 4 0.967
Gdf5 growth differentiation factor 5 0.966
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.955
Lhx1 LIM homeobox protein 1 0.951
Wnt10b wingless related MMTV integration site 10b 0.932
Pax8 paired box gene 8 0.918
T brachyury 0.917
Bmp7 bone morphogenetic protein 7 0.904
Wnt3a wingless-related MMTV integration site 3A 0.895
Pax2 paired box gene 2 0.883
Fgf8 fibroblast growth factor 8 0.848
Hoxa13 homeobox A13 0.843
Fzd8 frizzled homolog 8 (Drosophila) 0.835
Gas1 growth arrest specific 1 0.818
Rarg retinoic acid receptor, gamma 0.784
Pou3f3 POU domain, class 3, transcription factor 3 0.776
Bmp4 bone morphogenetic protein 4 0.733
Smad6 MAD homolog 6 (Drosophila) 0.713
Fgf18 fibroblast growth factor 18 0.700
Wnt6 wingless-related MMTV integration site 6 0.679
Gdnf glial cell line derived neurotrophic factor 0.654
Wnt3 wingless-related MMTV integration site 3 0.647
Shh sonic hedgehog 0.644
Rpgrip1l Rpgrip1-like 0.628
Adra2b adrenergic receptor, alpha 2b 0.625
Hoxd13 homeobox D13 0.612
Fgfr1 fibroblast growth factor receptor 1 0.610
Msx2 homeobox, msh-like 2 0.606
Fgf15 fibroblast growth factor 15 0.605
Emid2 EMI domain containing 2 0.589
Msx1 homeobox, msh-like 1 0.570
Gdf6 growth differentiation factor 6 0.551
Gli1 GLI-Kruppel family member GLI1 0.540
Tbx2 T-box 2 0.537
Wnt9a wingless-type MMTV integration site 9A 0.535
Rara retinoic acid receptor, alpha 0.529
Prop1 paired like homeodomain factor 1 0.523
Ppap2b phosphatidic acid phosphatase type 2B 0.486
Axin2 axin2 0.485
Lrp6 low density lipoprotein receptor-related protein 6 0.485
Col13a1 collagen, type XIII, alpha 1 0.484
Fgfr2 fibroblast growth factor receptor 2 0.480
Hoxd9 homeobox D9 0.471
Gsk3b glycogen synthase kinase 3 beta 0.466
Npas1 neuronal PAS domain protein 1 0.461
Wnt2b wingless related MMTV integration site 2b 0.439
Amhr2 anti-Mullerian hormone type 2 receptor 0.438
Foxc1 forkhead box C1 0.430
Bmpr1a bone morphogenetic protein receptor, type 1A 0.410
Irs1 insulin receptor substrate 1 0.403
Ctnna1 catenin (cadherin associated protein), alpha 1 0.401
Fgf5 fibroblast growth factor 5 0.400
Gli3 GLI-Kruppel family member GLI3 0.394
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.377
Wnt5a wingless-related MMTV integration site 5A 0.372
Hoxd11 homeobox D11 0.368
Hic1 hypermethylated in cancer 1 0.367
Dlx4 distal-less homeobox 4 0.365
Tbx3 T-box 3 0.358
Htt huntingtin 0.355
Tcf7 transcription factor 7, T-cell specific 0.355
Hoxa2 homeobox A2 0.348
Foxf2 forkhead box F2 0.348
Tbx1 T-box 1 0.346
Cdx2 caudal type homeobox 2 0.335
Hoxa4 homeobox A4 0.324
Nodal nodal 0.322
Gpc3 glypican 3 0.315
Gata6 GATA binding protein 6 0.314
Acan aggrecan 0.312
Fgfr4 fibroblast growth factor receptor 4 0.304
Prrx2 paired related homeobox 2 0.302
Klk4 kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) 0.297
Fzd7 frizzled homolog 7 (Drosophila) 0.297
Fzd1 frizzled homolog 1 (Drosophila) 0.296
Hoxb6 homeobox B6 0.295
Tbx15 T-box 15 0.293
Efna4 ephrin A4 0.289
Pten phosphatase and tensin homolog 0.280
Wnt11 wingless-related MMTV integration site 11 0.271
Pou3f1 POU domain, class 3, transcription factor 1 0.261
3110079O15Rik RIKEN cDNA 3110079O15 gene 0.260
Apc adenomatosis polyposis coli 0.260
Foxd2 forkhead box D2 0.260
Sox7 SRY-box containing gene 7 0.256
Ihh Indian hedgehog 0.255
Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric 0.255
Hoxb3 homeobox B3 0.254
Gli2 GLI-Kruppel family member GLI2 0.254
Cilp2 cartilage intermediate layer protein 2 0.250
Foxf1a forkhead box F1a 0.249
Bnc1 basonuclin 1 0.248
Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 0.247
Emx2 empty spiracles homolog 2 (Drosophila) 0.238
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.237
Foxn1 forkhead box N1 0.233
Smo smoothened homolog (Drosophila) 0.230
Rspo1 R-spondin homolog (Xenopus laevis) 0.219
Neurog1 neurogenin 1 0.219
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
eor-1 Protein EOR-1 0.764
sas-4 Protein SAS-4 0.476
pop-1 Protein POP-1 0.405
lit-1 Protein LIT-1 0.247
nhr-25 Protein NHR-25 0.127
ceh-18 Protein CEH-18 0.121
wrm-1 Protein WRM-1 0.116
sys-1 Protein SYS-1 0.075
W02B12.11 Protein W02B12.11 0.054
psa-3 Protein PSA-3 0.053
lgc-39 Protein LGC-39 0.048
rpy-1 Protein RPY-1 0.046
C02B10.5 Protein C02B10.5 0.043
ztf-22 Protein ZTF-22 0.042
cdc-26 Protein CDC-26 0.041
ZK1053.4 Protein ZK1053.4 0.039
R02D5.1 Protein R02D5.1 0.036
tag-260 Protein TAG-260 0.035
lin-36 Protein LIN-36 0.032
R05D3.2 Protein R05D3.2 0.032
mps-2 Protein MPS-2 0.030
pry-1 Protein PRY-1 0.029
cye-1 Protein CYE-1 0.027
K07B1.7 Protein K07B1.7 0.026
nud-2 Protein NUD-2 0.026
sma-9 Protein SMA-9 0.026
lin-17 Protein LIN-17 0.025
trim-9 Protein TRIM-9 0.025
CELE_Y40D12A.1 Protein Y40D12A.1 0.025
tpk-1 Protein TPK-1 0.024
pes-7 Protein PES-7 0.023
C14A4.12 Protein C14A4.12 0.022
inx-3 Protein INX-3 0.022
ZK54.1 Protein ZK54.1 0.021
F25H2.7 Protein F25H2.7 0.020
R10E12.2 Protein R10E12.2 0.019
CELE_F54D5.5 Protein F54D5.5 0.019
C32D5.10 Protein C32D5.10 0.018
asd-1 Protein ASD-1 0.018
gck-2 Protein GCK-2 0.018
jmjd-3.1 Protein JMJD-3.1 0.017
mnp-1 Protein MNP-1 0.016
F55A3.2 Protein F55A3.2 0.015
F23F1.4 Protein F23F1.4 0.015
hlh-30 Protein HLH-30 0.015
rig-6 Protein RIG-6 0.015
klp-18 Protein KLP-18 0.015
F25H5.5 Protein F25H5.5 0.015
C49H3.6 Protein C49H3.6 0.014
C14F11.2 Protein C14F11.2 0.014
CELE_B0281.5 Protein B0281.5 0.014
CELE_C33D9.3 Protein C33D9.3 0.014
rga-1 Protein RGA-1 0.014
Y65A5A.1 Protein Y65A5A.1 0.014
Y9D1A.2 Protein Y9D1A.2 0.013
pole-2 Protein POLE-2 0.013
unc-5 Protein UNC-5 0.013
flh-1 Protein FLH-1 0.012
emb-30 Protein EMB-30 0.012
lip-1 Protein LIP-1 0.012
ZK484.4 Protein ZK484.4 0.012
ZK930.1 Protein ZK930.1 0.012
F39F10.3 Protein F39F10.3 0.012
CELE_F59A6.5 Protein F59A6.5 0.011
R12E2.1 Protein R12E2.1 0.011
dog-1 Protein DOG-1 0.011
jmjd-1.2 Protein JMJD-1.2 0.011
sma-3 Protein SMA-3 0.011
irx-1 Protein IRX-1 0.010
lron-11 Protein LRON-11 0.010
CELE_Y113G7B.11 Protein Y113G7B.11 0.010
ain-1 Protein AIN-1 0.010
cpna-1 Protein CPNA-1 0.010
F13G3.6 Protein F13G3.6 0.010
pha-4 Protein PHA-4 0.010
F25B5.5 Protein F25B5.5 0.010
ceh-6 Protein CEH-6 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism