IMP
Process View
The network for 'ubiquitin dependent smad protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
ubiquitin dependent smad protein catabolic process
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Smad6 | MAD homolog 6 (Drosophila) | 0.908 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.714 | |
| T | brachyury | 0.665 | |
| Lhx1 | LIM homeobox protein 1 | 0.661 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.638 | |
| Axin1 | axin 1 | 0.531 | |
| Wnt4 | wingless-related MMTV integration site 4 | 0.496 | |
| Rac1 | RAS-related C3 botulinum substrate 1 | 0.489 | |
| Ilk | integrin linked kinase | 0.464 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.409 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.408 | |
| Fgf8 | fibroblast growth factor 8 | 0.373 | |
| Fgf18 | fibroblast growth factor 18 | 0.351 | |
| Wnt10b | wingless related MMTV integration site 10b | 0.342 | |
| Pax8 | paired box gene 8 | 0.316 | |
| Wnt9a | wingless-type MMTV integration site 9A | 0.304 | |
| Rarg | retinoic acid receptor, gamma | 0.297 | |
| Axin2 | axin2 | 0.274 | |
| Tbx2 | T-box 2 | 0.250 | |
| Pou3f3 | POU domain, class 3, transcription factor 3 | 0.218 | |
| Hoxd9 | homeobox D9 | 0.211 | |
| Smad7 | MAD homolog 7 (Drosophila) | 0.201 | |
| Emid2 | EMI domain containing 2 | 0.193 | |
| Col13a1 | collagen, type XIII, alpha 1 | 0.190 | |
| Wnt6 | wingless-related MMTV integration site 6 | 0.186 | |
| Fzd8 | frizzled homolog 8 (Drosophila) | 0.185 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.183 | |
| Vax1 | ventral anterior homeobox containing gene 1 | 0.175 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.169 | |
| Amh | anti-Mullerian hormone | 0.167 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.157 | |
| Pou3f1 | POU domain, class 3, transcription factor 1 | 0.155 | |
| Clic3 | chloride intracellular channel 3 | 0.145 | |
| Kl | klotho | 0.142 | |
| Des | desmin | 0.124 | |
| Hoxa13 | homeobox A13 | 0.122 | |
| Fgf5 | fibroblast growth factor 5 | 0.119 | |
| Slc34a2 | solute carrier family 34 (sodium phosphate), member 2 | 0.119 | |
| Gata6 | GATA binding protein 6 | 0.118 | |
| Snai1 | snail homolog 1 (Drosophila) | 0.113 | |
| Lama5 | laminin, alpha 5 | 0.111 | |
| Barx2 | BarH-like homeobox 2 | 0.110 | |
| Padi3 | peptidyl arginine deiminase, type III | 0.107 | |
| Smad2 | MAD homolog 2 (Drosophila) | 0.106 | |
| Foxf1a | forkhead box F1a | 0.105 | |
| Fgfr4 | fibroblast growth factor receptor 4 | 0.103 | |
| Muc5ac | mucin 5, subtypes A and C, tracheobronchial/gastric | 0.102 | |
| Foxn1 | forkhead box N1 | 0.101 | |
| Tead3 | TEA domain family member 3 | 0.098 | |
| Map3k2 | mitogen-activated protein kinase kinase kinase 2 | 0.096 | |
| Cnn1 | calponin 1 | 0.096 | |
| Nkd2 | naked cuticle 2 homolog (Drosophila) | 0.096 | |
| Barx1 | BarH-like homeobox 1 | 0.096 | |
| Tctex1d4 | Tctex1 domain containing 4 | 0.095 | |
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.095 | |
| Npas1 | neuronal PAS domain protein 1 | 0.094 | |
| Dvl1 | dishevelled, dsh homolog 1 (Drosophila) | 0.094 | |
| Pcsk5 | proprotein convertase subtilisin/kexin type 5 | 0.092 | |
| Cldn3 | claudin 3 | 0.091 | |
| Ttc16 | tetratricopeptide repeat domain 16 | 0.089 | |
| Foxd2 | forkhead box D2 | 0.088 | |
| Mbd3 | methyl-CpG binding domain protein 3 | 0.088 | |
| Sftpb | surfactant associated protein B | 0.088 | |
| Sox7 | SRY-box containing gene 7 | 0.084 | |
| Acan | aggrecan | 0.084 | |
| Dlx4 | distal-less homeobox 4 | 0.083 | |
| Zfp651 | zinc finger protein 651 | 0.083 | |
| Emp2 | epithelial membrane protein 2 | 0.083 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.083 | |
| Actg2 | actin, gamma 2, smooth muscle, enteric | 0.083 | |
| Sema3b | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.081 | |
| Lyzl4 | lysozyme-like 4 | 0.080 | |
| Pcdh12 | protocadherin 12 | 0.080 | |
| Cdx1 | caudal type homeobox 1 | 0.080 | |
| Efna2 | ephrin A2 | 0.079 | |
| Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | 0.079 | |
| Epha1 | Eph receptor A1 | 0.077 | |
| Ihh | Indian hedgehog | 0.077 | |
| Ppl | periplakin | 0.077 | |
| Gli1 | GLI-Kruppel family member GLI1 | 0.077 | |
| Bmp7 | bone morphogenetic protein 7 | 0.076 | |
| Grin2d | glutamate receptor, ionotropic, NMDA2D (epsilon 4) | 0.075 | |
| Neurog1 | neurogenin 1 | 0.074 | |
| Adra2b | adrenergic receptor, alpha 2b | 0.074 | |
| Fgf10 | fibroblast growth factor 10 | 0.074 | |
| Fzd10 | frizzled homolog 10 (Drosophila) | 0.074 | |
| Adra2c | adrenergic receptor, alpha 2c | 0.072 | |
| Zbtb7c | zinc finger and BTB domain containing 7C | 0.072 | |
| Nrtn | neurturin | 0.072 | |
| Wnt2b | wingless related MMTV integration site 2b | 0.071 | |
| Adra2a | adrenergic receptor, alpha 2a | 0.071 | |
| Sult5a1 | sulfotransferase family 5A, member 1 | 0.070 | |
| Sh3pxd2a | SH3 and PX domains 2A | 0.070 | |
| Hsd11b2 | hydroxysteroid 11-beta dehydrogenase 2 | 0.070 | |
| Foxb1 | forkhead box B1 | 0.070 | |
| Rspo1 | R-spondin homolog (Xenopus laevis) | 0.068 | |
| Fgf15 | fibroblast growth factor 15 | 0.067 | |
| Trp73 | transformation related protein 73 | 0.067 | |
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.067 | |
| Gpr50 | G-protein-coupled receptor 50 | 0.067 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.999 | |
| NCK2 | NCK adaptor protein 2 | 0.675 | |
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 | 0.646 | |
| SMAD4 | SMAD family member 4 | 0.636 | |
| RNF11 | ring finger protein 11 | 0.611 | |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.575 | |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.555 | |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.505 | |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4 | 0.483 | |
| XIAP | X-linked inhibitor of apoptosis | 0.414 | |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.407 | |
| SMAD7 | SMAD family member 7 | 0.348 | |
| ANKRD13A | ankyrin repeat domain 13A | 0.320 | |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.307 | |
| FBXL15 | F-box and leucine-rich repeat protein 15 | 0.303 | |
| ILK | integrin-linked kinase | 0.301 | |
| FHL2 | four and a half LIM domains 2 | 0.248 | |
| HOXA1 | homeobox A1 | 0.210 | |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.156 | |
| SCNN1B | sodium channel, nonvoltage-gated 1, beta | 0.139 | |
| RNF5 | ring finger protein 5 | 0.134 | |
| LPXN | leupaxin | 0.130 | |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.120 | |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.111 | |
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.102 | |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.096 | |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.081 | |
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.080 | |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like | 0.067 | |
| BAG1 | BCL2-associated athanogene | 0.065 | |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.064 | |
| UBQLN2 | ubiquilin 2 | 0.050 | |
| TRAF4 | TNF receptor-associated factor 4 | 0.047 | |
| VCL | vinculin | 0.044 | |
| SMAD5 | SMAD family member 5 | 0.043 | |
| PPIL4 | peptidylprolyl isomerase (cyclophilin)-like 4 | 0.042 | |
| RNF168 | ring finger protein 168 | 0.040 | |
| FAM173A | family with sequence similarity 173, member A | 0.039 | |
| HSPB1 | heat shock 27kDa protein 1 | 0.036 | |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 0.034 | |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) | 0.033 | |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.032 | |
| ADRBK1 | adrenergic, beta, receptor kinase 1 | 0.031 | |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.031 | |
| CCDC127 | coiled-coil domain containing 127 | 0.028 | |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 | 0.028 | |
| SPG20 | spastic paraplegia 20 (Troyer syndrome) | 0.027 | |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.025 | |
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 | 0.024 | |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | 0.023 | |
| ZYX | zyxin | 0.023 | |
| NUBP2 | nucleotide binding protein 2 (MinD homolog, E. coli) | 0.023 | |
| PARVA | parvin, alpha | 0.023 | |
| HSF1 | heat shock transcription factor 1 | 0.023 | |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.023 | |
| UBE4A | ubiquitination factor E4A (UFD2 homolog, yeast) | 0.022 | |
| SNX9 | sorting nexin 9 | 0.022 | |
| HSPA1B | heat shock 70kDa protein 1B | 0.020 | |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.019 | |
| ARRDC3 | arrestin domain containing 3 | 0.019 | |
| SMAD1 | SMAD family member 1 | 0.019 | |
| ZNF426 | zinc finger protein 426 | 0.019 | |
| PHF21A | PHD finger protein 21A | 0.018 | |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.017 | |
| BFAR | bifunctional apoptosis regulator | 0.017 | |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | 0.016 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.015 | |
| STAM2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 0.015 | |
| BAG3 | BCL2-associated athanogene 3 | 0.015 | |
| ZNRF1 | zinc and ring finger 1 | 0.014 | |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.014 | |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.013 | |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.013 | |
| PARVB | parvin, beta | 0.012 | |
| RHOA | ras homolog gene family, member A | 0.012 | |
| ERCC6 | excision repair cross-complementing rodent repair deficiency, complementation group 6 | 0.012 | |
| TP73 | tumor protein p73 | 0.011 | |
| ING2 | inhibitor of growth family, member 2 | 0.011 | |
| UBE2Q1 | ubiquitin-conjugating enzyme E2Q family member 1 | 0.011 | |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | 0.011 | |
| SCNN1A | sodium channel, nonvoltage-gated 1 alpha | 0.010 | |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.010 |