IMP
Process View
The network for 'positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ren1 | renin 1 structural | 1.000 | |
| Lepr | leptin receptor | 0.988 | |
| Adrb1 | adrenergic receptor, beta 1 | 0.981 | |
| Pnpla2 | patatin-like phospholipase domain containing 2 | 0.975 | |
| Myh11 | myosin, heavy polypeptide 11, smooth muscle | 0.924 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.885 | |
| Drd2 | dopamine receptor D2 | 0.856 | |
| Kl | klotho | 0.850 | |
| Cckbr | cholecystokinin B receptor | 0.826 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.752 | |
| Crhr1 | corticotropin releasing hormone receptor 1 | 0.730 | |
| Tgfbr3 | transforming growth factor, beta receptor III | 0.716 | |
| Ednrb | endothelin receptor type B | 0.693 | |
| Ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 0.685 | |
| Npy2r | neuropeptide Y receptor Y2 | 0.602 | |
| Grin1 | glutamate receptor, ionotropic, NMDA1 (zeta 1) | 0.557 | |
| ND6 | NADH dehydrogenase subunit 6 | 0.550 | |
| Pdgfb | platelet derived growth factor, B polypeptide | 0.548 | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.534 | |
| Kcna2 | potassium voltage-gated channel, shaker-related subfamily, member 2 | 0.531 | |
| Sstr4 | somatostatin receptor 4 | 0.493 | |
| Prrx1 | paired related homeobox 1 | 0.466 | |
| Htr4 | 5 hydroxytryptamine (serotonin) receptor 4 | 0.459 | |
| Pcdh12 | protocadherin 12 | 0.457 | |
| Fbn1 | fibrillin 1 | 0.445 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.441 | |
| Kcnk3 | potassium channel, subfamily K, member 3 | 0.423 | |
| Htr1d | 5-hydroxytryptamine (serotonin) receptor 1D | 0.417 | |
| Pecam1 | platelet/endothelial cell adhesion molecule 1 | 0.412 | |
| Chrm1 | cholinergic receptor, muscarinic 1, CNS | 0.395 | |
| Oprd1 | opioid receptor, delta 1 | 0.392 | |
| Ret | ret proto-oncogene | 0.381 | |
| Oprm1 | opioid receptor, mu 1 | 0.347 | |
| Apln | apelin | 0.339 | |
| Cga | glycoprotein hormones, alpha subunit | 0.333 | |
| Htr1a | 5-hydroxytryptamine (serotonin) receptor 1A | 0.332 | |
| Mas1 | MAS1 oncogene | 0.324 | |
| Kcnj6 | potassium inwardly-rectifying channel, subfamily J, member 6 | 0.320 | |
| Htr5a | 5-hydroxytryptamine (serotonin) receptor 5A | 0.308 | |
| Itpr3 | inositol 1,4,5-triphosphate receptor 3 | 0.299 | |
| Msx1 | homeobox, msh-like 1 | 0.295 | |
| Acvr1 | activin A receptor, type 1 | 0.294 | |
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.292 | |
| She | src homology 2 domain-containing transforming protein E | 0.289 | |
| Edn1 | endothelin 1 | 0.283 | |
| Adra2c | adrenergic receptor, alpha 2c | 0.283 | |
| Sstr1 | somatostatin receptor 1 | 0.279 | |
| Prkch | protein kinase C, eta | 0.279 | |
| Lhx6 | LIM homeobox protein 6 | 0.277 | |
| Htr7 | 5-hydroxytryptamine (serotonin) receptor 7 | 0.276 | |
| Npy1r | neuropeptide Y receptor Y1 | 0.258 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.251 | |
| Klk4 | kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) | 0.244 | |
| Chrm3 | cholinergic receptor, muscarinic 3, cardiac | 0.243 | |
| Itpr2 | inositol 1,4,5-triphosphate receptor 2 | 0.240 | |
| Tacr1 | tachykinin receptor 1 | 0.233 | |
| Ednra | endothelin receptor type A | 0.227 | |
| Agtrap | angiotensin II, type I receptor-associated protein | 0.226 | |
| Abp1 | amiloride binding protein 1 (amine oxidase, copper-containing) | 0.222 | |
| Npy5r | neuropeptide Y receptor Y5 | 0.220 | |
| Grm2 | glutamate receptor, metabotropic 2 | 0.220 | |
| Ece1 | endothelin converting enzyme 1 | 0.213 | |
| Sema6d | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 0.211 | |
| Agt | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 0.207 | |
| Adrb2 | adrenergic receptor, beta 2 | 0.201 | |
| Ar | androgen receptor | 0.201 | |
| Vegfa | vascular endothelial growth factor A | 0.197 | |
| Adamts1 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 | 0.195 | |
| Sprr2f | small proline-rich protein 2F | 0.192 | |
| Kcna1 | potassium voltage-gated channel, shaker-related subfamily, member 1 | 0.188 | |
| Alx3 | aristaless-like homeobox 3 | 0.179 | |
| Syt6 | synaptotagmin VI | 0.179 | |
| Chia | chitinase, acidic | 0.179 | |
| Fgf23 | fibroblast growth factor 23 | 0.178 | |
| Chrna7 | cholinergic receptor, nicotinic, alpha polypeptide 7 | 0.175 | |
| Grid1 | glutamate receptor, ionotropic, delta 1 | 0.175 | |
| Hoxb5 | homeobox B5 | 0.175 | |
| Fgf4 | fibroblast growth factor 4 | 0.167 | |
| Kcns2 | K+ voltage-gated channel, subfamily S, 2 | 0.167 | |
| Mc5r | melanocortin 5 receptor | 0.166 | |
| Col4a3 | collagen, type IV, alpha 3 | 0.166 | |
| Vip | vasoactive intestinal polypeptide | 0.162 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.160 | |
| Slc12a1 | solute carrier family 12, member 1 | 0.158 | |
| Has1 | hyaluronan synthase1 | 0.157 | |
| Htra3 | HtrA serine peptidase 3 | 0.156 | |
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.156 | |
| Grin2a | glutamate receptor, ionotropic, NMDA2A (epsilon 1) | 0.155 | |
| Prss32 | protease, serine, 32 | 0.154 | |
| Lox | lysyl oxidase | 0.153 | |
| Lep | leptin | 0.152 | |
| Pgr | progesterone receptor | 0.151 | |
| Uts2r | urotensin 2 receptor | 0.144 | |
| Mc3r | melanocortin 3 receptor | 0.142 | |
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.140 | |
| Fzd1 | frizzled homolog 1 (Drosophila) | 0.136 | |
| 3110079O15Rik | RIKEN cDNA 3110079O15 gene | 0.135 | |
| Wt1 | Wilms tumor 1 homolog | 0.134 | |
| Tyr | tyrosinase | 0.132 | |
| Ppp1r1b | protein phosphatase 1, regulatory (inhibitor) subunit 1B | 0.131 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| MPDZ | multiple PDZ domain protein | 0.986 | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.963 | |
| PPP1R9B | protein phosphatase 1, regulatory (inhibitor) subunit 9B | 0.961 | |
| ADORA2A | adenosine A2a receptor | 0.927 | |
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.926 | |
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.766 | |
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | 0.741 | |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.678 | |
| RLN3 | relaxin 3 | 0.532 | |
| PTEN | phosphatase and tensin homolog | 0.380 | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.256 | |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.236 | |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.215 | |
| SSTR3 | somatostatin receptor 3 | 0.123 | |
| CAV2 | caveolin 2 | 0.122 | |
| FN1 | fibronectin 1 | 0.094 | |
| THBS1 | thrombospondin 1 | 0.068 | |
| C3 | complement component 3 | 0.062 | |
| ARRDC3 | arrestin domain containing 3 | 0.062 | |
| KCNJ9 | potassium inwardly-rectifying channel, subfamily J, member 9 | 0.057 | |
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.053 | |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.051 | |
| DLGAP2 | discs, large (Drosophila) homolog-associated protein 2 | 0.047 | |
| ARRB1 | arrestin, beta 1 | 0.044 | |
| TBC1D10A | TBC1 domain family, member 10A | 0.040 | |
| GPR6 | G protein-coupled receptor 6 | 0.039 | |
| CALCRL | calcitonin receptor-like | 0.037 | |
| TRPC3 | transient receptor potential cation channel, subfamily C, member 3 | 0.036 | |
| RHO | rhodopsin | 0.034 | |
| SLC9A3 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | 0.033 | |
| GAD2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 0.031 | |
| ADORA1 | adenosine A1 receptor | 0.031 | |
| CCKBR | cholecystokinin B receptor | 0.030 | |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.028 | |
| CALCA | calcitonin-related polypeptide alpha | 0.028 | |
| AFF2 | AF4/FMR2 family, member 2 | 0.023 | |
| KCNJ5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.022 | |
| FEZF2 | FEZ family zinc finger 2 | 0.021 | |
| DRD2 | dopamine receptor D2 | 0.020 | |
| GFRA4 | GDNF family receptor alpha 4 | 0.020 | |
| HTR1A | 5-hydroxytryptamine (serotonin) receptor 1A | 0.019 | |
| OR2AG1 | olfactory receptor, family 2, subfamily AG, member 1 | 0.018 | |
| CTGF | connective tissue growth factor | 0.018 | |
| CRHR2 | corticotropin releasing hormone receptor 2 | 0.018 | |
| CACNG3 | calcium channel, voltage-dependent, gamma subunit 3 | 0.017 | |
| FOXN1 | forkhead box N1 | 0.017 | |
| MAG | myelin associated glycoprotein | 0.017 | |
| GHRHR | growth hormone releasing hormone receptor | 0.016 | |
| PLCD1 | phospholipase C, delta 1 | 0.016 | |
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.016 | |
| ODF1 | outer dense fiber of sperm tails 1 | 0.014 | |
| OR2H1 | olfactory receptor, family 2, subfamily H, member 1 | 0.014 | |
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | 0.014 | |
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4 | 0.013 | |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.012 | |
| EMX1 | empty spiracles homeobox 1 | 0.012 | |
| NALCN | sodium leak channel, non-selective | 0.012 | |
| TSHR | thyroid stimulating hormone receptor | 0.012 | |
| OPRK1 | opioid receptor, kappa 1 | 0.011 | |
| SSTR4 | somatostatin receptor 4 | 0.011 | |
| SIX6 | SIX homeobox 6 | 0.011 | |
| GLRA1 | glycine receptor, alpha 1 | 0.011 | |
| FSTL4 | follistatin-like 4 | 0.011 | |
| OPRM1 | opioid receptor, mu 1 | 0.011 | |
| NCR2 | natural cytotoxicity triggering receptor 2 | 0.011 | |
| NGB | neuroglobin | 0.011 | |
| GABRA1 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 0.011 | |
| SMR3A | submaxillary gland androgen regulated protein 3A | 0.010 | |
| CALCB | calcitonin-related polypeptide beta | 0.010 | |
| EDNRB | endothelin receptor type B | 0.010 | |
| NPY2R | neuropeptide Y receptor Y2 | 0.010 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ednra | endothelin receptor type A | 0.017 | |
| Padi2 | peptidyl arginine deiminase, type II | 0.015 | |
| Calcrl | calcitonin receptor-like | 0.014 | |
| Vom2r53 | vomeronasal 2 receptor, 53 | 0.014 | |
| Flt1 | FMS-related tyrosine kinase 1 | 0.013 | |
| Plp1 | proteolipid protein 1 | 0.013 | |
| Pax6 | paired box 6 | 0.012 |