The network for 'regulation of interleukin 1 alpha production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 1 alpha production

Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production.

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 0.984
Emx2 empty spiracles homolog 2 (Drosophila) 0.980
Pitx2 paired-like homeodomain transcription factor 2 0.958
Gbp5 guanylate binding protein 5 0.934
Pax6 paired box gene 6 0.863
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.839
Pax2 paired box gene 2 0.836
Casp1 caspase 1 0.802
Lhx1 LIM homeobox protein 1 0.752
Lhx9 LIM homeobox protein 9 0.738
Gbx2 gastrulation brain homeobox 2 0.722
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.705
Kiss1 KiSS-1 metastasis-suppressor 0.693
Il18 interleukin 18 0.617
Wt1 Wilms tumor 1 homolog 0.580
Fgf8 fibroblast growth factor 8 0.527
Ret ret proto-oncogene 0.454
En1 engrailed 1 0.452
Neurog2 neurogenin 2 0.368
Shh sonic hedgehog 0.365
Insm1 insulinoma-associated 1 0.354
Pycard PYD and CARD domain containing 0.302
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.279
Gata4 GATA binding protein 4 0.276
Foxh1 forkhead box H1 0.271
Gbp2 guanylate binding protein 2 0.263
Nodal nodal 0.220
Sox11 SRY-box containing gene 11 0.207
Atoh7 atonal homolog 7 (Drosophila) 0.202
Myd88 myeloid differentiation primary response gene 88 0.196
Pou4f2 POU domain, class 4, transcription factor 2 0.190
Isl1 ISL1 transcription factor, LIM/homeodomain 0.189
Aim2 absent in melanoma 2 0.188
Mab21l2 mab-21-like 2 (C. elegans) 0.183
Pax3 paired box gene 3 0.180
Tlr4 toll-like receptor 4 0.177
Hoxd13 homeobox D13 0.172
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.155
Fadd Fas (TNFRSF6)-associated via death domain 0.150
Fas Fas (TNF receptor superfamily member 6) 0.143
Foxe3 forkhead box E3 0.141
Phox2b paired-like homeobox 2b 0.140
Lmx1b LIM homeobox transcription factor 1 beta 0.128
Ripk3 receptor-interacting serine-threonine kinase 3 0.123
Pitx1 paired-like homeodomain transcription factor 1 0.119
Kiss1r KISS1 receptor 0.116
Cd14 CD14 antigen 0.113
Lhx3 LIM homeobox protein 3 0.108
Prokr2 prokineticin receptor 2 0.105
Neurod1 neurogenic differentiation 1 0.102
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.100
Nmi N-myc (and STAT) interactor 0.100
Otx1 orthodenticle homolog 1 (Drosophila) 0.097
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.096
Zic3 zinc finger protein of the cerebellum 3 0.096
Tcfap2a transcription factor AP-2, alpha 0.095
Gdnf glial cell line derived neurotrophic factor 0.093
Trim30a tripartite motif-containing 30A 0.093
Gh growth hormone 0.091
Ly96 lymphocyte antigen 96 0.091
Anxa4 annexin A4 0.089
Ldb2 LIM domain binding 2 0.088
Gpr50 G-protein-coupled receptor 50 0.087
Hoxb7 homeobox B7 0.086
Prop1 paired like homeodomain factor 1 0.085
Nlrp3 NLR family, pyrin domain containing 3 0.084
Gja5 gap junction protein, alpha 5 0.082
Gbp7 guanylate binding protein 7 0.082
Eya1 eyes absent 1 homolog (Drosophila) 0.081
Hoxc6 homeobox C6 0.079
Sim1 single-minded homolog 1 (Drosophila) 0.078
Osr1 odd-skipped related 1 (Drosophila) 0.078
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.077
En2 engrailed 2 0.077
Gbp3 guanylate binding protein 3 0.073
Casp7 caspase 7 0.072
Casp8 caspase 8 0.070
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.069
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.066
Hand2 heart and neural crest derivatives expressed transcript 2 0.065
Gli3 GLI-Kruppel family member GLI3 0.062
Sox3 SRY-box containing gene 3 0.062
Il1b interleukin 1 beta 0.062
Ctsz cathepsin Z 0.059
Wnt9b wingless-type MMTV integration site 9B 0.059
Nrg1 neuregulin 1 0.058
Ptf1a pancreas specific transcription factor, 1a 0.058
Myf6 myogenic factor 6 0.055
Cxcl2 chemokine (C-X-C motif) ligand 2 0.054
Fgf3 fibroblast growth factor 3 0.053
Bmp15 bone morphogenetic protein 15 0.051
Pnmt phenylethanolamine-N-methyltransferase 0.051
Hand1 heart and neural crest derivatives expressed transcript 1 0.051
S1pr2 sphingosine-1-phosphate receptor 2 0.050
Hoxd11 homeobox D11 0.049
Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.049
Birc3 baculoviral IAP repeat-containing 3 0.049
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.048
Neurod4 neurogenic differentiation 4 0.047
Gata3 GATA binding protein 3 0.047
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl2 chemokine (C-C motif) ligand 2 0.264
Il1b interleukin 1 beta 0.187
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.103
Il1a interleukin 1 alpha 0.067
Cxcl10 chemokine (C-X-C motif) ligand 10 0.049
Gzmb granzyme B 0.045
Prf1 perforin 1 (pore forming protein) 0.043
Ccl3 chemokine (C-C motif) ligand 3 0.035
Ccl4 chemokine (C-C motif) ligand 4 0.033
Cxcl2 chemokine (C-X-C motif) ligand 2 0.033
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.031
Il6 interleukin 6 0.026
Cd14 CD14 molecule 0.025
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.024
Hpgds hematopoietic prostaglandin D synthase 0.024
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.022
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.021
Gzmk granzyme K 0.020
Fosl1 fos-like antigen 1 0.019
Cd247 Cd247 molecule 0.019
Rgs1 regulator of G-protein signaling 1 0.018
Igsf6 immunoglobulin superfamily, member 6 0.018
Cst7 cystatin F (leukocystatin) 0.017
Neurl3 neuralized homolog 3 (Drosophila) 0.017
Cd8a CD8a molecule 0.016
Clec4a3 C-type lectin domain family 4, member a3 0.016
Xcl1 chemokine (C motif) ligand 1 0.015
Nkg7 natural killer cell group 7 sequence 0.015
Reg3b regenerating islet-derived 3 beta 0.015
Il1r2 interleukin 1 receptor, type II 0.015
Galr2 galanin receptor 2 0.014
Il2rb interleukin 2 receptor, beta 0.014
Fut2 fucosyltransferase 2 (secretor status included) 0.014
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.014
Gzmc granzyme C 0.013
Tlr2 toll-like receptor 2 0.012
RT1-Ba RT1 class II, locus Ba 0.012
Mmp12 matrix metallopeptidase 12 0.012
Ccl20 chemokine (C-C motif) ligand 20 0.011
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.011
Capn8 calpain 8 0.011
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.011
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.011
Mcpt8 mast cell protease 8 0.011
Tcrb T-cell receptor beta chain 0.010
Ptprc protein tyrosine phosphatase, receptor type, C 0.010
Cd86 CD86 molecule 0.010
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism