The network for 'cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell fate specification

The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Emx1 empty spiracles homolog 1 (Drosophila) 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Pax6 paired box gene 6 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Sox2 SRY-box containing gene 2 0.999
Hoxd13 homeobox D13 0.999
Msx1 homeobox, msh-like 1 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.998
Pax2 paired box gene 2 0.997
Pbx1 pre B-cell leukemia transcription factor 1 0.997
Foxg1 forkhead box G1 0.996
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.996
Sox9 SRY-box containing gene 9 0.995
Gli3 GLI-Kruppel family member GLI3 0.995
Alx4 aristaless-like homeobox 4 0.995
Pax3 paired box gene 3 0.993
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.993
Gbx2 gastrulation brain homeobox 2 0.993
Lef1 lymphoid enhancer binding factor 1 0.993
Hoxa13 homeobox A13 0.990
Tbx1 T-box 1 0.989
Eya1 eyes absent 1 homolog (Drosophila) 0.989
Notch1 Notch gene homolog 1 (Drosophila) 0.987
Fgf8 fibroblast growth factor 8 0.979
Wnt3a wingless-related MMTV integration site 3A 0.976
Hoxa1 homeobox A1 0.974
Tal1 T-cell acute lymphocytic leukemia 1 0.973
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.973
Hes1 hairy and enhancer of split 1 (Drosophila) 0.969
Prrx1 paired related homeobox 1 0.968
Tbx15 T-box 15 0.964
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.963
Hoxd11 homeobox D11 0.955
Pitx1 paired-like homeodomain transcription factor 1 0.954
Nodal nodal 0.953
Foxc1 forkhead box C1 0.943
Lhx3 LIM homeobox protein 3 0.942
Vangl2 vang-like 2 (van gogh, Drosophila) 0.941
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.940
Tcfap2a transcription factor AP-2, alpha 0.939
Dlx5 distal-less homeobox 5 0.930
Tcf21 transcription factor 21 0.929
Bmp7 bone morphogenetic protein 7 0.929
Hoxa10 homeobox A10 0.923
Gli2 GLI-Kruppel family member GLI2 0.919
Otx1 orthodenticle homolog 1 (Drosophila) 0.916
Lmx1a LIM homeobox transcription factor 1 alpha 0.910
Tgfbr2 transforming growth factor, beta receptor II 0.908
Ntf3 neurotrophin 3 0.906
Hoxa2 homeobox A2 0.905
Lhx1 LIM homeobox protein 1 0.899
Hoxa11 homeobox A11 0.896
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.892
Bdnf brain derived neurotrophic factor 0.889
Fgfr1 fibroblast growth factor receptor 1 0.887
Rarg retinoic acid receptor, gamma 0.887
Sall3 sal-like 3 (Drosophila) 0.882
Chd7 chromodomain helicase DNA binding protein 7 0.878
Hoxa9 homeobox A9 0.871
Wnt1 wingless-related MMTV integration site 1 0.868
Zeb1 zinc finger E-box binding homeobox 1 0.866
Msx2 homeobox, msh-like 2 0.862
Pax9 paired box gene 9 0.861
Ptf1a pancreas specific transcription factor, 1a 0.857
Neurog2 neurogenin 2 0.857
Emx2 empty spiracles homolog 2 (Drosophila) 0.856
Fgf15 fibroblast growth factor 15 0.855
En1 engrailed 1 0.848
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.847
Tbx3 T-box 3 0.847
Gdf5 growth differentiation factor 5 0.842
Pou4f3 POU domain, class 4, transcription factor 3 0.838
Alx3 aristaless-like homeobox 3 0.838
Insm1 insulinoma-associated 1 0.829
Prrx2 paired related homeobox 2 0.829
Pax8 paired box gene 8 0.828
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.819
Lmx1b LIM homeobox transcription factor 1 beta 0.815
Tlx3 T-cell leukemia, homeobox 3 0.807
Gata3 GATA binding protein 3 0.807
Neurod1 neurogenic differentiation 1 0.786
Wnt6 wingless-related MMTV integration site 6 0.784
Hoxd9 homeobox D9 0.778
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.777
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.773
Atoh1 atonal homolog 1 (Drosophila) 0.773
Sall4 sal-like 4 (Drosophila) 0.772
Hoxd10 homeobox D10 0.769
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.766
Tlx2 T-cell leukemia, homeobox 2 0.759
Gli1 GLI-Kruppel family member GLI1 0.758
Pou4f2 POU domain, class 4, transcription factor 2 0.745
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.742
Foxa2 forkhead box A2 0.723
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.723
Apc adenomatosis polyposis coli 0.713
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
hoxc8a homeo box C8a 0.994
sox1a SRY-box containing gene 1a 0.990
hoxd10a homeo box D10a 0.988
hoxb5b homeo box B5b 0.987
chd chordin 0.987
ndr2 nodal-related 2 0.982
foxi1 forkhead box I1 0.972
lhx1a LIM homeobox 1a 0.964
six4b sine oculis homeobox homolog 4b 0.957
hoxa9b homeo box A9b 0.954
hoxb8a homeo box B8a 0.952
hoxc6a homeo box C6a 0.946
hoxa4a homeo box A4a 0.936
bmp4 bone morphogenetic protein 4 0.932
jag1b jagged 1b 0.923
msxc muscle segment homeobox C 0.918
gata3 GATA-binding protein 3 0.915
fgf3 fibroblast growth factor 3 0.914
hoxa2b homeo box A2b 0.886
notch1a notch homolog 1a 0.885
dkk1b dickkopf 1b 0.880
hoxb3a homeo box B3a 0.877
six3a sine oculis homeobox homolog 3a 0.872
hoxb1b homeo box B1b 0.865
bmp2b bone morphogenetic protein 2b 0.856
gli2a GLI-Kruppel family member GLI2a 0.844
atoh1b atonal homolog 1b 0.840
hoxa9a homeo box A9a 0.839
otpb orthopedia homolog b 0.832
gdf6a growth differentiation factor 6a 0.800
flh floating head 0.795
sox3 SRY-box containing gene 3 0.791
msxe muscle segment homeobox E 0.786
nkx2.2a NK2 transcription factor related 2a 0.785
hoxb2a homeo box B2a 0.783
dlx2b distal-less homeobox gene 2b 0.778
hoxc4a homeo box C4a 0.774
eya1 eyes absent homolog 1 0.770
hmx3 homeo box (H6 family) 3 0.759
shha sonic hedgehog a 0.759
hoxa11a homeo box A11a 0.744
spaw southpaw 0.733
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.713
lhx5 LIM homeobox 5 0.712
gli1 GLI-Kruppel family member 1 0.711
neurod4 neurogenic differentiation 4 0.710
mab21l2 mab-21-like 2 0.700
gata4 GATA-binding protein 4 0.700
zic4 zic family member 4 0.698
dlx5a distal-less homeobox gene 5a 0.697
hhip hedgehog interacting protein 0.695
ascl1a achaete-scute complex-like 1a (Drosophila) 0.695
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.684
notch1b notch homolog 1b 0.683
dharma dharma 0.668
lft1 lefty1 0.664
evx1 even-skipped homeobox 1 0.661
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.656
nog1 noggin 1 0.654
isl2a islet2a 0.652
hoxb6b homeo box B6b 0.649
emx3 empty spiracles homeobox 3 0.641
prl prolactin 0.638
dlx4b distal-less homeobox gene 4b 0.635
hoxb5a homeo box B5a 0.608
atoh1a atonal homolog 1a 0.606
dusp6 dual specificity phosphatase 6 0.601
pitx2 paired-like homeodomain transcription factor 2 0.599
irx4b iroquois homeobox protein 4b 0.599
sox4b SRY-box containing gene 4b 0.595
foxa1 forkhead box A1 0.588
fgf8a fibroblast growth factor 8 a 0.587
arx aristaless related homeobox 0.581
ntla no tail a 0.577
cdx4 caudal type homeo box transcription factor 4 0.575
tp63 tumor protein p63 0.572
wnt8b wingless-type MMTV integration site family, member 8b 0.569
wif1 wnt inhibitory factor 1 0.556
fzd8a frizzled homolog 8a 0.551
gbx2 gastrulation brain homeo box 2 0.550
jag2 jagged 2 0.547
ascl1b achaete-scute complex-like 1b (Drosophila) 0.535
eng2a engrailed 2a 0.535
wls wntless homolog (Drosophila) 0.532
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.528
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.524
lef1 lymphocyte enhancer binding factor 1 0.524
neurod neurogenic differentiation 0.521
tbx6 T-box gene 6 0.519
hoxc10a homeo box C10a and homeobox protein Hox-C10a-like 0.519
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.517
foxi3a forkhead box I3a 0.510
foxh1 forkhead box H1 0.508
dlx1a distal-less homeobox gene 1a 0.507
gbx1 gastrulation brain homeobox 1 0.506
fezf2 FEZ family zinc finger 2 0.502
bhlhe22 basic helix-loop-helix family, member e22 0.495
si:ch211-173o4.2 si:ch211-173o4.2 0.491
tbx1 T-box 1 0.491
rx2 retinal homeobox gene 2 0.487
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.998
N Notch 0.997
HLHm7 E(spl) region transcript m7 0.996
ttk tramtrack 0.987
Ras85D Ras oncogene at 85D 0.985
en engrailed 0.979
Mad Mothers against dpp 0.972
tkv thickveins 0.972
put punt 0.970
Ser Serrate 0.966
E(spl) Enhancer of split 0.952
dsh dishevelled 0.940
dpp decapentaplegic 0.927
abd-A abdominal A 0.927
sca scabrous 0.923
argos CG4531 gene product from transcript CG4531-RA 0.920
ac achaete 0.912
HLHmgamma E(spl) region transcript mgamma 0.890
ato atonal 0.875
vvl ventral veins lacking 0.861
HLHm5 E(spl) region transcript m5 0.845
Ubx Ultrabithorax 0.843
Su(H) Suppressor of Hairless 0.839
mxc multi sex combs 0.822
m4 E(spl) region transcript m4 0.814
HLHmdelta E(spl) region transcript mdelta 0.813
hh hedgehog 0.810
ci cubitus interruptus 0.795
nkd naked cuticle 0.791
phl pole hole 0.790
sens senseless 0.789
HLHmbeta E(spl) region transcript mbeta 0.767
stumps CG31317 gene product from transcript CG31317-RC 0.758
mid midline 0.747
eve even skipped 0.744
hbs hibris 0.740
Atg1 Autophagy-specific gene 1 0.739
ex expanded 0.732
emc extra macrochaetae 0.723
sty sprouty 0.722
Tom Twin of m4 0.710
eya eyes absent 0.703
rap retina aberrant in pattern 0.687
ase asense 0.683
ara araucan 0.652
pyd polychaetoid 0.637
sns sticks and stones 0.621
gcm glial cells missing 0.604
tin tinman 0.604
babo baboon 0.590
gbb glass bottom boat 0.574
Pc Polycomb 0.573
malpha E(spl) region transcript malpha 0.569
B-H2 BarH2 0.567
Doc2 Dorsocross2 0.558
run runt 0.546
eyg eyegone 0.545
ey eyeless 0.544
gro groucho 0.537
kuz kuzbanian 0.533
m2 E(spl) region transcript m2 0.531
ro rough 0.529
hep hemipterous 0.523
sli slit 0.521
dac dachshund 0.517
disco disconnected 0.507
nub nubbin 0.506
InR Insulin-like receptor 0.502
sax saxophone 0.483
Dad Daughters against dpp 0.479
bib big brain 0.474
arm armadillo 0.463
slp1 sloppy paired 1 0.460
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.459
Wnt4 Wnt oncogene analog 4 0.458
Dll Distal-less 0.441
ed echinoid 0.436
Notum CG13076 gene product from transcript CG13076-RB 0.429
pan pangolin 0.427
spen split ends 0.423
csw corkscrew 0.415
fkh fork head 0.399
comm commissureless 0.399
sc scute 0.395
pros prospero 0.388
btl breathless 0.376
Alk CG8250 gene product from transcript CG8250-RA 0.373
sd scalloped 0.370
lea leak 0.363
htl heartless 0.350
salm spalt major 0.324
aop anterior open 0.323
ttv tout-velu 0.320
al aristaless 0.319
gt giant 0.318
dally division abnormally delayed 0.309
Egfr Epidermal growth factor receptor 0.306
dco discs overgrown 0.296
Gap1 GTPase-activating protein 1 0.295
CG12424 CG12424 gene product from transcript CG12424-RC 0.294
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.998
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.998
FGFR2 fibroblast growth factor receptor 2 0.872
TP53 tumor protein p53 0.827
JAG1 jagged 1 0.681
PBX1 pre-B-cell leukemia homeobox 1 0.634
AR androgen receptor 0.596
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.558
BBS10 Bardet-Biedl syndrome 10 0.514
TAL1 T-cell acute lymphocytic leukemia 1 0.440
POU3F2 POU class 3 homeobox 2 0.432
BMP2 bone morphogenetic protein 2 0.417
SMAD4 SMAD family member 4 0.396
DAXX death-domain associated protein 0.340
FOXD3 forkhead box D3 0.327
PDX1 pancreatic and duodenal homeobox 1 0.281
PAX3 paired box 3 0.256
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.237
SMAD1 SMAD family member 1 0.223
HDAC1 histone deacetylase 1 0.211
FGF1 fibroblast growth factor 1 (acidic) 0.193
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.193
EP300 E1A binding protein p300 0.192
PSEN1 presenilin 1 0.189
HDAC4 histone deacetylase 4 0.182
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.181
FGFR1 fibroblast growth factor receptor 1 0.156
PBK PDZ binding kinase 0.152
SP1 Sp1 transcription factor 0.141
BMPR1A bone morphogenetic protein receptor, type IA 0.134
NOTCH1 notch 1 0.133
FOXA2 forkhead box A2 0.131
POU5F1 POU class 5 homeobox 1 0.109
HDAC2 histone deacetylase 2 0.104
LRP6 low density lipoprotein receptor-related protein 6 0.098
HOXB9 homeobox B9 0.092
HCFC1 host cell factor C1 (VP16-accessory protein) 0.085
CREBBP CREB binding protein 0.079
RAX retina and anterior neural fold homeobox 0.075
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.072
PLCG1 phospholipase C, gamma 1 0.070
CSNK1E casein kinase 1, epsilon 0.070
SOX2 SRY (sex determining region Y)-box 2 0.069
HOXA10 homeobox A10 0.066
AHR aryl hydrocarbon receptor 0.064
TP73 tumor protein p73 0.059
MSX1 msh homeobox 1 0.058
MAP2K1 mitogen-activated protein kinase kinase 1 0.057
E2F4 E2F transcription factor 4, p107/p130-binding 0.056
SMAD7 SMAD family member 7 0.055
C2orf65 chromosome 2 open reading frame 65 0.054
RB1 retinoblastoma 1 0.054
CDK2 cyclin-dependent kinase 2 0.053
GDA guanine deaminase 0.052
MYOD1 myogenic differentiation 1 0.051
BTBD2 BTB (POZ) domain containing 2 0.049
MEIS1 Meis homeobox 1 0.047
BMP7 bone morphogenetic protein 7 0.047
HOXC11 homeobox C11 0.044
MEIS2 Meis homeobox 2 0.042
HOXA11 homeobox A11 0.041
YAP1 Yes-associated protein 1 0.041
MDFI MyoD family inhibitor 0.039
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.038
KDM1A lysine (K)-specific demethylase 1A 0.037
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.036
RBBP4 retinoblastoma binding protein 4 0.035
E2F6 E2F transcription factor 6 0.035
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.034
PTCH1 patched 1 0.034
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.032
AXIN1 axin 1 0.031
RBL1 retinoblastoma-like 1 (p107) 0.031
CDX2 caudal type homeobox 2 0.030
HNF1A HNF1 homeobox A 0.028
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.028
FGF3 fibroblast growth factor 3 0.028
NOTCH3 notch 3 0.027
HIC1 hypermethylated in cancer 1 0.027
RUNX1 runt-related transcription factor 1 0.026
LBX1 ladybird homeobox 1 0.026
SETD8 SET domain containing (lysine methyltransferase) 8 0.026
TCF4 transcription factor 4 0.026
HOXD9 homeobox D9 0.025
SYK spleen tyrosine kinase 0.024
APC adenomatous polyposis coli 0.024
HOXD13 homeobox D13 0.023
FGF10 fibroblast growth factor 10 0.023
SOX21 SRY (sex determining region Y)-box 21 0.022
NEUROG3 neurogenin 3 0.022
ZFPM1 zinc finger protein, multitype 1 0.022
ARID1A AT rich interactive domain 1A (SWI-like) 0.021
HOXB13 homeobox B13 0.021
SIM2 single-minded homolog 2 (Drosophila) 0.021
GLI1 GLI family zinc finger 1 0.021
OTP orthopedia homeobox 0.021
LDB1 LIM domain binding 1 0.021
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.021
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.020
RBBP7 retinoblastoma binding protein 7 0.020
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism