The network for 'endocardial cushion morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endocardial cushion morphogenesis

The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.993
fgf8a fibroblast growth factor 8 a 0.987
bmp4 bone morphogenetic protein 4 0.923
bmp2b bone morphogenetic protein 2b 0.833
kdrl kinase insert domain receptor like 0.684
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.569
aldoab aldolase a, fructose-bisphosphate, b 0.512
msxc muscle segment homeobox C 0.508
wls wntless homolog (Drosophila) 0.461
pax2a paired box gene 2a 0.380
shha sonic hedgehog a 0.351
lmo4a LIM domain only 4a 0.350
myod1 myogenic differentiation 1 0.332
cdh2 cadherin 2, neuronal 0.328
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.322
hand2 heart and neural crest derivatives expressed transcript 2 0.292
tbx5a T-box 5a 0.248
tbx18 T-box 18 0.227
chd chordin 0.226
vmhc ventricular myosin heavy chain 0.191
dlx2a distal-less homeobox gene 2a 0.166
snai1a snail homolog 1a (Drosophila) 0.165
fsta follistatin a 0.163
fgf3 fibroblast growth factor 3 0.160
ptch2 patched 2 0.160
wnt5b wingless-type MMTV integration site family, member 5b 0.159
hnf1ba HNF1 homeobox Ba 0.145
dlc deltaC 0.140
foxn4 forkhead box N4 0.139
nkx2.5 NK2 transcription factor related 5 0.136
gsc goosecoid 0.130
myf5 myogenic factor 5 0.122
dlx4b distal-less homeobox gene 4b 0.119
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.116
notch1b notch homolog 1b 0.115
actc1a actin, alpha, cardiac muscle 1a 0.111
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.108
has2 hyaluronan synthase 2 0.105
myog myogenin 0.104
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.102
wnt11 wingless-type MMTV integration site family, member 11 0.101
mmp2 matrix metalloproteinase 2 0.099
eya1 eyes absent homolog 1 0.096
wnt11r wingless-type MMTV integration site family, member 11, related 0.094
bactin1 bactin1 0.090
desma desmin a 0.089
myl10 myosin, light chain 10, regulatory 0.087
tbx16 T-box gene 16 0.083
ntla no tail a 0.083
ascl1a achaete-scute complex-like 1a (Drosophila) 0.077
myl1 myosin, light chain 1, alkali; skeletal, fast 0.074
actc1b actin, alpha, cardiac muscle 1b 0.072
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.071
ctgf connective tissue growth factor 0.071
vasa vasa homolog 0.070
cmlc1 cardiac myosin light chain-1 0.069
pld1a phospholipase D1a 0.068
twist1a twist1a 0.066
myl7 myosin, light polypeptide 7, regulatory 0.066
hoxa2b homeo box A2b 0.066
ryk receptor-like tyrosine kinase 0.064
dld deltaD 0.064
ptch1 patched 1 0.063
cdh1 cadherin 1, epithelial 0.063
tnnt2a troponin T2a, cardiac 0.060
smad5 MAD homolog 5 (Drosophila) 0.059
vasp vasodilator-stimulated phosphoprotein 0.059
nkx3.2 NK3 homeobox 2 0.058
zfand5a zinc finger, AN1-type domain 5a 0.058
lhx2b LIM homeobox 2b 0.058
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.058
ckma creatine kinase, muscle a 0.055
mib mind bomb 0.055
dlx5a distal-less homeobox gene 5a 0.054
edn1 endothelin 1 0.054
unc45b unc-45 homolog B (C. elegans) 0.054
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.054
stat1b signal transducer and activator of transcription 1b 0.053
krt4 keratin 4 0.053
wu:fb99e06 wu:fb99e06 0.051
atoh1a atonal homolog 1a 0.051
cdh5 cadherin 5 0.050
frem3 Fras1 related extracellular matrix 3 0.049
tgfbi transforming growth factor, beta-induced 0.049
oep one-eyed pinhead 0.049
dlx3b distal-less homeobox gene 3b 0.048
sox11b SRY-box containing gene 11b 0.047
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.047
tfap2a transcription factor AP-2 alpha 0.046
tagln transgelin 0.044
tmem2 transmembrane protein 2 0.044
dlx6a distal-less homeobox gene 6a 0.044
aplnrb apelin receptor b 0.043
tnnc2 troponin C type 2 (fast) 0.043
sox10 SRY-box containing gene 10 0.042
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.042
efna5a ephrin A5a 0.042
pax3a paired box gene 3a 0.042
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.041
tbx2b T-box 2b 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Nodal nodal 0.999
Gata4 GATA binding protein 4 0.999
Fgf8 fibroblast growth factor 8 0.999
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.999
Pax3 paired box gene 3 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.996
Otx2 orthodenticle homolog 2 (Drosophila) 0.994
Foxc1 forkhead box C1 0.987
Tbx3 T-box 3 0.977
Gli3 GLI-Kruppel family member GLI3 0.975
Jag1 jagged 1 0.970
Notch1 Notch gene homolog 1 (Drosophila) 0.967
Smad4 MAD homolog 4 (Drosophila) 0.967
Pitx1 paired-like homeodomain transcription factor 1 0.952
Pax6 paired box gene 6 0.939
Tcfap2a transcription factor AP-2, alpha 0.934
Meox2 mesenchyme homeobox 2 0.930
Pax2 paired box gene 2 0.922
Fgfr2 fibroblast growth factor receptor 2 0.921
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.912
Zic3 zinc finger protein of the cerebellum 3 0.904
Bmp4 bone morphogenetic protein 4 0.901
Hand1 heart and neural crest derivatives expressed transcript 1 0.900
Lhx1 LIM homeobox protein 1 0.890
Hoxa1 homeobox A1 0.881
Tgfbr2 transforming growth factor, beta receptor II 0.881
Smad6 MAD homolog 6 (Drosophila) 0.871
Tgfb2 transforming growth factor, beta 2 0.863
Prrx1 paired related homeobox 1 0.849
Hoxd13 homeobox D13 0.833
Bmpr1a bone morphogenetic protein receptor, type 1A 0.803
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.793
Foxc2 forkhead box C2 0.785
Gsc goosecoid homeobox 0.772
Apc adenomatosis polyposis coli 0.772
Tlx3 T-cell leukemia, homeobox 3 0.759
Sox11 SRY-box containing gene 11 0.758
Dll4 delta-like 4 (Drosophila) 0.751
Neurog2 neurogenin 2 0.736
Lhx3 LIM homeobox protein 3 0.714
Wt1 Wilms tumor 1 homolog 0.710
Snai1 snail homolog 1 (Drosophila) 0.679
Sox2 SRY-box containing gene 2 0.639
Gata6 GATA binding protein 6 0.639
Isl1 ISL1 transcription factor, LIM/homeodomain 0.627
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.622
Tbx1 T-box 1 0.601
Alx4 aristaless-like homeobox 4 0.601
She src homology 2 domain-containing transforming protein E 0.596
Foxh1 forkhead box H1 0.589
Smad1 MAD homolog 1 (Drosophila) 0.571
En1 engrailed 1 0.571
Gdnf glial cell line derived neurotrophic factor 0.538
Twist2 twist homolog 2 (Drosophila) 0.523
Sox7 SRY-box containing gene 7 0.523
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.490
Acvrl1 activin A receptor, type II-like 1 0.488
Neurod1 neurogenic differentiation 1 0.473
Hoxa13 homeobox A13 0.468
Vegfa vascular endothelial growth factor A 0.458
Sox9 SRY-box containing gene 9 0.458
Foxf1a forkhead box F1a 0.451
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.410
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.380
Hoxa11 homeobox A11 0.369
Sox17 SRY-box containing gene 17 0.368
Prrx2 paired related homeobox 2 0.367
Nos3 nitric oxide synthase 3, endothelial cell 0.366
Eng endoglin 0.359
Lhx9 LIM homeobox protein 9 0.354
Insm1 insulinoma-associated 1 0.353
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.348
Gbx2 gastrulation brain homeobox 2 0.345
Meox1 mesenchyme homeobox 1 0.319
Alx3 aristaless-like homeobox 3 0.310
Ptf1a pancreas specific transcription factor, 1a 0.301
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.300
Msx1 homeobox, msh-like 1 0.298
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.296
Ebf3 early B-cell factor 3 0.296
Ctnnb1 catenin (cadherin associated protein), beta 1 0.294
Tbx4 T-box 4 0.289
Hes1 hairy and enhancer of split 1 (Drosophila) 0.288
Pou3f3 POU domain, class 3, transcription factor 3 0.282
Fgf10 fibroblast growth factor 10 0.272
Ntf3 neurotrophin 3 0.272
Kiss1 KiSS-1 metastasis-suppressor 0.265
Vangl2 vang-like 2 (van gogh, Drosophila) 0.264
Bnc1 basonuclin 1 0.256
Acvr1 activin A receptor, type 1 0.255
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.251
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.244
Lmx1b LIM homeobox transcription factor 1 beta 0.238
Tcf21 transcription factor 21 0.236
Hes5 hairy and enhancer of split 5 (Drosophila) 0.232
Efnb2 ephrin B2 0.231
Onecut1 one cut domain, family member 1 0.224
Smad3 MAD homolog 3 (Drosophila) 0.220
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism