The network for 'blood vessel development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

blood vessel development

The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.999
notch3 notch homolog 3 0.999
fbn2b fibrillin 2b 0.998
fgfrl1b fibroblast growth factor receptor-like 1b 0.995
gata2a GATA-binding protein 2a 0.990
etv2 ets variant gene 2 0.986
cxcr4a chemokine (C-X-C motif) receptor 4a 0.984
dlc deltaC 0.984
shha sonic hedgehog a 0.980
lamb1a laminin, beta 1a 0.978
tal1 T-cell acute lymphocytic leukemia 1 0.972
wu:fv91b12 wu:fv91b12 0.970
edn1 endothelin 1 0.969
dll4 delta-like 4 (Drosophila) 0.967
mib mind bomb 0.965
osr1 odd-skipped related 1 (Drosophila) 0.963
efnb2a ephrin B2a 0.957
traf4a tnf receptor-associated factor 4a 0.954
fn1 fibronectin 1 0.948
cdh5 cadherin 5 0.947
vegfc vascular endothelial growth factor c 0.939
spry4 sprouty (Drosophila) homolog 4 0.937
foxa2 forkhead box A2 0.937
sox9a SRY-box containing gene 9a 0.936
jag2 jagged 2 0.931
nrp1a neuropilin 1a 0.927
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.924
evx1 even-skipped homeobox 1 0.922
tp53 tumor protein p53 0.920
wnt3a wingless-type MMTV integration site family, member 3A 0.918
jag1b jagged 1b 0.916
col1a1a collagen, type I, alpha 1a 0.909
ephb4b eph receptor B4b 0.908
sulf1 sulfatase 1 0.908
wnt3 wingless-type MMTV integration site family, member 3 0.906
mmp2 matrix metalloproteinase 2 0.904
ccm2 cerebral cavernous malformation 2 0.901
sox7 SRY-box containing gene 7 0.896
birc2 baculoviral IAP repeat-containing 2 0.896
tbx1 T-box 1 0.886
aplnra apelin receptor a 0.879
foxn4 forkhead box N4 0.876
wnt5b wingless-type MMTV integration site family, member 5b 0.868
twist1a twist1a 0.864
unc5b unc-5 homolog B (C. elegans) 0.860
plxnd1 plexin D1 0.859
col12a1 collagen, type XII, alpha 1 0.856
pitx3 paired-like homeodomain transcription factor 3 0.852
cdx4 caudal type homeo box transcription factor 4 0.849
alcama activated leukocyte cell adhesion molecule a 0.847
tie2 endothelium-specific receptor tyrosine kinase 2 0.847
foxi1 forkhead box I1 0.843
col8a1a collagen, type VIII, alpha 1a 0.842
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.841
bmp2b bone morphogenetic protein 2b 0.838
fgfr2 fibroblast growth factor receptor 2 0.837
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.826
fli1a friend leukemia integration 1a 0.825
tp63 tumor protein p63 0.821
hand2 heart and neural crest derivatives expressed transcript 2 0.820
myf5 myogenic factor 5 0.800
nrarpa notch-regulated ankyrin repeat protein a 0.783
pcdh8 protocadherin 8 0.782
hhex hematopoietically expressed homeobox 0.781
myod1 myogenic differentiation 1 0.768
sox2 SRY-box containing gene 2 0.767
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.762
cxcr4b chemokine (C-X-C motif), receptor 4b 0.754
rarga retinoic acid receptor gamma a 0.751
ilk integrin linked kinase 0.750
flt4 fms-related tyrosine kinase 4 0.750
notch1a notch homolog 1a 0.740
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.735
dld deltaD 0.728
tbx20 T-box 20 0.725
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.723
si:ch211-235f6.2 si:ch211-235f6.2 0.714
si:ch211-212m21.5 si:ch211-212m21.5 0.710
atoh8 atonal homolog 8 0.704
gli2a GLI-Kruppel family member GLI2a 0.701
emx3 empty spiracles homeobox 3 0.701
mpx myeloid-specific peroxidase 0.697
her9 hairy-related 9 0.695
hoxd4a homeo box D4a 0.695
lft2 lefty2 0.695
dkk1b dickkopf 1b 0.695
apc adenomatosis polyposis coli 0.692
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.686
fabp11a fatty acid binding protein 11a 0.684
boc brother of CDO 0.678
dla deltaA 0.678
meis1 myeloid ecotropic viral integration 1 0.670
vcanb versican b 0.668
flh floating head 0.667
sema3fa semaphorin 3fa 0.667
dlx5a distal-less homeobox gene 5a 0.665
wnt11r wingless-type MMTV integration site family, member 11, related 0.659
lft1 lefty1 0.657
gng2 guanine nucleotide binding protein (G protein), gamma 2 0.652
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.651
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CREBBP CREB binding protein 1.000
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.999
JUN jun proto-oncogene 0.998
EP300 E1A binding protein p300 0.997
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.995
JAG1 jagged 1 0.995
CAV1 caveolin 1, caveolae protein, 22kDa 0.994
AR androgen receptor 0.993
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.992
RUNX1 runt-related transcription factor 1 0.991
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.989
NOTCH1 notch 1 0.988
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.986
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.983
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.983
FHL2 four and a half LIM domains 2 0.981
FN1 fibronectin 1 0.974
TAL1 T-cell acute lymphocytic leukemia 1 0.972
ACTB actin, beta 0.968
FGFR1 fibroblast growth factor receptor 1 0.965
ENG endoglin 0.963
TEK TEK tyrosine kinase, endothelial 0.963
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.961
CYR61 cysteine-rich, angiogenic inducer, 61 0.956
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.956
VEGFA vascular endothelial growth factor A 0.943
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.936
FOS FBJ murine osteosarcoma viral oncogene homolog 0.933
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.927
NOTCH3 notch 3 0.908
NRP1 neuropilin 1 0.903
PAX3 paired box 3 0.888
CDH5 cadherin 5, type 2 (vascular endothelium) 0.884
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.884
ANGPTL2 angiopoietin-like 2 0.884
SMAD3 SMAD family member 3 0.875
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.874
IL8 interleukin 8 0.864
YAP1 Yes-associated protein 1 0.855
CTGF connective tissue growth factor 0.854
DUSP1 dual specificity phosphatase 1 0.849
CFLAR CASP8 and FADD-like apoptosis regulator 0.844
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.842
TP53 tumor protein p53 0.842
EGFR epidermal growth factor receptor 0.841
SMAD2 SMAD family member 2 0.840
BRCA1 breast cancer 1, early onset 0.833
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.830
CD34 CD34 molecule 0.825
THBS1 thrombospondin 1 0.818
HOXB5 homeobox B5 0.810
COL6A1 collagen, type VI, alpha 1 0.795
EGR1 early growth response 1 0.793
COL3A1 collagen, type III, alpha 1 0.787
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.777
COL1A2 collagen, type I, alpha 2 0.769
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.760
SMAD4 SMAD family member 4 0.754
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.753
FAS Fas (TNF receptor superfamily, member 6) 0.746
FGF1 fibroblast growth factor 1 (acidic) 0.739
VEGFC vascular endothelial growth factor C 0.735
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.734
PLCG1 phospholipase C, gamma 1 0.731
ATF3 activating transcription factor 3 0.730
MET met proto-oncogene (hepatocyte growth factor receptor) 0.729
TIMP2 TIMP metallopeptidase inhibitor 2 0.725
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.720
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.718
FLNA filamin A, alpha 0.716
COL2A1 collagen, type II, alpha 1 0.714
TIMP3 TIMP metallopeptidase inhibitor 3 0.713
CAV2 caveolin 2 0.712
TBX5 T-box 5 0.705
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.696
IQGAP1 IQ motif containing GTPase activating protein 1 0.688
COL1A1 collagen, type I, alpha 1 0.686
FKBP1A FK506 binding protein 1A, 12kDa 0.680
TCF4 transcription factor 4 0.675
FGFR2 fibroblast growth factor receptor 2 0.673
NID1 nidogen 1 0.670
BCL6 B-cell CLL/lymphoma 6 0.670
JUNB jun B proto-oncogene 0.660
FOXO1 forkhead box O1 0.657
MSN moesin 0.651
BMP4 bone morphogenetic protein 4 0.644
E2F7 E2F transcription factor 7 0.644
TGFB1 transforming growth factor, beta 1 0.641
KAT2B K(lysine) acetyltransferase 2B 0.637
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.631
ILK integrin-linked kinase 0.629
PML promyelocytic leukemia 0.625
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.624
COL4A1 collagen, type IV, alpha 1 0.623
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.620
PTGIS prostaglandin I2 (prostacyclin) synthase 0.615
SMAD1 SMAD family member 1 0.615
COL5A1 collagen, type V, alpha 1 0.614
LTBP2 latent transforming growth factor beta binding protein 2 0.611
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.610
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Fos FBJ osteosarcoma oncogene 0.750
Il8rb interleukin 8 receptor, beta 0.698
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.575
Ccl3 chemokine (C-C motif) ligand 3 0.570
Il1r1 interleukin 1 receptor, type I 0.527
Ccl2 chemokine (C-C motif) ligand 2 0.476
Edn1 endothelin 1 0.444
Igfbp5 insulin-like growth factor binding protein 5 0.416
Alb albumin 0.387
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.384
Col12a1 collagen, type XII, alpha 1 0.381
Fgfr1 Fibroblast growth factor receptor 1 0.375
Mmp2 matrix metallopeptidase 2 0.369
Timp1 TIMP metallopeptidase inhibitor 1 0.367
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.351
Tgfbr2 transforming growth factor, beta receptor II 0.343
Nos3 nitric oxide synthase 3, endothelial cell 0.339
Trim47 tripartite motif-containing 47 0.305
Dab2 disabled homolog 2 (Drosophila) 0.302
Il9r interleukin 9 receptor 0.299
Ednrb endothelin receptor type B 0.294
Ccr5 chemokine (C-C motif) receptor 5 0.285
Mmp3 matrix metallopeptidase 3 0.284
Pecam1 platelet/endothelial cell adhesion molecule 1 0.279
Id3 inhibitor of DNA binding 3 0.273
Il1rl1 interleukin 1 receptor-like 1 0.268
Pou2f3 POU class 2 homeobox 3 0.264
Fgfr2 fibroblast growth factor receptor 2 0.252
Ccr2 chemokine (C-C motif) receptor 2 0.246
Col1a1 collagen, type I, alpha 1 0.245
Acvrl1 activin A receptor type II-like 1 0.239
Mdfic MyoD family inhibitor domain containing 0.233
Fgl2 fibrinogen-like 2 0.231
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.227
Cxcl2 chemokine (C-X-C motif) ligand 2 0.226
Junb jun B proto-oncogene 0.224
Mrc1 mannose receptor, C type 1 0.224
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.221
Bgn biglycan 0.219
Mmp10 matrix metallopeptidase 10 0.219
Gper G protein-coupled estrogen receptor 1 0.216
Met met proto-oncogene 0.212
Egfl7 EGF-like-domain, multiple 7 0.209
Vcan versican 0.207
Col3a1 collagen, type III, alpha 1 0.203
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.203
Il6 interleukin 6 0.200
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.194
Mmp9 matrix metallopeptidase 9 0.190
F13a1 coagulation factor XIII, A1 polypeptide 0.187
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.184
Cdh5 cadherin 5 0.179
Tpsab1 tryptase alpha/beta 1 0.172
Pmp22 peripheral myelin protein 22 0.172
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.172
Atp12a ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.166
Kdr kinase insert domain receptor 0.163
Gpr20 G protein-coupled receptor 20 0.163
RGD1564327 similar to integrin alpha 8 0.162
Bcl2 B-cell CLL/lymphoma 2 0.162
Sell selectin L 0.161
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.158
Cd14 CD14 molecule 0.156
Socs3 suppressor of cytokine signaling 3 0.156
Emcn endomucin 0.153
Stip1 stress-induced phosphoprotein 1 0.152
Adora2a adenosine A2a receptor 0.152
Thbd thrombomodulin 0.151
Rgs14 regulator of G-protein signaling 14 0.149
Cpxm2 carboxypeptidase X (M14 family), member 2 0.149
Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 0.148
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.148
Crisp1 cysteine-rich secretory protein 1 0.148
Ccl4 chemokine (C-C motif) ligand 4 0.145
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.145
Fgf2 fibroblast growth factor 2 0.144
Utrn utrophin 0.141
Trib1 tribbles homolog 1 (Drosophila) 0.140
Il1b interleukin 1 beta 0.139
Ptprc protein tyrosine phosphatase, receptor type, C 0.138
Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A 0.137
Csf1 colony stimulating factor 1 (macrophage) 0.137
Ednra endothelin receptor type A 0.137
Hspa8 heat shock protein 8 0.136
Il7 interleukin 7 0.133
Arnt aryl hydrocarbon receptor nuclear translocator 0.133
Tek TEK tyrosine kinase, endothelial 0.132
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.132
Twist2 twist homolog 2 (Drosophila) 0.130
Mpeg1 macrophage expressed 1 0.129
Cmklr1 chemokine-like receptor 1 0.129
Hpx hemopexin 0.128
Flt1 FMS-related tyrosine kinase 1 0.126
Gc group specific component 0.125
Col5a1 collagen, type V, alpha 1 0.124
Fstl1 follistatin-like 1 0.123
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.122
Mapk1 mitogen activated protein kinase 1 0.121
Cd200r1 CD200 receptor 1 0.121
Stc1 stanniocalcin 1 0.119
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism