The network for 'collagen metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

collagen metabolic process

The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

Danio rerio
Name Description Probability Func Analog Organism
col1a2 collagen, type I, alpha 2 0.981
col1a1a collagen, type I, alpha 1a 0.902
itgb1b.2 integrin, beta 1b.2 0.847
ctsk cathepsin K 0.822
itgb1b integrin, beta 1b 0.811
sparc secreted acidic cysteine rich glycoprotein 0.761
tgfbi transforming growth factor, beta-induced 0.617
col12a1 collagen, type XII, alpha 1 0.614
col2a1a collagen type II, alpha-1a 0.602
col5a1 procollagen, type V, alpha 1 0.553
rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.452
itgb1a integrin, beta 1a 0.426
hapln1a hyaluronan and proteoglycan link protein 1a 0.389
itgb1b.1 integrin, beta 1b.1 0.343
ctgf connective tissue growth factor 0.340
cd63 Cd63 antigen 0.325
mtp microsomal triglyceride transfer protein 0.320
cdx1b caudal type homeobox 1 b 0.319
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.311
postn periostin, osteoblast specific factor 0.304
LOC569128 hypothetical protein LOC569128 0.298
pkd2 polycystic kidney disease 2 0.259
prrx1a paired related homeobox 1a 0.257
vcanb versican b 0.246
bmp2b bone morphogenetic protein 2b 0.235
xbp1 X-box binding protein 1 0.229
mpx myeloid-specific peroxidase 0.225
LOC100334210 growth/differentiation factor 5-like 0.214
ntd5 ntl-dependent gene 5 0.208
osr1 odd-skipped related 1 (Drosophila) 0.207
rhag Rhesus blood group-associated glycoprotein 0.203
mmp14b matrix metalloproteinase 14b (membrane-inserted) 0.202
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.194
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.189
spry4 sprouty (Drosophila) homolog 4 0.187
matn4 matrilin 4 0.179
igf2b insulin-like growth factor 2b 0.179
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.179
gcm2 glial cells missing homolog 2 (Drosophila) 0.178
col1a1b collagen, type I, alpha 1b 0.172
tpm4 tropomyosin 4 0.169
ctsc cathepsin C 0.168
fbn2b fibrillin 2b 0.162
satb2 SATB homeobox 2 0.159
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.153
ctsba cathepsin B, a 0.149
mmp13a matrix metalloproteinase 13a 0.146
fstl1b follistatin-like 1b 0.146
fabp11a fatty acid binding protein 11a 0.145
jag1b jagged 1b 0.145
col27a1a collagen, type XXVII, alpha 1a 0.138
ahr2 aryl hydrocarbon receptor 2 0.135
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.132
mmp15b matrix metallopeptidase 15b 0.132
ppib peptidylprolyl isomerase B (cyclophilin B) 0.124
ctsz cathepsin Z 0.124
b2m beta-2-microglobulin 0.118
angptl2 angiopoietin-like 2 0.117
twist1b twist1b 0.111
psap prosaposin 0.110
igfbp6b insulin-like growth factor binding protein 6b 0.108
col11a1a collagen, type XI, alpha 1a 0.107
tgfb2 transforming growth factor, beta 2 0.106
ucp2 uncoupling protein 2 0.104
ptgs2a prostaglandin-endoperoxide synthase 2a 0.103
drl draculin 0.101
col5a2l collagen, type V, alpha 2-like 0.100
si:ch211-212m21.5 si:ch211-212m21.5 0.096
ctsd cathepsin D 0.096
crabp2a cellular retinoic acid binding protein 2, a 0.095
vasn vasorin 0.090
hspa5 heat shock protein 5 0.090
runx2a runt-related transcription factor 2a 0.090
zgc:55891 zgc:55891 0.090
zgc:92903 zgc:92903 0.088
id1 inhibitor of DNA binding 1 0.088
wu:fv91b12 wu:fv91b12 0.086
anxa2a annexin A2a 0.086
id3 inhibitor of DNA binding 3 0.085
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.084
bhlhe41 basic helix-loop-helix family, member e41 0.083
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.083
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.082
myh10 myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle 0.082
timp2a tissue inhibitor of metalloproteinase 2a 0.081
igfbp6a insulin-like growth factor binding protein 6a 0.080
sat1a spermidine/spermine N1-acetyltransferase 1a 0.079
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.079
ctsl1a cathepsin L, 1 a 0.079
fabp6 fatty acid binding protein 6, ileal (gastrotropin) 0.077
ehd2 EH-domain containing 2 0.077
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.076
ctssb.1 cathepsin S, b.1 0.076
il6st interleukin 6 signal transducer 0.075
bnc2 basonuclin 2 0.075
ssr4 signal sequence receptor, delta 0.075
fxyd1 FXYD domain containing ion transport regulator 1 (phospholemman) 0.074
twist2 twist2 0.073
zgc:172161 zgc:172161 0.072
ptch2 patched 2 0.072
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.982
COL6A1 collagen, type VI, alpha 1 0.968
COL3A1 collagen, type III, alpha 1 0.905
TEK TEK tyrosine kinase, endothelial 0.863
COL6A2 collagen, type VI, alpha 2 0.780
BMPR1A bone morphogenetic protein receptor, type IA 0.721
COL1A2 collagen, type I, alpha 2 0.704
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.693
FLNA filamin A, alpha 0.639
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.627
COL4A1 collagen, type IV, alpha 1 0.506
BMP1 bone morphogenetic protein 1 0.496
FGA fibrinogen alpha chain 0.495
BGN biglycan 0.472
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.451
COL4A2 collagen, type IV, alpha 2 0.416
CAV1 caveolin 1, caveolae protein, 22kDa 0.390
POSTN periostin, osteoblast specific factor 0.384
COL5A2 collagen, type V, alpha 2 0.322
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.303
COL5A1 collagen, type V, alpha 1 0.275
DDR2 discoidin domain receptor tyrosine kinase 2 0.262
TIMP1 TIMP metallopeptidase inhibitor 1 0.260
PCOLCE procollagen C-endopeptidase enhancer 0.242
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.219
PXDN peroxidasin homolog (Drosophila) 0.218
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.199
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.198
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.191
ALB albumin 0.186
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.180
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.177
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.158
FSTL1 follistatin-like 1 0.147
COL6A3 collagen, type VI, alpha 3 0.133
ANGPT2 angiopoietin 2 0.131
ADAM12 ADAM metallopeptidase domain 12 0.130
THY1 Thy-1 cell surface antigen 0.128
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.111
THBS2 thrombospondin 2 0.103
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.103
MXRA5 matrix-remodelling associated 5 0.102
FBN1 fibrillin 1 0.102
CYR61 cysteine-rich, angiogenic inducer, 61 0.101
CD248 CD248 molecule, endosialin 0.097
THBS1 thrombospondin 1 0.094
LAMB1 laminin, beta 1 0.094
PDIA3 protein disulfide isomerase family A, member 3 0.091
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.089
LTBP2 latent transforming growth factor beta binding protein 2 0.086
FKBP10 FK506 binding protein 10, 65 kDa 0.082
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.081
FGG fibrinogen gamma chain 0.078
WISP1 WNT1 inducible signaling pathway protein 1 0.078
CYTH1 cytohesin 1 0.077
LUM lumican 0.072
MFAP2 microfibrillar-associated protein 2 0.071
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.071
TIMP2 TIMP metallopeptidase inhibitor 2 0.069
ANGPTL2 angiopoietin-like 2 0.068
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.067
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.063
GRB7 growth factor receptor-bound protein 7 0.063
PRSS3 protease, serine, 3 0.062
PLXDC1 plexin domain containing 1 0.060
CDCP1 CUB domain containing protein 1 0.060
PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.057
FBLN2 fibulin 2 0.055
WNT2 wingless-type MMTV integration site family member 2 0.054
S100B S100 calcium binding protein B 0.054
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.053
NID2 nidogen 2 (osteonidogen) 0.053
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.053
CD63 CD63 molecule 0.051
TMSB4X thymosin beta 4, X-linked 0.051
HSPG2 heparan sulfate proteoglycan 2 0.051
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.050
EMILIN1 elastin microfibril interfacer 1 0.049
COMP cartilage oligomeric matrix protein 0.048
IGFBP3 insulin-like growth factor binding protein 3 0.047
PRKCDBP protein kinase C, delta binding protein 0.046
COL13A1 collagen, type XIII, alpha 1 0.046
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.046
C1S complement component 1, s subcomponent 0.045
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.043
PLEC plectin 0.043
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.043
VCAN versican 0.042
FGF18 fibroblast growth factor 18 0.042
COL11A1 collagen, type XI, alpha 1 0.042
PTRF polymerase I and transcript release factor 0.041
SDF4 stromal cell derived factor 4 0.041
LOXL2 lysyl oxidase-like 2 0.041
GLRX glutaredoxin (thioltransferase) 0.040
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.040
LRRC15 leucine rich repeat containing 15 0.039
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.039
A2M alpha-2-macroglobulin 0.038
COL14A1 collagen, type XIV, alpha 1 0.037
EHD2 EH-domain containing 2 0.037
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Mus musculus
Name Description Probability Func Analog Organism
Nos3 nitric oxide synthase 3, endothelial cell 0.800
Neurod1 neurogenic differentiation 1 0.790
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.470
Neurog2 neurogenin 2 0.430
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.425
Pkd1 polycystic kidney disease 1 homolog 0.414
Gli3 GLI-Kruppel family member GLI3 0.379
Hand1 heart and neural crest derivatives expressed transcript 1 0.353
Bgn biglycan 0.293
Loxl1 lysyl oxidase-like 1 0.261
Hif1a hypoxia inducible factor 1, alpha subunit 0.261
Il6st interleukin 6 signal transducer 0.227
Onecut1 one cut domain, family member 1 0.221
Acvrl1 activin A receptor, type II-like 1 0.216
Pax3 paired box gene 3 0.205
Ptf1a pancreas specific transcription factor, 1a 0.194
Pten phosphatase and tensin homolog 0.183
Nhlh1 nescient helix loop helix 1 0.182
Hoxd13 homeobox D13 0.176
Pax6 paired box gene 6 0.162
Gata6 GATA binding protein 6 0.152
Col2a1 collagen, type II, alpha 1 0.148
Gli2 GLI-Kruppel family member GLI2 0.145
Adam17 a disintegrin and metallopeptidase domain 17 0.140
Ctsd cathepsin D 0.139
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.138
Gata1 GATA binding protein 1 0.136
Vhl von Hippel-Lindau tumor suppressor 0.135
Fbn1 fibrillin 1 0.135
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.134
Neurod4 neurogenic differentiation 4 0.130
Tcf4 transcription factor 4 0.124
Lep leptin 0.120
Foxc2 forkhead box C2 0.118
Sox11 SRY-box containing gene 11 0.116
Fgfr2 fibroblast growth factor receptor 2 0.115
Csf1 colony stimulating factor 1 (macrophage) 0.114
Irx3 Iroquois related homeobox 3 (Drosophila) 0.114
Nkx3-2 NK3 homeobox 2 0.109
Twist2 twist homolog 2 (Drosophila) 0.107
Zeb1 zinc finger E-box binding homeobox 1 0.106
Ltbp2 latent transforming growth factor beta binding protein 2 0.104
Tcf3 transcription factor 3 0.103
Hic1 hypermethylated in cancer 1 0.103
Foxf1a forkhead box F1a 0.101
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.097
Tlr4 toll-like receptor 4 0.095
Sox9 SRY-box containing gene 9 0.094
Irx5 Iroquois related homeobox 5 (Drosophila) 0.089
Fkbp10 FK506 binding protein 10 0.088
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.088
Apoe apolipoprotein E 0.087
Otx2 orthodenticle homolog 2 (Drosophila) 0.087
Fgf18 fibroblast growth factor 18 0.082
Npr2 natriuretic peptide receptor 2 0.082
Ccl2 chemokine (C-C motif) ligand 2 0.081
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.077
Lyz2 lysozyme 2 0.072
Foxd2 forkhead box D2 0.071
Smo smoothened homolog (Drosophila) 0.069
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.069
Lhx5 LIM homeobox protein 5 0.067
Sim2 single-minded homolog 2 (Drosophila) 0.066
Mmp2 matrix metallopeptidase 2 0.064
Col1a2 collagen, type I, alpha 2 0.064
Fstl1 follistatin-like 1 0.061
Olig2 oligodendrocyte transcription factor 2 0.060
Gdnf glial cell line derived neurotrophic factor 0.060
Col22a1 collagen, type XXII, alpha 1 0.060
Shh sonic hedgehog 0.058
Irx2 Iroquois related homeobox 2 (Drosophila) 0.058
Ltbp3 latent transforming growth factor beta binding protein 3 0.058
Leprel2 leprecan-like 2 0.057
Col6a1 collagen, type VI, alpha 1 0.057
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.057
Neurog3 neurogenin 3 0.056
Efna2 ephrin A2 0.056
Nos2 nitric oxide synthase 2, inducible 0.055
Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.054
Lmna lamin A 0.053
Thbs1 thrombospondin 1 0.052
Pdx1 pancreatic and duodenal homeobox 1 0.052
Hoxa11 homeobox A11 0.051
Pax7 paired box gene 7 0.051
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.051
Pnpla2 patatin-like phospholipase domain containing 2 0.050
Mfap4 microfibrillar-associated protein 4 0.050
Gja1 gap junction protein, alpha 1 0.050
Tcfap2a transcription factor AP-2, alpha 0.049
Fgf15 fibroblast growth factor 15 0.046
Sost sclerostin 0.045
Saa4 serum amyloid A 4 0.045
Eng endoglin 0.044
Notch2 Notch gene homolog 2 (Drosophila) 0.044
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.044
Glra1 glycine receptor, alpha 1 subunit 0.043
Foxc1 forkhead box C1 0.043
Clec4d C-type lectin domain family 4, member d 0.042
Tgfb3 transforming growth factor, beta 3 0.042
Gpr50 G-protein-coupled receptor 50 0.042
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd4 Cd4 molecule 0.064
Mmp23 matrix metallopeptidase 23 0.064
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.053
Loxl1 lysyl oxidase-like 1 0.051
Col12a1 collagen, type XII, alpha 1 0.042
Olfml2b olfactomedin-like 2B 0.038
Fgfr1 Fibroblast growth factor receptor 1 0.036
Asam adipocyte-specific adhesion molecule 0.036
Eln elastin 0.030
Plau plasminogen activator, urokinase 0.030
Cox4i1 cytochrome c oxidase subunit IV isoform 1 0.027
Lect1 leukocyte cell derived chemotaxin 1 0.027
Col4a1 collagen, type IV, alpha 1 0.026
Fn1 fibronectin 1 0.026
Edn1 endothelin 1 0.026
Eef2 eukaryotic translation elongation factor 2 0.025
Calcb calcitonin-related polypeptide, beta 0.024
Lox lysyl oxidase 0.023
Fkbp10 FK506 binding protein 10 0.023
Axl Axl receptor tyrosine kinase 0.023
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.023
B2m beta-2 microglobulin 0.021
S100a10 S100 calcium binding protein A10 0.021
Egr2 early growth response 2 0.020
Fuca1 fucosidase, alpha-L- 1, tissue 0.019
Mmp3 matrix metallopeptidase 3 0.019
Hck hemopoietic cell kinase 0.019
Col15a1 collagen, type XV, alpha 1 0.018
Rab1b RAB1B, member RAS oncogene family 0.018
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.018
Vcan versican 0.018
Bok BCL2-related ovarian killer 0.018
Cpxm2 carboxypeptidase X (M14 family), member 2 0.018
Il2ra interleukin 2 receptor, alpha 0.017
Bgn biglycan 0.017
Fam198b family with sequence similarity 198, member B 0.017
Aspg asparaginase homolog (S. cerevisiae) 0.017
Fgfr2 fibroblast growth factor receptor 2 0.017
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.017
Plxnd1 plexin D1 0.017
Copz2 coatomer protein complex, subunit zeta 2 0.017
Clic4 chloride intracellular channel 4 0.016
Il1a interleukin 1 alpha 0.016
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.016
Cercam cerebral endothelial cell adhesion molecule 0.015
Serpinb2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.015
Aebp1 AE binding protein 1 0.015
Mmp2 matrix metallopeptidase 2 0.015
Arhgap10 Rho GTPase activating protein 10 0.015
Fmnl1 formin-like 1 0.015
Clec11a C-type lectin domain family 11, member a 0.015
Col3a1 collagen, type III, alpha 1 0.014
Hist1h1a histone cluster 1, H1a 0.014
Ldb3 LIM domain binding 3 0.014
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.014
Fstl1 follistatin-like 1 0.014
Hr hairless 0.014
Prrx2 paired related homeobox 2 0.013
Trim47 tripartite motif-containing 47 0.013
Id3 inhibitor of DNA binding 3 0.013
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.013
Ctss cathepsin S 0.012
Aqp8 aquaporin 8 0.012
P4hb prolyl 4-hydroxylase, beta polypeptide 0.012
Prr13 proline rich 13 0.012
LOC683313 similar to keratin complex 2, basic, gene 6a 0.012
F2rl3 coagulation factor II (thrombin) receptor-like 3 0.012
Mmp9 matrix metallopeptidase 9 0.012
Il1r1 interleukin 1 receptor, type I 0.012
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.012
Fzd2 frizzled homolog 2 (Drosophila) 0.012
LOC286980 putative pheromone receptor (Go-VN13B) 0.012
RGD1561143 similar to cell surface receptor FDFACT 0.012
Ccnd3 cyclin D3 0.012
Calu calumenin 0.012
Cd63 Cd63 molecule 0.012
Ltbp2 latent transforming growth factor beta binding protein 2 0.012
Ptk2b PTK2B protein tyrosine kinase 2 beta 0.012
Fth1 ferritin, heavy polypeptide 1 0.012
Irf5 interferon regulatory factor 5 0.012
Igfbp6 insulin-like growth factor binding protein 6 0.011
Ly6al lymphocyte antigen 6 complex, locus A-like 0.011
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.011
Gprc5a G protein-coupled receptor, family C, group 5, member A 0.011
Egr1 early growth response 1 0.011
Col18a1 collagen, type XVIII, alpha 1 0.011
Bmp1 bone morphogenetic protein 1 0.011
Rabac1 Rab acceptor 1 (prenylated) 0.011
Ibsp integrin-binding sialoprotein 0.011
Afm afamin 0.011
Sprr3 small proline-rich protein 3 0.011
Gper G protein-coupled estrogen receptor 1 0.011
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.010
Foxa3 forkhead box A3 0.010
Stat6 signal transducer and activator of transcription 6 0.010
Epas1 endothelial PAS domain protein 1 0.010
Pdpn podoplanin 0.010
Wnt5a wingless-type MMTV integration site family, member 5A 0.010
Proc protein C 0.010
Scamp2 secretory carrier membrane protein 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism