The network for 'renal tubule morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

renal tubule morphogenesis

The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.

Danio rerio
Name Description Probability Func Analog Organism
pax2a paired box gene 2a 0.981
osr2 odd-skipped related 2 (Drosophila) 0.971
wt1b wilms tumor 1b 0.964
six4b sine oculis homeobox homolog 4b 0.892
bmp2b bone morphogenetic protein 2b 0.877
bmp2a bone morphogenetic protein 2a 0.835
eya1 eyes absent homolog 1 0.823
gyltl1b glycosyltransferase-like 1b 0.741
cdh2 cadherin 2, neuronal 0.734
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.732
tbx1 T-box 1 0.720
wnt5b wingless-type MMTV integration site family, member 5b 0.666
fgf8a fibroblast growth factor 8 a 0.654
shha sonic hedgehog a 0.635
notch3 notch homolog 3 0.632
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.628
hnf1bb HNF1 homeobox Bb 0.626
mib mind bomb 0.596
sim1a single-minded homolog 1a (Drosophila) 0.583
hoxa9a homeo box A9a 0.559
aplnrb apelin receptor b 0.559
mecom MDS1 and EVI1 complex locus 0.530
hoxa9b homeo box A9b 0.520
hs3st3b1a heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a 0.519
foxd3 forkhead box D3 0.488
gdnf glial cell derived neurotrophic factor 0.486
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.478
lrrc50 leucine rich repeat containing 50 0.469
hoxd4a homeo box D4a 0.461
wnt4a wingless-type MMTV integration site family, member 4a 0.456
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.456
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.455
myod1 myogenic differentiation 1 0.438
dkk1b dickkopf 1b 0.392
dla deltaA 0.361
wt1a wilms tumor 1a 0.354
jag1b jagged 1b 0.351
tbx18 T-box 18 0.345
bmp4 bone morphogenetic protein 4 0.344
hoxd10a homeo box D10a 0.344
her8a hairy-related 8a 0.337
myf5 myogenic factor 5 0.317
lhx1a LIM homeobox 1a 0.317
prdm1a PR domain containing 1a, with ZNF domain 0.315
hoxa10b homeo box A10b 0.307
spry1 sprouty homolog 1 (Drosophila) 0.287
jag2 jagged 2 0.286
wnt10a wingless-type MMTV integration site family, member 10a 0.282
nkx3.2 NK3 homeobox 2 0.281
dusp6 dual specificity phosphatase 6 0.273
boc brother of CDO 0.272
ism1 isthmin 1 0.270
wtip Wilms tumor 1 interacting protein 0.269
fgf24 fibroblast growth factor 24 0.257
igfbp3 insulin-like growth factor binding protein 3 0.254
osr1 odd-skipped related 1 (Drosophila) 0.237
hoxa11a homeo box A11a 0.233
hoxb2a homeo box B2a 0.231
msxb muscle segment homeobox B 0.228
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.227
hoxd11a homeo box D11a 0.227
fgf3 fibroblast growth factor 3 0.222
foxn4 forkhead box N4 0.219
cobl cordon-bleu homolog (mouse) 0.216
itga3b integrin, alpha 3b 0.216
foxi1 forkhead box I1 0.189
six4a sine oculis homeobox homolog 4a 0.186
her12 hairy-related 12 0.186
grhl2a grainyhead-like 2a (Drosophila) 0.186
spaw southpaw 0.185
fgf10a fibroblast growth factor 10a 0.185
six2a sine oculis-related homeobox 2a 0.184
frem3 Fras1 related extracellular matrix 3 0.182
vegfaa vascular endothelial growth factor Aa 0.177
twist1a twist1a 0.171
twist3 twist3 0.169
sox2 SRY-box containing gene 2 0.168
gbx2 gastrulation brain homeo box 2 0.167
znf503 zinc finger protein 503 0.165
hoxa13b homeo box A13b 0.165
tnnt2a troponin T2a, cardiac 0.164
pcdh8 protocadherin 8 0.162
hoxd9a homeo box D9a 0.157
her6 hairy-related 6 0.157
si:ch211-173o4.2 si:ch211-173o4.2 0.156
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.156
nog2 noggin 2 0.156
ptgs1 prostaglandin-endoperoxide synthase 1 0.154
epha4a eph receptor A4a 0.154
traf4a tnf receptor-associated factor 4a 0.153
foxj1b forkhead box J1b 0.151
lpin1 lipin 1 0.149
spry2 sprouty homolog 2 0.146
foxo3b forkhead box O3b 0.145
epb4.1l4 erythrocyte protein band 4.1-like 4 0.139
hand2 heart and neural crest derivatives expressed transcript 2 0.139
pea3 ETS-domain transcription factor pea3 0.138
foxp2 forkhead box P2 0.138
evx1 even-skipped homeobox 1 0.137
lef1 lymphocyte enhancer binding factor 1 0.137
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
E(spl) Enhancer of split 0.984
emc extra macrochaetae 0.983
abd-A abdominal A 0.970
wg wingless 0.955
tkv thickveins 0.955
Egfr Epidermal growth factor receptor 0.954
rib ribbon 0.943
ato atonal 0.909
l(2)gl lethal (2) giant larvae 0.863
ci cubitus interruptus 0.856
N Notch 0.850
argos CG4531 gene product from transcript CG4531-RA 0.850
HLHm7 E(spl) region transcript m7 0.842
Mad Mothers against dpp 0.825
HLHmgamma E(spl) region transcript mgamma 0.822
fkh fork head 0.807
Ubx Ultrabithorax 0.774
HLHmdelta E(spl) region transcript mdelta 0.743
mys myospheroid 0.686
bowl brother of odd with entrails limited 0.653
tll tailless 0.594
hkb huckebein 0.569
slp1 sloppy paired 1 0.557
sax saxophone 0.549
HLHmbeta E(spl) region transcript mbeta 0.540
shn schnurri 0.525
yki yorkie 0.460
sc scute 0.455
sna snail 0.442
dpp decapentaplegic 0.436
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.420
ac achaete 0.418
pan pangolin 0.411
Fas2 Fasciclin 2 0.397
bi bifid 0.395
Ser Serrate 0.386
sqh spaghetti squash 0.378
byn brachyenteron 0.377
ro rough 0.360
kni knirps 0.353
par-1 CG8201 gene product from transcript CG8201-RA 0.349
H Hairless 0.347
Stat92E Signal-transducer and activator of transcription protein at 92E 0.337
fz2 frizzled 2 0.327
scb scab 0.326
dm diminutive 0.321
sog short gastrulation 0.316
twi twist 0.315
en engrailed 0.308
btl breathless 0.290
malpha E(spl) region transcript malpha 0.286
Dad Daughters against dpp 0.269
Poxn Pox neuro 0.266
Rac1 CG2248 gene product from transcript CG2248-RA 0.258
Dfd Deformed 0.246
tin tinman 0.244
Abd-B Abdominal B 0.244
kek1 kekkon-1 0.241
sens senseless 0.240
fng fringe 0.239
LanB1 CG7123 gene product from transcript CG7123-RA 0.227
eyg eyegone 0.218
LanB2 Laminin B2 0.217
Notum CG13076 gene product from transcript CG13076-RB 0.204
disco disconnected 0.203
ex expanded 0.199
baz bazooka 0.190
gbb glass bottom boat 0.188
bab1 bric a brac 1 0.185
hh hedgehog 0.183
Mef2 Myocyte enhancer factor 2 0.179
ara araucan 0.174
Tom Twin of m4 0.172
rg rugose 0.168
dia diaphanous 0.165
CG32711 CG32711 gene product from transcript CG32711-RA 0.163
pyd polychaetoid 0.160
if inflated 0.159
Dll Distal-less 0.157
Appl beta amyloid protein precursor-like 0.155
Nrx-IV Neurexin IV 0.154
mew multiple edematous wings 0.149
Rel Relish 0.147
bap bagpipe 0.147
grk gurken 0.145
kuz kuzbanian 0.144
bab2 CG9102 gene product from transcript CG9102-RA 0.142
fas faint sausage 0.139
stumps CG31317 gene product from transcript CG31317-RC 0.136
m2 E(spl) region transcript m2 0.133
Antp Antennapedia 0.132
amos absent MD neurons and olfactory sensilla 0.132
sev sevenless 0.131
Myo31DF Myosin 31DF 0.131
Hop Hsp70/Hsp90 organizing protein homolog 0.127
tld tolloid 0.127
m4 E(spl) region transcript m4 0.126
egh egghead 0.123
klu klumpfuss 0.117
Mrtf Myocardin-related transcription factor 0.117
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.999
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.778
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.760
CUL3 cullin 3 0.726
SMAD3 SMAD family member 3 0.620
FGF1 fibroblast growth factor 1 (acidic) 0.558
TP53 tumor protein p53 0.539
FSTL1 follistatin-like 1 0.492
FGF10 fibroblast growth factor 10 0.487
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.375
BMPR1A bone morphogenetic protein receptor, type IA 0.338
MEIS1 Meis homeobox 1 0.324
NRP1 neuropilin 1 0.320
HDAC4 histone deacetylase 4 0.288
MSN moesin 0.206
COL4A5 collagen, type IV, alpha 5 0.201
COL4A4 collagen, type IV, alpha 4 0.194
EGR2 early growth response 2 0.192
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.189
ADAM17 ADAM metallopeptidase domain 17 0.181
MEIS2 Meis homeobox 2 0.178
FGFR1 fibroblast growth factor receptor 1 0.169
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.167
NKX2-1 NK2 homeobox 1 0.158
FGF8 fibroblast growth factor 8 (androgen-induced) 0.136
KLHL12 kelch-like 12 (Drosophila) 0.135
EGR3 early growth response 3 0.133
ZFYVE9 zinc finger, FYVE domain containing 9 0.123
DAPK1 death-associated protein kinase 1 0.102
COL4A6 collagen, type IV, alpha 6 0.102
BCL2L1 BCL2-like 1 0.087
FGF4 fibroblast growth factor 4 0.087
KLHL2 kelch-like 2, Mayven (Drosophila) 0.087
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.086
PJA1 praja ring finger 1 0.083
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.082
MEOX1 mesenchyme homeobox 1 0.080
PAX8 paired box 8 0.073
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.070
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.070
WNT1 wingless-type MMTV integration site family, member 1 0.067
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.064
EGR1 early growth response 1 0.062
NCOR2 nuclear receptor corepressor 2 0.058
FGF18 fibroblast growth factor 18 0.056
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.056
FGF3 fibroblast growth factor 3 0.054
SKIL SKI-like oncogene 0.054
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.054
HOXB5 homeobox B5 0.053
FN1 fibronectin 1 0.052
MAGED2 melanoma antigen family D, 2 0.051
TSC22D4 TSC22 domain family, member 4 0.050
GLIS2 GLIS family zinc finger 2 0.048
BMP7 bone morphogenetic protein 7 0.048
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.045
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.045
ENG endoglin 0.043
PAX3 paired box 3 0.043
HOXA10 homeobox A10 0.038
THBS1 thrombospondin 1 0.038
TGFBR1 transforming growth factor, beta receptor 1 0.038
LBX1 ladybird homeobox 1 0.037
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.036
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.032
HDAC9 histone deacetylase 9 0.031
HMGA2 high mobility group AT-hook 2 0.031
COL7A1 collagen, type VII, alpha 1 0.030
WNT7A wingless-type MMTV integration site family, member 7A 0.030
COL2A1 collagen, type II, alpha 1 0.029
PARVA parvin, alpha 0.028
MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.027
PAX2 paired box 2 0.027
EPAS1 endothelial PAS domain protein 1 0.024
GDNF glial cell derived neurotrophic factor 0.024
TGFB3 transforming growth factor, beta 3 0.024
DGCR14 DiGeorge syndrome critical region gene 14 0.024
TGFB2 transforming growth factor, beta 2 0.023
BCAM basal cell adhesion molecule (Lutheran blood group) 0.023
AMBRA1 autophagy/beclin-1 regulator 1 0.023
BMP4 bone morphogenetic protein 4 0.022
FGFR3 fibroblast growth factor receptor 3 0.021
SNAI1 snail homolog 1 (Drosophila) 0.021
GABARAP GABA(A) receptor-associated protein 0.021
BCL6 B-cell CLL/lymphoma 6 0.020
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.020
CTGF connective tissue growth factor 0.020
HNF1A HNF1 homeobox A 0.019
INHBB inhibin, beta B 0.019
NFIB nuclear factor I/B 0.019
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.018
IER2 immediate early response 2 0.018
TAOK1 TAO kinase 1 0.018
HOXD13 homeobox D13 0.018
SIM2 single-minded homolog 2 (Drosophila) 0.018
WT1 Wilms tumor 1 0.018
PKN2 protein kinase N2 0.018
ZNF331 zinc finger protein 331 0.017
SFRP1 secreted frizzled-related protein 1 0.017
SOX1 SRY (sex determining region Y)-box 1 0.017
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 0.999
Wt1 Wilms tumor 1 homolog 0.999
Pax2 paired box gene 2 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Hoxd11 homeobox D11 0.998
Fgf8 fibroblast growth factor 8 0.993
Pax8 paired box gene 8 0.993
Nog noggin 0.989
Ret ret proto-oncogene 0.986
Emx2 empty spiracles homolog 2 (Drosophila) 0.986
Lhx1 LIM homeobox protein 1 0.985
Foxc1 forkhead box C1 0.972
Gli2 GLI-Kruppel family member GLI2 0.971
Gdnf glial cell line derived neurotrophic factor 0.969
Tcf21 transcription factor 21 0.966
Tbx2 T-box 2 0.947
Pbx1 pre B-cell leukemia transcription factor 1 0.937
Smad6 MAD homolog 6 (Drosophila) 0.934
Gata6 GATA binding protein 6 0.927
Gata4 GATA binding protein 4 0.924
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.923
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.921
Pten phosphatase and tensin homolog 0.919
Hoxd3 homeobox D3 0.918
Bcl2 B-cell leukemia/lymphoma 2 0.915
Nos3 nitric oxide synthase 3, endothelial cell 0.902
Bmp4 bone morphogenetic protein 4 0.900
Fgfr1 fibroblast growth factor receptor 1 0.890
Sall4 sal-like 4 (Drosophila) 0.887
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.885
Pitx2 paired-like homeodomain transcription factor 2 0.884
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.858
Hoxd9 homeobox D9 0.858
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.849
Sox2 SRY-box containing gene 2 0.846
Ctnnb1 catenin (cadherin associated protein), beta 1 0.841
Hand1 heart and neural crest derivatives expressed transcript 1 0.841
Hoxa10 homeobox A10 0.836
Mef2d myocyte enhancer factor 2D 0.836
Nkx2-1 NK2 homeobox 1 0.830
Hes1 hairy and enhancer of split 1 (Drosophila) 0.812
Sox7 SRY-box containing gene 7 0.810
Hoxd4 homeobox D4 0.803
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.803
Meox2 mesenchyme homeobox 2 0.800
Pax3 paired box gene 3 0.791
Smad3 MAD homolog 3 (Drosophila) 0.788
Kiss1 KiSS-1 metastasis-suppressor 0.778
Hoxb6 homeobox B6 0.778
Tbx3 T-box 3 0.771
Hoxa9 homeobox A9 0.767
Hoxa1 homeobox A1 0.764
Hand2 heart and neural crest derivatives expressed transcript 2 0.760
Foxa2 forkhead box A2 0.741
Jag1 jagged 1 0.725
Hoxc8 homeobox C8 0.714
Hoxb5 homeobox B5 0.712
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.704
Wnt6 wingless-related MMTV integration site 6 0.703
Bnc1 basonuclin 1 0.700
En1 engrailed 1 0.698
Wnt4 wingless-related MMTV integration site 4 0.676
Lef1 lymphoid enhancer binding factor 1 0.674
Pax6 paired box gene 6 0.671
Vax1 ventral anterior homeobox containing gene 1 0.662
Flt4 FMS-like tyrosine kinase 4 0.661
Efnb2 ephrin B2 0.636
Rxra retinoid X receptor alpha 0.628
Hoxa3 homeobox A3 0.615
Drd2 dopamine receptor D2 0.612
Nynrin NYN domain and retroviral integrase containing 0.608
Vegfa vascular endothelial growth factor A 0.599
Hoxa5 homeobox A5 0.598
Foxd2 forkhead box D2 0.595
Fgf3 fibroblast growth factor 3 0.594
Fgf10 fibroblast growth factor 10 0.592
Tgfb2 transforming growth factor, beta 2 0.575
Pkd1 polycystic kidney disease 1 homolog 0.572
Hoxb4 homeobox B4 0.572
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.563
Hoxd10 homeobox D10 0.559
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.555
Eya1 eyes absent 1 homolog (Drosophila) 0.535
Ren1 renin 1 structural 0.520
Tbx1 T-box 1 0.514
Bax BCL2-associated X protein 0.512
Hoxa11 homeobox A11 0.509
Ntf3 neurotrophin 3 0.483
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.480
Sall1 sal-like 1 (Drosophila) 0.479
Hoxb3 homeobox B3 0.477
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.474
Tcfap2c transcription factor AP-2, gamma 0.473
Col13a1 collagen, type XIII, alpha 1 0.473
Wnt2b wingless related MMTV integration site 2b 0.471
Nodal nodal 0.465
Otx1 orthodenticle homolog 1 (Drosophila) 0.464
Rarg retinoic acid receptor, gamma 0.462
Foxc2 forkhead box C2 0.450
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism