IMP

Process View

Homo sapiens

21 genes annotated in human

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circadian rhythm

GO:0007623

Any biological process in an organism that recurs with a regularity of approximately 24 hours.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "circadian rhythm"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "circadian rhythm" (in gray)

Name	Description	Probability	Func Analog Organism
CREBBP	CREB binding protein	0.995
SIRT1	sirtuin 1	0.787
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.565
DLG4	discs, large homolog 4 (Drosophila)	0.551	Fly
NCOR2	nuclear receptor corepressor 2	0.519
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.483	Mouse
GSK3B	glycogen synthase kinase 3 beta	0.421	Mouse Fly
NCOR1	nuclear receptor corepressor 1	0.391	Mouse
EGFR	epidermal growth factor receptor	0.314
NCOA3	nuclear receptor coactivator 3	0.278
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.267	Mouse
BCL3	B-cell CLL/lymphoma 3	0.228
HDAC1	histone deacetylase 1	0.205	Mouse
AR	androgen receptor	0.190
ADORA2A	adenosine A2a receptor	0.177	Rat
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.167
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.153
KAT2B	K(lysine) acetyltransferase 2B	0.149
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.141
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.139
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.137
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.135	Fly
NCL	nucleolin	0.134
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.134
BTRC	beta-transducin repeat containing	0.121
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.120
JUND	jun D proto-oncogene	0.115
DRD2	dopamine receptor D2	0.111	Mouse Rat
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.106	Fly
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.102
SFPQ	splicing factor proline/glutamine-rich	0.101	Mouse
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.099
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.097	Mouse
HNF4A	hepatocyte nuclear factor 4, alpha	0.094
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.091
KDM1A	lysine (K)-specific demethylase 1A	0.091
ILF3	interleukin enhancer binding factor 3, 90kDa	0.090
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.089
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.089
HDAC2	histone deacetylase 2	0.089	Mouse
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.086
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.083
ACACA	acetyl-CoA carboxylase alpha	0.080
DDIT3	DNA-damage-inducible transcript 3	0.074
BHLHE40	basic helix-loop-helix family, member e40	0.072
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.072
CAV1	caveolin 1, caveolae protein, 22kDa	0.067
GDA	guanine deaminase	0.064
LIN7B	lin-7 homolog B (C. elegans)	0.063
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.061
PTBP1	polypyrimidine tract binding protein 1	0.061
ACTN2	actinin, alpha 2	0.060
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.060
ATF3	activating transcription factor 3	0.060	Fly
JUNB	jun B proto-oncogene	0.058
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.058
IGF1R	insulin-like growth factor 1 receptor	0.058	Fly
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.058
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.056	Mouse
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.054
NLRC4	NLR family, CARD domain containing 4	0.054
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.054	Fly
FUS	fused in sarcoma	0.052
CUL1	cullin 1	0.052
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.052
ZMYND11	zinc finger, MYND-type containing 11	0.051
CREB1	cAMP responsive element binding protein 1	0.050	Mouse Rat
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.050
EED	embryonic ectoderm development	0.049
CLOCK	clock homolog (mouse)	0.047
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.046
AHR	aryl hydrocarbon receptor	0.046	Mouse
INSR	insulin receptor	0.045	Fly
NCOA1	nuclear receptor coactivator 1	0.045
JUN	jun proto-oncogene	0.044	Rat
ESR1	estrogen receptor 1	0.043
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.043
TOP1	topoisomerase (DNA) I	0.043
PJA1	praja ring finger 1	0.040
SF1	splicing factor 1	0.040
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.039
AXIN1	axin 1	0.039
C2orf65	chromosome 2 open reading frame 65	0.039
SMAD2	SMAD family member 2	0.039
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.038
NGF	nerve growth factor (beta polypeptide)	0.038	Mouse
DUSP1	dual specificity phosphatase 1	0.037
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.035
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.033
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.032
MATR3	matrin 3	0.032
TRIB3	tribbles homolog 3 (Drosophila)	0.031
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.031
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.031
HLF	hepatic leukemia factor	0.029
HES1	hairy and enhancer of split 1, (Drosophila)	0.028
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.028	Mouse
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.028
NFIL3	nuclear factor, interleukin 3 regulated	0.027
NONO	non-POU domain containing, octamer-binding	0.027	Mouse Rat
FGFR1	fibroblast growth factor receptor 1	0.024
CSNK2B	casein kinase 2, beta polypeptide	0.024
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.024
EGR3	early growth response 3	0.023
IER2	immediate early response 2	0.023
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.022
LDOC1	leucine zipper, down-regulated in cancer 1	0.022
AKAP1	A kinase (PRKA) anchor protein 1	0.022
STAT5A	signal transducer and activator of transcription 5A	0.022
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.022	Fly
SMAD3	SMAD family member 3	0.022
SOCS3	suppressor of cytokine signaling 3	0.022
ZMYM2	zinc finger, MYM-type 2	0.021
RB1	retinoblastoma 1	0.020
PGR	progesterone receptor	0.020
C5orf41	chromosome 5 open reading frame 41	0.020
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.020
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.020
MBNL1	muscleblind-like (Drosophila)	0.019
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.019	Fly
RARA	retinoic acid receptor, alpha	0.019
CPE	carboxypeptidase E	0.018
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.018
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.018
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.018
NCOA2	nuclear receptor coactivator 2	0.018
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.018
EP300	E1A binding protein p300	0.018	Mouse
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.018
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.017
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.017
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.017
ESRRG	estrogen-related receptor gamma	0.016
EEF2K	eukaryotic elongation factor-2 kinase	0.016
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.016
DAXX	death-domain associated protein	0.016
STAT5B	signal transducer and activator of transcription 5B	0.016
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.015
RBBP4	retinoblastoma binding protein 4	0.015
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.015
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.015
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.015	Fly
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.015
MAGED2	melanoma antigen family D, 2	0.015
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.015
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.015
FOSL2	FOS-like antigen 2	0.014	Fly
CREBZF	CREB/ATF bZIP transcription factor	0.014
PPARG	peroxisome proliferator-activated receptor gamma	0.014
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.014
SIK1	salt-inducible kinase 1	0.014	Mouse
IRS2	insulin receptor substrate 2	0.014
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.014
PAX8	paired box 8	0.013
EPOR	erythropoietin receptor	0.013
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.013
PER1	period homolog 1 (Drosophila)	0.013
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.013	Fly
HMGA1	high mobility group AT-hook 1	0.013
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.013
AKAP2	A kinase (PRKA) anchor protein 2	0.013
CDCA4	cell division cycle associated 4	0.013
GADD45B	growth arrest and DNA-damage-inducible, beta	0.013
FBXW11	F-box and WD repeat domain containing 11	0.013	Human Mouse Fly
KLF10	Kruppel-like factor 10	0.013	Mouse Rat
AKIP1	A kinase (PRKA) interacting protein 1	0.013
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.013
ADAM17	ADAM metallopeptidase domain 17	0.012
CDK9	cyclin-dependent kinase 9	0.012
HIPK2	homeodomain interacting protein kinase 2	0.012
SCRIB	scribbled homolog (Drosophila)	0.012
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.012
AKAP11	A kinase (PRKA) anchor protein 11	0.012
RUNX1	runt-related transcription factor 1	0.012
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.012
NTF4	neurotrophin 4	0.012
PML	promyelocytic leukemia	0.012	Mouse
JAK2	Janus kinase 2	0.012	Fly
FOSL1	FOS-like antigen 1	0.012	Fly
FHL1	four and a half LIM domains 1	0.011
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.011
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.011
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.011	Mouse
PRKCE	protein kinase C, epsilon	0.011
PBK	PDZ binding kinase	0.011
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.011
MYBBP1A	MYB binding protein (P160) 1a	0.011
PHF19	PHD finger protein 19	0.011
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.011
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.010
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.010
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.010
RXRA	retinoid X receptor, alpha	0.010
APP	amyloid beta (A4) precursor protein	0.010
FASLG	Fas ligand (TNF superfamily, member 6)	0.010
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.010