IMP

Process View

Homo sapiens

16 genes annotated in human

cellular response to unfolded protein

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to unfolded protein"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to unfolded protein" (in gray)

Name	Description	Probability	Func Analog Organism
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1.000	Mouse Worm
PDIA3	protein disulfide isomerase family A, member 3	0.999
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.998	Fly
BCL2L1	BCL2-like 1	0.912	Human
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.899
DERL1	Der1-like domain family, member 1	0.890
P4HB	prolyl 4-hydroxylase, beta polypeptide	0.876	Worm
HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.859	Mouse
GHR	growth hormone receptor	0.852
VCP	valosin containing protein	0.753	Worm
CANX	calnexin	0.681	Worm
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.538
STON2	stonin 2	0.514
BCL2	B-cell CLL/lymphoma 2	0.440	Human
SELS	selenoprotein S	0.427
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.420
PDIA6	protein disulfide isomerase family A, member 6	0.347	Worm
PDIA4	protein disulfide isomerase family A, member 4	0.332	Worm
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.320
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.310
BAK1	BCL2-antagonist/killer 1	0.271
BAX	BCL2-associated X protein	0.189
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.160	Human
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.158
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.157
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.155
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.147
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.117
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.108
HYOU1	hypoxia up-regulated 1	0.105
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.091	Worm
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.091
BAD	BCL2-associated agonist of cell death	0.085
C4orf14	chromosome 4 open reading frame 14	0.084
JUND	jun D proto-oncogene	0.079
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.075
PLCG1	phospholipase C, gamma 1	0.074
GANAB	glucosidase, alpha; neutral AB	0.071
SOS1	son of sevenless homolog 1 (Drosophila)	0.069
WDR83	WD repeat domain 83	0.066
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.062
ATF3	activating transcription factor 3	0.055
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.055
CCND3	cyclin D3	0.054
PTPRB	protein tyrosine phosphatase, receptor type, B	0.052
CDK6	cyclin-dependent kinase 6	0.050
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.047
NUCB2	nucleobindin 2	0.045
RNF144B	ring finger protein 144B	0.044
ERN1	endoplasmic reticulum to nucleus signaling 1	0.041
AMFR	autocrine motility factor receptor	0.040
SURF4	surfeit 4	0.039
RABAC1	Rab acceptor 1 (prenylated)	0.038
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.038
RPN2	ribophorin II	0.036
ERO1L	ERO1-like (S. cerevisiae)	0.035	Mouse
RNR2	l-rRNA	0.031
CSRNP1	cysteine-serine-rich nuclear protein 1	0.030
HM13	histocompatibility (minor) 13	0.028
VDAC1	voltage-dependent anion channel 1	0.028
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.025
ATXN3	ataxin 3	0.024
DDIT3	DNA-damage-inducible transcript 3	0.024	Mouse
RPN1	ribophorin I	0.022
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.022
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.022
BHLHE40	basic helix-loop-helix family, member e40	0.021
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	0.021	Human
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.021
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.021
STX8	syntaxin 8	0.020
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.020
HBP1	HMG-box transcription factor 1	0.019
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.018
PDIA5	protein disulfide isomerase family A, member 5	0.018
OSBPL9	oxysterol binding protein-like 9	0.018
UBXN2A	UBX domain protein 2A	0.018
IL8	interleukin 8	0.018
KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	0.017
DBP	D site of albumin promoter (albumin D-box) binding protein	0.017
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.016
CALR	calreticulin	0.016	Worm
JUN	jun proto-oncogene	0.016
IFRD1	interferon-related developmental regulator 1	0.016
NFIL3	nuclear factor, interleukin 3 regulated	0.016
EIF3CL	eukaryotic translation initiation factor 3, subunit C-like	0.015
SSR1	signal sequence receptor, alpha	0.015
STAT5A	signal transducer and activator of transcription 5A	0.015
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.015	Human
KLF6	Kruppel-like factor 6	0.015
IER2	immediate early response 2	0.015
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.015
HSPB1	heat shock 27kDa protein 1	0.015
DERL2	Der1-like domain family, member 2	0.014
FKBP4	FK506 binding protein 4, 59kDa	0.014
SART1	squamous cell carcinoma antigen recognized by T cells	0.014
VEGFA	vascular endothelial growth factor A	0.014
KEAP1	kelch-like ECH-associated protein 1	0.014
EIF1	eukaryotic translation initiation factor 1	0.014
NCL	nucleolin	0.014
GRB2	growth factor receptor-bound protein 2	0.014
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.014
CALU	calumenin	0.013
SLC33A1	solute carrier family 33 (acetyl-CoA transporter), member 1	0.013
TMED9	transmembrane emp24 protein transport domain containing 9	0.013
PTPN9	protein tyrosine phosphatase, non-receptor type 9	0.013	Human
GOLGA8A	golgin A8 family, member A	0.013
GRB10	growth factor receptor-bound protein 10	0.013
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.013
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.012
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.012
SSR2	signal sequence receptor, beta (translocon-associated protein beta)	0.011
XBP1	X-box binding protein 1	0.011
TACC1	transforming, acidic coiled-coil containing protein 1	0.011
TMED2	transmembrane emp24 domain trafficking protein 2	0.010
KLHL24	kelch-like 24 (Drosophila)	0.010