IMP

Process View

Homo sapiens

2 genes annotated in human

pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pharyngeal system development"

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Name	Description	Probability	Func Analog Organism
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.967
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.907	Mouse
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.893
TBX5	T-box 5	0.889	Human
GATA4	GATA binding protein 4	0.250
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.248
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.236
SPDEF	SAM pointed domain containing ets transcription factor	0.233
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.223
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.191
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.183
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.153
SMO	smoothened homolog (Drosophila)	0.152
PBRM1	polybromo 1	0.139
SMAD7	SMAD family member 7	0.139
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.130
ARID1A	AT rich interactive domain 1A (SWI-like)	0.130
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.124
TGFB1	transforming growth factor, beta 1	0.092
HOXD9	homeobox D9	0.085
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.074
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.071
FN1	fibronectin 1	0.052
BBS10	Bardet-Biedl syndrome 10	0.051
SP1	Sp1 transcription factor	0.050
NRP1	neuropilin 1	0.046
COL1A1	collagen, type I, alpha 1	0.045
PIAS1	protein inhibitor of activated STAT, 1	0.044
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.039
ADAM12	ADAM metallopeptidase domain 12	0.037
NCOR1	nuclear receptor corepressor 1	0.034
CSNK1E	casein kinase 1, epsilon	0.033
ITGB5	integrin, beta 5	0.029
YY1	YY1 transcription factor	0.029
PTK2	PTK2 protein tyrosine kinase 2	0.029
CHD4	chromodomain helicase DNA binding protein 4	0.027
CARM1	coactivator-associated arginine methyltransferase 1	0.025
PAX9	paired box 9	0.024
FNDC3B	fibronectin type III domain containing 3B	0.024
PBX2	pre-B-cell leukemia homeobox 2	0.024
TBX21	T-box 21	0.024	Human
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.024
JAG1	jagged 1	0.024
SMARCD2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	0.023
EYA2	eyes absent homolog 2 (Drosophila)	0.023
ZNF331	zinc finger protein 331	0.022
MTA2	metastasis associated 1 family, member 2	0.022
MYOD1	myogenic differentiation 1	0.022
SORBS3	sorbin and SH3 domain containing 3	0.022
PDGFC	platelet derived growth factor C	0.022
MDFI	MyoD family inhibitor	0.021
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.021
EYA1	eyes absent homolog 1 (Drosophila)	0.021
TBX1	T-box 1	0.020
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.020
PABPN1	poly(A) binding protein, nuclear 1	0.020
ACAN	aggrecan	0.020
THBS1	thrombospondin 1	0.019
BCL2	B-cell CLL/lymphoma 2	0.019
FSTL1	follistatin-like 1	0.019
SOX18	SRY (sex determining region Y)-box 18	0.019
TAL1	T-cell acute lymphocytic leukemia 1	0.019
GATAD2B	GATA zinc finger domain containing 2B	0.019
NLRP2	NLR family, pyrin domain containing 2	0.019
RCOR1	REST corepressor 1	0.019
KIAA1199	KIAA1199	0.019
AXIN1	axin 1	0.019
GATA5	GATA binding protein 5	0.019
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.019
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.018
HOXB13	homeobox B13	0.018
SKIL	SKI-like oncogene	0.018
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.018
COL3A1	collagen, type III, alpha 1	0.018
ANTXR2	anthrax toxin receptor 2	0.018
FAM110C	family with sequence similarity 110, member C	0.017
ENG	endoglin	0.017
IGFBP7	insulin-like growth factor binding protein 7	0.017
FANCC	Fanconi anemia, complementation group C	0.017
SMAD2	SMAD family member 2	0.016
TP53BP1	tumor protein p53 binding protein 1	0.016
HOXB9	homeobox B9	0.016
FANCE	Fanconi anemia, complementation group E	0.016
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.016
RAX	retina and anterior neural fold homeobox	0.016
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.016
ACACA	acetyl-CoA carboxylase alpha	0.016
SIX2	SIX homeobox 2	0.016
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.016
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.016
CALD1	caldesmon 1	0.015
ZFYVE9	zinc finger, FYVE domain containing 9	0.015
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.015
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.015
MCC	mutated in colorectal cancers	0.015
PAM	peptidylglycine alpha-amidating monooxygenase	0.015
SMAD1	SMAD family member 1	0.015
RNF8	ring finger protein 8	0.015
CTGF	connective tissue growth factor	0.015
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.014
SMAD6	SMAD family member 6	0.014
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.014
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.014
FAM46A	family with sequence similarity 46, member A	0.014
LBX1	ladybird homeobox 1	0.014
MTA1	metastasis associated 1	0.014
SLAMF7	SLAM family member 7	0.014
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.014
GNG11	guanine nucleotide binding protein (G protein), gamma 11	0.013
LHX3	LIM homeobox 3	0.013
FHL1	four and a half LIM domains 1	0.013
MSX1	msh homeobox 1	0.013
DLG5	discs, large homolog 5 (Drosophila)	0.013
SLURP1	secreted LY6/PLAUR domain containing 1	0.013
PARP1	poly (ADP-ribose) polymerase 1	0.013
LHFP	lipoma HMGIC fusion partner	0.013
CXCR6	chemokine (C-X-C motif) receptor 6	0.013
FASLG	Fas ligand (TNF superfamily, member 6)	0.013
SPHK1	sphingosine kinase 1	0.013
INHBB	inhibin, beta B	0.013
TOP3A	topoisomerase (DNA) III alpha	0.013
PRKG1	protein kinase, cGMP-dependent, type I	0.013
HOXC11	homeobox C11	0.013
GATA3	GATA binding protein 3	0.013	Mouse
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.013
PPP1R12C	protein phosphatase 1, regulatory (inhibitor) subunit 12C	0.013
IL2RB	interleukin 2 receptor, beta	0.012
CHD7	chromodomain helicase DNA binding protein 7	0.012
NKG7	natural killer cell group 7 sequence	0.012
OCLN	occludin	0.012
MEF2A	myocyte enhancer factor 2A	0.012
ZNF576	zinc finger protein 576	0.012
HOXD12	homeobox D12	0.012
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.012
NOTCH3	notch 3	0.012
TF	transferrin	0.012
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.012
AHNAK	AHNAK nucleoprotein	0.012
SIX3	SIX homeobox 3	0.012
DLX4	distal-less homeobox 4	0.012
NPTN	neuroplastin	0.012
GCM2	glial cells missing homolog 2 (Drosophila)	0.012
SMAD4	SMAD family member 4	0.012
TLX1	T-cell leukemia homeobox 1	0.012
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.012
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
SOX1	SRY (sex determining region Y)-box 1	0.011
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.011
IFNG	interferon, gamma	0.011
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.011
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.011
ANXA5	annexin A5	0.011
PYY	peptide YY	0.011
LAMB1	laminin, beta 1	0.011
IL24	interleukin 24	0.011
SDC2	syndecan 2	0.011
PER1	period homolog 1 (Drosophila)	0.011
NGFR	nerve growth factor receptor	0.011
EFNA1	ephrin-A1	0.011
CD8A	CD8a molecule	0.011
TRIM28	tripartite motif containing 28	0.011
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.011
SOX4	SRY (sex determining region Y)-box 4	0.011
FOXO1	forkhead box O1	0.011
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.011
NT5C1A	5'-nucleotidase, cytosolic IA	0.011
CD7	CD7 molecule	0.011
MCAM	melanoma cell adhesion molecule	0.011
VCL	vinculin	0.011
AP3D1	adaptor-related protein complex 3, delta 1 subunit	0.011
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.011
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.011
FAM110A	family with sequence similarity 110, member A	0.011
ARRDC3	arrestin domain containing 3	0.011
SOX13	SRY (sex determining region Y)-box 13	0.011
CLIC4	chloride intracellular channel 4	0.011
MDC1	mediator of DNA-damage checkpoint 1	0.011
APCS	amyloid P component, serum	0.011
PGCP	plasma glutamate carboxypeptidase	0.011
DLL4	delta-like 4 (Drosophila)	0.011
HOXD11	homeobox D11	0.011
FOXF1	forkhead box F1	0.011
PRDM8	PR domain containing 8	0.011
STK11	serine/threonine kinase 11	0.011
HES2	hairy and enhancer of split 2 (Drosophila)	0.011
FYN	FYN oncogene related to SRC, FGR, YES	0.010
NTN1	netrin 1	0.010
HIC1	hypermethylated in cancer 1	0.010
GNLY	granulysin	0.010
IRX5	iroquois homeobox 5	0.010
TAOK1	TAO kinase 1	0.010
EPHA2	EPH receptor A2	0.010
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.010
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.010
ACY3	aspartoacylase (aminocyclase) 3	0.010
TGFB3	transforming growth factor, beta 3	0.010
STRADA	STE20-related kinase adaptor alpha	0.010
GBX1	gastrulation brain homeobox 1	0.010
PROS1	protein S (alpha)	0.010
TIMP3	TIMP metallopeptidase inhibitor 3	0.010
LSR	lipolysis stimulated lipoprotein receptor	0.010
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.010
PDLIM5	PDZ and LIM domain 5	0.010
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.010
CD160	CD160 molecule	0.010
HOXC10	homeobox C10	0.010
MYF6	myogenic factor 6 (herculin)	0.010
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.010
SCUBE3	signal peptide, CUB domain, EGF-like 3	0.010