IMP

Process View

Homo sapiens

3 genes annotated in human

negative regulation of posttranscriptional gene silencing

Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of posttranscriptional gene silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of posttranscriptional gene silencing" (in gray)

Name	Description	Probability	Func Analog Organism
FOXD3	forkhead box D3	1.000
SP1	Sp1 transcription factor	0.999
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.997
PAX3	paired box 3	0.995
SOX10	SRY (sex determining region Y)-box 10	0.992
SOX2	SRY (sex determining region Y)-box 2	0.972
HCFC1	host cell factor C1 (VP16-accessory protein)	0.875
DAZL	deleted in azoospermia-like	0.840
PUM2	pumilio homolog 2 (Drosophila)	0.768
CSNK2B	casein kinase 2, beta polypeptide	0.749
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.595
EXOSC10	exosome component 10	0.535
HTT	huntingtin	0.502
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.467
TARDBP	TAR DNA binding protein	0.329
MOCS3	molybdenum cofactor synthesis 3	0.323
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.294
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.227
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.181
MEOX2	mesenchyme homeobox 2	0.138
CUL1	cullin 1	0.126
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.124
SOX21	SRY (sex determining region Y)-box 21	0.121
DTX3L	deltex 3-like (Drosophila)	0.108
FTSJD2	FtsJ methyltransferase domain containing 2	0.103
SOX11	SRY (sex determining region Y)-box 11	0.091
POGZ	pogo transposable element with ZNF domain	0.089
SMAD7	SMAD family member 7	0.072
HOXD12	homeobox D12	0.069
SOX1	SRY (sex determining region Y)-box 1	0.065
NOVA2	neuro-oncological ventral antigen 2	0.062
SH3RF3	SH3 domain containing ring finger 3	0.059
ESR2	estrogen receptor 2 (ER beta)	0.057
HMGA1	high mobility group AT-hook 1	0.057
POU3F2	POU class 3 homeobox 2	0.056	Human
UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	0.054
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.050
OLIG2	oligodendrocyte lineage transcription factor 2	0.048
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.048
CHN2	chimerin (chimaerin) 2	0.047
OTP	orthopedia homeobox	0.044
TOP1	topoisomerase (DNA) I	0.043
SH3RF1	SH3 domain containing ring finger 1	0.042
ADARB1	adenosine deaminase, RNA-specific, B1	0.041
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.040
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.040
PDLIM7	PDZ and LIM domain 7 (enigma)	0.039
MEX3B	mex-3 homolog B (C. elegans)	0.038
LHX1	LIM homeobox 1	0.038
POU3F3	POU class 3 homeobox 3	0.037	Human
CHD8	chromodomain helicase DNA binding protein 8	0.037
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.037
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.036
NKX2-1	NK2 homeobox 1	0.035
ATF7IP	activating transcription factor 7 interacting protein	0.035
FHOD1	formin homology 2 domain containing 1	0.034
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.034
XIAP	X-linked inhibitor of apoptosis	0.034
XPO7	exportin 7	0.033
POU4F1	POU class 4 homeobox 1	0.032	Human
NEUROG3	neurogenin 3	0.031
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.030
DZIP1	DAZ interacting protein 1	0.029
GRIP1	glutamate receptor interacting protein 1	0.028
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.027
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.025
DICER1	dicer 1, ribonuclease type III	0.025
ESR1	estrogen receptor 1	0.025
POU3F4	POU class 3 homeobox 4	0.023	Human
OCRL	oculocerebrorenal syndrome of Lowe	0.023
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.023
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.022
RAX	retina and anterior neural fold homeobox	0.022
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.022
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.021
TLX2	T-cell leukemia homeobox 2	0.021
NPAS1	neuronal PAS domain protein 1	0.021
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.020
POU3F1	POU class 3 homeobox 1	0.020	Human
KPNA6	karyopherin alpha 6 (importin alpha 7)	0.020
C10orf46	chromosome 10 open reading frame 46	0.019
NKX6-1	NK6 homeobox 1	0.019
DIDO1	death inducer-obliterator 1	0.019
GATA5	GATA binding protein 5	0.019
PURB	purine-rich element binding protein B	0.019
RNF114	ring finger protein 114	0.018
TP73	tumor protein p73	0.018
PRMT2	protein arginine methyltransferase 2	0.018
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.018
GALR1	galanin receptor 1	0.018
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.018
ZBTB17	zinc finger and BTB domain containing 17	0.017
MTA2	metastasis associated 1 family, member 2	0.017
ARFIP2	ADP-ribosylation factor interacting protein 2	0.017
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.017
POU4F2	POU class 4 homeobox 2	0.017	Human
ZNF143	zinc finger protein 143	0.017
NHLH2	nescient helix loop helix 2	0.016
FLNB	filamin B, beta	0.016
LILRA4	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	0.016
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.016
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.016
SOX3	SRY (sex determining region Y)-box 3	0.016
SP3	Sp3 transcription factor	0.015
NKX2-8	NK2 homeobox 8	0.015
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.015
TRIM26	tripartite motif containing 26	0.015
GSC2	goosecoid homeobox 2	0.015
COMT	catechol-O-methyltransferase	0.015
DCX	doublecortin	0.015
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.015
ISL1	ISL LIM homeobox 1	0.015
DRD4	dopamine receptor D4	0.015
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.015
HOXB7	homeobox B7	0.014
FBXL15	F-box and leucine-rich repeat protein 15	0.014
PAX2	paired box 2	0.014
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.014
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.014
GCM2	glial cells missing homolog 2 (Drosophila)	0.014
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.014
NEUROD1	neurogenic differentiation 1	0.014
IRX4	iroquois homeobox 4	0.014
YTHDF1	YTH domain family, member 1	0.014
FGF3	fibroblast growth factor 3	0.014
PGR	progesterone receptor	0.014
DPPA4	developmental pluripotency associated 4	0.014
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.014
PPP5C	protein phosphatase 5, catalytic subunit	0.014
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.014
NELL1	NEL-like 1 (chicken)	0.014
CD22	CD22 molecule	0.014
MTA3	metastasis associated 1 family, member 3	0.014
NFYC	nuclear transcription factor Y, gamma	0.014
MLL2	myeloid/lymphoid or mixed-lineage leukemia 2	0.014
PAX5	paired box 5	0.013
PAX6	paired box 6	0.013
SETD1A	SET domain containing 1A	0.013
NCKAP1	NCK-associated protein 1	0.013
SFRP5	secreted frizzled-related protein 5	0.013
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.013
DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	0.013
HIC1	hypermethylated in cancer 1	0.013
FOXA2	forkhead box A2	0.013
SALL3	sal-like 3 (Drosophila)	0.013
SSTR5	somatostatin receptor 5	0.013
TRIM39	tripartite motif containing 39	0.013
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.013
S1PR4	sphingosine-1-phosphate receptor 4	0.013
NFYA	nuclear transcription factor Y, alpha	0.013
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
GDI2	GDP dissociation inhibitor 2	0.013
RNF4	ring finger protein 4	0.013
PITX2	paired-like homeodomain 2	0.012
FGF20	fibroblast growth factor 20	0.012
MKRN1	makorin ring finger protein 1	0.012
SALL2	sal-like 2 (Drosophila)	0.012
GBX2	gastrulation brain homeobox 2	0.012
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.012
NEUROD2	neurogenic differentiation 2	0.012
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.012
SIX6	SIX homeobox 6	0.012
TLX1	T-cell leukemia homeobox 1	0.012
VSX1	visual system homeobox 1	0.012
ZNF157	zinc finger protein 157	0.012
NCOR2	nuclear receptor corepressor 2	0.012
HOXB13	homeobox B13	0.012
VRTN	vertebrae development homolog (pig)	0.012
ELF1	E74-like factor 1 (ets domain transcription factor)	0.012
MAGEB4	melanoma antigen family B, 4	0.012
LHX5	LIM homeobox 5	0.012
PDX1	pancreatic and duodenal homeobox 1	0.012
GJD2	gap junction protein, delta 2, 36kDa	0.012
SIX2	SIX homeobox 2	0.011
FOXG1	forkhead box G1	0.011
RAG1	recombination activating gene 1	0.011
ADRB1	adrenergic, beta-1-, receptor	0.011
FGF8	fibroblast growth factor 8 (androgen-induced)	0.011
DSPP	dentin sialophosphoprotein	0.011
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.011
WDR48	WD repeat domain 48	0.011
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.011	Worm
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
ELAVL2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.011
VAX2	ventral anterior homeobox 2	0.011
B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	0.011
HES2	hairy and enhancer of split 2 (Drosophila)	0.011
HOXD3	homeobox D3	0.011
BARX1	BARX homeobox 1	0.011
EYA1	eyes absent homolog 1 (Drosophila)	0.011
CRHR2	corticotropin releasing hormone receptor 2	0.011
CASC3	cancer susceptibility candidate 3	0.011
HOXC4	homeobox C4	0.011
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.010
KIF5C	kinesin family member 5C	0.010
PNOC	prepronociceptin	0.010
OSBP	oxysterol binding protein	0.010
APC2	adenomatosis polyposis coli 2	0.010
EXOC2	exocyst complex component 2	0.010
EVX1	even-skipped homeobox 1	0.010
NHLH1	nescient helix loop helix 1	0.010
ZNF346	zinc finger protein 346	0.010
ASCL2	achaete-scute complex homolog 2 (Drosophila)	0.010
DLX2	distal-less homeobox 2	0.010
HAND2	heart and neural crest derivatives expressed 2	0.010