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Homo sapiens

32 genes annotated in human

dilated cardiomyopathy

DOID:12930

An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dilated cardiomyopathy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dilated cardiomyopathy" (in gray)

Name	Description	Probability	Func Analog Organism
TRIM63	tripartite motif containing 63	0.999
FLNC	filamin C, gamma	0.997
HSPB8	heat shock 22kDa protein 8	0.985	Human
HSPB1	heat shock 27kDa protein 1	0.983
HSPB2	heat shock 27kDa protein 2	0.967	Human
FLNB	filamin B, beta	0.960
NEB	nebulin	0.959
TNNI1	troponin I type 1 (skeletal, slow)	0.940	Human
ACTN2	actinin, alpha 2	0.918
TPM2	tropomyosin 2 (beta)	0.876	Human
PSEN2	presenilin 2 (Alzheimer disease 4)	0.830
TTN	titin	0.764
DTNA	dystrobrevin, alpha	0.739
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.591
MYOZ1	myozenin 1	0.581
ACTA1	actin, alpha 1, skeletal muscle	0.564	Human
BCL2L1	BCL2-like 1	0.564
PSEN1	presenilin 1	0.548
FLNA	filamin A, alpha	0.532
TNNT2	troponin T type 2 (cardiac)	0.406
TNNI2	troponin I type 2 (skeletal, fast)	0.387	Human
TRIP6	thyroid hormone receptor interactor 6	0.349
SNTG2	syntrophin, gamma 2	0.329
NCSTN	nicastrin	0.324
TCAP	titin-cap (telethonin)	0.318
FHL2	four and a half LIM domains 2	0.276
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.250
TNNT1	troponin T type 1 (skeletal, slow)	0.248	Human
PKP4	plakophilin 4	0.228
MYOZ2	myozenin 2	0.226
BAG3	BCL2-associated athanogene 3	0.215
PTN	pleiotrophin	0.210
CNN1	calponin 1, basic, smooth muscle	0.203
TNNC1	troponin C type 1 (slow)	0.181
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.176
HSPA1B	heat shock 70kDa protein 1B	0.166
SYNM	synemin, intermediate filament protein	0.125	Human
ACTA2	actin, alpha 2, smooth muscle, aorta	0.124	Human
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.108
TNNI3K	TNNI3 interacting kinase	0.106
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.106
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.105
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.105
TNNT3	troponin T type 3 (skeletal, fast)	0.102	Human
ACTN1	actinin, alpha 1	0.097
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.095
MRPL41	mitochondrial ribosomal protein L41	0.095
LMCD1	LIM and cysteine-rich domains 1	0.088
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.087
CRYAB	crystallin, alpha B	0.084
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.082
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.070
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.068	Human
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.067
MYL9	myosin, light chain 9, regulatory	0.067
CAPN3	calpain 3, (p94)	0.065
CALD1	caldesmon 1	0.064
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.063	Human
ZHX1	zinc fingers and homeoboxes 1	0.063
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.060
CASQ2	calsequestrin 2 (cardiac muscle)	0.060
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.060
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.059
CIB1	calcium and integrin binding 1 (calmyrin)	0.058
SMPX	small muscle protein, X-linked	0.056
MYOM1	myomesin 1, 185kDa	0.056
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.055
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.054
MYH9	myosin, heavy chain 9, non-muscle	0.054
GFM1	G elongation factor, mitochondrial 1	0.051
TAGLN	transgelin	0.050
APP	amyloid beta (A4) precursor protein	0.048
TNNI3	troponin I type 3 (cardiac)	0.047
HSPB3	heat shock 27kDa protein 3	0.047	Human
ANK1	ankyrin 1, erythrocytic	0.045
UTRN	utrophin	0.043	Human
ZKSCAN1	zinc finger with KRAB and SCAN domains 1	0.040
ILK	integrin-linked kinase	0.039
DTNB	dystrobrevin, beta	0.038
SRI	sorcin	0.037
MAP2K1	mitogen-activated protein kinase kinase 1	0.037
OBSL1	obscurin-like 1	0.037
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.036	Human
CKM	creatine kinase, muscle	0.036
DES	desmin	0.035
BAG1	BCL2-associated athanogene	0.035
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.035
SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	0.033
MYH11	myosin, heavy chain 11, smooth muscle	0.033
FN1	fibronectin 1	0.032
HSPA1A	heat shock 70kDa protein 1A	0.031
SYNPO2	synaptopodin 2	0.030
ALB	albumin	0.030
MYBPC1	myosin binding protein C, slow type	0.030
MYOT	myotilin	0.029
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.029
TUBB6	tubulin, beta 6	0.028
PKD2L1	polycystic kidney disease 2-like 1	0.028
MYOD1	myogenic differentiation 1	0.026
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.025
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.025
TRIM54	tripartite motif containing 54	0.025
SORBS1	sorbin and SH3 domain containing 1	0.025
PTRF	polymerase I and transcript release factor	0.025
JUP	junction plakoglobin	0.025
PYGM	phosphorylase, glycogen, muscle	0.024
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.024
MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	0.024	Human
LDB3	LIM domain binding 3	0.024
SORBS2	sorbin and SH3 domain containing 2	0.024
FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	0.023
DCAF6	DDB1 and CUL4 associated factor 6	0.023
MYLK	myosin light chain kinase	0.023
CSRP1	cysteine and glycine-rich protein 1	0.023	Human
MYH1	myosin, heavy chain 1, skeletal muscle, adult	0.023	Human
NDUFV1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	0.023
KRT18	keratin 18	0.022
MYL1	myosin, light chain 1, alkali; skeletal, fast	0.022
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.022
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.022
TRIM55	tripartite motif containing 55	0.021
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.021
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.021
SLN	sarcolipin	0.021
ACTC1	actin, alpha, cardiac muscle 1	0.021
ARL15	ADP-ribosylation factor-like 15	0.021
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.021
TMEM47	transmembrane protein 47	0.020
PXN	paxillin	0.020
ANK2	ankyrin 2, neuronal	0.020
CTNND1	catenin (cadherin-associated protein), delta 1	0.020
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.020
FBLIM1	filamin binding LIM protein 1	0.020
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.020
FHL1	four and a half LIM domains 1	0.020
HSF1	heat shock transcription factor 1	0.020
PDLIM3	PDZ and LIM domain 3	0.020	Human
ANXA3	annexin A3	0.019
MYBPC2	myosin binding protein C, fast type	0.019
TUBA1A	tubulin, alpha 1a	0.019
TPM4	tropomyosin 4	0.019	Human
DSP	desmoplakin	0.019
TRIM32	tripartite motif containing 32	0.019
ALPK3	alpha-kinase 3	0.019
GNG11	guanine nucleotide binding protein (G protein), gamma 11	0.019
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.019
ITGA7	integrin, alpha 7	0.019
CASQ1	calsequestrin 1 (fast-twitch, skeletal muscle)	0.019
PRRX1	paired related homeobox 1	0.019
FGF7	fibroblast growth factor 7	0.019
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.019
PKP2	plakophilin 2	0.018
CAV3	caveolin 3	0.018
DAAM2	dishevelled associated activator of morphogenesis 2	0.018
SYNPO2L	synaptopodin 2-like	0.018
WDR1	WD repeat domain 1	0.018
CNN2	calponin 2	0.018
ANXA2	annexin A2	0.018
TGFB2	transforming growth factor, beta 2	0.018
HOXA1	homeobox A1	0.017
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.017
TUBB2A	tubulin, beta 2A	0.017
STX16	syntaxin 16	0.017
MYOM2	myomesin (M-protein) 2, 165kDa	0.017
SVIL	supervillin	0.017
UBQLN1	ubiquilin 1	0.017
AHNAK	AHNAK nucleoprotein	0.017
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.017
ACTG2	actin, gamma 2, smooth muscle, enteric	0.017	Human
ENO3	enolase 3 (beta, muscle)	0.017
EEF1G	eukaryotic translation elongation factor 1 gamma	0.016
TNNC2	troponin C type 2 (fast)	0.016	Human
GMEB1	glucocorticoid modulatory element binding protein 1	0.016
TPD52L1	tumor protein D52-like 1	0.016
TRAF6	TNF receptor-associated factor 6	0.016
CRYAA	crystallin, alpha A	0.016	Human
TP53BP1	tumor protein p53 binding protein 1	0.016
ANGPTL2	angiopoietin-like 2	0.016
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.016
MFAP5	microfibrillar associated protein 5	0.015
GSN	gelsolin	0.015
ATXN3	ataxin 3	0.015
GSK3B	glycogen synthase kinase 3 beta	0.015
PEBP1	phosphatidylethanolamine binding protein 1	0.015
RBMS3	RNA binding motif, single stranded interacting protein 3	0.015
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.015
ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	0.015
DIO2	deiodinase, iodothyronine, type II	0.015
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.014
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.014
MRAS	muscle RAS oncogene homolog	0.014
ZFPM2	zinc finger protein, multitype 2	0.014
DFNA5	deafness, autosomal dominant 5	0.014
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.014
MYBPH	myosin binding protein H	0.014
PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.014
PDLIM1	PDZ and LIM domain 1	0.013	Human
FHOD3	formin homology 2 domain containing 3	0.013
MYF5	myogenic factor 5	0.013
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.013
LMOD1	leiomodin 1 (smooth muscle)	0.013
NCAM1	neural cell adhesion molecule 1	0.013
PCDHA4	protocadherin alpha 4	0.013
HIST2H3C	histone cluster 2, H3c	0.013
SNCAIP	synuclein, alpha interacting protein	0.013
GIPC2	GIPC PDZ domain containing family, member 2	0.013
EMD	emerin	0.013
PGM5	phosphoglucomutase 5	0.013
BCHE	butyrylcholinesterase	0.013
CKMT2	creatine kinase, mitochondrial 2 (sarcomeric)	0.013
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.013
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.013	Human
FHL3	four and a half LIM domains 3	0.012
RAP1A	RAP1A, member of RAS oncogene family	0.012
COX7A1	cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)	0.012
IGFBP5	insulin-like growth factor binding protein 5	0.012
PRKG1	protein kinase, cGMP-dependent, type I	0.012
ITGB5	integrin, beta 5	0.012
NOMO1	NODAL modulator 1	0.012
MYH2	myosin, heavy chain 2, skeletal muscle, adult	0.012	Human
APH1B	anterior pharynx defective 1 homolog B (C. elegans)	0.012
MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2	0.012
FAM176A	family with sequence similarity 176, member A	0.012
MED31	mediator complex subunit 31	0.012
PMF1	polyamine-modulated factor 1	0.012
KCNJ8	potassium inwardly-rectifying channel, subfamily J, member 8	0.012
HSPA2	heat shock 70kDa protein 2	0.012
SCN7A	sodium channel, voltage-gated, type VII, alpha	0.012
BAD	BCL2-associated agonist of cell death	0.012
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.012
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.012
SRPK3	SRSF protein kinase 3	0.012
APOD	apolipoprotein D	0.012
PALMD	palmdelphin	0.012
PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A	0.012
ACTN4	actinin, alpha 4	0.012
MYH8	myosin, heavy chain 8, skeletal muscle, perinatal	0.012	Human
PGAM2	phosphoglycerate mutase 2 (muscle)	0.011
NLRP2	NLR family, pyrin domain containing 2	0.011
ALOX12	arachidonate 12-lipoxygenase	0.011
MITF	microphthalmia-associated transcription factor	0.011
ECSIT	ECSIT homolog (Drosophila)	0.011
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.011
XIRP1	xin actin-binding repeat containing 1	0.011
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.011
OGN	osteoglycin	0.011
FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	0.011
ENDOD1	endonuclease domain containing 1	0.011
MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.011
MYOG	myogenin (myogenic factor 4)	0.011
ACTB	actin, beta	0.011	Human
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	0.011
GAS2L1	growth arrest-specific 2 like 1	0.011
CDH13	cadherin 13, H-cadherin (heart)	0.011
PALLD	palladin, cytoskeletal associated protein	0.011
RERGL	RERG/RAS-like	0.011
MYOF	myoferlin	0.011
CA3	carbonic anhydrase III, muscle specific	0.011
STC2	stanniocalcin 2	0.011
PLN	phospholamban	0.011
ACADL	acyl-CoA dehydrogenase, long chain	0.011
FYCO1	FYVE and coiled-coil domain containing 1	0.011
CDH10	cadherin 10, type 2 (T2-cadherin)	0.010
PARP3	poly (ADP-ribose) polymerase family, member 3	0.010
RRAD	Ras-related associated with diabetes	0.010
TSPAN2	tetraspanin 2	0.010
AKAP12	A kinase (PRKA) anchor protein 12	0.010
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.010
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.010
RHOJ	ras homolog gene family, member J	0.010
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.010
TMEM168	transmembrane protein 168	0.010
DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.010
ACO2	aconitase 2, mitochondrial	0.010
PLA2G16	phospholipase A2, group XVI	0.010
MAP4	microtubule-associated protein 4	0.010
HK2	hexokinase 2	0.010
NEXN	nexilin (F actin binding protein)	0.010
DMD	dystrophin	0.008
EYA4	eyes absent homolog 4 (Drosophila)	0.007
DSG2	desmoglein 2	0.006
RBM20	RNA binding motif protein 20	0.005
LAMA4	laminin, alpha 4	0.005
ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	0.005
GATAD1	GATA zinc finger domain containing 1	0.005
FKTN	fukutin	0.004
SCN5A	sodium channel, voltage-gated, type V, alpha subunit	0.004
TPM1	tropomyosin 1 (alpha)	0.002
VCL	vinculin	0.002
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.002
LMNA	lamin A/C	0.002
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.001
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.001