IMP

Process View

Homo sapiens

24 genes annotated in human

positive regulation of autophagy

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of autophagy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of autophagy" (in gray)

Name	Description	Probability	Func Analog Organism
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.997
SQSTM1	sequestosome 1	0.992
GABARAP	GABA(A) receptor-associated protein	0.987
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	0.985
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.981
CREBBP	CREB binding protein	0.971
TSC2	tuberous sclerosis 2	0.929	Fly
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.841
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.837
ATG5	ATG5 autophagy related 5 homolog (S. cerevisiae)	0.672
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.642
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.566
AR	androgen receptor	0.490
TRIM63	tripartite motif containing 63	0.465	Human
KAT2B	K(lysine) acetyltransferase 2B	0.381
JUN	jun proto-oncogene	0.365
GFM1	G elongation factor, mitochondrial 1	0.322
ULK1	unc-51-like kinase 1 (C. elegans)	0.313
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.272
NBR1	neighbor of BRCA1 gene 1	0.234
SCHIP1	schwannomin interacting protein 1	0.224
RB1CC1	RB1-inducible coiled-coil 1	0.212
FOXO3	forkhead box O3	0.201	Human
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.185
IRAK2	interleukin-1 receptor-associated kinase 2	0.182
MAPK8	mitogen-activated protein kinase 8	0.173	Fly
TSC1	tuberous sclerosis 1	0.170	Fly
BAD	BCL2-associated agonist of cell death	0.167
NCOA1	nuclear receptor coactivator 1	0.167
GABARAPL1	GABA(A) receptor-associated protein like 1	0.160
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.155
S100B	S100 calcium binding protein B	0.140
NCOA2	nuclear receptor coactivator 2	0.136
AMBRA1	autophagy/beclin-1 regulator 1	0.115
TFRC	transferrin receptor (p90, CD71)	0.111
ARNT	aryl hydrocarbon receptor nuclear translocator	0.110
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.109
ACACA	acetyl-CoA carboxylase alpha	0.107
ATG16L1	ATG16 autophagy related 16-like 1 (S. cerevisiae)	0.104
ARRB1	arrestin, beta 1	0.093
MRPL41	mitochondrial ribosomal protein L41	0.086
EP300	E1A binding protein p300	0.081
OTUD6B	OTU domain containing 6B	0.080
FOXO1	forkhead box O1	0.078
TTN	titin	0.075
EGLN1	egl nine homolog 1 (C. elegans)	0.070
SESN2	sestrin 2	0.068
COASY	CoA synthase	0.064
PINK1	PTEN induced putative kinase 1	0.064
NCOA6	nuclear receptor coactivator 6	0.064
DAPK1	death-associated protein kinase 1	0.063
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.060
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.053
VHL	von Hippel-Lindau tumor suppressor	0.049
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.049
PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.048
SIRT1	sirtuin 1	0.047
ATG14	ATG14 autophagy related 14 homolog (S. cerevisiae)	0.045
NEB	nebulin	0.045
EGLN3	egl nine homolog 3 (C. elegans)	0.044
ACTA1	actin, alpha 1, skeletal muscle	0.044
RUNX1	runt-related transcription factor 1	0.039
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.038
HDAC5	histone deacetylase 5	0.038
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.036
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.035
MBIP	MAP3K12 binding inhibitory protein 1	0.035
CIZ1	CDKN1A interacting zinc finger protein 1	0.035
PIK3C3	phosphoinositide-3-kinase, class 3	0.035
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.035
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.033
TP53BP2	tumor protein p53 binding protein, 2	0.033
CHIC2	cysteine-rich hydrophobic domain 2	0.032
SREBF2	sterol regulatory element binding transcription factor 2	0.031
TNNT1	troponin T type 1 (skeletal, slow)	0.031
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.030
SMAD3	SMAD family member 3	0.030
EEF1G	eukaryotic translation elongation factor 1 gamma	0.030
BCL2L1	BCL2-like 1	0.029
BCL2	B-cell CLL/lymphoma 2	0.028
IRS2	insulin receptor substrate 2	0.026
HDAC4	histone deacetylase 4	0.026
KDM2A	lysine (K)-specific demethylase 2A	0.026
STBD1	starch binding domain 1	0.025
CRTC2	CREB regulated transcription coactivator 2	0.024
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.024
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.024
FAM190B	family with sequence similarity 190, member B	0.024
MYOZ1	myozenin 1	0.023
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.023
EXOC8	exocyst complex component 8	0.023
OPTN	optineurin	0.023
IRF3	interferon regulatory factor 3	0.023
TCAP	titin-cap (telethonin)	0.022
ZFYVE1	zinc finger, FYVE domain containing 1	0.021
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.021
FNIP1	folliculin interacting protein 1	0.021
UVRAG	UV radiation resistance associated gene	0.021
NF2	neurofibromin 2 (merlin)	0.020
DAZAP2	DAZ associated protein 2	0.020
ZFYVE9	zinc finger, FYVE domain containing 9	0.020
TP53	tumor protein p53	0.020	Fly
ATF2	activating transcription factor 2	0.019
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.019
GPBP1L1	GC-rich promoter binding protein 1-like 1	0.019
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.019
CALCOCO2	calcium binding and coiled-coil domain 2	0.019
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.019
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.019
DDIT3	DNA-damage-inducible transcript 3	0.019
MAP1B	microtubule-associated protein 1B	0.018
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.018
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.017
MEAF6	MYST/Esa1-associated factor 6	0.017
BIK	BCL2-interacting killer (apoptosis-inducing)	0.017
PDPK1	3-phosphoinositide dependent protein kinase-1	0.017
LRP6	low density lipoprotein receptor-related protein 6	0.017
RCN2	reticulocalbin 2, EF-hand calcium binding domain	0.017
ATF3	activating transcription factor 3	0.017
DES	desmin	0.017
LNX1	ligand of numb-protein X 1	0.017
DIXDC1	DIX domain containing 1	0.017
TRIP10	thyroid hormone receptor interactor 10	0.016
GBAS	glioblastoma amplified sequence	0.016
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.016
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.016
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.016
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.016
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.016
YY1	YY1 transcription factor	0.015
CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	0.015
ATG10	ATG10 autophagy related 10 homolog (S. cerevisiae)	0.015
C4orf14	chromosome 4 open reading frame 14	0.015
KBTBD7	kelch repeat and BTB (POZ) domain containing 7	0.015
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	0.015
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.015
IRF2	interferon regulatory factor 2	0.015
SPAG9	sperm associated antigen 9	0.015
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.015
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.015
TJP2	tight junction protein 2 (zona occludens 2)	0.014
WASH1	WAS protein family homolog 1	0.014
MAPK14	mitogen-activated protein kinase 14	0.014
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.014
RAB5B	RAB5B, member RAS oncogene family	0.014
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.014
SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)	0.014
MKRN1	makorin ring finger protein 1	0.014
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.014
C18orf32	chromosome 18 open reading frame 32	0.014
CHMP7	CHMP family, member 7	0.014
GDI1	GDP dissociation inhibitor 1	0.014
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.014
EPAS1	endothelial PAS domain protein 1	0.014	Fly
KLF13	Kruppel-like factor 13	0.013
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.013
BECN1	beclin 1, autophagy related	0.013	Mouse
SETDB1	SET domain, bifurcated 1	0.013
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.013
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.013
DEDD	death effector domain containing	0.013
FAM82A2	family with sequence similarity 82, member A2	0.013
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.013
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.013
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.013
MYD88	myeloid differentiation primary response gene (88)	0.012
FLNC	filamin C, gamma	0.012
S100A1	S100 calcium binding protein A1	0.012
ZNF32	zinc finger protein 32	0.012
WBP2	WW domain binding protein 2	0.012
LMBRD1	LMBR1 domain containing 1	0.012
IKZF5	IKAROS family zinc finger 5 (Pegasus)	0.012
ZFYVE26	zinc finger, FYVE domain containing 26	0.012
EEF2K	eukaryotic elongation factor-2 kinase	0.012
PRKCZ	protein kinase C, zeta	0.012
RICTOR	RPTOR independent companion of MTOR, complex 2	0.012
STAT5A	signal transducer and activator of transcription 5A	0.012
LDLR	low density lipoprotein receptor	0.012
OGFOD2	2-oxoglutarate and iron-dependent oxygenase domain containing 2	0.012
SDCBP2	syndecan binding protein (syntenin) 2	0.012
PI4KB	phosphatidylinositol 4-kinase, catalytic, beta	0.012
KEAP1	kelch-like ECH-associated protein 1	0.012
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.012
NCKAP1	NCK-associated protein 1	0.012
ACTN2	actinin, alpha 2	0.012
NOMO1	NODAL modulator 1	0.011
FHL2	four and a half LIM domains 2	0.011
UNC119	unc-119 homolog (C. elegans)	0.011
ITM2B	integral membrane protein 2B	0.011
TRIM55	tripartite motif containing 55	0.011	Human
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.011
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011
BBC3	BCL2 binding component 3	0.011
BEND7	BEN domain containing 7	0.011
SEC24C	SEC24 family, member C (S. cerevisiae)	0.011
SRCAP	Snf2-related CREBBP activator protein	0.011
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.011
CDKN2AIP	CDKN2A interacting protein	0.011
TRAF6	TNF receptor-associated factor 6	0.011
TBC1D25	TBC1 domain family, member 25	0.011
GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	0.011
ZBTB37	zinc finger and BTB domain containing 37	0.011
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.010
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.010
C10orf54	chromosome 10 open reading frame 54	0.010
KIAA0930	KIAA0930	0.010
ZEB2	zinc finger E-box binding homeobox 2	0.010
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.010
XPO7	exportin 7	0.010
FAM134A	family with sequence similarity 134, member A	0.010
TTR	transthyretin	0.010