IMP

Process View

Homo sapiens

9 genes annotated in human

dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest" (in gray)

Name	Description	Probability	Func Analog Organism
XIAP	X-linked inhibitor of apoptosis	0.998
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.992	Human
RB1	retinoblastoma 1	0.979
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.979
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.974	Human
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.964
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.900
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.829
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.750
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.729	Human
APAF1	apoptotic peptidase activating factor 1	0.716
FAS	Fas (TNF receptor superfamily, member 6)	0.708
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.658
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.636
BCL2	B-cell CLL/lymphoma 2	0.579
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.554	Human
POU3F2	POU class 3 homeobox 2	0.533
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.395
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.318
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.299
FADD	Fas (TNFRSF6)-associated via death domain	0.276
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.258
CFLAR	CASP8 and FADD-like apoptosis regulator	0.228
TP53	tumor protein p53	0.193	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.177	Human
LRDD	leucine-rich repeats and death domain containing	0.165
POU5F1	POU class 5 homeobox 1	0.139
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.126
SMAD7	SMAD family member 7	0.124
IER3	immediate early response 3	0.118
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.113	Human
NLRC4	NLR family, CARD domain containing 4	0.110
RIPK2	receptor-interacting serine-threonine kinase 2	0.095
FASLG	Fas ligand (TNF superfamily, member 6)	0.094
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.089
CCND1	cyclin D1	0.088
CDK2	cyclin-dependent kinase 2	0.085
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.069
PAX3	paired box 3	0.067
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.052	Human
BIRC2	baculoviral IAP repeat containing 2	0.051
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.046	Human
DAXX	death-domain associated protein	0.042
CCND3	cyclin D3	0.040
ELF4	E74-like factor 4 (ets domain transcription factor)	0.036
CDK6	cyclin-dependent kinase 6	0.033
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.031	Human
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.030	Human
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.025
RBL2	retinoblastoma-like 2 (p130)	0.023
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.022
MAPK1	mitogen-activated protein kinase 1	0.020
TGIF1	TGFB-induced factor homeobox 1	0.020
FOXD3	forkhead box D3	0.020
CCNE1	cyclin E1	0.020
DZIP1	DAZ interacting protein 1	0.018
HDAC4	histone deacetylase 4	0.017
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.017
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.017
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.017
IFI16	interferon, gamma-inducible protein 16	0.016
NUCB2	nucleobindin 2	0.014
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.012
MARCKSL1	MARCKS-like 1	0.012
NOTCH1	notch 1	0.012
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.010
PLSCR1	phospholipid scramblase 1	0.010