IMP

Process View

Homo sapiens

21 genes annotated in human

myoblast differentiation

The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "myoblast differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "myoblast differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
SRF	serum response factor (c-fos serum response element-binding transcription factor)	1.000
RB1	retinoblastoma 1	0.976
NOTCH1	notch 1	0.970
TTN	titin	0.950
JAG1	jagged 1	0.925
E2F1	E2F transcription factor 1	0.589
HDAC4	histone deacetylase 4	0.508
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.494	Mouse
JUN	jun proto-oncogene	0.488
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.446
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.409
ATF2	activating transcription factor 2	0.358
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.308
MYH7B	myosin, heavy chain 7B, cardiac muscle, beta	0.264
BMPR1A	bone morphogenetic protein receptor, type IA	0.241
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.237
TCF4	transcription factor 4	0.167
CNOT8	CCR4-NOT transcription complex, subunit 8	0.156
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.143	Rat
CREBBP	CREB binding protein	0.133
NOTCH3	notch 3	0.131	Human
ATF3	activating transcription factor 3	0.130
INO80B	INO80 complex subunit B	0.127
FBLN1	fibulin 1	0.121
DUSP1	dual specificity phosphatase 1	0.119
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.106
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.103
OBSL1	obscurin-like 1	0.100
ITGB1BP3	integrin beta 1 binding protein 3	0.096
EGLN3	egl nine homolog 3 (C. elegans)	0.077
PARVA	parvin, alpha	0.062
DLL1	delta-like 1 (Drosophila)	0.061
MKL1	megakaryoblastic leukemia (translocation) 1	0.061	Human
SMAD4	SMAD family member 4	0.061
RBL1	retinoblastoma-like 1 (p107)	0.061	Human
MYOCD	myocardin	0.061
TGFB3	transforming growth factor, beta 3	0.057
HDAC9	histone deacetylase 9	0.054
CPNE6	copine VI (neuronal)	0.053
AR	androgen receptor	0.052
MAPK14	mitogen-activated protein kinase 14	0.051	Human Mouse
MAP2K4	mitogen-activated protein kinase kinase 4	0.049
CXCL11	chemokine (C-X-C motif) ligand 11	0.048
EP300	E1A binding protein p300	0.046
NCOR2	nuclear receptor corepressor 2	0.045
FSTL1	follistatin-like 1	0.045
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.042
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.042
ARRB1	arrestin, beta 1	0.039
ARNT	aryl hydrocarbon receptor nuclear translocator	0.036
PTPRC	protein tyrosine phosphatase, receptor type, C	0.036
IGF2R	insulin-like growth factor 2 receptor	0.036
TMSB10	thymosin beta 10	0.035
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.035
AHR	aryl hydrocarbon receptor	0.035
CDT1	chromatin licensing and DNA replication factor 1	0.035
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.034
MYOG	myogenin (myogenic factor 4)	0.034	Mouse
JUND	jun D proto-oncogene	0.034
MAML1	mastermind-like 1 (Drosophila)	0.033	Mouse
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.032
DBP	D site of albumin promoter (albumin D-box) binding protein	0.032
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.032
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.031
ZFYVE9	zinc finger, FYVE domain containing 9	0.031
ENG	endoglin	0.031
GATA4	GATA binding protein 4	0.030
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.030
SMAD1	SMAD family member 1	0.030
E2F5	E2F transcription factor 5, p130-binding	0.029
HIC1	hypermethylated in cancer 1	0.028
CELF1	CUGBP, Elav-like family member 1	0.027
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.027
GLIS2	GLIS family zinc finger 2	0.026
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.026
SPTBN1	spectrin, beta, non-erythrocytic 1	0.026
RBL2	retinoblastoma-like 2 (p130)	0.026	Human
NOTCH2	notch 2	0.025	Human
E2F2	E2F transcription factor 2	0.025
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.025
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.025
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.024
EGLN1	egl nine homolog 1 (C. elegans)	0.024
TIMP3	TIMP metallopeptidase inhibitor 3	0.024
PNRC1	proline-rich nuclear receptor coactivator 1	0.024
PSEN1	presenilin 1	0.024
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.024
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.024
MKL2	MKL/myocardin-like 2	0.023	Human
IGFBP5	insulin-like growth factor binding protein 5	0.022	Human
APC	adenomatous polyposis coli	0.022
RNF7	ring finger protein 7	0.022
VEGFA	vascular endothelial growth factor A	0.022
NOV	nephroblastoma overexpressed gene	0.022
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.022
MEF2C	myocyte enhancer factor 2C	0.022
MYOD1	myogenic differentiation 1	0.021	Mouse
CUX1	cut-like homeobox 1	0.021
SMAD9	SMAD family member 9	0.021
APP	amyloid beta (A4) precursor protein	0.020
CCND1	cyclin D1	0.020
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.020
CDK2	cyclin-dependent kinase 2	0.020
NOTCH2NL	notch 2 N-terminal like	0.019
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.019
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.019
PARVB	parvin, beta	0.018
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.018
E2F4	E2F transcription factor 4, p107/p130-binding	0.017
CDK6	cyclin-dependent kinase 6	0.017
TRIM43	tripartite motif containing 43	0.017
MCPH1	microcephalin 1	0.016
NCOA6	nuclear receptor coactivator 6	0.016
TNIK	TRAF2 and NCK interacting kinase	0.016
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.015
LIMS1	LIM and senescent cell antigen-like domains 1	0.015
INVS	inversin	0.015
JAG2	jagged 2	0.015
RUNX3	runt-related transcription factor 3	0.015
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.014
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.014
SOX18	SRY (sex determining region Y)-box 18	0.013
IGFBP3	insulin-like growth factor binding protein 3	0.013
CCNG2	cyclin G2	0.013
DPP4	dipeptidyl-peptidase 4	0.013
ATXN1L	ataxin 1-like	0.013
VHL	von Hippel-Lindau tumor suppressor	0.013
TF	transferrin	0.012
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	0.012	Human
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.012
KAT2B	K(lysine) acetyltransferase 2B	0.012
RBM4B	RNA binding motif protein 4B	0.012
FOXF1	forkhead box F1	0.012
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.012
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.012	Human
ASB13	ankyrin repeat and SOCS box containing 13	0.012
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012
RBPMS	RNA binding protein with multiple splicing	0.012
TNRC6A	trinucleotide repeat containing 6A	0.012
HBP1	HMG-box transcription factor 1	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
CXCR3	chemokine (C-X-C motif) receptor 3	0.012
SOCS3	suppressor of cytokine signaling 3	0.011
MAP2K7	mitogen-activated protein kinase kinase 7	0.011
ARRB2	arrestin, beta 2	0.011
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.011
FERMT2	fermitin family member 2	0.011
IFNG	interferon, gamma	0.011
ZEB2	zinc finger E-box binding homeobox 2	0.011
UBD	ubiquitin D	0.011
COL1A1	collagen, type I, alpha 1	0.011
CDH5	cadherin 5, type 2 (vascular endothelium)	0.011
IQGAP1	IQ motif containing GTPase activating protein 1	0.011
LEF1	lymphoid enhancer-binding factor 1	0.011	Human
TAGLN	transgelin	0.011
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.011
PURA	purine-rich element binding protein A	0.011
BTG1	B-cell translocation gene 1, anti-proliferative	0.011
CCNE1	cyclin E1	0.010
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.010
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.010