IMP

Process View

Homo sapiens

3 genes annotated in human

retina layer formation

The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "retina layer formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "retina layer formation" (in gray)

Name	Description	Probability	Func Analog Organism
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.915
DCAF7	DDB1 and CUL4 associated factor 7	0.811
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.523
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.520
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.397
RB1	retinoblastoma 1	0.338
EP300	E1A binding protein p300	0.326
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.298
RUNX1	runt-related transcription factor 1	0.271
DAXX	death-domain associated protein	0.218
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.195
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.172
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.131
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.125
BCAR1	breast cancer anti-estrogen resistance 1	0.116
ELK1	ELK1, member of ETS oncogene family	0.096
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.096
HDAC2	histone deacetylase 2	0.088
TIMP2	TIMP metallopeptidase inhibitor 2	0.076
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.070
SEC31A	SEC31 homolog A (S. cerevisiae)	0.068
CDK5	cyclin-dependent kinase 5	0.066	Zebrafish
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.066
SFN	stratifin	0.065
PARP1	poly (ADP-ribose) polymerase 1	0.063
PML	promyelocytic leukemia	0.058
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.056	Zebrafish
HDAC1	histone deacetylase 1	0.054
TRIM27	tripartite motif containing 27	0.052
TRPV5	transient receptor potential cation channel, subfamily V, member 5	0.046
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.046
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.045
CABLES1	Cdk5 and Abl enzyme substrate 1	0.043
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.043
SH3BP4	SH3-domain binding protein 4	0.042
CAV1	caveolin 1, caveolae protein, 22kDa	0.041
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.041
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.040
SIRT1	sirtuin 1	0.039
KCTD1	potassium channel tetramerisation domain containing 1	0.036
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.034
FIBP	fibroblast growth factor (acidic) intracellular binding protein	0.034
SKIL	SKI-like oncogene	0.033
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.031
SMAD4	SMAD family member 4	0.031
PIAS2	protein inhibitor of activated STAT, 2	0.031
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.031
LUM	lumican	0.029
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.029
TP53	tumor protein p53	0.028
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.028
ALAS1	aminolevulinate, delta-, synthase 1	0.027
HIPK2	homeodomain interacting protein kinase 2	0.027	Mouse
FURIN	furin (paired basic amino acid cleaving enzyme)	0.025
CAV2	caveolin 2	0.025
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.024
ZBTB4	zinc finger and BTB domain containing 4	0.024
CHD4	chromodomain helicase DNA binding protein 4	0.023
TAL1	T-cell acute lymphocytic leukemia 1	0.023
LIMK1	LIM domain kinase 1	0.022
CTBP1	C-terminal binding protein 1	0.022
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.021
FAM160A2	family with sequence similarity 160, member A2	0.020
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.020
PTK2	PTK2 protein tyrosine kinase 2	0.019
LZTS2	leucine zipper, putative tumor suppressor 2	0.019
RANGAP1	Ran GTPase activating protein 1	0.018
ING2	inhibitor of growth family, member 2	0.018
GLUL	glutamate-ammonia ligase	0.018
ATN1	atrophin 1	0.016
RSBN1	round spermatid basic protein 1	0.016
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.016
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.016
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.015
CABLES2	Cdk5 and Abl enzyme substrate 2	0.015
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.015
YY1	YY1 transcription factor	0.015
SRCIN1	SRC kinase signaling inhibitor 1	0.015
SNIP1	Smad nuclear interacting protein 1	0.014
AATK	apoptosis-associated tyrosine kinase	0.014
EED	embryonic ectoderm development	0.014
CDK6	cyclin-dependent kinase 6	0.014
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.014
GOLGB1	golgin B1	0.014
ZMYM2	zinc finger, MYM-type 2	0.014
S100A4	S100 calcium binding protein A4	0.013
PTPRN	protein tyrosine phosphatase, receptor type, N	0.013
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.013
PTPRD	protein tyrosine phosphatase, receptor type, D	0.013	Human
MEF2A	myocyte enhancer factor 2A	0.013
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.013
TUBB2A	tubulin, beta 2A	0.013
RNF4	ring finger protein 4	0.013
CTBP2	C-terminal binding protein 2	0.013
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.013
STK4	serine/threonine kinase 4	0.013
CDK2AP2	cyclin-dependent kinase 2 associated protein 2	0.013
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.013
NLK	nemo-like kinase	0.012
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.012
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.012
BBS4	Bardet-Biedl syndrome 4	0.012
SSR2	signal sequence receptor, beta (translocon-associated protein beta)	0.012
GRB10	growth factor receptor-bound protein 10	0.012
OTP	orthopedia homeobox	0.012
LRP1	low density lipoprotein receptor-related protein 1	0.012
ARIH2	ariadne homolog 2 (Drosophila)	0.012
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.012
EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	0.012
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.012
ARL3	ADP-ribosylation factor-like 3	0.012
ELF4	E74-like factor 4 (ets domain transcription factor)	0.011
HDAC4	histone deacetylase 4	0.011
MNX1	motor neuron and pancreas homeobox 1	0.011
CCKBR	cholecystokinin B receptor	0.011
RCOR1	REST corepressor 1	0.011
SEPT7	septin 7	0.011
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.011
ARID1A	AT rich interactive domain 1A (SWI-like)	0.011
EGF	epidermal growth factor	0.011
NRIP1	nuclear receptor interacting protein 1	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
NCL	nucleolin	0.011
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.011
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.011
TTF2	transcription termination factor, RNA polymerase II	0.011
PPP4C	protein phosphatase 4, catalytic subunit	0.011
PPP1R13L	protein phosphatase 1, regulatory (inhibitor) subunit 13 like	0.011
MBD1	methyl-CpG binding domain protein 1	0.010
USP42	ubiquitin specific peptidase 42	0.010
JMY	junction mediating and regulatory protein, p53 cofactor	0.010
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.010
HIPK1	homeodomain interacting protein kinase 1	0.010	Mouse
ZNF451	zinc finger protein 451	0.010
RRAD	Ras-related associated with diabetes	0.010
UBQLN2	ubiquilin 2	0.010
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.010
BBS7	Bardet-Biedl syndrome 7	0.010
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.010
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.010
TRIP6	thyroid hormone receptor interactor 6	0.010
SDC1	syndecan 1	0.010
SLIT1	slit homolog 1 (Drosophila)	0.010