IMP
Process View
positive regulation of natural killer cell mediated cytotoxicity
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of natural killer cell mediated cytotoxicity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 1.000 | ||
| CD84 | CD84 molecule | 0.998 | ||
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.997 | ||
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.991 | Human | |
| SH2D1A | SH2 domain containing 1A | 0.982 | Mouse | |
| PVRL4 | poliovirus receptor-related 4 | 0.915 | ||
| IL2RB | interleukin 2 receptor, beta | 0.900 | ||
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.680 | ||
| SH2D1B | SH2 domain containing 1B | 0.628 | Mouse | |
| BCR | breakpoint cluster region | 0.589 | ||
| GBA | glucosidase, beta, acid | 0.472 | ||
| FYB | FYN binding protein | 0.412 | ||
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.386 | ||
| KLRC3 | killer cell lectin-like receptor subfamily C, member 3 | 0.371 | Human | |
| IL23A | interleukin 23, alpha subunit p19 | 0.309 | ||
| IFNG | interferon, gamma | 0.298 | ||
| RAB14 | RAB14, member RAS oncogene family | 0.211 | ||
| KLRC2 | killer cell lectin-like receptor subfamily C, member 2 | 0.188 | Human | |
| CD244 | CD244 molecule, natural killer cell receptor 2B4 | 0.174 | ||
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.172 | ||
| TJP1 | tight junction protein 1 (zona occludens 1) | 0.138 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.086 | ||
| DOK1 | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | 0.085 | ||
| CXCR6 | chemokine (C-X-C motif) receptor 6 | 0.081 | ||
| PRF1 | perforin 1 (pore forming protein) | 0.077 | ||
| NCSTN | nicastrin | 0.075 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.073 | ||
| CD2 | CD2 molecule | 0.073 | ||
| STAP2 | signal transducing adaptor family member 2 | 0.069 | ||
| INSR | insulin receptor | 0.068 | ||
| IL12A | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 0.064 | ||
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.059 | ||
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 0.053 | ||
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.050 | ||
| EPHB3 | EPH receptor B3 | 0.050 | ||
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.049 | Mouse | |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.046 | ||
| KLRG1 | killer cell lectin-like receptor subfamily G, member 1 | 0.043 | Human | |
| CCR5 | chemokine (C-C motif) receptor 5 | 0.040 | ||
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.040 | ||
| JAK1 | Janus kinase 1 | 0.040 | ||
| IL18RAP | interleukin 18 receptor accessory protein | 0.039 | ||
| GNLY | granulysin | 0.035 | ||
| LY9 | lymphocyte antigen 9 | 0.034 | ||
| KLRC4 | killer cell lectin-like receptor subfamily C, member 4 | 0.033 | Human | |
| CD8A | CD8a molecule | 0.032 | ||
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | 0.031 | ||
| CD247 | CD247 molecule | 0.030 | ||
| CD160 | CD160 molecule | 0.029 | ||
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.028 | ||
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.027 | ||
| ITK | IL2-inducible T-cell kinase | 0.026 | ||
| JAK2 | Janus kinase 2 | 0.026 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.026 | ||
| PYHIN1 | pyrin and HIN domain family, member 1 | 0.025 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.025 | ||
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.024 | ||
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.022 | ||
| GNS | glucosamine (N-acetyl)-6-sulfatase | 0.022 | ||
| KLRC1 | killer cell lectin-like receptor subfamily C, member 1 | 0.021 | Human | |
| SH2D2A | SH2 domain containing 2A | 0.021 | ||
| XCL2 | chemokine (C motif) ligand 2 | 0.021 | ||
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 0.019 | ||
| GPR65 | G protein-coupled receptor 65 | 0.018 | ||
| TXK | TXK tyrosine kinase | 0.017 | ||
| MRAS | muscle RAS oncogene homolog | 0.017 | ||
| CD96 | CD96 molecule | 0.017 | ||
| PRKCQ | protein kinase C, theta | 0.016 | ||
| LEPROT | leptin receptor overlapping transcript | 0.016 | ||
| GPR171 | G protein-coupled receptor 171 | 0.016 | ||
| CD80 | CD80 molecule | 0.015 | ||
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.015 | ||
| CCL4 | chemokine (C-C motif) ligand 4 | 0.014 | ||
| CD28 | CD28 molecule | 0.014 | ||
| GPR18 | G protein-coupled receptor 18 | 0.014 | ||
| CD226 | CD226 molecule | 0.014 | ||
| STAT5B | signal transducer and activator of transcription 5B | 0.013 | Mouse | |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.013 | ||
| HEXB | hexosaminidase B (beta polypeptide) | 0.013 | ||
| CTSW | cathepsin W | 0.013 | ||
| ITM2B | integral membrane protein 2B | 0.013 | ||
| ATF7IP | activating transcription factor 7 interacting protein | 0.012 | ||
| HCST | hematopoietic cell signal transducer | 0.012 | ||
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.012 | ||
| SLAMF6 | SLAM family member 6 | 0.012 | ||
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.012 | ||
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.011 | ||
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.011 | ||
| EPHB2 | EPH receptor B2 | 0.011 | ||
| ICOS | inducible T-cell co-stimulator | 0.011 | ||
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.010 | ||
| IRF4 | interferon regulatory factor 4 | 0.010 | ||
| CD69 | CD69 molecule | 0.010 | ||
| CLINT1 | clathrin interactor 1 | 0.010 | ||
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.010 | ||
| THEMIS | thymocyte selection associated | 0.010 | ||
| XCL1 | chemokine (C motif) ligand 1 | 0.010 | ||
| CLEC5A | C-type lectin domain family 5, member A | 0.010 |