IMP

Process View

Homo sapiens

17 genes annotated in human

Multi-species View

negative regulation of bmp signaling pathway

GO:0030514

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of bmp signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of bmp signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	1.000	Fly
SMAD4	SMAD family member 4	1.000	Human
SMAD3	SMAD family member 3	1.000	Human
SMAD2	SMAD family member 2	0.996	Human
SKIL	SKI-like oncogene	0.995	Human
SMAD7	SMAD family member 7	0.987
TRIM33	tripartite motif containing 33	0.979
BMPR1A	bone morphogenetic protein receptor, type IA	0.968
SMAD1	SMAD family member 1	0.961	Human
SMAD5	SMAD family member 5	0.853	Human
ELN	elastin	0.695
FBLN1	fibulin 1	0.674
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.640
LRP6	low density lipoprotein receptor-related protein 6	0.622
JAG1	jagged 1	0.600
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.596
EP300	E1A binding protein p300	0.542
CREBBP	CREB binding protein	0.486
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.459	Fly
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.441
BMP1	bone morphogenetic protein 1	0.295
NCOR1	nuclear receptor corepressor 1	0.271
TGFBR1	transforming growth factor, beta receptor 1	0.251
AR	androgen receptor	0.249
NOTCH3	notch 3	0.226
ADAM12	ADAM metallopeptidase domain 12	0.207
SP1	Sp1 transcription factor	0.188
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.174
ZFYVE9	zinc finger, FYVE domain containing 9	0.169
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.167
BMP2	bone morphogenetic protein 2	0.160	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.151
LIMD1	LIM domains containing 1	0.145
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.137
PIAS1	protein inhibitor of activated STAT, 1	0.126
WNT5A	wingless-type MMTV integration site family, member 5A	0.105	Human Mouse
TGFB1	transforming growth factor, beta 1	0.097
COL1A1	collagen, type I, alpha 1	0.095
CTGF	connective tissue growth factor	0.086
CAV1	caveolin 1, caveolae protein, 22kDa	0.079
PDGFC	platelet derived growth factor C	0.078
FSTL1	follistatin-like 1	0.077	Human
CXXC5	CXXC finger protein 5	0.077
SOCS5	suppressor of cytokine signaling 5	0.075
FN1	fibronectin 1	0.074
SMAD6	SMAD family member 6	0.074
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.074
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.066
BMP7	bone morphogenetic protein 7	0.066
SFRP1	secreted frizzled-related protein 1	0.059	Mouse
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.057
MFAP4	microfibrillar-associated protein 4	0.056
PRKCDBP	protein kinase C, delta binding protein	0.055
MTMR4	myotubularin related protein 4	0.053
TCF12	transcription factor 12	0.053
FGF18	fibroblast growth factor 18	0.052
NOTCH2	notch 2	0.051
RNF111	ring finger protein 111	0.051
FZD8	frizzled homolog 8 (Drosophila)	0.050
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.049
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.047
HIC1	hypermethylated in cancer 1	0.045
FZD1	frizzled homolog 1 (Drosophila)	0.045	Mouse
RUNX1	runt-related transcription factor 1	0.043
GSK3B	glycogen synthase kinase 3 beta	0.042
SPRY2	sprouty homolog 2 (Drosophila)	0.042
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.041
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.040	Human
YY1	YY1 transcription factor	0.040
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.040
DCAF7	DDB1 and CUL4 associated factor 7	0.039
ATN1	atrophin 1	0.039
INHBA	inhibin, beta A	0.038
TRAF4	TNF receptor-associated factor 4	0.038
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.037
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.036
MAML1	mastermind-like 1 (Drosophila)	0.034
SORBS3	sorbin and SH3 domain containing 3	0.033
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.033
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.032
ZEB2	zinc finger E-box binding homeobox 2	0.031
GAS6	growth arrest-specific 6	0.031
LOX	lysyl oxidase	0.030
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.029
SIRT1	sirtuin 1	0.028
FBXL15	F-box and leucine-rich repeat protein 15	0.028
EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	0.027
HDAC3	histone deacetylase 3	0.027
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.027
FZD7	frizzled homolog 7 (Drosophila)	0.027
ING2	inhibitor of growth family, member 2	0.027
FOXF2	forkhead box F2	0.026
RSBN1	round spermatid basic protein 1	0.026
SOX7	SRY (sex determining region Y)-box 7	0.025
MEST	mesoderm specific transcript homolog (mouse)	0.025
TGFB2	transforming growth factor, beta 2	0.024
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.024
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.024
PPARA	peroxisome proliferator-activated receptor alpha	0.023
FBN2	fibrillin 2	0.023
LAMB1	laminin, beta 1	0.023
CAV2	caveolin 2	0.023	Human
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.022
F3	coagulation factor III (thromboplastin, tissue factor)	0.022
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.021
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.021
WIF1	WNT inhibitory factor 1	0.021
MAGEA2	melanoma antigen family A, 2	0.021
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.020
VEZF1	vascular endothelial zinc finger 1	0.020
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.019
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.019
ITIH5	inter-alpha (globulin) inhibitor H5	0.018
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.018
WNT1	wingless-type MMTV integration site family, member 1	0.018
SON	SON DNA binding protein	0.018
WNT2	wingless-type MMTV integration site family member 2	0.018	Human
LTBP4	latent transforming growth factor beta binding protein 4	0.018
JAG2	jagged 2	0.018
PTRF	polymerase I and transcript release factor	0.018
HDAC4	histone deacetylase 4	0.018
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.017
GLIS2	GLIS family zinc finger 2	0.016
COL6A2	collagen, type VI, alpha 2	0.016
IGFBP3	insulin-like growth factor binding protein 3	0.016	Zebrafish
PAM	peptidylglycine alpha-amidating monooxygenase	0.016
HOXB1	homeobox B1	0.016
WNT4	wingless-type MMTV integration site family, member 4	0.016	Human
GJA1	gap junction protein, alpha 1, 43kDa	0.015
FBLN2	fibulin 2	0.015
EPAS1	endothelial PAS domain protein 1	0.015
FERMT2	fermitin family member 2	0.015
FRMD6	FERM domain containing 6	0.015
ATXN7	ataxin 7	0.015
MKL2	MKL/myocardin-like 2	0.015
CSNK1D	casein kinase 1, delta	0.015
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.015
VEGFC	vascular endothelial growth factor C	0.014
BPTF	bromodomain PHD finger transcription factor	0.014
COL6A1	collagen, type VI, alpha 1	0.014
TRAF5	TNF receptor-associated factor 5	0.014
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.014
ESR1	estrogen receptor 1	0.014
DSE	dermatan sulfate epimerase	0.014
NFAT5	nuclear factor of activated T-cells 5, tonicity-responsive	0.014
FNDC3B	fibronectin type III domain containing 3B	0.013
TFPI2	tissue factor pathway inhibitor 2	0.013
AXIN1	axin 1	0.013
HOXC8	homeobox C8	0.013
GAS1	growth arrest-specific 1	0.013
PTEN	phosphatase and tensin homolog	0.013
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.013
YAP1	Yes-associated protein 1	0.013
TCF4	transcription factor 4	0.013
FBLN5	fibulin 5	0.013
PTPRF	protein tyrosine phosphatase, receptor type, F	0.013
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.012
SDC2	syndecan 2	0.012
HRG	histidine-rich glycoprotein	0.012
BMP4	bone morphogenetic protein 4	0.012	Human
NOG	noggin	0.012
RAX	retina and anterior neural fold homeobox	0.012
ZMYND11	zinc finger, MYND-type containing 11	0.012	Zebrafish
CREB1	cAMP responsive element binding protein 1	0.012
LHFP	lipoma HMGIC fusion partner	0.012
TRAF3	TNF receptor-associated factor 3	0.012
WNT3	wingless-type MMTV integration site family, member 3	0.012	Human
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.012
LBX1	ladybird homeobox 1	0.011
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.011
TNIK	TRAF2 and NCK interacting kinase	0.011
MFAP2	microfibrillar-associated protein 2	0.011
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.011
ACAN	aggrecan	0.011
GATAD2B	GATA zinc finger domain containing 2B	0.011
FGF4	fibroblast growth factor 4	0.011
TAL1	T-cell acute lymphocytic leukemia 1	0.011
FOXF1	forkhead box F1	0.011
C3orf64	chromosome 3 open reading frame 64	0.011
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.011
SLIT2	slit homolog 2 (Drosophila)	0.011
MED13	mediator complex subunit 13	0.011
IGFBP6	insulin-like growth factor binding protein 6	0.011
LTBP1	latent transforming growth factor beta binding protein 1	0.011
DCP1A	DCP1 decapping enzyme homolog A (S. cerevisiae)	0.011
IHH	Indian hedgehog	0.011
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.010
ATXN1	ataxin 1	0.010
MRC2	mannose receptor, C type 2	0.010
CDX1	caudal type homeobox 1	0.010
FAM46A	family with sequence similarity 46, member A	0.010
FST	follistatin	0.010	Human
SIAH2	seven in absentia homolog 2 (Drosophila)	0.010
GMEB1	glucocorticoid modulatory element binding protein 1	0.010
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.010
SMAD9	SMAD family member 9	0.010