IMP

Process View

Homo sapiens

26 genes annotated in human

modification by host of symbiont morphology or physiology

The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "modification by host of symbiont morphology or physiology"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "modification by host of symbiont morphology or physiology" (in gray)

Name	Description	Probability	Func Analog Organism
SP1	Sp1 transcription factor	1.000
IL8	interleukin 8	0.944
CXCL2	chemokine (C-X-C motif) ligand 2	0.906	Mouse
CXCL3	chemokine (C-X-C motif) ligand 3	0.899	Mouse
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.894
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.858	Mouse
JUN	jun proto-oncogene	0.777
CCR5	chemokine (C-C motif) receptor 5	0.753
HDAC1	histone deacetylase 1	0.695
CCL2	chemokine (C-C motif) ligand 2	0.607	Human
ARID1A	AT rich interactive domain 1A (SWI-like)	0.605
IL1B	interleukin 1, beta	0.496
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.446
ESR1	estrogen receptor 1	0.442
HMGA1	high mobility group AT-hook 1	0.422	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.399
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.399
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.383
ATF3	activating transcription factor 3	0.370
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.351
SMAD3	SMAD family member 3	0.347
CCL4	chemokine (C-C motif) ligand 4	0.333
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.315
IL6	interleukin 6 (interferon, beta 2)	0.310
CREBBP	CREB binding protein	0.307	Human
SMAD4	SMAD family member 4	0.223
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.209
PAX3	paired box 3	0.192
SOX10	SRY (sex determining region Y)-box 10	0.178
HCFC1	host cell factor C1 (VP16-accessory protein)	0.176
CCL5	chemokine (C-C motif) ligand 5	0.160
KDM6A	lysine (K)-specific demethylase 6A	0.146
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.143
CCL20	chemokine (C-C motif) ligand 20	0.140	Human
JUNB	jun B proto-oncogene	0.128	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.122	Human
SMN1	survival of motor neuron 1, telomeric	0.107
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.106
CCL8	chemokine (C-C motif) ligand 8	0.100	Human
DPP4	dipeptidyl-peptidase 4	0.099
CCR7	chemokine (C-C motif) receptor 7	0.094
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.087
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.085
CXCL10	chemokine (C-X-C motif) ligand 10	0.082
EP300	E1A binding protein p300	0.080
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.078
CCL7	chemokine (C-C motif) ligand 7	0.077	Human
CCL3	chemokine (C-C motif) ligand 3	0.076
SS18	synovial sarcoma translocation, chromosome 18	0.069
RAB5A	RAB5A, member RAS oncogene family	0.067
HTT	huntingtin	0.063
FOSL1	FOS-like antigen 1	0.061
SOX2	SRY (sex determining region Y)-box 2	0.059
NCOR1	nuclear receptor corepressor 1	0.058
CCL13	chemokine (C-C motif) ligand 13	0.058	Human
CXCL5	chemokine (C-X-C motif) ligand 5	0.058	Mouse
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.057
IDE	insulin-degrading enzyme	0.057
OCIAD1	OCIA domain containing 1	0.056
TBP	TATA box binding protein	0.055
TP53	tumor protein p53	0.054
TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	0.047
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.046
RAB6A	RAB6A, member RAS oncogene family	0.045
CCL22	chemokine (C-C motif) ligand 22	0.045	Human
POU2F1	POU class 2 homeobox 1	0.045	Human
YY1	YY1 transcription factor	0.044
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.043
KCTD17	potassium channel tetramerisation domain containing 17	0.042
DDIT3	DNA-damage-inducible transcript 3	0.041
AR	androgen receptor	0.041
RBBP4	retinoblastoma binding protein 4	0.039
JDP2	Jun dimerization protein 2	0.039
SIRT1	sirtuin 1	0.037
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.037
CCL19	chemokine (C-C motif) ligand 19	0.035	Human
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.034
KAT2B	K(lysine) acetyltransferase 2B	0.033
UTY	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	0.033
TIAL1	TIA1 cytotoxic granule-associated RNA binding protein-like 1	0.032
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.031
BATF	basic leucine zipper transcription factor, ATF-like	0.031
ADAMTSL4	ADAMTS-like 4	0.031
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.030
TNF	tumor necrosis factor	0.030
NFYA	nuclear transcription factor Y, alpha	0.030
HIPK2	homeodomain interacting protein kinase 2	0.029
CXCL9	chemokine (C-X-C motif) ligand 9	0.028
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.027
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.027
SELE	selectin E	0.027
CCR1	chemokine (C-C motif) receptor 1	0.026
CXCL13	chemokine (C-X-C motif) ligand 13	0.026
CCR4	chemokine (C-C motif) receptor 4	0.026
CLTC	clathrin, heavy chain (Hc)	0.026
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.026
IL10	interleukin 10	0.025
CH25H	cholesterol 25-hydroxylase	0.025
CRP	C-reactive protein, pentraxin-related	0.024	Human
GLIS2	GLIS family zinc finger 2	0.024
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.023
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.022
DARC	Duffy blood group, chemokine receptor	0.022
TCF4	transcription factor 4	0.021
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.021
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.021
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.021
PDPK1	3-phosphoinositide dependent protein kinase-1	0.021
BTRC	beta-transducin repeat containing	0.020
RGS1	regulator of G-protein signaling 1	0.020
NCOA6	nuclear receptor coactivator 6	0.020
CCL11	chemokine (C-C motif) ligand 11	0.020	Human
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.019
IFNG	interferon, gamma	0.019
TOP2B	topoisomerase (DNA) II beta 180kDa	0.018
CD83	CD83 molecule	0.018
MEOX2	mesenchyme homeobox 2	0.018
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.018
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.017
RUNX1	runt-related transcription factor 1	0.017
SMAD7	SMAD family member 7	0.017
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.017
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.017
INHBA	inhibin, beta A	0.017
CREBZF	CREB/ATF bZIP transcription factor	0.017
HIC1	hypermethylated in cancer 1	0.016
RAB14	RAB14, member RAS oncogene family	0.016
SOX11	SRY (sex determining region Y)-box 11	0.016
INADL	InaD-like (Drosophila)	0.016
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.016
CCL1	chemokine (C-C motif) ligand 1	0.015	Human
JUND	jun D proto-oncogene	0.015	Human
LTF	lactotransferrin	0.015
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.015
ARRB1	arrestin, beta 1	0.015
CCR3	chemokine (C-C motif) receptor 3	0.015
IL11	interleukin 11	0.015
LRP1	low density lipoprotein receptor-related protein 1	0.015
PABPN1	poly(A) binding protein, nuclear 1	0.015
SOD2	superoxide dismutase 2, mitochondrial	0.014
EBI3	Epstein-Barr virus induced 3	0.014
APTX	aprataxin	0.014
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.014
JUP	junction plakoglobin	0.014
ATF7IP	activating transcription factor 7 interacting protein	0.014
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.014
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.014
CXCL11	chemokine (C-X-C motif) ligand 11	0.013
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.013
IL1A	interleukin 1, alpha	0.013
IL7R	interleukin 7 receptor	0.013
GLTPD1	glycolipid transfer protein domain containing 1	0.013
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.013
IL2RB	interleukin 2 receptor, beta	0.013
CTNNBIP1	catenin, beta interacting protein 1	0.013
ICAM1	intercellular adhesion molecule 1	0.013
HSF2	heat shock transcription factor 2	0.013
IL21R	interleukin 21 receptor	0.013
LEF1	lymphoid enhancer-binding factor 1	0.012
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.012
PRMT6	protein arginine methyltransferase 6	0.012
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.012
NCL	nucleolin	0.012
CXCR6	chemokine (C-X-C motif) receptor 6	0.012
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.012
CSF3	colony stimulating factor 3 (granulocyte)	0.012
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.012
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.012
MTA2	metastasis associated 1 family, member 2	0.012
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.012
IRF4	interferon regulatory factor 4	0.012
APCS	amyloid P component, serum	0.011
ICOS	inducible T-cell co-stimulator	0.011
ATF2	activating transcription factor 2	0.011	Human
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.011
EMD	emerin	0.011
EGR1	early growth response 1	0.011
TNIK	TRAF2 and NCK interacting kinase	0.011
PRTN3	proteinase 3	0.011
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.011
SMAD9	SMAD family member 9	0.011
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.011
VCAM1	vascular cell adhesion molecule 1	0.011
PRKCD	protein kinase C, delta	0.011
DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	0.011
MPO	myeloperoxidase	0.011
PSEN1	presenilin 1	0.011
RFWD2	ring finger and WD repeat domain 2	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
HMOX2	heme oxygenase (decycling) 2	0.010
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.010
LAMC3	laminin, gamma 3	0.010
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.010
IL1R2	interleukin 1 receptor, type II	0.010
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.010
BCL2A1	BCL2-related protein A1	0.010