IMP

Process View

Homo sapiens

3 genes annotated in human

attachment of mitotic spindle microtubules to kinetochore

The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "attachment of mitotic spindle microtubules to kinetochore"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "attachment of mitotic spindle microtubules to kinetochore" (in gray)

Name	Description	Probability	Func Analog Organism
NUP133	nucleoporin 133kDa	0.712
CENPE	centromere protein E, 312kDa	0.491
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.413
SMC2	structural maintenance of chromosomes 2	0.400
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.274
NCAPG	non-SMC condensin I complex, subunit G	0.262
SMC4	structural maintenance of chromosomes 4	0.238
NCAPG2	non-SMC condensin II complex, subunit G2	0.217
KIF14	kinesin family member 14	0.163
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.148
FANCI	Fanconi anemia, complementation group I	0.137
NCAPD2	non-SMC condensin I complex, subunit D2	0.124
KIF23	kinesin family member 23	0.114
ECT2	epithelial cell transforming sequence 2 oncogene	0.109
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.107
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.087
NCAPH2	non-SMC condensin II complex, subunit H2	0.073
LBR	lamin B receptor	0.069
KIF1B	kinesin family member 1B	0.068
RACGAP1	Rac GTPase activating protein 1	0.067
NCAPH	non-SMC condensin I complex, subunit H	0.065
KIF15	kinesin family member 15	0.061
RBBP8	retinoblastoma binding protein 8	0.057
PHAX	phosphorylated adaptor for RNA export	0.055
KIF18A	kinesin family member 18A	0.055	Fly
MKI67	antigen identified by monoclonal antibody Ki-67	0.055
DEPDC1	DEP domain containing 1	0.055
ZWINT	ZW10 interactor	0.053
VCP	valosin containing protein	0.052	Yeast
TMEM194A	transmembrane protein 194A	0.051
MPHOSPH9	M-phase phosphoprotein 9	0.050
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.049
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.047
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.045
GPSM2	G-protein signaling modulator 2	0.044
UBXN2A	UBX domain protein 2A	0.043
SGOL2	shugoshin-like 2 (S. pombe)	0.042
SASS6	spindle assembly 6 homolog (C. elegans)	0.039
SKA1	spindle and kinetochore associated complex subunit 1	0.037
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.037
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.034
PRC1	protein regulator of cytokinesis 1	0.034
ATXN3	ataxin 3	0.032
ATAD2	ATPase family, AAA domain containing 2	0.032
E2F5	E2F transcription factor 5, p130-binding	0.031
LIN52	lin-52 homolog (C. elegans)	0.030
CASC5	cancer susceptibility candidate 5	0.030
MIS18BP1	MIS18 binding protein 1	0.029
CENPF	centromere protein F, 350/400kDa (mitosin)	0.029	Worm
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.029
LIN54	lin-54 homolog (C. elegans)	0.028
STIL	SCL/TAL1 interrupting locus	0.028
ANLN	anillin, actin binding protein	0.026
TTF2	transcription termination factor, RNA polymerase II	0.024
KIF11	kinesin family member 11	0.024
HELLS	helicase, lymphoid-specific	0.024
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.024
CEP55	centrosomal protein 55kDa	0.024
KIF20B	kinesin family member 20B	0.024
RBL2	retinoblastoma-like 2 (p130)	0.022	Human
GEN1	Gen homolog 1, endonuclease (Drosophila)	0.022
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.022
AMFR	autocrine motility factor receptor	0.021
CEP152	centrosomal protein 152kDa	0.021
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.021
NSFL1C	NSFL1 (p97) cofactor (p47)	0.021	Yeast
TTK	TTK protein kinase	0.020	Yeast
C12orf48	chromosome 12 open reading frame 48	0.020
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.020
OR5AR1	olfactory receptor, family 5, subfamily AR, member 1	0.019
DNA2	DNA replication helicase 2 homolog (yeast)	0.019
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.019
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.019
CCNE2	cyclin E2	0.018
TROAP	trophinin associated protein (tastin)	0.018
CENPQ	centromere protein Q	0.018
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.017
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.016
C1orf109	chromosome 1 open reading frame 109	0.016
MELK	maternal embryonic leucine zipper kinase	0.015
KIF20A	kinesin family member 20A	0.014
CCDC138	coiled-coil domain containing 138	0.014
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.014
RBL1	retinoblastoma-like 1 (p107)	0.013	Human
ANAPC7	anaphase promoting complex subunit 7	0.013
WDR67	WD repeat domain 67	0.013
SMC1A	structural maintenance of chromosomes 1A	0.013
TACC2	transforming, acidic coiled-coil containing protein 2	0.013
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.013
CENPI	centromere protein I	0.013
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.013
PLK4	polo-like kinase 4	0.013
USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.012
CBX5	chromobox homolog 5	0.012
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.012
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.012
PSRC1	proline/serine-rich coiled-coil 1	0.011
ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1	0.011
CREBBP	CREB binding protein	0.011
NUP107	nucleoporin 107kDa	0.011
UBQLN1	ubiquilin 1	0.011
CASP8AP2	caspase 8 associated protein 2	0.011
C18orf54	chromosome 18 open reading frame 54	0.010
ARHGAP11A	Rho GTPase activating protein 11A	0.010
E2F4	E2F transcription factor 4, p107/p130-binding	0.010
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.010