IMP

Process View

Homo sapiens

1 genes annotated in human

negative regulation of cd4 positive alpha beta t cell proliferation

GO:2000562

Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cd4 positive alpha beta t cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cd4 positive alpha beta t cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CCL4	chemokine (C-C motif) ligand 4	1.000	Human
IL8	interleukin 8	0.999
CCL2	chemokine (C-C motif) ligand 2	0.996	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.996
IL1B	interleukin 1, beta	0.989
CXCL2	chemokine (C-X-C motif) ligand 2	0.985
CCL8	chemokine (C-C motif) ligand 8	0.983	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.983
CCL5	chemokine (C-C motif) ligand 5	0.974	Human
IL6	interleukin 6 (interferon, beta 2)	0.968
CXCL3	chemokine (C-X-C motif) ligand 3	0.957
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.955
DPP4	dipeptidyl-peptidase 4	0.915
CCL13	chemokine (C-C motif) ligand 13	0.903	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.873
ICAM1	intercellular adhesion molecule 1	0.869
CCR7	chemokine (C-C motif) receptor 7	0.866
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.860	Human
CCL22	chemokine (C-C motif) ligand 22	0.791	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.724
CD83	CD83 molecule	0.695
IDE	insulin-degrading enzyme	0.687
RGS1	regulator of G-protein signaling 1	0.592
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.559
IFNG	interferon, gamma	0.547
CCL20	chemokine (C-C motif) ligand 20	0.507	Human
GNLY	granulysin	0.503
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.446
CCL7	chemokine (C-C motif) ligand 7	0.395	Human
CXCL5	chemokine (C-X-C motif) ligand 5	0.388
IL7R	interleukin 7 receptor	0.369
CCL19	chemokine (C-C motif) ligand 19	0.347	Human
IL10	interleukin 10	0.326
CCL11	chemokine (C-C motif) ligand 11	0.301	Human
IL2RB	interleukin 2 receptor, beta	0.299
CCR1	chemokine (C-C motif) receptor 1	0.272
VCAM1	vascular cell adhesion molecule 1	0.255
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.248
BCL2A1	BCL2-related protein A1	0.248
SELE	selectin E	0.225
CCL3	chemokine (C-C motif) ligand 3	0.223	Human
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.220
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.217
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.189
CD69	CD69 molecule	0.189
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.186
FPR3	formyl peptide receptor 3	0.184
CH25H	cholesterol 25-hydroxylase	0.173
TNF	tumor necrosis factor	0.170
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.168
TRAF1	TNF receptor-associated factor 1	0.156
CCR4	chemokine (C-C motif) receptor 4	0.155
EBI3	Epstein-Barr virus induced 3	0.154
BIRC3	baculoviral IAP repeat containing 3	0.146
SRGN	serglycin	0.127
UBD	ubiquitin D	0.117
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.116
LAMP3	lysosomal-associated membrane protein 3	0.114
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.111
IL2RG	interleukin 2 receptor, gamma	0.101
DARC	Duffy blood group, chemokine receptor	0.101
STAT4	signal transducer and activator of transcription 4	0.100
IL18RAP	interleukin 18 receptor accessory protein	0.100
CD80	CD80 molecule	0.099
ADAMDEC1	ADAM-like, decysin 1	0.092
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.092
IL32	interleukin 32	0.091
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.087
SLAMF8	SLAM family member 8	0.081
IL10RA	interleukin 10 receptor, alpha	0.077
CD40	CD40 molecule, TNF receptor superfamily member 5	0.077
IDO1	indoleamine 2,3-dioxygenase 1	0.075
ZC3H12A	zinc finger CCCH-type containing 12A	0.074
SLAMF7	SLAM family member 7	0.073
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.073
ARRB1	arrestin, beta 1	0.072
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.068
SOD2	superoxide dismutase 2, mitochondrial	0.066
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.062
PLAUR	plasminogen activator, urokinase receptor	0.062
CCR3	chemokine (C-C motif) receptor 3	0.061
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.060
CD2	CD2 molecule	0.059
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.056
IL1RN	interleukin 1 receptor antagonist	0.053
PLEK	pleckstrin	0.051
IL21R	interleukin 21 receptor	0.049
INHBA	inhibin, beta A	0.047
ZFYVE9	zinc finger, FYVE domain containing 9	0.046
CXCR6	chemokine (C-X-C motif) receptor 6	0.045
XCL2	chemokine (C motif) ligand 2	0.044	Human
IL2RA	interleukin 2 receptor, alpha	0.041
SLAMF1	signaling lymphocytic activation molecule family member 1	0.040
C1QA	complement component 1, q subcomponent, A chain	0.040
CCRL2	chemokine (C-C motif) receptor-like 2	0.035
RGS16	regulator of G-protein signaling 16	0.034
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.032
IL1A	interleukin 1, alpha	0.031
CCL17	chemokine (C-C motif) ligand 17	0.031	Human
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.030
CCL21	chemokine (C-C motif) ligand 21	0.029
PLAU	plasminogen activator, urokinase	0.029
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.028
MSC	musculin	0.028
NKG7	natural killer cell group 7 sequence	0.028
CSF1	colony stimulating factor 1 (macrophage)	0.027
XCL1	chemokine (C motif) ligand 1	0.025
C5AR1	complement component 5a receptor 1	0.025
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.025
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.025
C2	complement component 2	0.025
C1QB	complement component 1, q subcomponent, B chain	0.024
GZMK	granzyme K (granzyme 3; tryptase II)	0.023
ICOS	inducible T-cell co-stimulator	0.023
SMAD3	SMAD family member 3	0.023
CD163	CD163 molecule	0.022
CD48	CD48 molecule	0.022
IL18R1	interleukin 18 receptor 1	0.022
NNMT	nicotinamide N-methyltransferase	0.021
AQP9	aquaporin 9	0.021
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.021
PI3	peptidase inhibitor 3, skin-derived	0.020
CST7	cystatin F (leukocystatin)	0.020
CXCR3	chemokine (C-X-C motif) receptor 3	0.019
GPR109B	G protein-coupled receptor 109B	0.019
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.019
DUSP2	dual specificity phosphatase 2	0.019
IRF4	interferon regulatory factor 4	0.019
CD160	CD160 molecule	0.018
GPR171	G protein-coupled receptor 171	0.018
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.017
TREM1	triggering receptor expressed on myeloid cells 1	0.017
PRDM1	PR domain containing 1, with ZNF domain	0.017
TLR2	toll-like receptor 2	0.017
IL1R2	interleukin 1 receptor, type II	0.017
CD86	CD86 molecule	0.017
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.017
LRRC32	leucine rich repeat containing 32	0.016
CD1B	CD1b molecule	0.016
TM7SF4	transmembrane 7 superfamily member 4	0.016
CYTIP	cytohesin 1 interacting protein	0.016
TARP	TCR gamma alternate reading frame protein	0.016
C1QC	complement component 1, q subcomponent, C chain	0.016
CXCR4	chemokine (C-X-C motif) receptor 4	0.016
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.015
PTX3	pentraxin 3, long	0.015
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.015
C3AR1	complement component 3a receptor 1	0.015
CD209	CD209 molecule	0.015
KYNU	kynureninase	0.015
RUNX3	runt-related transcription factor 3	0.015
CMKLR1	chemokine-like receptor 1	0.015
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.015
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.014
CCL1	chemokine (C-C motif) ligand 1	0.014	Human
NLRP3	NLR family, pyrin domain containing 3	0.014
GPR84	G protein-coupled receptor 84	0.014
DEDD	death effector domain containing	0.014
TNIP3	TNFAIP3 interacting protein 3	0.014
SCARF1	scavenger receptor class F, member 1	0.014
GBP1	guanylate binding protein 1, interferon-inducible	0.014
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.014
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.013
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.013
IL13	interleukin 13	0.013
IL1R1	interleukin 1 receptor, type I	0.013
PDPN	podoplanin	0.013
TFEC	transcription factor EC	0.013
PLA2G2D	phospholipase A2, group IID	0.013
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.013
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.013
IER3	immediate early response 3	0.013
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.013
G0S2	G0/G1switch 2	0.013
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.013
APOC1	apolipoprotein C-I	0.013
GPR183	G protein-coupled receptor 183	0.012
EPAS1	endothelial PAS domain protein 1	0.012
DNASE1L3	deoxyribonuclease I-like 3	0.012
EGR2	early growth response 2	0.012
ACP5	acid phosphatase 5, tartrate resistant	0.012
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.011
CTSW	cathepsin W	0.011
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.011
CD84	CD84 molecule	0.011
CD28	CD28 molecule	0.011
MMP19	matrix metallopeptidase 19	0.011
CSF3	colony stimulating factor 3 (granulocyte)	0.011
LAG3	lymphocyte-activation gene 3	0.011
IL11	interleukin 11	0.011
CD40LG	CD40 ligand	0.011
OASL	2'-5'-oligoadenylate synthetase-like	0.011
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.011
IFNB1	interferon, beta 1, fibroblast	0.011
CRMP1	collapsin response mediator protein 1	0.011
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
PRF1	perforin 1 (pore forming protein)	0.011
ITK	IL2-inducible T-cell kinase	0.011
CHIT1	chitinase 1 (chitotriosidase)	0.011
IL4	interleukin 4	0.011
IL1F9	interleukin 1 family, member 9	0.010
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.010
IL7	interleukin 7	0.010
TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	0.010
ADORA3	adenosine A3 receptor	0.010