IMP

Process View

Homo sapiens

12 genes annotated in human

regulation of cartilage development

Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cartilage development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of cartilage development" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD7	SMAD family member 7	0.967
LTBP2	latent transforming growth factor beta binding protein 2	0.886	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.827
ELN	elastin	0.769
SMAD2	SMAD family member 2	0.767
FBLN1	fibulin 1	0.638	Human
SMAD4	SMAD family member 4	0.605
SMAD1	SMAD family member 1	0.555	Mouse
SMAD5	SMAD family member 5	0.551
BMPR1A	bone morphogenetic protein receptor, type IA	0.504
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.489
ATN1	atrophin 1	0.486
CTGF	connective tissue growth factor	0.469	Mouse
FSTL1	follistatin-like 1	0.459
POU3F2	POU class 3 homeobox 2	0.456
COL1A1	collagen, type I, alpha 1	0.352
COL6A1	collagen, type VI, alpha 1	0.342
LOXL1	lysyl oxidase-like 1	0.337
SMAD3	SMAD family member 3	0.321	Mouse
PAX3	paired box 3	0.320
LOX	lysyl oxidase	0.255
FN1	fibronectin 1	0.246
FBN1	fibrillin 1	0.227
TGFB1	transforming growth factor, beta 1	0.221	Mouse
CHRD	chordin	0.200
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.199	Human
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.168
COL6A2	collagen, type VI, alpha 2	0.167
FBLN5	fibulin 5	0.152	Human
RXRA	retinoid X receptor, alpha	0.138
TGFB3	transforming growth factor, beta 3	0.132	Zebrafish
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.114
NCOA1	nuclear receptor coactivator 1	0.111
BMPR1B	bone morphogenetic protein receptor, type IB	0.107
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.096
BMP7	bone morphogenetic protein 7	0.095
COL5A1	collagen, type V, alpha 1	0.090
BGN	biglycan	0.090
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.090
MEOX2	mesenchyme homeobox 2	0.088
ENG	endoglin	0.088
ZFYVE9	zinc finger, FYVE domain containing 9	0.086
BMP2	bone morphogenetic protein 2	0.083
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.078
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.078
CYR61	cysteine-rich, angiogenic inducer, 61	0.078	Mouse
EGR1	early growth response 1	0.074
MED25	mediator complex subunit 25	0.074
BTRC	beta-transducin repeat containing	0.072
THBS1	thrombospondin 1	0.060
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.059
TGFBR1	transforming growth factor, beta receptor 1	0.058	Mouse
PCOLCE	procollagen C-endopeptidase enhancer	0.057
PML	promyelocytic leukemia	0.056
COL1A2	collagen, type I, alpha 2	0.055
HSPG2	heparan sulfate proteoglycan 2	0.051
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.048
SMAD6	SMAD family member 6	0.045
TNC	tenascin C	0.045
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.041
COL3A1	collagen, type III, alpha 1	0.035
DCN	decorin	0.034
COL18A1	collagen, type XVIII, alpha 1	0.033
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.033
MRC2	mannose receptor, C type 2	0.032
SUFU	suppressor of fused homolog (Drosophila)	0.031
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.031
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.030
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.030
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.030
COL2A1	collagen, type II, alpha 1	0.028
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.027	Human
CALD1	caldesmon 1	0.027
MFAP2	microfibrillar-associated protein 2	0.027
CTBP2	C-terminal binding protein 2	0.025
AXIN1	axin 1	0.025
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.025
WISP1	WNT1 inducible signaling pathway protein 1	0.023
CREBBP	CREB binding protein	0.023
SOX11	SRY (sex determining region Y)-box 11	0.023	Human
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.023
BMP1	bone morphogenetic protein 1	0.022
FZD1	frizzled homolog 1 (Drosophila)	0.022
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.022
LAMB2	laminin, beta 2 (laminin S)	0.021
IGFBP5	insulin-like growth factor binding protein 5	0.021
LTBP4	latent transforming growth factor beta binding protein 4	0.021	Human
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.021
COMP	cartilage oligomeric matrix protein	0.020
TGFB2	transforming growth factor, beta 2	0.020	Mouse
AMOTL2	angiomotin like 2	0.020
NRP2	neuropilin 2	0.020
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.020
HOXA10	homeobox A10	0.019
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.019
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.019
CD248	CD248 molecule, endosialin	0.019
MXRA8	matrix-remodelling associated 8	0.018
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.018
PRKD2	protein kinase D2	0.018
COL13A1	collagen, type XIII, alpha 1	0.018
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.018
EHD2	EH-domain containing 2	0.018
MFAP4	microfibrillar-associated protein 4	0.017
FOXF2	forkhead box F2	0.016
GAS1	growth arrest-specific 1	0.016
PRRX2	paired related homeobox 2	0.016
HMGA2	high mobility group AT-hook 2	0.016
COL11A1	collagen, type XI, alpha 1	0.016
SKIL	SKI-like oncogene	0.015
COL5A2	collagen, type V, alpha 2	0.015
NOG	noggin	0.015	Mouse
RUNX2	runt-related transcription factor 2	0.015	Mouse
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.015
FOXD3	forkhead box D3	0.015
TGFBR3	transforming growth factor, beta receptor III	0.015
NRP1	neuropilin 1	0.015
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.015
CRIP2	cysteine-rich protein 2	0.015
AR	androgen receptor	0.014
CBX8	chromobox homolog 8	0.014
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.014
HIC1	hypermethylated in cancer 1	0.014
ACAN	aggrecan	0.014
TP53	tumor protein p53	0.014
SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	0.014
SFRP4	secreted frizzled-related protein 4	0.014
TIMP3	TIMP metallopeptidase inhibitor 3	0.013
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.013
FBLN2	fibulin 2	0.013	Human
COL5A3	collagen, type V, alpha 3	0.013
BMP4	bone morphogenetic protein 4	0.013
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.013
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.013
POU5F1	POU class 5 homeobox 1	0.013
GATA2	GATA binding protein 2	0.013
CXXC5	CXXC finger protein 5	0.013
NOTCH3	notch 3	0.013
INHBA	inhibin, beta A	0.013
WNT2	wingless-type MMTV integration site family member 2	0.013
SFRP1	secreted frizzled-related protein 1	0.013
SALL2	sal-like 2 (Drosophila)	0.012
RBMS3	RNA binding motif, single stranded interacting protein 3	0.012
LENG8	leukocyte receptor cluster (LRC) member 8	0.012
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.012
POSTN	periostin, osteoblast specific factor	0.012
RUNX1	runt-related transcription factor 1	0.012
ITGB4	integrin, beta 4	0.012
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.012
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.012
TWIST1	twist homolog 1 (Drosophila)	0.012
HTRA1	HtrA serine peptidase 1	0.012
HOXB5	homeobox B5	0.012
RNF4	ring finger protein 4	0.012
BNC2	basonuclin 2	0.012
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.012
EHF	ets homologous factor	0.012
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.011
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.011
SOX5	SRY (sex determining region Y)-box 5	0.011
GCSH	glycine cleavage system protein H (aminomethyl carrier)	0.011
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.011
DAXX	death-domain associated protein	0.011
ADAM12	ADAM metallopeptidase domain 12	0.011
FAP	fibroblast activation protein, alpha	0.011
EDN1	endothelin 1	0.011
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.011
IGFBP3	insulin-like growth factor binding protein 3	0.011
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011
SDC2	syndecan 2	0.011
PGRMC1	progesterone receptor membrane component 1	0.011
FOXF1	forkhead box F1	0.011
FOXC1	forkhead box C1	0.011
FGF18	fibroblast growth factor 18	0.011
COL6A3	collagen, type VI, alpha 3	0.010
FZD7	frizzled homolog 7 (Drosophila)	0.010
SOX7	SRY (sex determining region Y)-box 7	0.010	Human
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.010
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.010