IMP

Process View

Homo sapiens

37 genes annotated in human

monocarboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "monocarboxylic acid catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "monocarboxylic acid catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PEX19	peroxisomal biogenesis factor 19	1.000
PEX14	peroxisomal biogenesis factor 14	0.999
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.998	Rat Fly
HADH	hydroxyacyl-CoA dehydrogenase	0.979	Rat
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.973
SCP2	sterol carrier protein 2	0.923
INSR	insulin receptor	0.874
CAT	catalase	0.776
ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	0.742
ACAT1	acetyl-CoA acetyltransferase 1	0.710
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.685
ECH1	enoyl CoA hydratase 1, peroxisomal	0.682
GRB10	growth factor receptor-bound protein 10	0.659
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.626	Mouse Fly
PRKCZ	protein kinase C, zeta	0.555	Human
ACAA1	acetyl-CoA acyltransferase 1	0.525
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.482
IGF1R	insulin-like growth factor 1 receptor	0.477
PEX12	peroxisomal biogenesis factor 12	0.474
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.460
PEX3	peroxisomal biogenesis factor 3	0.446
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.426
PXMP2	peroxisomal membrane protein 2, 22kDa	0.367
CPT2	carnitine palmitoyltransferase 2	0.351
NOXA1	NADPH oxidase activator 1	0.333
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.298
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.287
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.286
ETFDH	electron-transferring-flavoprotein dehydrogenase	0.275
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.262
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.257
ACADVL	acyl-CoA dehydrogenase, very long chain	0.249	Mouse Rat
F11R	F11 receptor	0.238
MUT	methylmalonyl CoA mutase	0.229
ALDOB	aldolase B, fructose-bisphosphate	0.156
GBAS	glioblastoma amplified sequence	0.155
NDUFB5	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa	0.154
SETD8	SET domain containing (lysine methyltransferase) 8	0.152
PEX11B	peroxisomal biogenesis factor 11 beta	0.150
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.148
CBWD2	COBW domain containing 2	0.144
ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	0.142
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.126
GATA2	GATA binding protein 2	0.125
IRS1	insulin receptor substrate 1	0.122
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.111
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.110
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.105
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.105
ULK1	unc-51-like kinase 1 (C. elegans)	0.095
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.090
CYB5A	cytochrome b5 type A (microsomal)	0.090
ECI2	enoyl-CoA delta isomerase 2	0.089
SQSTM1	sequestosome 1	0.086
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.085
HSDL2	hydroxysteroid dehydrogenase like 2	0.083
ACOX1	acyl-CoA oxidase 1, palmitoyl	0.080
FYN	FYN oncogene related to SRC, FGR, YES	0.076
ZNF71	zinc finger protein 71	0.072
PDHB	pyruvate dehydrogenase (lipoamide) beta	0.071
PEX13	peroxisomal biogenesis factor 13	0.069	Mouse
NNT	nicotinamide nucleotide transhydrogenase	0.068
SLC25A20	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	0.066
NUMB	numb homolog (Drosophila)	0.064
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.062
SH3RF1	SH3 domain containing ring finger 1	0.058
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.058
MDH1	malate dehydrogenase 1, NAD (soluble)	0.056
HRSP12	heat-responsive protein 12	0.054
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.054
GABARAPL1	GABA(A) receptor-associated protein like 1	0.053
GRHPR	glyoxylate reductase/hydroxypyruvate reductase	0.053
ZNF277	zinc finger protein 277	0.052
PHYH	phytanoyl-CoA 2-hydroxylase	0.052
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.051
PEX16	peroxisomal biogenesis factor 16	0.050
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.049
RUNX1	runt-related transcription factor 1	0.045
TST	thiosulfate sulfurtransferase (rhodanese)	0.045
NCF1	neutrophil cytosolic factor 1	0.045
ACAA2	acetyl-CoA acyltransferase 2	0.043	Rat
CDCP1	CUB domain containing protein 1	0.042
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.040
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.039
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.039
C21orf33	chromosome 21 open reading frame 33	0.039
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.038
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.037
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.037
CCDC115	coiled-coil domain containing 115	0.036
SH2B1	SH2B adaptor protein 1	0.036
PCCB	propionyl CoA carboxylase, beta polypeptide	0.036
PRDX6	peroxiredoxin 6	0.036
BAG3	BCL2-associated athanogene 3	0.035
RPTOR	regulatory associated protein of MTOR, complex 1	0.034
DLD	dihydrolipoamide dehydrogenase	0.033
UBA5	ubiquitin-like modifier activating enzyme 5	0.033
ALDH9A1	aldehyde dehydrogenase 9 family, member A1	0.032
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.032	Rat
CRAT	carnitine O-acetyltransferase	0.030	Human
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.030
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.029	Human
CBR4	carbonyl reductase 4	0.029
KDM1A	lysine (K)-specific demethylase 1A	0.029
PGM1	phosphoglucomutase 1	0.029
PHKB	phosphorylase kinase, beta	0.028
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.028
IRS2	insulin receptor substrate 2	0.028
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.027
PRKCB	protein kinase C, beta	0.027
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.027
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.027
PICK1	protein interacting with PRKCA 1	0.026
TOM1L1	target of myb1 (chicken)-like 1	0.026
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.025
F8	coagulation factor VIII, procoagulant component	0.025
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.025
NMT2	N-myristoyltransferase 2	0.025
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.025
PNPLA2	patatin-like phospholipase domain containing 2	0.024
HIPK2	homeodomain interacting protein kinase 2	0.024
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.024	Human
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.024
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.023
TALDO1	transaldolase 1	0.023
SMAD3	SMAD family member 3	0.022
PRKCA	protein kinase C, alpha	0.022
FHOD3	formin homology 2 domain containing 3	0.022
CRYZ	crystallin, zeta (quinone reductase)	0.021
ECI1	enoyl-CoA delta isomerase 1	0.021
GATA4	GATA binding protein 4	0.021
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.021
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.020
IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	0.020
STAT5B	signal transducer and activator of transcription 5B	0.020
AUH	AU RNA binding protein/enoyl-CoA hydratase	0.020
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.020
C14orf1	chromosome 14 open reading frame 1	0.020
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.020
RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)	0.019
PHOX2A	paired-like homeobox 2a	0.019
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.019
ACOT13	acyl-CoA thioesterase 13	0.019
FABP1	fatty acid binding protein 1, liver	0.019	Rat
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.019
MCEE	methylmalonyl CoA epimerase	0.019
PDPK1	3-phosphoinositide dependent protein kinase-1	0.019
ISOC1	isochorismatase domain containing 1	0.019
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.019
SH2D2A	SH2 domain containing 2A	0.019
RARA	retinoic acid receptor, alpha	0.019
SLC25A17	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	0.019
COQ5	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	0.018
RAB4A	RAB4A, member RAS oncogene family	0.018
LMF2	lipase maturation factor 2	0.018
KAT2B	K(lysine) acetyltransferase 2B	0.018
PRKCI	protein kinase C, iota	0.018	Human
ECHDC2	enoyl CoA hydratase domain containing 2	0.018
MAT1A	methionine adenosyltransferase I, alpha	0.018
SUCLG1	succinate-CoA ligase, alpha subunit	0.017
TRIM9	tripartite motif containing 9	0.017
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.017
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.017	Rat
SESN2	sestrin 2	0.017	Mouse
GSTK1	glutathione S-transferase kappa 1	0.017
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.017
ALAD	aminolevulinate dehydratase	0.017
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.017
HIBADH	3-hydroxyisobutyrate dehydrogenase	0.016
BCKDK	branched chain ketoacid dehydrogenase kinase	0.016
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.016
FAM82B	family with sequence similarity 82, member B	0.015
SORBS2	sorbin and SH3 domain containing 2	0.015
LRRK2	leucine-rich repeat kinase 2	0.015
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.015
FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	0.015
HOXD12	homeobox D12	0.015
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.015	Human
ESD	esterase D	0.015
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.015
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.015
NME3	non-metastatic cells 3, protein expressed in	0.014
C8A	complement component 8, alpha polypeptide	0.014
KLHDC2	kelch domain containing 2	0.014
DGAT1	diacylglycerol O-acyltransferase 1	0.014
SCCPDH	saccharopine dehydrogenase (putative)	0.014
SUOX	sulfite oxidase	0.014
GLYAT	glycine-N-acyltransferase	0.014
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.014
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.014
G6PC	glucose-6-phosphatase, catalytic subunit	0.014
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.014
AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	0.014
HAL	histidine ammonia-lyase	0.014
PDX1	pancreatic and duodenal homeobox 1	0.014
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.014
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.014
C4BPA	complement component 4 binding protein, alpha	0.014
PEBP1	phosphatidylethanolamine binding protein 1	0.013
PCTP	phosphatidylcholine transfer protein	0.013
HIST1H3B	histone cluster 1, H3b	0.013
CTBP1	C-terminal binding protein 1	0.013
PPARA	peroxisome proliferator-activated receptor alpha	0.013
RNPEPL1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.013
SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	0.013
POFUT1	protein O-fucosyltransferase 1	0.013
MGST2	microsomal glutathione S-transferase 2	0.013
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.013
MIER1	mesoderm induction early response 1 homolog (Xenopus laevis)	0.013
CA5A	carbonic anhydrase VA, mitochondrial	0.013
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.013
PEX5	peroxisomal biogenesis factor 5	0.013	Mouse
EPOR	erythropoietin receptor	0.013
ACO2	aconitase 2, mitochondrial	0.013
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.013
CYBA	cytochrome b-245, alpha polypeptide	0.013
ABCD1	ATP-binding cassette, sub-family D (ALD), member 1	0.013
PPA2	pyrophosphatase (inorganic) 2	0.013
TAL1	T-cell acute lymphocytic leukemia 1	0.012	Human
ACSL1	acyl-CoA synthetase long-chain family member 1	0.012
ACO1	aconitase 1, soluble	0.012
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.012
EPHX2	epoxide hydrolase 2, cytoplasmic	0.012
BHMT	betaine--homocysteine S-methyltransferase	0.012
DEPTOR	DEP domain containing MTOR-interacting protein	0.012
BDH2	3-hydroxybutyrate dehydrogenase, type 2	0.012
TYSND1	trypsin domain containing 1	0.012
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.012
C8B	complement component 8, beta polypeptide	0.012
VHL	von Hippel-Lindau tumor suppressor	0.012
LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	0.012
SLC38A3	solute carrier family 38, member 3	0.012
GPR12	G protein-coupled receptor 12	0.012
FOXD3	forkhead box D3	0.012
SETDB1	SET domain, bifurcated 1	0.012
WWC1	WW and C2 domain containing 1	0.012
SPATA20	spermatogenesis associated 20	0.012
AKR7A2	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	0.012
OXA1L	oxidase (cytochrome c) assembly 1-like	0.012
AGXT2	alanine--glyoxylate aminotransferase 2	0.012
LMO1	LIM domain only 1 (rhombotin 1)	0.012
RDH16	retinol dehydrogenase 16 (all-trans)	0.012
SEPP1	selenoprotein P, plasma, 1	0.012
DDA1	DET1 and DDB1 associated 1	0.011
TTPA	tocopherol (alpha) transfer protein	0.011
GRB14	growth factor receptor-bound protein 14	0.011
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.011
SORD	sorbitol dehydrogenase	0.011
AQP7	aquaporin 7	0.011
OTC	ornithine carbamoyltransferase	0.011
CDK5RAP3	CDK5 regulatory subunit associated protein 3	0.011
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.011
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.011
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	0.011
ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	0.011
HDAC11	histone deacetylase 11	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
DAO	D-amino-acid oxidase	0.011
NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	0.011
GAMT	guanidinoacetate N-methyltransferase	0.011
MAN2C1	mannosidase, alpha, class 2C, member 1	0.011
PDSS2	prenyl (decaprenyl) diphosphate synthase, subunit 2	0.011
MAPT	microtubule-associated protein tau	0.011
CCHCR1	coiled-coil alpha-helical rod protein 1	0.011
TXNDC11	thioredoxin domain containing 11	0.011
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.011
ALDH7A1	aldehyde dehydrogenase 7 family, member A1	0.011
SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	0.011
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.011
ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	0.011
TLX3	T-cell leukemia homeobox 3	0.011
HRG	histidine-rich glycoprotein	0.011
GSTA3	glutathione S-transferase alpha 3	0.011
LMO2	LIM domain only 2 (rhombotin-like 1)	0.011
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.011
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.011
ACAD8	acyl-CoA dehydrogenase family, member 8	0.011
CASP6	caspase 6, apoptosis-related cysteine peptidase	0.011
MIPEP	mitochondrial intermediate peptidase	0.011
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.011
LIPC	lipase, hepatic	0.011
DECR2	2,4-dienoyl CoA reductase 2, peroxisomal	0.011
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.011
SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	0.010
METTL7A	methyltransferase like 7A	0.010
ADORA2A	adenosine A2a receptor	0.010
TRADD	TNFRSF1A-associated via death domain	0.010
EGF	epidermal growth factor	0.010
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.010
POU4F3	POU class 4 homeobox 3	0.010
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.010
POU3F4	POU class 3 homeobox 4	0.010
GSTM2	glutathione S-transferase mu 2 (muscle)	0.010
NEUROG1	neurogenin 1	0.010	Human
TSC22D1	TSC22 domain family, member 1	0.010
PEX26	peroxisomal biogenesis factor 26	0.010
MRPL38	mitochondrial ribosomal protein L38	0.010