IMP
Process View
translesion synthesis
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "translesion synthesis"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| RAD18 | RAD18 homolog (S. cerevisiae) | 0.996 | ||
| PCNA | proliferating cell nuclear antigen | 0.992 | ||
| POLE3 | polymerase (DNA directed), epsilon 3 (p17 subunit) | 0.895 | Yeast | |
| POLH | polymerase (DNA directed), eta | 0.888 | Fly | |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 0.689 | ||
| MSH6 | mutS homolog 6 (E. coli) | 0.575 | ||
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.545 | ||
| RAD51 | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 0.335 | ||
| DR1 | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 0.296 | ||
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.272 | ||
| FANCD2 | Fanconi anemia, complementation group D2 | 0.224 | ||
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 0.155 | ||
| REV3L | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 0.153 | ||
| ING2 | inhibitor of growth family, member 2 | 0.145 | ||
| REV1 | REV1 homolog (S. cerevisiae) | 0.136 | Yeast Mouse | |
| DTL | denticleless homolog (Drosophila) | 0.112 | ||
| RPA2 | replication protein A2, 32kDa | 0.110 | ||
| POLI | polymerase (DNA directed) iota | 0.108 | Fly | |
| ALDOA | aldolase A, fructose-bisphosphate | 0.106 | ||
| RFC1 | replication factor C (activator 1) 1, 145kDa | 0.103 | ||
| POLE2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.100 | Yeast | |
| MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 0.099 | ||
| POLE | polymerase (DNA directed), epsilon | 0.085 | Yeast | |
| RPA3 | replication protein A3, 14kDa | 0.077 | ||
| RPA1 | replication protein A1, 70kDa | 0.053 | ||
| PGK1 | phosphoglycerate kinase 1 | 0.052 | ||
| CHRAC1 | chromatin accessibility complex 1 | 0.048 | ||
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.044 | ||
| POLK | polymerase (DNA directed) kappa | 0.043 | ||
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.040 | ||
| DZIP3 | DAZ interacting protein 3, zinc finger | 0.037 | ||
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.036 | ||
| EXO1 | exonuclease 1 | 0.036 | ||
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.034 | ||
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.032 | ||
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | 0.031 | ||
| UBE2A | ubiquitin-conjugating enzyme E2A (RAD6 homolog) | 0.029 | Yeast | |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.028 | ||
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.028 | ||
| BRCA1 | breast cancer 1, early onset | 0.027 | ||
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 0.027 | ||
| FEN1 | flap structure-specific endonuclease 1 | 0.026 | ||
| GMNN | geminin, DNA replication inhibitor | 0.018 | ||
| FANCL | Fanconi anemia, complementation group L | 0.017 | ||
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.016 | ||
| ZNF302 | zinc finger protein 302 | 0.016 | ||
| MSH3 | mutS homolog 3 (E. coli) | 0.014 | ||
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 0.013 | ||
| MCM3 | minichromosome maintenance complex component 3 | 0.013 | ||
| RBBP8 | retinoblastoma binding protein 8 | 0.012 | ||
| FANCI | Fanconi anemia, complementation group I | 0.012 | ||
| LIG1 | ligase I, DNA, ATP-dependent | 0.011 | ||
| POLE4 | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 0.011 | Yeast | |
| RFC4 | replication factor C (activator 1) 4, 37kDa | 0.011 | ||
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 | 0.011 | ||
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 0.011 | ||
| RAD1 | RAD1 homolog (S. pombe) | 0.011 | ||
| FANCA | Fanconi anemia, complementation group A | 0.010 | ||
| ENO1 | enolase 1, (alpha) | 0.010 | ||
| BLM | Bloom syndrome, RecQ helicase-like | 0.010 | ||
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.010 |