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Homo sapiens

12 genes annotated in human

chromatin silencing

Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chromatin silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chromatin silencing" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	1.000	Human Fly
HDAC2	histone deacetylase 2	0.996
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.995
RB1	retinoblastoma 1	0.984
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.970	Yeast Mouse
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.950
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.916
TP53	tumor protein p53	0.844
EED	embryonic ectoderm development	0.822	Fly
PARP1	poly (ADP-ribose) polymerase 1	0.786
RBBP4	retinoblastoma binding protein 4	0.773	Yeast Fly
MCM7	minichromosome maintenance complex component 7	0.756	Yeast
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.665	Yeast
WDR5	WD repeat domain 5	0.619
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.549
BMI1	BMI1 polycomb ring finger oncogene	0.542	Fly
H2AFX	H2A histone family, member X	0.514	Yeast
ACTL6A	actin-like 6A	0.498
PCNA	proliferating cell nuclear antigen	0.497
MCM5	minichromosome maintenance complex component 5	0.488	Yeast
ESR1	estrogen receptor 1	0.486
CBX5	chromobox homolog 5	0.483	Fly
EP300	E1A binding protein p300	0.475
HIST1H3B	histone cluster 1, H3b	0.469
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.446
HCFC1	host cell factor C1 (VP16-accessory protein)	0.414
CHD4	chromodomain helicase DNA binding protein 4	0.410
SIRT1	sirtuin 1	0.408
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.380
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.380
BRCA1	breast cancer 1, early onset	0.360
CREBBP	CREB binding protein	0.354
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.353
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.338	Yeast
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.317
SP1	Sp1 transcription factor	0.300
RUVBL1	RuvB-like 1 (E. coli)	0.298
MCM2	minichromosome maintenance complex component 2	0.262
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.242
NBN	nibrin	0.216
MCM6	minichromosome maintenance complex component 6	0.201
MCM3	minichromosome maintenance complex component 3	0.194	Yeast
TMPO	thymopoietin	0.191
DAXX	death-domain associated protein	0.186
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.176
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.164
HIST1H3D	histone cluster 1, H3d	0.156	Yeast
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.155	Yeast Mouse
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.152
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.145
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.132
THOC4	THO complex 4	0.132
HIST1H2BG	histone cluster 1, H2bg	0.131
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.128	Fly
HDAC3	histone deacetylase 3	0.125
HIST1H2AE	histone cluster 1, H2ae	0.123	Yeast
KDM1A	lysine (K)-specific demethylase 1A	0.117
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.113
BCOR	BCL6 corepressor	0.107
TRIM28	tripartite motif containing 28	0.105
SSRP1	structure specific recognition protein 1	0.096
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.093
MRFAP1	Morf4 family associated protein 1	0.090
MTA1	metastasis associated 1	0.089
MSH6	mutS homolog 6 (E. coli)	0.087
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.083
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.070
SAP30	Sin3A-associated protein, 30kDa	0.069
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.068
HIST2H3C	histone cluster 2, H3c	0.068
NCOR2	nuclear receptor corepressor 2	0.067
HIST1H2AM	histone cluster 1, H2am	0.066
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.063
TOP2B	topoisomerase (DNA) II beta 180kDa	0.056	Fly
MYST1	MYST histone acetyltransferase 1	0.054
HIST1H3A	histone cluster 1, H3a	0.054
USP11	ubiquitin specific peptidase 11	0.053
HIST1H4H	histone cluster 1, H4h	0.049	Yeast
HIST1H2AI	histone cluster 1, H2ai	0.049	Yeast
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.047
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.047	Yeast Mouse
HIST1H4B	histone cluster 1, H4b	0.046	Yeast
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.046
DICER1	dicer 1, ribonuclease type III	0.044
E2F3	E2F transcription factor 3	0.043
NCAPH	non-SMC condensin I complex, subunit H	0.043
HIST1H4D	histone cluster 1, H4d	0.043	Yeast
NCOR1	nuclear receptor corepressor 1	0.041
HDGF	hepatoma-derived growth factor	0.041
MEN1	multiple endocrine neoplasia I	0.040
CBX8	chromobox homolog 8	0.040
TFDP1	transcription factor Dp-1	0.039
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.038
ORC3	origin recognition complex, subunit 3	0.038
SMAD3	SMAD family member 3	0.037
SETD7	SET domain containing (lysine methyltransferase) 7	0.037
GATAD2A	GATA zinc finger domain containing 2A	0.037
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.037
HIST1H2AL	histone cluster 1, H2al	0.036	Yeast
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.036	Yeast
ILF3	interleukin enhancer binding factor 3, 90kDa	0.036
ILF2	interleukin enhancer binding factor 2, 45kDa	0.036
RBBP7	retinoblastoma binding protein 7	0.036	Yeast Fly
MORF4L1	mortality factor 4 like 1	0.035	Fly
HIST1H2AJ	histone cluster 1, H2aj	0.034	Yeast
NRIP1	nuclear receptor interacting protein 1	0.033
CBX3	chromobox homolog 3	0.033	Fly
ORC4	origin recognition complex, subunit 4	0.032	Yeast
NCBP1	nuclear cap binding protein subunit 1, 80kDa	0.032
HIST1H1C	histone cluster 1, H1c	0.032
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.032	Mouse
HIST2H2BE	histone cluster 2, H2be	0.031
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.031
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.031	Yeast
RNF2	ring finger protein 2	0.031	Fly
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.030
HIST1H2BM	histone cluster 1, H2bm	0.029
HIST1H4A	histone cluster 1, H4a	0.029	Yeast
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.029	Fly
ADNP	activity-dependent neuroprotector homeobox	0.028
PAX3	paired box 3	0.028
HIST1H2BJ	histone cluster 1, H2bj	0.028
MCM4	minichromosome maintenance complex component 4	0.028
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.028
HIST2H2AA4	histone cluster 2, H2aa4	0.027
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.027
RCOR1	REST corepressor 1	0.026
ORC6	origin recognition complex, subunit 6	0.026
KAT5	K(lysine) acetyltransferase 5	0.026	Yeast
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.025
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.024
NCOA1	nuclear receptor coactivator 1	0.024
HIST1H4F	histone cluster 1, H4f	0.024	Yeast
HIST1H2AB	histone cluster 1, H2ab	0.024	Yeast
MAPK14	mitogen-activated protein kinase 14	0.024
SET	SET nuclear oncogene	0.023
FANCD2	Fanconi anemia, complementation group D2	0.023
E2F1	E2F transcription factor 1	0.023
ARID4B	AT rich interactive domain 4B (RBP1-like)	0.022
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.022
MTA3	metastasis associated 1 family, member 3	0.022
MDC1	mediator of DNA-damage checkpoint 1	0.022
CBX1	chromobox homolog 1	0.022	Fly
HIST1H3H	histone cluster 1, H3h	0.021
HIST1H2AG	histone cluster 1, H2ag	0.021	Yeast
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.021
AR	androgen receptor	0.021
HIST1H4E	histone cluster 1, H4e	0.020	Yeast
ARID1A	AT rich interactive domain 1A (SWI-like)	0.020	Mouse
LMNB2	lamin B2	0.019	Fly
NCL	nucleolin	0.019
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.019
PTMA	prothymosin, alpha	0.019
MCM10	minichromosome maintenance complex component 10	0.019	Fly
DEK	DEK oncogene	0.018
SMAD2	SMAD family member 2	0.018
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.018	Fly
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.018
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.018
HIST1H2BD	histone cluster 1, H2bd	0.018
GATAD2B	GATA zinc finger domain containing 2B	0.018
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.017
SOX10	SRY (sex determining region Y)-box 10	0.017
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.017
KAT2B	K(lysine) acetyltransferase 2B	0.016
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.016
H3F3A	H3 histone, family 3A	0.016
CHD8	chromodomain helicase DNA binding protein 8	0.016
HIST2H4A	histone cluster 2, H4a	0.016
MBD2	methyl-CpG binding domain protein 2	0.016
HIST1H2BC	histone cluster 1, H2bc	0.016
TYMS	thymidylate synthetase	0.016
MTA2	metastasis associated 1 family, member 2	0.016
CDYL	chromodomain protein, Y-like	0.015
POLE	polymerase (DNA directed), epsilon	0.015	Yeast
CDK11B	cyclin-dependent kinase 11B	0.015
LIG1	ligase I, DNA, ATP-dependent	0.015
MBD3	methyl-CpG binding domain protein 3	0.015	Mouse
RNF20	ring finger protein 20	0.015
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.015
RSBN1	round spermatid basic protein 1	0.015
POGZ	pogo transposable element with ZNF domain	0.015
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.015
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.015
FOXD3	forkhead box D3	0.014
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.014
NONO	non-POU domain containing, octamer-binding	0.014
RYBP	RING1 and YY1 binding protein	0.014
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.014
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.014	Mouse
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.013	Yeast
KIAA0101	KIAA0101	0.013
HAT1	histone acetyltransferase 1	0.013	Yeast
CAD	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.013
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.013	Mouse
MRFAP1L1	Morf4 family associated protein 1-like 1	0.013
PHF19	PHD finger protein 19	0.013
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.012
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.012
YBX1	Y box binding protein 1	0.012
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.012
SLBP	stem-loop binding protein	0.012
TACC3	transforming, acidic coiled-coil containing protein 3	0.012
CDK2	cyclin-dependent kinase 2	0.012
DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	0.011	Yeast
HIST1H1E	histone cluster 1, H1e	0.011
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.011	Yeast
HIST1H2BH	histone cluster 1, H2bh	0.011
HIST1H2BI	histone cluster 1, H2bi	0.011
EPC2	enhancer of polycomb homolog 2 (Drosophila)	0.011
MBD1	methyl-CpG binding domain protein 1	0.011
HIST1H2BB	histone cluster 1, H2bb	0.011
H2AFZ	H2A histone family, member Z	0.011	Yeast
RAD21	RAD21 homolog (S. pombe)	0.011
CDK2AP1	cyclin-dependent kinase 2 associated protein 1	0.011
RANBP2	RAN binding protein 2	0.010
HIST1H4I	histone cluster 1, H4i	0.010	Yeast
DTL	denticleless homolog (Drosophila)	0.010
HIST1H3G	histone cluster 1, H3g	0.010
SMC4	structural maintenance of chromosomes 4	0.010
HIST1H2AK	histone cluster 1, H2ak	0.010	Yeast
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.010