IMP

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Homo sapiens

3 genes annotated in human

Multi-species View

methylation dependent chromatin silencing

GO:0006346

Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "methylation dependent chromatin silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "methylation dependent chromatin silencing" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	1.000
DNMT1	DNA (cytosine-5-)-methyltransferase 1	1.000
UHRF1	ubiquitin-like with PHD and ring finger domains 1	1.000
HDAC2	histone deacetylase 2	1.000
MTA1	metastasis associated 1	0.998
CHD4	chromodomain helicase DNA binding protein 4	0.998
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.996	Mouse
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.995
EED	embryonic ectoderm development	0.994
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.987
SP1	Sp1 transcription factor	0.985
RBBP4	retinoblastoma binding protein 4	0.979
KDM1A	lysine (K)-specific demethylase 1A	0.973
MTA3	metastasis associated 1 family, member 3	0.962
ESR1	estrogen receptor 1	0.955
MTA2	metastasis associated 1 family, member 2	0.915
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.901
FOXD3	forkhead box D3	0.893
GATAD2A	GATA zinc finger domain containing 2A	0.879
PAX3	paired box 3	0.837
SOX10	SRY (sex determining region Y)-box 10	0.830
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.822	Mouse
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.816
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.639	Mouse
E2F3	E2F transcription factor 3	0.570
GATAD2B	GATA zinc finger domain containing 2B	0.546
SOX2	SRY (sex determining region Y)-box 2	0.509
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.502
HCFC1	host cell factor C1 (VP16-accessory protein)	0.461
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.457
NRIP1	nuclear receptor interacting protein 1	0.422
CBX5	chromobox homolog 5	0.383
RB1	retinoblastoma 1	0.370
MBD2	methyl-CpG binding domain protein 2	0.310
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.306
CHD3	chromodomain helicase DNA binding protein 3	0.297
TRIM28	tripartite motif containing 28	0.273
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.202
RCOR1	REST corepressor 1	0.187
RBBP7	retinoblastoma binding protein 7	0.163
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.151
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.143
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.126
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.122
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.118
POGZ	pogo transposable element with ZNF domain	0.105
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.087
DAXX	death-domain associated protein	0.083
HTT	huntingtin	0.083
CTBP1	C-terminal binding protein 1	0.075
SAP30	Sin3A-associated protein, 30kDa	0.070
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.065
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.064
CDK2AP1	cyclin-dependent kinase 2 associated protein 1	0.061
PELP1	proline, glutamate and leucine rich protein 1	0.061
MBD1	methyl-CpG binding domain protein 1	0.060
KIAA0101	KIAA0101	0.052
PBRM1	polybromo 1	0.049
SMARCD2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	0.049
KHSRP	KH-type splicing regulatory protein	0.048
NCOR2	nuclear receptor corepressor 2	0.046
CSNK1G2	casein kinase 1, gamma 2	0.046
MEOX2	mesenchyme homeobox 2	0.043
HMGA1	high mobility group AT-hook 1	0.041
ARID1A	AT rich interactive domain 1A (SWI-like)	0.041
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.038
SOX11	SRY (sex determining region Y)-box 11	0.037
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.035
C14orf43	chromosome 14 open reading frame 43	0.033
SOX1	SRY (sex determining region Y)-box 1	0.031
CARM1	coactivator-associated arginine methyltransferase 1	0.030
H3F3B	H3 histone, family 3B (H3.3B)	0.029
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.028
ZBTB17	zinc finger and BTB domain containing 17	0.027
ESR2	estrogen receptor 2 (ER beta)	0.027
POU4F1	POU class 4 homeobox 1	0.027	Human
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.026
MYOD1	myogenic differentiation 1	0.025
EP300	E1A binding protein p300	0.025
HOXD12	homeobox D12	0.024
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.024
NOVA2	neuro-oncological ventral antigen 2	0.024
SOX21	SRY (sex determining region Y)-box 21	0.023
FANCC	Fanconi anemia, complementation group C	0.023
GRIP1	glutamate receptor interacting protein 1	0.022
POU3F2	POU class 3 homeobox 2	0.021	Human
YY1	YY1 transcription factor	0.021
CENPB	centromere protein B, 80kDa	0.020
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.020
CDCA7	cell division cycle associated 7	0.020
BCL6	B-cell CLL/lymphoma 6	0.019
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.019
CEP152	centrosomal protein 152kDa	0.019
LHX1	LIM homeobox 1	0.019
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.019
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.019
CAD	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	0.019
SMAD7	SMAD family member 7	0.018
NKX2-1	NK2 homeobox 1	0.018
C16orf87	chromosome 16 open reading frame 87	0.018
OTP	orthopedia homeobox	0.018
NEUROG3	neurogenin 3	0.018
HIST1H3B	histone cluster 1, H3b	0.018
DNTTIP1	deoxynucleotidyltransferase, terminal, interacting protein 1	0.017
BTBD2	BTB (POZ) domain containing 2	0.017
C10orf46	chromosome 10 open reading frame 46	0.017
EWSR1	Ewing sarcoma breakpoint region 1	0.017
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.017
PNOC	prepronociceptin	0.017
HIPK2	homeodomain interacting protein kinase 2	0.016
DAZAP1	DAZ associated protein 1	0.016
CTBP2	C-terminal binding protein 2	0.016
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.016
ZGPAT	zinc finger, CCCH-type with G patch domain	0.016
TP73	tumor protein p73	0.016
STRADA	STE20-related kinase adaptor alpha	0.016
TP53BP1	tumor protein p53 binding protein 1	0.015
TAL1	T-cell acute lymphocytic leukemia 1	0.015
OLIG2	oligodendrocyte lineage transcription factor 2	0.015
RNF8	ring finger protein 8	0.015
BRCA1	breast cancer 1, early onset	0.015
E4F1	E4F transcription factor 1	0.015
MIER1	mesoderm induction early response 1 homolog (Xenopus laevis)	0.015
C17orf70	chromosome 17 open reading frame 70	0.015
GINS1	GINS complex subunit 1 (Psf1 homolog)	0.015
POU4F2	POU class 4 homeobox 2	0.015	Human
FANCE	Fanconi anemia, complementation group E	0.015
S1PR2	sphingosine-1-phosphate receptor 2	0.014
FBXW8	F-box and WD repeat domain containing 8	0.014
KIF18B	kinesin family member 18B	0.014
NHLH2	nescient helix loop helix 2	0.014
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.013
TRIM27	tripartite motif containing 27	0.013
PGR	progesterone receptor	0.013
CDYL	chromodomain protein, Y-like	0.013
FOXA2	forkhead box A2	0.013
NLRP2	NLR family, pyrin domain containing 2	0.013
PHF10	PHD finger protein 10	0.013
PRMT2	protein arginine methyltransferase 2	0.013
DUSP23	dual specificity phosphatase 23	0.013
HIST3H3	histone cluster 3, H3	0.013
GRIK3	glutamate receptor, ionotropic, kainate 3	0.013
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.012
PRDM13	PR domain containing 13	0.012
POU3F3	POU class 3 homeobox 3	0.012	Human
EYA2	eyes absent homolog 2 (Drosophila)	0.012
SETDB1	SET domain, bifurcated 1	0.012
BIN1	bridging integrator 1	0.012
EHMT1	euchromatic histone-lysine N-methyltransferase 1	0.012
NKX6-1	NK6 homeobox 1	0.012
DCX	doublecortin	0.012
GEN1	Gen homolog 1, endonuclease (Drosophila)	0.012
PLEKHJ1	pleckstrin homology domain containing, family J member 1	0.012
PHF21A	PHD finger protein 21A	0.012
NCOR1	nuclear receptor corepressor 1	0.012
PRR11	proline rich 11	0.012
PAX6	paired box 6	0.011
KIAA0182	KIAA0182	0.011
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.011
CDX2	caudal type homeobox 2	0.011
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
PARP1	poly (ADP-ribose) polymerase 1	0.011
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.011
CSK	c-src tyrosine kinase	0.011
PYY	peptide YY	0.011
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.011
THAP11	THAP domain containing 11	0.011
RUNX1	runt-related transcription factor 1	0.011
FOXO1	forkhead box O1	0.011
NELL1	NEL-like 1 (chicken)	0.011
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.011
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.011
SOX4	SRY (sex determining region Y)-box 4	0.011
BCOR	BCL6 corepressor	0.011
PAX5	paired box 5	0.011
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.011
PDX1	pancreatic and duodenal homeobox 1	0.011
ISL1	ISL LIM homeobox 1	0.011
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.011
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.011
TLX2	T-cell leukemia homeobox 2	0.011
NKX2-8	NK2 homeobox 8	0.011
SFRP5	secreted frizzled-related protein 5	0.011
BCL7A	B-cell CLL/lymphoma 7A	0.011
UBTF	upstream binding transcription factor, RNA polymerase I	0.011
SIX2	SIX homeobox 2	0.010
CHD7	chromodomain helicase DNA binding protein 7	0.010
SIX6	SIX homeobox 6	0.010
ZNF367	zinc finger protein 367	0.010
GALR1	galanin receptor 1	0.010
MAX	MYC associated factor X	0.010
PABPN1	poly(A) binding protein, nuclear 1	0.010
SALL2	sal-like 2 (Drosophila)	0.010
DGCR8	DiGeorge syndrome critical region gene 8	0.010
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.010
GRAP	GRB2-related adaptor protein	0.010
HDAC3	histone deacetylase 3	0.010
PWWP2A	PWWP domain containing 2A	0.010
LBX1	ladybird homeobox 1	0.010
HOXC4	homeobox C4	0.010
PITX2	paired-like homeodomain 2	0.010
NRTN	neurturin	0.010
CD22	CD22 molecule	0.010
TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	0.010
PPARA	peroxisome proliferator-activated receptor alpha	0.010