IMP

Process View

Homo sapiens

13 genes annotated in human

Multi-species View

regulation of insulin receptor signaling pathway

GO:0046626

Any process that modulates the frequency, rate or extent of insulin receptor signaling.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of insulin receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of insulin receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
INSR	insulin receptor	0.995
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.991	Rat
CREBBP	CREB binding protein	0.941
NCOA1	nuclear receptor coactivator 1	0.910
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.880
EGFR	epidermal growth factor receptor	0.811
FBXW11	F-box and WD repeat domain containing 11	0.683	Fly
CUL1	cullin 1	0.674	Fly
GRB10	growth factor receptor-bound protein 10	0.662	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.585
FYN	FYN oncogene related to SRC, FGR, YES	0.579
TSC2	tuberous sclerosis 2	0.523	Mouse Fly
IRS2	insulin receptor substrate 2	0.442
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.405
SH2B1	SH2B adaptor protein 1	0.321	Fly
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.297
JAK2	Janus kinase 2	0.295
BTRC	beta-transducin repeat containing	0.234	Fly
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.216
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.207
IRS1	insulin receptor substrate 1	0.191	Rat
NOXA1	NADPH oxidase activator 1	0.190
IL1R1	interleukin 1 receptor, type I	0.159
KAT2B	K(lysine) acetyltransferase 2B	0.154
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.148	Rat
CREB1	cAMP responsive element binding protein 1	0.134
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.133
IGF1R	insulin-like growth factor 1 receptor	0.115
BCAR1	breast cancer anti-estrogen resistance 1	0.108
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.104	Rat
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.102
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.085
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.084
SH3RF1	SH3 domain containing ring finger 1	0.084
SOS1	son of sevenless homolog 1 (Drosophila)	0.082
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.081
PLCG1	phospholipase C, gamma 1	0.081
SMAD3	SMAD family member 3	0.080
CAV1	caveolin 1, caveolae protein, 22kDa	0.079
AR	androgen receptor	0.077
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.071
RXRA	retinoid X receptor, alpha	0.069
GSK3B	glycogen synthase kinase 3 beta	0.066	Human
NCF1	neutrophil cytosolic factor 1	0.066
TSC1	tuberous sclerosis 1	0.063	Fly
STAT5B	signal transducer and activator of transcription 5B	0.057
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.056
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.055
GHR	growth hormone receptor	0.055
NCOA3	nuclear receptor coactivator 3	0.052
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.051
NCK1	NCK adaptor protein 1	0.051	Fly
SKP1	S-phase kinase-associated protein 1	0.050	Fly
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.047
PRKCA	protein kinase C, alpha	0.045	Mouse
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.043
EP300	E1A binding protein p300	0.043
RAB6A	RAB6A, member RAS oncogene family	0.040
IL1RAP	interleukin 1 receptor accessory protein	0.040
SORBS1	sorbin and SH3 domain containing 1	0.040
ABI1	abl-interactor 1	0.039
SIRT1	sirtuin 1	0.039
PRKCB	protein kinase C, beta	0.037
MAPT	microtubule-associated protein tau	0.035
MAPK3	mitogen-activated protein kinase 3	0.032
MAPK14	mitogen-activated protein kinase 14	0.032
CEP250	centrosomal protein 250kDa	0.032
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.031
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.031
DOCK1	dedicator of cytokinesis 1	0.029
NCOA2	nuclear receptor coactivator 2	0.028
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.027
ITGB1BP3	integrin beta 1 binding protein 3	0.026
FOXO1	forkhead box O1	0.026	Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.026
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.025
EEF2K	eukaryotic elongation factor-2 kinase	0.025
RHOU	ras homolog gene family, member U	0.025
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.024
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.023
EPOR	erythropoietin receptor	0.023
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.022
GRB2	growth factor receptor-bound protein 2	0.022
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.021
PRKCZ	protein kinase C, zeta	0.021
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.021
ITSN1	intersectin 1 (SH3 domain protein)	0.020
ESR1	estrogen receptor 1	0.020
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.020
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.019
PDPK1	3-phosphoinositide dependent protein kinase-1	0.019
KIAA1217	KIAA1217	0.019
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.019
COASY	CoA synthase	0.018
STAT5A	signal transducer and activator of transcription 5A	0.018
MAPK1	mitogen-activated protein kinase 1	0.018
SOCS3	suppressor of cytokine signaling 3	0.017	Mouse
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.017
SFN	stratifin	0.017
YAP1	Yes-associated protein 1	0.016
RARA	retinoic acid receptor, alpha	0.016
C17orf28	chromosome 17 open reading frame 28	0.016
LAT	linker for activation of T cells	0.016
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.015
PTK2	PTK2 protein tyrosine kinase 2	0.015
SOCS1	suppressor of cytokine signaling 1	0.015	Mouse
FBXW2	F-box and WD repeat domain containing 2	0.015
FOXO3	forkhead box O3	0.015	Fly
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.015
ATF2	activating transcription factor 2	0.015
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.014
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.014
ARHGAP5	Rho GTPase activating protein 5	0.014
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.013
CDCP1	CUB domain containing protein 1	0.013
DLG1	discs, large homolog 1 (Drosophila)	0.013
HMOX2	heme oxygenase (decycling) 2	0.013
AXIN1	axin 1	0.013
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.013
IL1RN	interleukin 1 receptor antagonist	0.013
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.012
PTPRE	protein tyrosine phosphatase, receptor type, E	0.012	Mouse Rat
TSC22D1	TSC22 domain family, member 1	0.012
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.011
LIMS1	LIM and senescent cell antigen-like domains 1	0.011
PRKCE	protein kinase C, epsilon	0.011
CREBZF	CREB/ATF bZIP transcription factor	0.011
NCOA6	nuclear receptor coactivator 6	0.011
FMR1	fragile X mental retardation 1	0.010	Fly
PTPRB	protein tyrosine phosphatase, receptor type, B	0.010
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.010
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.010
GLTPD1	glycolipid transfer protein domain containing 1	0.010
TRIM9	tripartite motif containing 9	0.010