IMP

Process View

Mus musculus

13 genes annotated in mouse

regulation of systemic arterial blood pressure by circulatory renin angiotensin

GO:0001991

The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of systemic arterial blood pressure by circulatory renin angiotensin"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of systemic arterial blood pressure by circulatory renin angiotensin" (in gray)

Name	Description	Probability	Func Analog Organism
Ren1	renin 1 structural	1.000
Agtr1a	angiotensin II receptor, type 1a	0.998
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.994
Bdkrb2	bradykinin receptor, beta 2	0.806	Mouse
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.718
Lepr	leptin receptor	0.649
Slc12a1	solute carrier family 12, member 1	0.579
Umod	uromodulin	0.496
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.359
Egfr	epidermal growth factor receptor	0.313
Cyp11b2	cytochrome P450, family 11, subfamily b, polypeptide 2	0.302
Cma1	chymase 1, mast cell	0.294	Mouse
Ptgs2	prostaglandin-endoperoxide synthase 2	0.270
Mcpt4	mast cell protease 4	0.262
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.255
Nos3	nitric oxide synthase 3, endothelial cell	0.251
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.247
Aqp2	aquaporin 2	0.227
Serpina12	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	0.212	Mouse
Vegfa	vascular endothelial growth factor A	0.183
Wt1	Wilms tumor 1 homolog	0.179
Nos2	nitric oxide synthase 2, inducible	0.168
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.132
Ctsb	cathepsin B	0.130
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.117	Mouse
Cpa3	carboxypeptidase A3, mast cell	0.115
F2	coagulation factor II	0.106
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.104
Ang2	angiogenin, ribonuclease A family, member 2	0.101
Scn5a	sodium channel, voltage-gated, type V, alpha	0.095
Col4a3	collagen, type IV, alpha 3	0.085
Rhox6	reproductive homeobox 6	0.084
Gpr182	G protein-coupled receptor 182	0.081
Tgfb1	transforming growth factor, beta 1	0.081
Mup4	major urinary protein 4	0.080
Adrb3	adrenergic receptor, beta 3	0.075
Kel	Kell blood group	0.072
Agtrap	angiotensin II, type I receptor-associated protein	0.067
Serpina1b	serine (or cysteine) preptidase inhibitor, clade A, member 1B	0.062	Mouse
Gzmb	granzyme B	0.059	Mouse
Pcdh12	protocadherin 12	0.059
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.053
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.052
H2-M9	histocompatibility 2, M region locus 9	0.050
Agtr2	angiotensin II receptor, type 2	0.050
Ccl22	chemokine (C-C motif) ligand 22	0.046
Serpina3c	serine (or cysteine) peptidase inhibitor, clade A, member 3C	0.044
Gzmc	granzyme C	0.042	Mouse
Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide	0.042
F12	coagulation factor XII (Hageman factor)	0.041
Cd3e	CD3 antigen, epsilon polypeptide	0.038
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.037
Mc2r	melanocortin 2 receptor	0.036
Gjb2	gap junction protein, beta 2	0.036	Mouse
Ahsg	alpha-2-HS-glycoprotein	0.036
Sprr1b	small proline-rich protein 1B	0.035
Aqp7	aquaporin 7	0.035
Gzma	granzyme A	0.035	Mouse
Fasl	Fas ligand (TNF superfamily, member 6)	0.034
Sva	seminal vesicle antigen	0.034
Klk6	kallikrein related-peptidase 6	0.034
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.034
Pitx2	paired-like homeodomain transcription factor 2	0.033
Serpina10	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.033
Spry4	sprouty homolog 4 (Drosophila)	0.033
Lamp1	lysosomal-associated membrane protein 1	0.033
Ccl11	chemokine (C-C motif) ligand 11	0.032
Il9r	interleukin 9 receptor	0.031
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.030
Tm4sf1	transmembrane 4 superfamily member 1	0.030
Aprt	adenine phosphoribosyl transferase	0.029
Lipc	lipase, hepatic	0.029
Vdr	vitamin D receptor	0.029
Ncr1	natural cytotoxicity triggering receptor 1	0.028
Mcpt8	mast cell protease 8	0.028	Mouse
Apof	apolipoprotein F	0.027
Gzmd	granzyme D	0.027	Mouse
Ccbp2	chemokine binding protein 2	0.027
Tpsb2	tryptase beta 2	0.026
Adipoq	adiponectin, C1Q and collagen domain containing	0.026
Try5	trypsin 5	0.026
Ccl8	chemokine (C-C motif) ligand 8	0.025
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.025
Mas1	MAS1 oncogene	0.025
Slpi	secretory leukocyte peptidase inhibitor	0.025
Krt27	keratin 27	0.024
Nkg7	natural killer cell group 7 sequence	0.023
Rnase1	ribonuclease, RNase A family, 1 (pancreatic)	0.022
Ubd	ubiquitin D	0.022
Xcl1	chemokine (C motif) ligand 1	0.022
Cxcl9	chemokine (C-X-C motif) ligand 9	0.022
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.022
Enam	enamelin	0.022
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.022
Fut2	fucosyltransferase 2	0.022
Dmgdh	dimethylglycine dehydrogenase precursor	0.021
Lamp2	lysosomal-associated membrane protein 2	0.021
Retn	resistin	0.021
Ngf	nerve growth factor	0.020
Fgfr4	fibroblast growth factor receptor 4	0.020
Cd209b	CD209b antigen	0.020
Kif7	kinesin family member 7	0.020
Dmkn	dermokine	0.020
Pah	phenylalanine hydroxylase	0.020
Slc6a12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.020
Cmklr1	chemokine-like receptor 1	0.020
Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	0.020
Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	0.019
Ngp	neutrophilic granule protein	0.019
Tjp1	tight junction protein 1	0.019
Fshb	follicle stimulating hormone beta	0.019
Asah1	N-acylsphingosine amidohydrolase 1	0.019
Mcpt1	mast cell protease 1	0.019	Mouse
Prl8a9	prolactin family8, subfamily a, member 9	0.018
Fcna	ficolin A	0.018
Sprr2i	small proline-rich protein 2I	0.018
Ccl24	chemokine (C-C motif) ligand 24	0.018
Ltc4s	leukotriene C4 synthase	0.018
Plau	plasminogen activator, urokinase	0.018
Galr2	galanin receptor 2	0.018
Ccr8	chemokine (C-C motif) receptor 8	0.017
Glis2	GLIS family zinc finger 2	0.017
Krt36	keratin 36	0.017
Pdcd1	programmed cell death 1	0.017
A2m	alpha-2-macroglobulin	0.017
Tbx5	T-box 5	0.017
Wnt7a	wingless-related MMTV integration site 7A	0.016
Pramel6	preferentially expressed antigen in melanoma like 6	0.016
Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	0.016
Gucy2e	guanylate cyclase 2e	0.016
Cela2a	chymotrypsin-like elastase family, member 2A	0.016
Akap4	A kinase (PRKA) anchor protein 4	0.016
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.016
Saa2	serum amyloid A 2	0.016
Ctrb1	chymotrypsinogen B1	0.016
Apoc4	apolipoprotein C-IV	0.016
Ly6d	lymphocyte antigen 6 complex, locus D	0.015
Psg19	pregnancy specific glycoprotein 19	0.015
Mcpt2	mast cell protease 2	0.015	Mouse
Ctsg	cathepsin G	0.015	Mouse
Aplnr	apelin receptor	0.015	Mouse
Dnase1l3	deoxyribonuclease 1-like 3	0.015
1700074P13Rik	RIKEN cDNA 1700074P13 gene	0.015
Ctsw	cathepsin W	0.015
Tg	thyroglobulin	0.014
Col13a1	collagen, type XIII, alpha 1	0.014
Lox	lysyl oxidase	0.014
Prss58	protease, serine 58	0.014
Fgf23	fibroblast growth factor 23	0.014
Lrrc15	leucine rich repeat containing 15	0.014
Elane	elastase, neutrophil expressed	0.014
Irs3	insulin receptor substrate 3	0.014
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.014
Ccl7	chemokine (C-C motif) ligand 7	0.014
Prl7a1	prolactin family 7, subfamily a, member 1	0.014
Klk1b11	kallikrein 1-related peptidase b11	0.014
Plg	plasminogen	0.014
Mobp	myelin-associated oligodendrocytic basic protein	0.013
Ivl	involucrin	0.013
Gm12597	predicted gene 12597	0.013
C1qc	complement component 1, q subcomponent, C chain	0.013
Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	0.013
Psap	prosaposin	0.013
Ret	ret proto-oncogene	0.013
Nobox	NOBOX oogenesis homeobox	0.013
Adora2b	adenosine A2b receptor	0.013
Hc	hemolytic complement	0.013
Aoc3	amine oxidase, copper containing 3	0.013
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.013
Il18rap	interleukin 18 receptor accessory protein	0.013
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.013
Slc27a5	solute carrier family 27 (fatty acid transporter), member 5	0.013
Mmp10	matrix metallopeptidase 10	0.013
Msln	mesothelin	0.013
Prss28	protease, serine, 28	0.013
Bdkrb1	bradykinin receptor, beta 1	0.013	Mouse
Scarb2	scavenger receptor class B, member 2	0.013
Pkp3	plakophilin 3	0.013
C2	complement component 2 (within H-2S)	0.013
Nppc	natriuretic peptide type C	0.012
Gnat1	guanine nucleotide binding protein, alpha transducing 1	0.012
Cd7	CD7 antigen	0.012
Sh2d2a	SH2 domain protein 2A	0.012
C5ar1	complement component 5a receptor 1	0.012
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.012
Slurp1	secreted Ly6/Plaur domain containing 1	0.012
G6pc	glucose-6-phosphatase, catalytic	0.012
Hp	haptoglobin	0.012
Sod3	superoxide dismutase 3, extracellular	0.012
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.012
Grn	granulin	0.011
Il1r2	interleukin 1 receptor, type II	0.011
Crygd	crystallin, gamma D	0.011
Sult1c1	sulfotransferase family, cytosolic, 1C, member 1	0.011
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.011
Kl	klotho	0.011
Cryba1	crystallin, beta A1	0.011
Prss2	protease, serine, 2	0.011
Ear11	eosinophil-associated, ribonuclease A family, member 11	0.011
Mog	myelin oligodendrocyte glycoprotein	0.011
Ly6i	lymphocyte antigen 6 complex, locus I	0.011
Tnp2	transition protein 2	0.011
Sprr1a	small proline-rich protein 1A	0.011
Mrap	melanocortin 2 receptor accessory protein	0.011
Akr1c6	aldo-keto reductase family 1, member C6	0.011
Ryr2	ryanodine receptor 2, cardiac	0.011
Il1rl1	interleukin 1 receptor-like 1	0.011
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.011
Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	0.011	Mouse
Retnlb	resistin like beta	0.011
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.011
Gm10334	predicted gene 10334	0.011
Trim10	tripartite motif-containing 10	0.011
F10	coagulation factor X	0.011
Sctr	secretin receptor	0.011
F9	coagulation factor IX	0.011
Afp	alpha fetoprotein	0.011
Ctrl	chymotrypsin-like	0.010
Ear5	eosinophil-associated, ribonuclease A family, member 5	0.010
Hcrtr1	hypocretin (orexin) receptor 1	0.010
Gjb5	gap junction protein, beta 5	0.010	Mouse
Acsm2	acyl-CoA synthetase medium-chain family member 2	0.010
Tshr	thyroid stimulating hormone receptor	0.010
Tpbpa	trophoblast specific protein alpha	0.010
Il5ra	interleukin 5 receptor, alpha	0.010
Saa4	serum amyloid A 4	0.010
Klk1b4	kallikrein 1-related pepidase b4	0.010
Apoa1	apolipoprotein A-I	0.010
Krt17	keratin 17	0.010
Ctsa	cathepsin A	0.010
Apoa5	apolipoprotein A-V	0.010
Ccl1	chemokine (C-C motif) ligand 1	0.010
Ceacam12	carcinoembryonic antigen-related cell adhesion molecule 12	0.010
Obox2	oocyte specific homeobox 2	0.010
Calcoco2	calcium binding and coiled-coil domain 2	0.010
Sox7	SRY-box containing gene 7	0.010