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Mus musculus

3 genes annotated in mouse

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germ line sex determination

GO:0018992

The determination of sex and sexual phenotype in an organism's germ line.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "germ line sex determination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "germ line sex determination" (in gray)

Name	Description	Probability	Func Analog Organism
Meox2	mesenchyme homeobox 2	0.951
Sox11	SRY-box containing gene 11	0.775	Mouse
Isl1	ISL1 transcription factor, LIM/homeodomain	0.699
Fgfr2	fibroblast growth factor receptor 2	0.589
Pitx1	paired-like homeodomain transcription factor 1	0.546
Gli3	GLI-Kruppel family member GLI3	0.480
Hes1	hairy and enhancer of split 1 (Drosophila)	0.402
Pax3	paired box gene 3	0.383
Pax6	paired box gene 6	0.332
Tcfap2a	transcription factor AP-2, alpha	0.294
Col2a1	collagen, type II, alpha 1	0.248
Alx1	ALX homeobox 1	0.237
Pou5f1	POU domain, class 5, transcription factor 1	0.235
Gli2	GLI-Kruppel family member GLI2	0.233
Col11a1	collagen, type XI, alpha 1	0.187
Nf1	neurofibromatosis 1	0.176
Alx3	aristaless-like homeobox 3	0.161
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.158
Edar	ectodysplasin-A receptor	0.153
Sox4	SRY-box containing gene 4	0.150	Mouse
Nkx6-1	NK6 homeobox 1	0.146
Mest	mesoderm specific transcript	0.130
She	src homology 2 domain-containing transforming protein E	0.129
Fgfr3	fibroblast growth factor receptor 3	0.125
Sall3	sal-like 3 (Drosophila)	0.122
Meox1	mesenchyme homeobox 1	0.120
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.109
Rab25	RAB25, member RAS oncogene family	0.105
Hes5	hairy and enhancer of split 5 (Drosophila)	0.103
Plxnd1	plexin D1	0.102
Rasip1	Ras interacting protein 1	0.102
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.101
Aplnr	apelin receptor	0.095
Cldn5	claudin 5	0.093
Sox3	SRY-box containing gene 3	0.086	Mouse
Sox18	SRY-box containing gene 18	0.080	Mouse
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.076
Insm1	insulinoma-associated 1	0.072
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.071
Fgf8	fibroblast growth factor 8	0.070
Otx2	orthodenticle homolog 2 (Drosophila)	0.070
Tcfap2c	transcription factor AP-2, gamma	0.066
Emx1	empty spiracles homolog 1 (Drosophila)	0.063
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.063
Sfrp2	secreted frizzled-related protein 2	0.063
Nanog	Nanog homeobox	0.062
Sall4	sal-like 4 (Drosophila)	0.060
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.059
Atoh7	atonal homolog 7 (Drosophila)	0.058
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.057
Kdr	kinase insert domain protein receptor	0.056
Bcl6b	B-cell CLL/lymphoma 6, member B	0.054
Efs	embryonal Fyn-associated substrate	0.052
Wnt6	wingless-related MMTV integration site 6	0.051
Shh	sonic hedgehog	0.051
Sox17	SRY-box containing gene 17	0.049	Mouse
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.048
Dlk1	delta-like 1 homolog (Drosophila)	0.048
Sox7	SRY-box containing gene 7	0.045	Mouse
Emcn	endomucin	0.044
Ret	ret proto-oncogene	0.043
Gata4	GATA binding protein 4	0.043
Hhex	hematopoietically expressed homeobox	0.043
Ptprb	protein tyrosine phosphatase, receptor type, B	0.040
Xpo4	exportin 4	0.040
Gja4	gap junction protein, alpha 4	0.039
Zeb1	zinc finger E-box binding homeobox 1	0.039
Pou3f3	POU domain, class 3, transcription factor 3	0.038
Egfl7	EGF-like domain 7	0.038
Pitx2	paired-like homeodomain transcription factor 2	0.038
Hesx1	homeobox gene expressed in ES cells	0.037
Gdnf	glial cell line derived neurotrophic factor	0.036
Irx5	Iroquois related homeobox 5 (Drosophila)	0.036
Mmrn2	multimerin 2	0.036
Nrk	Nik related kinase	0.035
Hand1	heart and neural crest derivatives expressed transcript 1	0.034
Sox2	SRY-box containing gene 2	0.034	Mouse
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.033
Tbx2	T-box 2	0.032
Slc44a3	solute carrier family 44, member 3	0.032
Ntf3	neurotrophin 3	0.032
Cldn3	claudin 3	0.032
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.032
Esam	endothelial cell-specific adhesion molecule	0.031
Mas1	MAS1 oncogene	0.031
Prrx1	paired related homeobox 1	0.031
Nrtn	neurturin	0.029
Sall1	sal-like 1 (Drosophila)	0.029
Fgf4	fibroblast growth factor 4	0.028
Atp2c2	ATPase, Ca++ transporting, type 2C, member 2	0.028
Cldn4	claudin 4	0.028
Ebf3	early B-cell factor 3	0.027
Sfn	stratifin	0.027
Phlda2	pleckstrin homology-like domain, family A, member 2	0.027
Gas1	growth arrest specific 1	0.027
Hoxb13	homeobox B13	0.027
Ednrb	endothelin receptor type B	0.027
Emx2	empty spiracles homolog 2 (Drosophila)	0.026
Icam2	intercellular adhesion molecule 2	0.026
Adcy4	adenylate cyclase 4	0.026
Epn3	epsin 3	0.026
Dlx1	distal-less homeobox 1	0.026
Twist1	twist homolog 1 (Drosophila)	0.025
Tshz3	teashirt zinc finger family member 3	0.025
Pthlh	parathyroid hormone-like peptide	0.025
Pou3f1	POU domain, class 3, transcription factor 1	0.025
Tpbg	trophoblast glycoprotein	0.025
Ihh	Indian hedgehog	0.024
Alx4	aristaless-like homeobox 4	0.024
Dctn1	dynactin 1	0.024
Nog	noggin	0.024
Kit	kit oncogene	0.023
Cux1	cut-like homeobox 1	0.023
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.023
Pbx1	pre B-cell leukemia transcription factor 1	0.023
Mtap7d1	microtubule-associated protein 7 domain containing 1	0.023
Epha1	Eph receptor A1	0.023
Mitf	microphthalmia-associated transcription factor	0.023
Lmx1a	LIM homeobox transcription factor 1 alpha	0.023
Dmrt1	doublesex and mab-3 related transcription factor 1	0.023
Lef1	lymphoid enhancer binding factor 1	0.022
Ldb2	LIM domain binding 2	0.022
Hoxd8	homeobox D8	0.022
Btbd17	BTB (POZ) domain containing 17	0.022
Olig2	oligodendrocyte transcription factor 2	0.022
Tnni1	troponin I, skeletal, slow 1	0.022
Efnb2	ephrin B2	0.021
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.021
Ildr1	immunoglobulin-like domain containing receptor 1	0.021
Elf3	E74-like factor 3	0.021
Flt1	FMS-like tyrosine kinase 1	0.021
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.021
Pyy	peptide YY	0.021
Kcnk2	potassium channel, subfamily K, member 2	0.021
Lrrc26	leucine rich repeat containing 26	0.021
Krt19	keratin 19	0.020
Crlf1	cytokine receptor-like factor 1	0.020
Peg10	paternally expressed 10	0.020
Krt17	keratin 17	0.020
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.019
BC021891	cDNA sequence BC021891	0.019
Smo	smoothened homolog (Drosophila)	0.019
Espn	espin	0.019
Vangl2	vang-like 2 (van gogh, Drosophila)	0.019
Dll4	delta-like 4 (Drosophila)	0.019
Clic3	chloride intracellular channel 3	0.018
Ski	ski sarcoma viral oncogene homolog (avian)	0.018
Fgf10	fibroblast growth factor 10	0.018
Chd7	chromodomain helicase DNA binding protein 7	0.018
Myo6	myosin VI	0.018
Smad6	MAD homolog 6 (Drosophila)	0.018
Fbn2	fibrillin 2	0.018
Efna2	ephrin A2	0.018
Foxj1	forkhead box J1	0.018
Nynrin	NYN domain and retroviral integrase containing	0.018
Ccdc92	coiled-coil domain containing 92	0.018
Llgl1	lethal giant larvae homolog 1 (Drosophila)	0.018
Prss8	protease, serine, 8 (prostasin)	0.018
Grb10	growth factor receptor bound protein 10	0.018
Eda	ectodysplasin-A	0.018
4930548H24Rik	RIKEN cDNA 4930548H24 gene	0.018
Ptgfrn	prostaglandin F2 receptor negative regulator	0.018
Fam65c	family with sequence similarity 65, member C	0.017
Tbx15	T-box 15	0.017
Ephb2	Eph receptor B2	0.017
Amn	amnionless	0.017
Gpr56	G protein-coupled receptor 56	0.017
Matn4	matrilin 4	0.017
Notch3	Notch gene homolog 3 (Drosophila)	0.017
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.016
Fgf3	fibroblast growth factor 3	0.016
Adam3	a disintegrin and metallopeptidase domain 3 (cyritestin)	0.016
Kank3	KN motif and ankyrin repeat domains 3	0.016
Satb2	special AT-rich sequence binding protein 2	0.016
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.016
Acan	aggrecan	0.016
Lrrc56	leucine rich repeat containing 56	0.016
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.016
Tcfcp2l1	transcription factor CP2-like 1	0.016
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.016
Hapln1	hyaluronan and proteoglycan link protein 1	0.016
Acvrl1	activin A receptor, type II-like 1	0.015
Spint1	serine protease inhibitor, Kunitz type 1	0.015
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.015
Pip5k1b	phosphatidylinositol-4-phosphate 5-kinase, type 1 beta	0.015
Tcf15	transcription factor 15	0.015
Esrp1	epithelial splicing regulatory protein 1	0.015
Sult4a1	sulfotransferase family 4A, member 1	0.015
Cachd1	cache domain containing 1	0.015
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.015
Esrrb	estrogen related receptor, beta	0.015
Pdgfb	platelet derived growth factor, B polypeptide	0.015
Itgb4	integrin beta 4	0.015
Hoxa5	homeobox A5	0.015
Sct	secretin	0.015
Arhgef16	Rho guanine nucleotide exchange factor (GEF) 16	0.015
Cblc	Casitas B-lineage lymphoma c	0.014
Robo4	roundabout homolog 4 (Drosophila)	0.014
Adamts20	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20	0.014
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.014
Tead2	TEA domain family member 2	0.014
Cabp7	calcium binding protein 7	0.014
Ushbp1	Usher syndrome 1C binding protein 1	0.014
Bmp6	bone morphogenetic protein 6	0.014
Wnt7b	wingless-related MMTV integration site 7B	0.014
Npas1	neuronal PAS domain protein 1	0.014
Hoxa4	homeobox A4	0.014
Gh	growth hormone	0.014
Kitl	kit ligand	0.014
Mgat1	mannoside acetylglucosaminyltransferase 1	0.014
Lad1	ladinin	0.014
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.014
Tgfb2	transforming growth factor, beta 2	0.014
Cd34	CD34 antigen	0.014
Sox10	SRY-box containing gene 10	0.014	Mouse
Rarb	retinoic acid receptor, beta	0.014
Edn3	endothelin 3	0.013
Ribc1	RIB43A domain with coiled-coils 1	0.013
Hspa12b	heat shock protein 12B	0.013
Pkd1	polycystic kidney disease 1 homolog	0.013
Lrp2	low density lipoprotein receptor-related protein 2	0.013
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.013
Mcam	melanoma cell adhesion molecule	0.013
Epha4	Eph receptor A4	0.013
Ovol1	OVO homolog-like 1 (Drosophila)	0.013	Fly
Ppy	pancreatic polypeptide	0.013
Fhl3	four and a half LIM domains 3	0.013
Rgl2	ral guanine nucleotide dissociation stimulator-like 2	0.013
Eng	endoglin	0.013
Col15a1	collagen, type XV, alpha 1	0.013
Foxi3	forkhead box I3	0.013
Hnf1b	HNF1 homeobox B	0.013
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.013
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.013
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.013
Crabp2	cellular retinoic acid binding protein II	0.013
Rnf208	ring finger protein 208	0.012
Dhh	desert hedgehog	0.012
Igf2	insulin-like growth factor 2	0.012
Pou3f4	POU domain, class 3, transcription factor 4	0.012
Vash2	vasohibin 2	0.012
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.012
Rb1	retinoblastoma 1	0.012
Morn3	MORN repeat containing 3	0.012
Wdr78	WD repeat domain 78	0.012
Zbtb46	zinc finger and BTB domain containing 46	0.012
Otx1	orthodenticle homolog 1 (Drosophila)	0.012
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.012
Epas1	endothelial PAS domain protein 1	0.012
Plcb2	phospholipase C, beta 2	0.012
Pla2g4f	phospholipase A2, group IVF	0.012
Il17re	interleukin 17 receptor E	0.012
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.012
Tspan1	tetraspanin 1	0.012
Zfp703	zinc finger protein 703	0.012
Ifi27l2b	interferon, alpha-inducible protein 27 like 2B	0.012
Crb3	crumbs homolog 3 (Drosophila)	0.012
Col1a1	collagen, type I, alpha 1	0.012
Sncg	synuclein, gamma	0.012
Ppfia3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	0.012
Hoxb6	homeobox B6	0.011
Cldn11	claudin 11	0.011
Cdh5	cadherin 5	0.011
Lrrc46	leucine rich repeat containing 46	0.011
Obsl1	obscurin-like 1	0.011
9030409G11Rik	RIKEN cDNA 9030409G11 gene	0.011
Tead4	TEA domain family member 4	0.011
Igsf10	immunoglobulin superfamily, member 10	0.011
Lhx2	LIM homeobox protein 2	0.011
Gyltl1b	glycosyltransferase-like 1B	0.011
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.011
Fzd8	frizzled homolog 8 (Drosophila)	0.011
Tek	endothelial-specific receptor tyrosine kinase	0.011
Ephb4	Eph receptor B4	0.011
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.011
Ugt8a	UDP galactosyltransferase 8A	0.011
Arhgap8	Rho GTPase activating protein 8	0.011
Mab21l1	mab-21-like 1 (C. elegans)	0.011
Rgnef	Rho-guanine nucleotide exchange factor	0.011
Shroom3	shroom family member 3	0.011
Zic1	zinc finger protein of the cerebellum 1	0.011
Neurog2	neurogenin 2	0.011
Vill	villin-like	0.011
Tnp1	transition protein 1	0.011
4930412F15Rik	RIKEN cDNA 4930412F15 gene	0.011
Tsx	testis specific X-linked gene	0.011
Bmp5	bone morphogenetic protein 5	0.011
Zfp503	zinc finger protein 503	0.011
Tmem100	transmembrane protein 100	0.011
1700008P20Rik	RIKEN cDNA 1700008P20 gene	0.011
Gcom1	GRINL1A complex locus	0.011
Hoxc4	homeobox C4	0.011
Tmem184a	transmembrane protein 184a	0.011
Wnt3	wingless-related MMTV integration site 3	0.011
Ivl	involucrin	0.011
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.011
Id4	inhibitor of DNA binding 4	0.011
H1foo	H1 histone family, member O, oocyte-specific	0.010
Irx2	Iroquois related homeobox 2 (Drosophila)	0.010
Wnt7a	wingless-related MMTV integration site 7A	0.010
Tmeff1	transmembrane protein with EGF-like and two follistatin-like domains 1	0.010
Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	0.010
Mrc2	mannose receptor, C type 2	0.010
Ribc2	RIB43A domain with coiled-coils 2	0.010
Sox8	SRY-box containing gene 8	0.010	Mouse
Myl7	myosin, light polypeptide 7, regulatory	0.010
Nes	nestin	0.010
Cby1	chibby homolog 1 (Drosophila)	0.010
Lefty1	left right determination factor 1	0.010
Gal3st1	galactose-3-O-sulfotransferase 1	0.010
Hoxd13	homeobox D13	0.010
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.010
Krt7	keratin 7	0.010
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.010
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.010
Apln	apelin	0.010
Wnt4	wingless-related MMTV integration site 4	0.010
Mfsd6l	major facilitator superfamily domain containing 6-like	0.010
Fgfrl1	fibroblast growth factor receptor-like 1	0.010
Dusp9	dual specificity phosphatase 9	0.010
Plekhg6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.010
Hmga2	high mobility group AT-hook 2	0.010
Mfap4	microfibrillar-associated protein 4	0.010