IMP

Process View

Mus musculus

8 genes annotated in mouse

Multi-species View

negative regulation of interleukin 2 production

GO:0032703

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of interleukin 2 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of interleukin 2 production" (in gray)

Name	Description	Probability	Func Analog Organism
Gata6	GATA binding protein 6	0.975	Mouse
Cd80	CD80 antigen	0.905
Irf1	interferon regulatory factor 1	0.841
Gata4	GATA binding protein 4	0.427	Mouse
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.404
Sox4	SRY-box containing gene 4	0.367
Pycard	PYD and CARD domain containing	0.340
Pdcd1	programmed cell death 1	0.311
Ikzf1	IKAROS family zinc finger 1	0.238
Socs1	suppressor of cytokine signaling 1	0.225
App	amyloid beta (A4) precursor protein	0.199
Il27ra	interleukin 27 receptor, alpha	0.172
Dmap1	DNA methyltransferase 1-associated protein 1	0.170
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.167
Il2	interleukin 2	0.161
Foxp2	forkhead box P2	0.150	Mouse
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.125
Tbx5	T-box 5	0.116
Foxp1	forkhead box P1	0.111	Mouse
Zfpm2	zinc finger protein, multitype 2	0.104
Foxp3	forkhead box P3	0.085
Dll1	delta-like 1 (Drosophila)	0.085
Tcra	T-cell receptor alpha chain	0.081
Card11	caspase recruitment domain family, member 11	0.081
Cd28	CD28 antigen	0.080
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.073
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.073
Gata5	GATA binding protein 5	0.068	Mouse
Foxn1	forkhead box N1	0.065
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.064
Ifngr1	interferon gamma receptor 1	0.052
Prf1	perforin 1 (pore forming protein)	0.049
Ep400	E1A binding protein p400	0.048
Il4	interleukin 4	0.047
Stat6	signal transducer and activator of transcription 6	0.046
Il2rb	interleukin 2 receptor, beta chain	0.045
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.044
Cd44	CD44 antigen	0.044
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.043
Myb	myeloblastosis oncogene	0.041
Aplp2	amyloid beta (A4) precursor-like protein 2	0.039
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.038
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.038
Mefv	Mediterranean fever	0.036
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.035
Ttc7	tetratricopeptide repeat domain 7	0.033
Tbx21	T-box 21	0.033
Tnip1	TNFAIP3 interacting protein 1	0.033
Atxn1	ataxin 1	0.032
Cd5	CD5 antigen	0.031
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.031
Ifng	interferon gamma	0.031
Max	Max protein	0.029
Hr	hairless	0.029
Cyp26c1	cytochrome P450, family 26, subfamily c, polypeptide 1	0.027
Gli2	GLI-Kruppel family member GLI2	0.026
Arid1b	AT rich interactive domain 1B (SWI-like)	0.025
Lat	linker for activation of T cells	0.024
Plp1	proteolipid protein (myelin) 1	0.022
Notch3	Notch gene homolog 3 (Drosophila)	0.022
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.022
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.021
Jak1	Janus kinase 1	0.020
Cd4	CD4 antigen	0.020
Zfp362	zinc finger protein 362	0.020
Epha1	Eph receptor A1	0.020
Rgs1	regulator of G-protein signaling 1	0.020
Rel	reticuloendotheliosis oncogene	0.019
Dsg4	desmoglein 4	0.019
Il22	interleukin 22	0.019
Sp110	Sp110 nuclear body protein	0.017
Casp1	caspase 1	0.017
Ctsl	cathepsin L	0.017
Cxcl9	chemokine (C-X-C motif) ligand 9	0.017
Ooep	oocyte expressed protein homolog (dog)	0.017
Cic	capicua homolog (Drosophila)	0.017
Hoxa1	homeobox A1	0.017
Traf6	TNF receptor-associated factor 6	0.016
Opcml	opioid binding protein/cell adhesion molecule-like	0.016
Tcrd	T-cell receptor delta chain	0.016
Batf	basic leucine zipper transcription factor, ATF-like	0.016
Icos	inducible T-cell co-stimulator	0.015
Tbx3	T-box 3	0.015
Clu	clusterin	0.015
Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.015
Tle6	transducin-like enhancer of split 6, homolog of Drosophila E(spl)	0.015
Naip6	NLR family, apoptosis inhibitory protein 6	0.015
Cd274	CD274 antigen	0.014	Mouse
Cd160	CD160 antigen	0.014
Rc3h1	RING CCCH (C3H) domains 1	0.014
Rxra	retinoid X receptor alpha	0.014
Inhba	inhibin beta-A	0.014
Ubd	ubiquitin D	0.014
Dusp2	dual specificity phosphatase 2	0.013
Runx1	runt related transcription factor 1	0.013
Wiz	widely-interspaced zinc finger motifs	0.013
Ccl24	chemokine (C-C motif) ligand 24	0.013
Tbx20	T-box 20	0.013
Cxcr2	chemokine (C-X-C motif) receptor 2	0.013
Ticam1	toll-like receptor adaptor molecule 1	0.013
Klf3	Kruppel-like factor 3 (basic)	0.013
Hhex	hematopoietically expressed homeobox	0.013
Il10rb	interleukin 10 receptor, beta	0.013	Mouse
Nlrp3	NLR family, pyrin domain containing 3	0.012	Mouse
Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	0.012
Slamf1	signaling lymphocytic activation molecule family member 1	0.012
Clstn1	calsyntenin 1	0.012
Gsdma3	gasdermin A3	0.012
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.012
Siglece	sialic acid binding Ig-like lectin E	0.012
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.012
Sod1	superoxide dismutase 1, soluble	0.012
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.012
Ncor2	nuclear receptor co-repressor 2	0.011
Bglap	bone gamma carboxyglutamate protein	0.011
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.011
Aim2	absent in melanoma 2	0.011
Nynrin	NYN domain and retroviral integrase containing	0.011
Slamf8	SLAM family member 8	0.011
Tcf3	transcription factor 3	0.011
Sox7	SRY-box containing gene 7	0.011
Il18	interleukin 18	0.011
Prr12	proline rich 12	0.011
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.010
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.010