IMP

Process View

Mus musculus

3 genes annotated in mouse

dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	1.000
Trp63	transformation related protein 63	0.940	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.925
Mdm2	transformed mouse 3T3 cell double minute 2	0.910	Human
Mdm4	transformed mouse 3T3 cell double minute 4	0.907
Apc	adenomatosis polyposis coli	0.881
Rb1	retinoblastoma 1	0.867
Pten	phosphatase and tensin homolog	0.845
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.775
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.597	Human
Kit	kit oncogene	0.528
Trp73	transformation related protein 73	0.479	Mouse
Col1a1	collagen, type I, alpha 1	0.436
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.410
Rara	retinoic acid receptor, alpha	0.402
Brca1	breast cancer 1	0.383
Daxx	Fas death domain-associated protein	0.321
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.317
Sox9	SRY-box containing gene 9	0.296
Thbs1	thrombospondin 1	0.288
Fgfr2	fibroblast growth factor receptor 2	0.265
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.261
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.241
Braf	Braf transforming gene	0.224
Meox2	mesenchyme homeobox 2	0.182
Vhl	von Hippel-Lindau tumor suppressor	0.169
Sfn	stratifin	0.135
Rxra	retinoid X receptor alpha	0.132
Skil	SKI-like	0.130
Esr2	estrogen receptor 2 (beta)	0.118
Runx1	runt related transcription factor 1	0.107
Nf1	neurofibromatosis 1	0.096
Hif1a	hypoxia inducible factor 1, alpha subunit	0.088
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.075
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.075
Brca2	breast cancer 2	0.075
Ptch1	patched homolog 1	0.073
Rag1	recombination activating gene 1	0.072
Psen1	presenilin 1	0.072
Esr1	estrogen receptor 1 (alpha)	0.060
E2f1	E2F transcription factor 1	0.053
Nf2	neurofibromatosis 2	0.051
Stk11	serine/threonine kinase 11	0.047
Ahr	aryl-hydrocarbon receptor	0.045
Ccnd1	cyclin D1	0.043
Shh	sonic hedgehog	0.043
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.040
Dsc3	desmocollin 3	0.038
Emx2	empty spiracles homolog 2 (Drosophila)	0.034
Krt14	keratin 14	0.034
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.034
Hipk1	homeodomain interacting protein kinase 1	0.033
Smn1	survival motor neuron 1	0.031
Smad3	MAD homolog 3 (Drosophila)	0.031
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.030
Rbl1	retinoblastoma-like 1 (p107)	0.027
Vegfa	vascular endothelial growth factor A	0.027
Atm	ataxia telangiectasia mutated homolog (human)	0.026
Irf6	interferon regulatory factor 6	0.026
Mybl2	myeloblastosis oncogene-like 2	0.026
Hr	hairless	0.025
Gli3	GLI-Kruppel family member GLI3	0.025
Tsc1	tuberous sclerosis 1	0.025
Yap1	yes-associated protein 1	0.024
Xpa	xeroderma pigmentosum, complementation group A	0.020
Hhat	hedgehog acyltransferase	0.019
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.019
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.018
Msh2	mutS homolog 2 (E. coli)	0.017
Lef1	lymphoid enhancer binding factor 1	0.017
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.017
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.017
Tcf3	transcription factor 3	0.016
Nfya	nuclear transcription factor-Y alpha	0.016
Rarb	retinoic acid receptor, beta	0.016
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.016
Bcl2	B-cell leukemia/lymphoma 2	0.015
Mta2	metastasis-associated gene family, member 2	0.014
Notch2	Notch gene homolog 2 (Drosophila)	0.014
Sin3a	transcriptional regulator, SIN3A (yeast)	0.013
Gata3	GATA binding protein 3	0.013
Cdk2	cyclin-dependent kinase 2	0.013
Kitl	kit ligand	0.013
Cdx2	caudal type homeobox 2	0.012
Men1	multiple endocrine neoplasia 1	0.012
Isl1	ISL1 transcription factor, LIM/homeodomain	0.012
Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	0.011
Tgfb1	transforming growth factor, beta 1	0.011
Rnf111	ring finger 111	0.011
Egfr	epidermal growth factor receptor	0.011
Krt19	keratin 19	0.011
Cxcr4	chemokine (C-X-C motif) receptor 4	0.011
Ar	androgen receptor	0.011
Bard1	BRCA1 associated RING domain 1	0.011
Bcl2l1	BCL2-like 1	0.011
Lrp6	low density lipoprotein receptor-related protein 6	0.011
Adam17	a disintegrin and metallopeptidase domain 17	0.010
Gtse1	G two S phase expressed protein 1	0.010
Lrdd	leucine-rich and death domain containing	0.010	Human
Wrn	Werner syndrome homolog (human)	0.010
Trpc2	transient receptor potential cation channel, subfamily C, member 2	0.010